Q2 2022 IsoPlexis Corp Earnings Call

August 10, 2022

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Good morning, ladies and gentlemen. Thank you for standing by and welcome to ISOPLIX's second quarter 2022 earnings conference call.

At this time, all participants are on the listen-only mode. After the speaker's presentation, there will be a question and answer session. To ask a question during the session, you will need to press the star 1-1.

Please be advised that today's conference may be recorded. I would now like to end the conference over to your speaker host, Carrie Mandeville. Please go ahead.

Thank you.

Earlier today, Isoplexis released financial results for the quarter and did June 30, 2022.

If you have not received this news release, or if you'd like to be added to the company's distribution list, please send an email to investors at isoflexus.com.

Joining me today from Isoplexis is Sean McKay, Chief Executive Officer, and John Straley, Financial Officer.

Before we begin, I'd like to remind you that management will make statements during this call that are forward-looking statements within the meaning of federal security laws.

These statements involve material risks and uncertainties that could cause actual results or events to materially differ from those anticipated. Additional information regarding these risks and uncertainties appears in the section entitled Forward-Looking Statements and the Press Release Isoplexes issued today. For a more complete list and description, please see the Risk Factors section on the company's annual report on Form 10-K filed on March 30, 2022, and on its other filings with the Securities and Exchange Commission.

Except as required by law, isoplexist disclaims any intention or obligation to update or revise any financial projections or forward-looking statements, whether because of new information, future events, or otherwise.

This conference call contains time-sensitive information and is accurate only as of the live broadcast, August 10, 2022.

With that, I'd like to turn the call over to Sean.

Thanks, Kerry. Good morning and thank you everyone for joining us for our second quarter 2022 earnings call. On today's call, I will provide an update on some of the operational and commercial progress we've made to lay the foundation as a leader in the proteomics market with a profitable, sustainable growth business. Then I will turn the call over to John for a closer look at our financial results and revised outlook for 2022.

Our second quarter represented a turning point to streamlining and simplifying our business to create a foundation for leadership in the fast-growing world for improved cell analysis and bulk targeted proteomic lab tools.

We have now reduced our workforce by approximately 35% since the end of Q1 and ended the second quarter with an $18.5 million Opex run rate.

Revenue in the second quarter decreased 7% year over year to $4 million with a 52% gross margin.

Our trailing 12 months revenue is 18.7 million dollars with a 51% gross margin.

The revenue impact in Q2 was driven by a combination of international macroeconomic realities and the previously announced isoplex reduction in force, i.e. the risk.

Driven by our shift to more profitable operations around the whole organization.

In particular, we were affected by 1. The China lockdown, 2. Overall economic slowness and inflationary challenges in Europe , and 3. Our own reorganization and RIF executed in Q2. To be clear, with the RIF, we retained the core innovation and growth assets embedded in the exoplexing culture, which I'll speak about with our lab-empowering CodePlex solution.

We see these macro oriented realities persisting in 2022.

Across many pipeline indicators, we also believe the market-driven depth is temporal and not reflective of the high need that we need.

As we cross the threshold to our 254th unit, with our highly affordable personalized lab system in the benchtop 18 inch footprint isospark,

We are also crossing the threshold to a more mainstream land and expand usage across organizations.

Our lab tools empower labs with effortless automation via easy to use hardware and software to the cells and proteome that drive the biologic and immune-based therapeutics that are changing biotech, pharma, medical centers, and overall human health.

The value of our accessible proteomics and cellular analysis instrumentation tools are beginning to provide critical, affordable lab infrastructure supporting this need for many years to come. Thank you.

Our RIF did provide a temporary disruption to the company as it involved people navigating new positions with around 35% less staff, details of which John will speak to later.

This caused slowness for the first month and a half in the quarter.

Yet our new operating structure is now better equipped to drive healthy, more profitable growth into the future, on top of conserving cash at this critical time in the capital markets.

We are focused on three core initiatives as we streamline our organizational structure. And we are flexible enough at this stage of the company's lifecycle to make a rapid impact in these areas.

One, process optimization in the commercial arena.

driving commercial sales productivity towards more profitable activities that are suited to selling higher volumes of accessible price point, small footprint, proteomic instruments built for any mainstream lab with a commercial group fit for purpose size-wise and according to skill set.

Two, process optimization in the operational arena.

