Q2 2022 Akoya Biosciences Inc Earnings Call
Thank you for standing by and welcome to the COIL Biosciences second quarter 2022 earnings conference call. At this time, all participants are in listen-only mode. After the speaker's presentation, there will be a question and answer session. To ask a question during the session, you'll need to press star 1-1 on your telephone. As a reminder, today's program may be recorded. And now I'd like to introduce your host for today's program, Priyam Shah, head of investor relations. Please go ahead.
Thank you, operator, and thank you to everyone who is joining us today on this call.
I'm Priyam Shah, Head of Investor Relations at Aquia Biosciences. On the call today we have Brian McKelligan, Chief Executive Officer, and Joe Driscoll, Chief Financial Officer.
Earlier today, Okoye released financial results for the second quarter and at June 30, 2022. A copy of the press release is available on the company's website.
Before we begin, I'd like to remind you that management will make statements during this call that include forward-looking statements within the meaning of federal securities laws, which are made pursuant to the Safe Harbor provisions of the Private Securities Litigation Reform Act of 1995. Any statements contained in this call that relate to expectations or predictions of future events, results, or performance are forward-looking statements. No results may differ materially from those expressed or implied.
in the forward-looking statements due to a variety of factors. For a list and description of the risks and uncertainties associated with the COIAS business, please refer to the risk factors section of Re Form 10-K filed with the Securities and Exchange Commission on March 15, 2022. We urge you to consider these factors, and you should be aware that these statements should be considered estimates only and are not a guarantee of future performance.
This conference call contains time-sensitive information and is accurate only as of the live broadcast today, August 8, 2022. The COIA disclaims any intention or obligation, except as required by law, to update or revise any financial projections or forward-looking statements, whether because of new information, future events, or otherwise.
Lastly, the coil will be participating in the UBS genomics 2.0 and the Canada growth conference this week. And we hope to see many of you in person, either in Dana point. Or Boston, and with that, I'll turn the call over to Brian .
Thank you Priyam and good afternoon to everyone and thank you for joining us today. Aquia had a very strong first half of 2022 and the second quarter was highlighted by the continuation of the successful commercial launch of our new phenotype perfusion system.
We reported record revenue of $17.9 million, representing a 37 percent growth compared to the second quarter of 2021.
We achieved success globally across multiple categories with record revenue and products and services.
We sold a total of 60 inert instruments in the second quarter consisting of 16 phenocyclers and 44 phenoimagers representing a 94% growth in placements from the prior year period.
And we ended the quarter with an install base of over 800 instruments.
This large install base
is a confirmation of our strong success to date. In addition, the rapidly accelerating publications featuring the Aquarius platform, now over 600 to date, nearly a doubling from a year ago.
is a key indicator that this trend will continue.
Our second quarter was further highlighted first with the announcement of our groundbreaking spatial companion diagnostic partnership with AcroVent Therapeutics.
further highlighted first with the announcement of our groundbreaking spatial companion diagnostic partnership with AcroVant Therapeutics. Second,
AZT were the first spatial biology company to demonstrate true multi-omic capabilities measuring both RNA and protein in a high-plex on the same slide.
These two milestones and our strong Q2 performance clearly demonstrate that, as a company solely focused on spatial biology, our diversified portfolio is seeing strong adoption and delivering meaningful value.
Discovery, Translational, and now Clinical Markets.
At the core, the speed and robustness of Acoia's industry-leading optics and cycling technologies are enabling whole-slide single-cell spatial phenotyping to become the go-to method for unbiased tissue analysis.
We are addressing key discovery and clinical questions in areas such as immunology, oncology, neurobiology, infectious disease, transplant medicine, and more.
Our continued and growing success in the downstream translational and clinical markets.
is a byproduct of the expanded utilization of digital pathology.
and spatially based biomarker strategies in ecology and...
the unique capabilities of our Fino Imager HD workflow to meet these requirements.
As I noted earlier, we recently announced an exclusive partnership
with Acrobon Therapeutics to co-develop a first-of-its-kind spatial signature companion diagnostic called the OncoSignature test.
The Oncosignature companion diagnostic will be used to identify cancer patients.
most likely to respond to AcroBahn's developmental agent ACR368.
a targeted DNA damage response inhibitor, entering phase two patient selection trials for platinum-resistant ovarian, endometrial, and bladder cancers.
The oncosignature test will leverage the spatial phenotyping capabilities of the pheno imager HT to localize and quantify.
the expression of clinically relevant protein biomarkers that signal response to acrobinase drug.
Once approved, OncoSignature will enable physicians to identify potential responders to ACR368.
prior to prescribing the drug.
together.
Aquoia and Acrovan will advance the Aqua signature test through development to commercialization.
This partnership provides our other bioforma partners the confidence and evidence.
Okoye has the internal expertise and capabilities to deliver on the necessary diligence and audits, development and validation work, and commercialization.
to deliver on a companion diagnostic program.
Our advanced biopharma solutions CLIA lab out of Marlboro has become a valued resource for our biopharmaceutical partners resulting in meaningful expansion of our pipeline and programs with industry leading oncology companies.
Since formally launching ABS and achieving this CLIA certification last year, we have scaled that organization to meet this growing demand and are optimistic for its continued and expanding contribution to our success in the translational and clinical markets.
Now moving on to the discovery side of our portfolio.
In addition to delivering on a commercial milestone, our focus in Q2 was to demonstrate our progress in expanding the capabilities of the phenocyclo-fusion to deliver ultra-high multiplexing in both RNA and protein applications.
with industry-leading speed and data quality.
at AGBT in June .
Okoye showcased the new data from the phenocyclo-fusion where we demonstrated our new RNA chemistry in both a 100-plex RNA panel and a greater than 100-plex RNA and protein panel on the same tissue.
This first of its kind multi-omic data set on the same tissue sample at single cell resolution.
highlights two unique and powerful capabilities of our system.
First, our phenocycle precisely and rapidly delivers reagents to and from a microscope slide in situ.
rapidly delivers reagents to and from a microscope slide in situ. And second...
The proprietary optics of the fusion deliver high resolution imagery at speed.
This AGBT data demonstration set followed a similar data showcase at AACR in April .
We demonstrated the ability of the fetal cycle diffusion to robustly run a 100-plex
protein spatial phenotyping panel.
The ability to perform whole slide spatial transcriptomics and proteomics with scale and speed at single cell resolution on the same tissue sample represents a major step forward in this field.
Throughout this year and next, we will migrate our 100-plex and multi-omic capabilities from demonstration...lit at the internal e site.
Early access.
to commercialization.
We are also on track to deliver additional advancements to our product portfolio.
providing our customers with ongoing improvements to the industry's most robust spatial phenotyping solution. These include the following.
Later this year and through our partnership with Biotechnique,
We will launch the automation of the RNA-scope chemistry.
on the phenocycle diffusion system.
As many of you know, RNA scope is the industry's most widely adopted solution for spatial RNA.
with over 4,500 publications and thousands of customers.
We anticipate RNA scope will be used primarily for targeted applications and validation studies in the lower plex range and will also provide a QIA.
with access to a new and motivated customer.
In parallel to enabling RNA scope,
we will deliver to our new and existing customers.
and upgrade to their phenocycle diffusion system that will double its throughput.
This capacity increase is part of our ongoing effort to simplify and accelerate our workflow.
For example, we included with diffusion at launch earlier this year a proprietary 30 file compression algorithm.
that converts our terabytes.
image data into a gigabyte file enabling real-time data analysis versus a serial very data intensive process.
This solves a major data storage and management expense and affords Okoye and our customers
the opportunity to focus on downstream interpretation.
And at the end of this year, we will also launch.
our universal chemistry.
This novel assay is a hybrid between our phenocycler and our HT chemistries.
When launched, it will enable rapid panel design and automation for high-volume translational studies and is ideal for validating biomarkers discovered using our Hi-Plex work.
flow. We will also leverage a quiz, antibodies and content and both of these benefits.
we'll drive further pull through on our fetal imager.
So let me now summarize our aggregate workflow and application advancements on the phenocycle diffusion to provide a clear understanding.
of the platform's full capabilities.
So we're first we're further advancing our leadership position and speed with the fusion upgrade later this year that doubles throughput.
Second, we will deliver high-plex multi-omic solutions that work on a single tissue.
enabling more discovery power per SAM.
Finally, we will launch RID scope in our new universal chemistry to enable our customers to rapidly validate the biomarkers discovered on the phenotype of the future.
It's worth reiterating a key point of competitive differentiation for Corey here that is of great benefit to our customers.
This validation work can happen on the instrument that they already have, the fusion, not a separate box requiring a second capital purchase.
That is, they perform discovery studies with high-plex multiomics on the phenotype perfusion and then validate.
using the fusion as a stand alone. This is one solution for both discovery and validation.
So to summarize our updates for the first half of 2022.
We're pleased with our strong financial and commercial performance.
As we continue to expand our leadership position in the spatial biology market, diversify our revenue and broaden our global reach.