Driving to a higher consumable gross margin in the 70% plus range in the near term, which we are implementing now, we will begin to see progress towards in Q1 2023.

Three, simplification and optimization in development.

We've simplified our broader portfolio to focus on a product we believe deeply in, CodePlex, a high margin, high need economic cell with a clear differentiation in both proteomics.

It's made for this moment in time, and we'll also release this in Q1 2023.

Keep in mind this CodePlex product also runs off our existing instrument with the ISO Spark, providing easy, small footprint access to any lab.

To focus and simplify, we will also de-emphasize Duomic in the beginning of 2023, despite fantastic data, until we establish our both proteomic foothold in the market.

CodePlex has a clear need in a large end market today via voice of customer interviews where Duomix and the wider multi-omic spatial market complexity and volume of new instruments on that market make the immediate timeframe for Duomix less attractive.

In actualizing these three core initiatives,

We achieve financial flexibility as our top line becomes higher margin based. Our OpEx structure makes profit centers out of our three core business areas, instruments, consumables, and services. And we come out with a suite of products that truly act as critical lab infrastructure at a moment in time that requires a shift to more effortless proteomic data.

Focusing on the commercial aspect of our organizational change.

With the right behaviors on instrument sales, we see proteomics end markets as strong with expansion in blue chip biotech pharma driven customer base in Q2.

We sold 20 instruments in Q2, bringing our total instruments to 254.

We are making progress with the BioPharma end market with several repeat purchases from these customers in the second quarter as well.

35% of the units sold in Q2 were to existing customers.

And more than a fourth of total instrument purchases to date are from customers who have bought multiple instruments.

We also now have instruments placed in more than 75% of US comprehensive cancer centers.

To drive profitable instrument sales behavior, we have mapped the value stream to our customers and begun to eliminate unneeded and costly activities to drive efficiencies.

Process improvements include stage-gated sales monitoring and strengthening of our early-stage pipeline through daily management of clarified funnel-based metrics.

Additionally, we have enabled the pipeline in which our sales operations team is feeding the most probable leads into our sales force, which historically closed these instrument opportunities over a four to five month sales cycle.

Additionally, we are optimizing the process to drive consumable usage as our install-based scales leveraging daily management of our trained field application scientist team to drive customer engagement.

Finally, a leaner field service team will drive greater usage of service contracts to build important longer term annuity and recurring revenue base off of our installed instruments.

Moving on to manufacturing operations, we're in the midst of a process to have a leaner, more integrated organization to increase operational productivity. And importantly, realize gains in consumable gross margin. To drive us to the mid 70% range in the near term and later to the 80 plus percentile range.

The main focus to accomplish this is by optimization taking the better part of a year, namely reagent conservation.

One of the benefits of our microfluidic technologies is reagent conservation in manufacturing and during usage on the instrument while maintaining quality. And we're just realizing this potential through our dedicated operational team.

Secondly, we're maturing our consumable supply chain by expanding our number of reagent partners across the board, resulting in a more competitive lower cost structure.

Moving on to development, we simplified our focus from several initiatives to one suite of high value products for early 2023 launch.

We are very focused on becoming critical lab infrastructure with high unmet need for effortlessly automated bulk bench top proteomics with our novel CodePlex product suite.

We believe this to be a blockbuster product for both proteomics and market.

with near-term mass market potential. The product has significant sales potential because of 1. Effortless automation, onboarding users quickly, and maximizing high-value lab resources, saving significant labor costs.

in a labor-constrained immune therapy market.

2. Excellent intra-appet consistency.

Confidence to move quickly to the next step with each sample in low CV triplicate at a higher throughput.

In three, improved lab economics. Ability to run triplicate assays and high throughput at a fraction of status quo cost.

With our cellular analysis products, i.e. single cell proteomics, we're focused on continuing the march as a new behavioral dimension to each cell type analyzed on the 40,000 flow cytometers in existence today.

The unique cell functional behavioral dimension that we add to the cell types or phenotypes captured on flow cytometry continue to prove high utility to labs and predictive response relative to flow cytometry.

We're focused on multiple metrics to expand our use cases that include publications, panels, phenotypes,

all on the affordable isospark system.

We've had a slew of publications in cancer immunology and cell therapy.

across cell types within our cell libraries. With multiple major medicine and cell papers back to back, utility of our cell behavior definitions

of a wide array of immune cells is becoming clear.