We remain focused on the following targeted initiatives for the balance of the year.
First, drive the continued adoption of the PhenoCycloFusion as the best in class in-situ imaging platform. This is a test of the PhenoCycloFusion as the best in-situ imaging platform.
for the spatial discovery market.
Second, drive further workflow and speed improvements as well as launch additional protein panels, RNA capabilities and our new universal chemistry.
Lastly, continue to partner with leading biopharma, medical centers, CROs.
and other industry leaders to drive the adoption of the Pheno Imager HT in the translational and clinical markets and deliver on our AcroVon companion diagnostic partnership.
And with that, I will now turn the call over to Joe to discuss our financial results. Joe.
Thanks Brian . Hello everyone.
As Brian highlighted total revenue for the 2nd quarter of 2022 was 17.9Million as compared to 13.1Million in the 2nd quarter of 2021, representing 37% growth. Year to date revenue of 34.8Million represents 38% growth over the prior year period.
Product revenue, which includes instruments, reagents, and software, was $14.2 million for the second quarter, compared to $10.7 million in the prior year period, representing 33% growth.
Within product revenue, instrument revenue was $9.5 million compared to $6.3 million in the prior year period, representing 51% growth.
We had another strong quarter with 60 total instruments sold, of which 16 were phenocyclers and 44 were from the PhenoImager portfolio.
The total installed base of instruments is now 808 as of June 30th, which includes 212 phenocyclers and 596 pheno imagers.
We are pleased to announce that as of June 30th,
A total of 62 fusion instruments have already been shipped since the commercial launch of the fusion, and we now have a total install base of 55 for the combined phenocycler fusion system.
Solved either as a combined system or upgraded from a previous standalone phenocycler instrument.
The number of combined units is an important metric because this combination is projected to drive significant increases in reagent pull-through.
We continue to track a very impressive fusion to phenocycler attached rate while maintaining our current estimates of 50 to 60% attached rate longer term.
Reagent revenue was 4.5 million for the quarter versus 4.3 million in the prior year period.
Recall that in Q2 of 2021, there was a significant improvement in customer activity as COVID shutdowns started to pull back. And we saw a very sharp increase in our consumables revenue at this time last year as researchers returned to the labs.
In addition, our second quarter reagent revenue this year was somewhat muted by COVID related lab shutdowns in China, particularly in April and May.
With an annualized pull-through in the mid $30,000 range per instrument for both the phenocycler and the pheno imager HT, we project two to three times that amount as the potential pull-through of the combined phenocycler fusion system, given that the increased speed and higher plex will in turn increase utilization. For more information, visit www.mercury.com.
We strongly believe that the future of the Fusion instrument lies in pairing it with the PhenoCycler to really drive the focus from largely discovery to now creating a one-stop shop for discovery and validation.
We expect that the rollout of our higher plex, multi-omic, and universal chemistry solutions throughout 2022 and 2023 will drive further meaningful growth in pull-through and share of wallet across the entire portfolio from the phenocyclar fusion to the pheno imager HT.
We continue to project that annual reagent revenue growth will be 40 plus percent per year for the next several years.
Services and other revenue totaled 3.7 million as compared to 2.4 million in the prior year period, representing 54% growth.
Our advanced biopharma solutions CLIA lab continues to gain significant traction directed to large pharma.
Gross profit was 10.3 million in the second quarter compared to 8.1 million in the prior year period. This resulted in a gross profit margin of 58%.
The promotional pricing to drive early adoption of the fusion had a slight impact on Q1 and Q2 gross margins, along with investments we made in the CLIA service lab to support clinical trial enrollment and enable additional clinical diagnostic partnerships such as Acrobon.
Operating expenses for the quarter totaled 26.7 million as compared to 25.7 million in Q1 of 2022.
Through the remainder of 2022, we will continue to make targeted investments in the company with a near term focus on the commercial launch of the phenotype fusion and R and D efforts to further enhance our speed. Multi-omic menu content and lab service capabilities.
We ended the quarter with approximately $88 million of cash and cash equivalents.
We project that cash will be in excess of 70M as of the end of fiscal 2022, which provides ample runway to continue to invest in the business.
Common shares outstanding are 37.8 million as of June 30th and fully diluted shares, including the impact of outstanding options and warrants, totals 40.3 million.
To summarize, we had another record-breaking quarter with $17.9 million in revenue. We sold 60 instruments in Q2 across the product portfolio, and the sales in the first six months of the Fusion launch have exceeded our expectations.
We remain very confident in our ability to deliver strong growth this year and are increasing our full year 2022 preliminary revenue guidance range to 71 to 74Million as we continue to see tailwinds for our business and the spatial biology market.
Now I'll turn it back over to Brian for closing remarks.
Well, thank you, Joe. And in summary, we're pleased to report a strong quarter and announce exciting new developments as we track the launch of the phenocycle refugia, expand our menu offerings, and build on our first mover advantage in the clinic.
We're thankful for the hard work of our fellow dedicated acquaintance as well as for the support of our customers and shareholders
while Chloe remains well positioned for growth and we're excited about the opportunities that lie ahead as We deliver new spatial solutions from the discovery to the clinical markets
At this point, we will open the call for questions. Operator.
Certainly. Ladies and gentlemen, if you have a question at this time, please press star 1-1 on your telephone. One moment for our first question.
And our first question comes from the line, T.T. Savant from Morgan Stanley . Your question, please. Do not Ever
Hi, this is Neil on for Vegas. We're out from the quarter and the strong instrument placements. To start, I just wanted to dig in on the competitive landscape. So, firstly, your peers have noticed some significant challenges in China as a result of the lockdowns. And given your approximate 70% exposure to the region, could you speak to some of the trends you're seeing today and what's baked into your guide in terms of recovery there?
Yeah, maybe you know, maybe what Joe can this is Brian . Thank you for the question you know, I think maybe what Joe can clarify is is really the extent of our of our exposure because you know why there was some impact or our overall exposure to China isn't huge.
So maybe Joe you want to speak more quantitatively to our the China impact for us in Q2
Sure, so total APEC revenue is about 25% of our total revenue. Out of that, China is going to be 70% of that number, so it's going to be about 16, 17% of our total revenue. So in Q2, what we saw is that instrument sales were very solid, no real issues there. We did have a slowdown in reagent revenue, primarily April and May, because they did have lab shutdowns.
We have such great balance in our revenue streams that we're able to cover that shortfall with other areas. So, overall, you know, it was a little bit of a blip, but we were able to manage through it pretty successfully.
Got it. And following up on the competitive landscape, some peers are going through some major commercial reorgs or reassessments of costs, with some also noting an unexpected mix shift towards spatial images, particularly following the excitement generated from LGBT. Are you seeing any similar trends? And what's driving the more resilient nature of your business versus peers? Well, I mean, let's talk about the last one. I mean, I think I won't comment on our peers. I think what's unique about a COI.
is that we really are single focused on spatial, part one. In part two,
spatial imagers is spatial biology. Those are all of the products that are either coming or those are ours that are not. So that's the direction of the entire market segment. Earlier on there was other methodologies to do spatial biology using additional instruments as a readout. But thisaah burst of Nationals.
I think that migration is something that is recognized across the market. But I think for us, part of our strengths is our entire portfolio has been image-based from the beginning. And the reason why that is necessary
pretty useful and of most power to the customers is because it is the imaging approach that gives you single cell whole slide across the entire tissue.
So the movement to an image-based approach, I think is a recognition that to get the most value out of your dollar and out of your science and out of your study across these precious tissue samples is you've got to maximize your real estate.
That is looking at every single slide across the whole tissue and imaging is the way to do that. And I think what's been instrumental into our success is that we really have the most powerful imaging technology on the market.
that initially came through that phenoptics acquisition that is in the HC and it is in the fusion. So that gives us not just speed.
to capture these images, but equally important.
is high quality images.
that give that single cell whole slide data, not just at speed, but also at high quality. That's kind of what we're seeing kind of in our universe, in the market dynamics where we're seeing success.
Great. Thank you for the color. So, turning to your pipeline, you have a number of launches coming up to build upon the breadth of your multi-omics capabilities. How should we teach you about the universal chemistry and the early access launch for 100-plex, serving as a jumping-off point to help set the stage for your 1000-plex launch next year?
Yeah, I think those are.
Maybe just to clarify, just as we think about our product launches, the value of the universal chemistry is really invalidation going from validating biomarkers to validating biomarkers.
on the protein side to then scaling those up for high volume, high throughput assay.
And so the value that this universal chemistry brings the customers.
is it not only simplifies automation, it speeds up panel design, but it also gives them opportunity to choose from a suite of already proven antibodies that we have in our current phenocyclic portfolio because it is a combinatorial approach.
So universal chemistry really is about us accelerating panel design and panel validation on the fusion standalone on the HT as a following one to the discovery work you do in HiPlex.