We've expanded the functional phenotypes within our cell library, and with that, we've also expanded more panels to run those cell types.

Secondly, as our isospark continues to proliferate at a faster rate than our isolite, it is clear to us that the low price point of the system relative to flow cytometers is going to be critical to penetrating the broader flow market and driving further consumable utilization.

The software also does not require technicians, which is a large benefit as we start approaching more mass-market cell analysis customers.

Last, we are evaluating early data on our system, which expands surface markers per cell, making a product more attractive within the traditional flow market.

We'll have more to discuss on this part of the pipeline in the future.

Our pipeline bulk proteomics products as a point of focus for Q1 2023 release become an important part of isoplex's future as critical lab infrastructure.

For targeted bulk proteomics, we are excited about our new CodePlex product.

which we are now planning to launch in early 2023.

As we work to simplify our business and concentrate on the most relevant solutions sought after today, Codeplex is important because we see this product as critical lab infrastructure around the entire proteomics universe.

We estimate there are roughly 20,000 labs doing some degree of multiplex proteomic work that would be accelerated with our effortlessly automated solution.

Codeplex empowers labs who need access to the proteome, yet have difficulty with the workflow and economics of the systems today.

For the first time, highly multiplexed data will come to market with effortless automation, eliminating a tremendous amount of labor costs for biopharma and biotech, and eventually medical coverage.

We believe CodePlex will form the backbone of many labs' daily proteomic work and the foundation for our product in the coming years.

We've moved single cell multi-omics as behind codeplexing priority based on the market opportunity.

First of all, we have released encouraging dual-mic data in multiple conferences to provide entirely new biology connecting our unique functional proteomic output of the cell and cell behavior metric to gene expression.

We're confident that Duomik will bring significant value to the market and our team worked hard in integrating various Duomik technologies to make this system work.

However, as we discuss the complexity facing customers in the coming months,

Through multi-omic and spatial multi-omic offerings make this market less near-term attractive for our company.

We believe this incredible new biology is better slated to come out after CodePlex, likely later in 2023 as a service.

Isoplexis is on a path to empower a wide range of mainstream labs to leverage the cells in the proteome they need to change the course of human health.

The advantages our ISO code offers, i.e. a new dimension of cell behavior, for every phenotype defined by flow cytometry, provides us a meaningful entry point to 40,000 labs.

In the advantages of CodePlex's effortless automation offers to roughly 20,000 both proteomic labs creates an additional large opportunity next year.

We have put ourselves on the path with differentiated technology advantages in two large markets to have a strong growth lab tools business with a high margin profile in the foreseeable future. Our team continues to make significant progress as we simplify our business.

to create a more profitable growth profile in single cell and bulk proteomics in the coming years.

I will now turn the call over to John for more detail on our financials.

Thanks Sean total revenue for the 2nd quarter of 2022 was 4Million. Down 7% from 4.3Million in the prior year period. As Sean mentioned, our revenue in the quarter was impacted by a few external and internal factors. 1st, with China, continued lockdown and shutdowns were in effect for nearly 80% of the quarter. Continued restrictions will likely have an impact on lab usage and instrument purchasing in broader APAC through the end of 2022.

Additionally, the impact of lingering supply chain headwinds affecting customers, inflationary pressures and economic slowness in Europe and elsewhere impacted our ability to effectively sell our instruments in the region.

These elements are manifested in longer purchasing cycles in Europe .

Second, while it's proven to be effective, our Q1 reorganization and efforts to drive operational efficiencies have taken time to execute and process.

While we are already realizing organizational productivity benefits and have substantially decreased quarterly cash usage for operating expenditures, the human impact of the RIF did take our team a month and a half or so to adjust to. We are focused on our OpEx plan and believe this will create long-term, durable value.

Product revenue was $3.3 million, a 19% decrease compared to $4.1 million in the prior year quarter. Our commercial team sold 20 instruments in the second quarter, which brings the total number of instruments sold to 254 since our commercial launch.

Service revenue for the second quarter was 682,000 compared to 200,000 for the prior year quarter, driven primarily by an increase in collaboration business this quarter.

Gross profit for the 2nd quarter of 2022 was 2.1M dollars. Compared to 2.3M dollars in the same period of 2021 gross margin was 52% in the 2nd quarter compared to 53% in the 2nd quarter of 2021.

Gross margin expansion is one of the key elements of our long-term growth plan and provides financial flexibility by increasing gross profit dollars realized on recurring sales.

As Sean mentioned in his comments, a lot of work has already been accomplished to reduce production costs and diversify the supplier base of our consumable business.

As we continue to leverage the installed instrument base and prove out the razor blade part of our business model with consumables contributing an increasingly higher percentage of our total revenue, we expect our total gross margin to reach the mid 60% range in the near term and eventually settling into the mid 70% range.

Excluding 3.7M of restructuring charges taken in April , operating expenses for the second quarter of 2022 were 22.8M compared to 20.6M in the second quarter of 2021. And importantly, represents a significant decrease from the 30.7M last quarter.

R&D expense was $7.1 million, an increase of $1.6 million over the prior year, and SG&A expense was $15.7 million, an increase of $0.6 million over the prior year period.

We ended the 2nd quarter with an 18.5M total quarterly OPEX run rate. As discussed on our last earnings call, we expect quarterly OPEX to be about 17M by the end of this year as we continue to identify opportunities to achieve additional efficiencies across departments. Importantly of our total Q2 operating expenses, approximately 2.5M were non-cash, primarily consisting of depreciation and amortization and stock based compensation.

We are on track to meet our end of year op-ed goals.

Our efforts to date have focused on four major themes that have contributed to the significant OpEx reduction we have achieved. First, a focus on projects that will generate the most financial benefits of the company over the next couple of years, which led to the April reduction in workforce.

Second, a continuous process to reduce the need for third-party professional services. The investments we've made to hire and train our core teams over the last couple of years has allowed us to provide more services internally as our teams mature and reduce the need for outside consultants.

Third, a concerted effort to reduce internal material consumption as our manufacturing and quality control teams continue to find efficient ways to operate and generate higher gross margin.

Finally, a reduction in support services no longer needed as our staff levels have been reduced in areas such as software licenses and other expenses indirectly related to organizational headcount.

As Sean described, we are focused on a continuous process to assess business activities and reduce costs and inefficiencies across the organization.

Following our reorganization in April , we are continuing to identify efficiencies to further reduce operating expense and leverage our existing infrastructure.

These actions will ensure we maintain a cash runway into mid-2024 and improve our financial profile on a path to profitability quarter after quarter. This includes our modified top line guidance we reported this morning.

We continue to expect our operating expenses to be around 17 million dollars per quarter by year end, bringing our full 2022 operating expense, excluding restructuring charges, to be in the 90 million dollar range, and which includes approximately 9 million dollars of non-cash expense for depreciation and amortization and stock-based compensation.

Our net loss was 25.6 million for the second quarter of 2022 compared to 20.6 million in the second quarter of 2021.

We ended the quarter with $71.6 million in cash on the balance sheet.

In June , we pulled the remaining seven and a half million available to us in our existing credit agreement.

We believe that the cash we have on hand now, coupled with our continuing strategic initiatives, extends our cash runway into mid-2024.

Turning to our revenue outlook for the full year 2022. We now expect revenue for the year to grow by at least 20% over 2021, which is 20.7Million dollars.

We remain confident and excited about our future and outlook. Nothing has changed with our end markets and our fundamentals remain strong. Our organization has made us a leaner, more efficient company which will allow us to continue to deliver high impact products and services, driving top line growth and managing expenses to provide a more clear path to profitability.

At this point, I would like to turn the call back to Sean for closing comments.

Thanks, John . This quarter, we have been focused on our three main initiatives I spoke of earlier. Our mission to empower labs with our cellular and proteomic solutions requires us to continue to execute these initiatives as we evolve the culture of innovation at Isoplexis.

We have strong conviction in our prospects in the coming years and are seeing their uniquely accessible products. This is the time we're in.

Labs need easier access at lower economic costs to accelerate powerful medicines.

And we are confident that our team and product suite will create a great deal of value for our customers, stakeholders, and the broader life sciences field.

With that, we will now open it up to questions.

Thank you ladies and gentlemen, as a reminder to ask a question, you will need to press star 1 1 please stand by. We'll be compiled in a roster.

Now first question coming from the line of Vijay Kumar from Evercore. Your line is open.