So that's the value to the customers, the value to us, it really drives pull through.
because we're getting antibody and detection reagents and we're hopefully driving increased utilization as that universal chemistry gets to launch becomes more prominent.
So that's the value of the universal chemistry. And on the RNA side, just to clarify, the RNA scope, we're tying that to the fusion 2.0 launch that I kind of referenced.
on the call, so we have kind of one full upgrade.
That's when the RNA-Scope partnership is going to be rolled out. And then the 100 Plats will start working with customers.
to give them visibility into our spatial transcriptomics approach, a higher-plex approach, so that when we hit the market in 2023, we've got a rich set of customers that are ready poised, ready to run. But what we'll also have is a really large install base.
of phenocycle refusions already up and running ready to catch that product.
and really catalyze utilization with quick speed out of the gate.
the clarification there and one last one from me from the AcroVox partnership. Could you provide more details on the scope of that agreement? Should we be expecting any major milestones and should this be due to the template for more of such partnerships in the future? That's a great question. Thank you for asking that. In reverse order, it absolutely is a template and I think it's a template in two regards. In terms of the nature of the agreement, it really is a classic companion diagnostic agreement with milestones.
throughout and up to commercialization. So not gonna really get into the specifics of the dollars and timing, but it is a template in that regard. But it's also a template that Acoia has now codified and established in being able to prove our capabilities with our platform, with our quality systems, with our regulatory expertise, our supply chain and manufacturing, our personnel, et cetera, that we now have a template.
that we can give other partners the confidence and belief.
that we can deliver on companion diagnostic partnerships. So it's sort of a template, I think, in two regards, Neil.
Got it. Thank you for the timing and on this round quarter. Thank you.
Thank you. And our next question comes from the line. Julia Chen from JP Morgan, your question, please.
So my first question is about the universal chemistry and the high-plex RNA transcriptomic platforms. So I'm just curious, could you share with us any initial insights from customer feedback? Like, what would be the proof of ramp-up look like for both the universal chemistry and the high-plex RNA? So I'm curious, could you share with us any initial insights from customer feedback? Thanks.
Is it going to be like the same scale as the current consumables or it's going to be faster? I'm just curious, you know, especially the data after the HBT. Yeah. Thank you. It's a great question Amy. Thank you I'm on the universal chemistry. I think you should think of that as a migration From the prior chemistry to the new chemistry for existing customers and then for new customers of the HT Where they will likely start?
So in terms of the universal chemistry's pull through impact on the HT system, it's going to be a gradual but meaningful process. And we've not given any specific guidance and quantified the impact of it. But as I alluded to in Neil's questions, I think in describing the qualitative benefit to the customers, we think it's going to be received very well. And on the high plus RRA side, one of the reasons why we look at
We've talked about on prior calls and that Joe alluded to, one of the reasons why we look at the attractiveness of the phenotype of the fusion pull-through isn't just because we're scaling up the speed, we're scaling up the protein flexing, but also that we're going multinomics, we'll be layering in our own RNA reagent. So it really is the aggregate of those increases in speed, layering in protein, layering in RNA and multinomics and delivering high quality.
images at speed. That's why we're talking about over time the 2 to 3x pull through on the phenocycler fusion relative to the phenocycler with a third-party microscope.
So again, you know don't mean to dodge the question maybe but we've not called out and quantified the high plex RNA pull through explicitly yet Also in part Amy because you know, we're doing a lot of ways to customers to really understand what they want
first and foremost from our platform.
We suspect it's really multi-omic, same slide, both RNA and protein, so they no longer choose between analytes, that it's all there on the same slide, rather than different slides, one for RNA and one for protein. But we're also trying to understand what Plex levels.
that they desire. Is it the thousand? Is it hundreds? So there's a lot of additional work that we're doing as we advance the technology on final product configuration.
Okay, thank you very much. My last question is on the cash. I appreciate you guys really prudent with the cash while expanding the pipeline, the development. I'm just curious, could you give me an update on the cash burn for this year and the years forward? Thanks. Yeah, that's the best question.
Yeah, Joe, you want to maybe speak to that.
Sure, so we have $88 million of cash as of the end of Q2. That's really more than two years of cash. So that gives us plenty of runway to continue to invest in the business. We don't need to do anything right away in terms of a fund raise, but we're going to continue to be opportunistic and look at opportunities to raise a small amount in the market if conditions are favorable over the next 12 to 15 months.
We're confident where we are right now with our cash position and, you know, as I said, we're going to continue to look at opportunities to boost that a little bit.
Yeah, and I think, Amy, the other thing to look at is.
We continue to see strong growth in the business.