Hey guys, thanks for taking my question. Sean, maybe just on the queue itself, so revenues were down year on year. You did cite China macro challenges. What was the China lockdown impact? What percentage of revenues are from China? It does feel like ex-China, perhaps growth slowed down. So maybe just break out China versus non-China. Still the leading

and what's happening in the US and Europe , customer activity? That sounds good, Vijay. So a couple of things. What I'm going to do is I'm going to break down where the revenue deceleration came from. I'll also talk about, I'll start with...

Just generalized, you spoke of the growth and where is the growth. I think you have to take a step back a little bit and think about the lab opportunity ahead, both with this sort of ISO code and CodePlex product suite. From our perspective, our vantage point, we see the ISO code is offering this.

new dimension of cell behavior to with a meaningful entry point with an accessible price point system to about 40,000 cytometry labs right the new code flex system for early next year offers effortless automation to about 20,000 bulk proteomics labs Which does create a large opportunity for us in which what we're starting to see is a very labor constrained biotech and pharma Market, so so you know as far as the opportunity goes we put ourselves in a unique position on a path with differentiated technology

actually more due to

the reduction in force that we had for about 35 percent, reducing in force about 35 percent of the organization. So within the China lockdown, it was just difficult to get the customers, right? Our team was actually, you know, in their apartments unable to get the customers. The usage based on our having our Shanghai headquarters out there, the usage was just very low. And so that was impacted. I think our European challenge was

roughly similar to some other growth players in the space, just based on what we see as economic slowness.

it's lower procurement process, et cetera. US, we still experienced, like I think we talked a little bit about a good deal of pharma purchases and repurchases, about 35% of our instruments were

Purchases from the same customers this quarter. But for about a month and a half people were getting used to their new roles. And from our perspective this sort of dip in Q2 is a temporal dip in nature. There's going to be some persistent, we think international headwinds which John will speak to and John alluded to in the guide. What we do …

see our team as gaining footing. We do have 120 people on the commercial team executing. The final thing I'll say is, you know, when you think of the, you know, you really have to look at our respective companies in our space in terms of the business opportunity. And the unique business opportunity we have is around a growth company. We revised our guide to 20% growth per year, right? But also it's a lab tools profile that I think is really attractive in that...

1. We can drive commercial productivity with a small bench shop instrument to drive land and expand, which we're already seeing as I alluded to again on a smaller number. But the 35% sort of repurchase in Q2, I think the consumable gross margin improvements are going to be incredibly important as we sort of.

Get some more of that razor blade segment of our revenue. And finally, just, you know.

OpEx efficiencies and simplifying the pipeline to CodePlex is also a big part of us sort of achieving that more profitable profile next year. I do want to, on just one, you asked for more details on the revenue.

I'll pass it to John just for a little more detailed revenue and optics just so you have it.

Yeah, just so, you know, given the queue, obviously, we took down the guide, which you saw this morning. So just a couple quick things on sort of how we view the balance of 2022 on the revenue and then and then a couple of comments on the effects. So, we did update the revenue this morning or guide. So we're looking at 20% year over year, at least 20% year over year growth. That'd be 20.7Million and we get there, we anticipate 110 total instrument sales for 2020.

We also expect a stronger second half in consumables versus the first half of 2022. And that still our full year 2022 year over year total consumable revenue growth to exceed 40% over last year. And that translates to about a 32K pull through. And just thinking about Q3 and Q4, we think that second half revenue guy.

will come in around 40% in Q3 and 60% in Q4. And just real quickly on the OpEx, we've made a lot of progress to reduce the OpEx in the quarter and on a non-GAAP basis, our operating expenses net of the restructuring charges declined 26% or $7.9 million in the quarter versus the first quarter. We're still working diligently on that and we would expect to tracking our guide.

We ended the quarter around an 18 and a half million dollar op ex run rate and we expect to be at or below 17M. Hotbacks quarterly run rate by the end of this year.

Just on the guide, John , you said 40% of the back half implied revenues are expected in the year, so that implies a 12% year-on-year growth.

And that steps up materially in Q4 to 27.

Any lingering 2Q issues that you're assuming, slip through to 3Q, just talk about the cadence here, 3Q versus Q4 growth.