You know just under 40% and and we're going to continue to Respond to our performance and the business and the market conditions. So, you know if we continue to outperform and show these improvements in our in our top line and
You know, show margin improvement, it's going to continue to dramatically reduce and mitigate any additional needs.
for financing and that's kind of how we've been tracking. So hopefully that helps.
Yeah, that's very helpful. I really appreciate it. Yeah.
Thank you. And our next question comes from the line of Kyle Nixon from Canda Corps Genuity. Your question, please.
Hey guys, thanks for taking the questions. Apologies for anything that has already been asked about the teletraun.
Can you just talk about like the traction of the interest among the genomics labs like the course etc. that you're seeing today and how that's evolved in recent quarters.
Well, it's a great question, Kyle. You know, and it's, I'm going to, I'm going to take some liberties to pull back a little bit and say there's.
So, I have a bug in the marketplace around products that sometimes.
Unless you're living in the forest in the weeds like we are, maybe you don't see the forest. Sometimes I think there's a...
a conflation of future products.
versus current products. So right now we are marching towards delivering a multi-omic solution.
But right now our product today is still focused on Hyplex protein.
And so the genomics customers that have interest in us have an explicit interest to layer in single cell whole slide high-plex protein.
Now, there's going to be some early movers that recognize that we're going into the genomic space here in short order, so there's going to be some early movers.
But overwhelmingly, our existing customer base are cores and customers that understand high-plex protein, that understand flow, that are interested in cell. Not for example, like you might see with some of our other peer companies, not really focused on genomics customer base. That said, that's going to change pretty rapidly as soon as we come out with products that do.
target that genomic segment. So we'll be actively participating in existing products with projects with those customers.
Okay, thanks, Brian . And then just kind of jumping off of all this buzz from ADBT, it sounds like there's quite a bit of interest in single cell and sub cell spatial. Any sense, perhaps sustainable that is, and where does the demand mix kind of shake out between profiling platforms for discovery and then the imagers that are more suitable for translational work? How do you think that kind of shakes that over time, Brian ? How do we think the market shakes out in terms of the needs for discovery versus translational customers, imager, non-imager? I just want to maybe make sure I'm addressing your question.
That's my opinion. That the future of spatial biology is going to be an imaging-based readout.
The difference between what a discovery customer wants versus what a translational customer wants, I think simply put really has to do with scale of plaques versus scale of sample.
So your discovery customer really wants
to maximize.
every single sample with a project that's going to be 10, 30, 40 samples, something like that.
Your translational customer is really now validating those discoveries on a smaller subset of markers and marching those farther downstream.
So that's kind of how we look at it. So there's gonna be an existing population...
of customers that may want to do readouts on other methodologies like a sequencing based readout, but I think that's a small minority in the future, maybe 10% of spatial on the discovery side.
But I think the real difference to reiterate between a discovery and a translational customer has to do with scale of throughput and desires around level of flex.
So we think the discovery customers want really high-plex, multi-omic, same slide, and then the ability to validate those. That's why we designed the phenocycle diffusion to be able to do that discovery and validation on the same system.
And then the same chemistry, the same imaging methodologies, the same universal chemistry, you can take those validated marker sets and move those to the HT system for much higher throughput, latter states translational studies to clinical.
So that's our approach is to try to own that continuum from discovery all the way through clinical.
and have non-overlapping products, so they stay on our portfolio as they move from one stage to the next.
Okay, are you seeing like a market shift right now at all? We're hearing that from others.
I say that that's the neighborhood we've only lived in.
Kyle, we've always only been imaging based.
And I think what you're going to see is that that's going to be the growing market requirement.
that people recognize, I think as
I think as Neil was asking, as people recognize that to get real high powerful spatial data
Imaging is the way to do that.
And that's the only way we've done it from the beginning. We're just continuing to improve on that.
Okay, perfect. V.P., just thinking about the near-term outlook, so the guidance was increased. Could you guys talk about what that kind of takes in for the acceleration of the fusion placements? Maybe that assumes a good deceleration. Good question.
It doesn't assume a deceleration. I think from an instrument sense, it's following what you would...
the near-term outlook, so the guidance was increased. Could you guys talk about what that kind of takes in for the acceleration of fusion placements, maybe that assumes a deceleration?
It doesn't assume a deceleration. I think from an instrument sense, it's following what you would expect from us.
based on first half and how we kind of seasonally move to the second half.
No, there's no deceleration in our fusion forecast. We're trying to maintain a very conservative posture in our guidance. We want to make sure we...
Beat and exceed every single quarter, so I wouldn't read into it too much other than we're trying to be very conservative and make sure we hit our numbers every quarter.
Okay, and then Joe, just the last one from me. So pull through looks like that was a little bit softer in the second quarter.
I'm doing math right now. I know that I'm sure there's a bunch of reasons why that would have been, but were there any other factors at play besides the placement strength and then probably more new users as well? Cuz you still have the guidance of like 40% growth of the long term. So I mean obviously the core is still strong, underlining strength, and templers, just curious what happened this quarter.
Very specifically, it was the China issue, so that impacted our reagent revenue in Q2. That far and away was the biggest issue in Q2. April and May were very light in terms of China reagent revenue, and we're expecting that to recover as the year moves along.
And Kyle for the first time, he's an aggregate, excuse me.
For the first half an aggregate, our reagent revenue growth is 40%. So I think we'll maintain that.
through second half.
Thanks, guys. Appreciate it. Thanks, guys.
Thank you. As a reminder, if you have a question at this time, please press star 11 on your telephone. One moment for our next question.
And our next question comes from the line of Mark Massaro from BTIG. Your question, please.
Hey, Brian and Joe, thanks for the questions. Congrats on the beaten raise. I guess you guys have a pretty diversified suite of customers ranging across core labs and academic medical centers, biopharma companies, CROs, and now selling into genomics customers. So I guess like in light of some macroeconomic concerns and potential budget constraints at any of these end users, can you just maybe
touch on what you're seeing. Obviously, you raised the guidance. I have to imagine that you carried over the beat a little bit, but maybe on the second half, how do you see budgets and macro potentially impacting your business?
Well, I would just say, thanks for the question, Mark. I would say, per Joe's prior comment, as you noted, while we've got a really diversified portfolio that hits across multiple market segments.
Instruments reagent software services.
You know that gives us lots of opportunities for growth and we're hitting across all of those and so that that buffers exposure
Our products are really not overlapping, so we don't, you know, with this diversified portfolio across multiple market segments, we don't see really any cannibalization.
So to the extent there's budgetary impact, I think we've got a lot of ways to respond. With capital purchases, for example, looking strained, we've got a really robust service business.
And so that affords us some buffer to any macro changes, but also, as was noted earlier, there's a growing recognition that an imager-based approach is a natural way of looking at the
is really what the market wants. And as I noted earlier, that's kind of the address we've been sitting in. And I think that's helping keep us.
really in a highly competitive position. And we're maintaining a conservative posture for second half just to make sure we protect against some of these macro things. So, you know, there's multiple legs to the stool and that's kind of how we're approaching it kind of in a very thoughtful manner. I hope that makes sense.
Yes, it does. Maybe one more two-part question. As you're planning to roll out the phenocycler from 50 to 100-plex, what's left remaining to do in order to ensure a successful launch? And then the second part is, is there any update on the work with PathAI and anything we can look forward to over the coming quarters? Yeah, on the PathAI front, I mean, those... All that stuff's confidential, but we've got really a great interactive partnership with them.
handoff, nothing yet that I think we can speak to externally. And to your question around the rollout from the 50 to 100, it's actually already happening. It's a gradual walk where customers prior could do a 40, 50-plex, now they're unable to do a 60, 70, 80-plex. So those sorts of capabilities are kind of rolling out gradually, Mark, and it's not a single step function. And I think the release...
of the capacity increase and the speed increase that we talked about for the end of the year is gonna further motivate our customers to even go to move into that higher plex.
because they'll be able to get more samples per unit time or more markers per unit time.
Thanks so much for the question.
Thanks, Mark.
Thank you. Our next question comes from the line of David Westenberg from Piper Sandler. Your question, please.
Thank you.
Well, I'll start with the consumables and sorry, I know everyone's hitting on this. It was a great quarter, great placement, but I guess generally speaking, everything's good and the one little count that didn't hit our numbers and of course we pick on that. So are you clear to quantify maybe what China would have done in a quarter? I'm just trying to get a magnitude of quantitatively what that might have done.
I mean, I'll let Joe answer that. I think there's two things to look at in terms of there's a number and then there's the growth percentage.
So let me take the latter one first and Joe can speak to you know how much granularity we want to get into the actual number David but
If you just look at last year, that first half was wild, right? Everything was still shut down in Q1.
So that's a relatively low comp. And what we saw in the first couple of months of Q2 was just this massive surge of orders.
a sort of bent up COVID demand that sort of now started to level out as you got to the rest of Q2 and second out. So there's a bit of a hyper comp as you look at Q2, but in terms of the raw numbers, Joe, you want to speak to that at the level of granularity we're comfortable? Yeah. So, you know, the April and May reductions in China cost us, if you look at what we did in Q1 in China versus what we did in Q2, it's probably 500, 600 grand of consumables revenue that
we went down in China in Q2. So that's the numeric impact. And as Brian said, you know last year's Q2 reagent number was very high. And you know it's very high because it actually came down in Q3 last year. It went from 4.3 million to 3.4. So Q2 of last year was really a kind of a, you know, a very, very big number. So those are a few factors at play here.
And David, as we noted with Kyle, David, as we get into the second half, we are projecting the continued 40%.
growth year over year.
Just to clarify. Got it. Yep. And then I guess the other, you know, you kind of answered it with Mark two on, on, on, on kind of, uh, what we're looking at in the second half and macro, but, you know, I think a lot of your peers, and I guess I'm just kind of reiterating the question, maybe asking it differently. I have really been talking about the slowdowns in Europe . Um, it definitely seems like in your guidance, you're not seeing that same kind of thing. Is there something specific with maybe your portfolio that makes you more?
or maybe I should say less susceptible to some of those slowdowns in Europe because it doesn't really seem to have as much rhyme and reason. It just seems like blanket every instrument companies have struggles there.
Well, I think I'll just reiterate what we said to Mark. We've got a portfolio.
of instruments.
that are really purpose built.
We've got an HT that's really purpose-built for that late translational clinical customer, clinical research customer.
And we have the FENUS Side Curler that is really ideally designed for that early discovery customer.
And then we have the fusion as an instrument.
that really helps bridge that gap.
As you look at the instrument portfolio,
They really stand alone in terms of the market segments that they serve.
So if I walk into the door to see you, I can talk to you about what is your interest.
Are you doing early discovery studies? Do you have something you want to validate? And I can point you to a portfolio. And so I've got a high probability of success.
I think that coupled to the recognition that single-cell whole-slide high-quality images of speed.
The spatial market has matured to where those are a given. And I think we're thankful that that's been our message from the beginning. And as we start layering in RNA and multinomics...
and people seeing where we're going, I think the existing capabilities and what we're doing in the future, I think are giving our customers a lot of hope that purchasing the phenocycle fusion, as an example, is a powerful box today that's also future proof, that we're going into multi-omic, we'll continue to invest in speed, we'll continue to invest in panels. So I think our customers have a lot of confidence, you know, that we'll continue to execute so we better.
Sorry, I was on mute. Got it. That's helpful. And maybe can you mention some of the currency stuff in the quarter too? And then both in the quarter and then also for anticipation the second half of the year because you know, you did again, you reiterate guidance is a good thing, but I just want to kind of quantify some of the stuff that's happening. Yeah, you got that. Yeah.
Yeah, the vast majority of our businesses is in US dollars, so the all the North America business, APAC as well as a good chunk of Europe . So it's a very, very minor impact and it's all baked into the guidance that we've given. So, as we sit here today, not a huge impact from that.
Got it. Maybe I'll just ask one more on the fusion. Good, Ram. How should we think about the launch cadence in terms of a yearly impact? Is this a product that's going to accelerate? Do you see this product as we're doing our 2023, 2024? Is it a lowest hanging fruit kind of thing? Any color there would be helpful. I've taken a lot of your time, so I'll stop there for now. Well, I think it's going to continue to grow, David. It's going to continue to grow on two fronts.
investments.
across the reagent portfolio that we outline, it's going to continue to scale and pull through.
And that's what's going to help drive further diversification of our revenue, smoothing out of the seasonality, and driving equally important.
margins and cash.
That's how we think about the phenocycular fusion really as an apex of our growth and discovery and translational market.
Got it. Thank you, guys.
Got it. Thank you guys. Thanks, David.
Thank you. This does conclude the question and answer session of today's program. I'd like to hand the program back to Brian McKellick for any further remarks.
Well, nothing further. All I would say is just kind of as noted in the closing comments during our opening statements. I just want to thank all of you for your time. Thank our fellow clients, our shareholders, Neil, Amy, Kyle, Mark, David, for your time. Really thank you all for your time and your support, and we look forward to following up with all of you. So have a great rest of your day and evening.
following up with all of you. So have a great rest of your participation at today's conference. This does conclude the program. You may now disconnect. Good day.
The conference will begin shortly. To raise your hand during Q&A, you can dial star 11. The conference will begin shortly. To raise your hand during Q&A, you can dial star 11.
I I have you.
you
you
You.