Yeah, nothing different than what Sean described and I think what we're just being very cognizant of the persistence of what sort of we saw in the. 2nd quarter, I think with every passing day, we're just moving past our risk from early April and. Getting better up to speed and improving the cadence overall.

that improvement. China in the lockdown continues to be sort of a tenuous situation. So that's really what we see, Vijay. The pipelines, we continue to gain visibility over the back half of this year. But that's our best assessment at the moment of how we see the second half Q3 and Q4 revenue.

Understood. And then one on gross margins. I think I heard a 70% number. Is that a 70% target for Q1 of 523? Are you referring to consumable gross margins or overall company gross margins? I think I heard a 70% target for Q1 of 523. Is that a 70% target for Q1 of 523?

That number was a consumable gross margin number and what we're saying is, and I think John talked about goals to get to 60% margins next year and then into the 70% total range. The point of us saying, BJ, 70% is to say that as our business becomes in the majority, the razor blade, via mainly reagent conservation and sort of

learning what we actually need from the entire technology stack of the reagents going into our chip. We're actually on the path. We're implementing it now, but you should see those consumable gross margins in the 70s next year. But the total, because still our instrument, we're not going to accelerate from the low 50s up to the 70 mark. The total mix will be in the 60 range next year.

need from the entire technology stack of the reagents going into our chip. We're actually on the path, we're implementing it now, but you should see the consumable gross margins in the 70s next year. But the total, because still our instrument, we're not going to accelerate from the low 50s up to the 70 mark, the total mix will be in the 60 range next year. Got it. Thanks guys.

Thanks, E.J. Thanks, E.J.

Thank you and our next question coming from the line of magnificent from Colin. Your line is open.

Hey, thanks for taking the questions, guys.

John , just to follow up on the gross margin target, related to that, I think it was near term gross margin target in the mid 60s range. Is that a target that you're looking ahead as you exit 2022 or is that more of a mid 2023 target?

Yes, the latter, Max. More of a mid-2023 and I think Sean just was describing, you know, really driven by the consumables. So, you know, we get that, you know, in the near term up to the 70% range. That will drive our total gross margin into that 60% range. You know, we would expect, you know, modest but incremental improvement over the, you know, gross margin over the balance of this year. We'll really start to see some of the benefits we think beginning in Q1.

of 2023. Okay, great. Just to follow up there and then I have one for Sean. So, I mean, it sounds like the ramping consumables margins, which I think are sort of marching towards that 70% gross margin level, you know, we'll start moving the needle starting in the first quarter of next year. It would just be great to hear, you know, how much of the gross margin increases that we do see at the beginning of 2023.

are attributable to CodePlex launch versus volume leverage with ISA code and if there's any meaningful difference in the gross margins for those two products.

So what I'll say is, when you think about the CodePlex product, it's likely to be a higher margin product. We're not gonna see the impact of the mix probably until Q3 or Q4 of next year. The CodePlex product itself is, if you think about it on a per sample per well basis, it's more like you're doing on an isospark line, you're doing something like...

80 wells or 80 samples per run in triplicate. So it's on a price point basis, on a margin basis, yes, it's a slightly higher margin product than isopode, but I just wouldn't expect that to be seen until the mix becomes greater into the...

the codeplex launch cycle. Does that make sense? Yeah, absolutely. And then just one on placements. You know, I saw in the slide deck 165 placements to immune monitoring labs, 89 to cell therapy companies.

or researchers. I'm just curious, you know, how is the growth in placements to, you know, cell therapy customers compared, you know, to placement growth to immune profiling labs? And then just similarly, if there's been any major difference in the consumable ramp that you've seen for cell therapy customers versus immune profiling labs, that'd be great.

Yeah, well, I think on the cell therapy side, what's interesting is our product profile, you know, and this has come release of, you know, more phenotypes or cell types, more panels, more publications, but it's expanded to a little bit wider view of the cell therapy market, meaning that, you know, we're doing, we, you know, we have these NK cell chips, we're doing a lot more NK cell work or IPSC derived NK cells.

We're doing a lot, we published a lot more in like TCRT to combine with CAR T. We published I believe the first quarter with, or sometime in the last three to six months with some gene edited cell therapy work as well as allogeneic cell therapy work. So we're broadening in that area. I think from a pipeline perspective, we see that product analysis is continuously really important for a wider and wider array of people.

whether they're biotech, biopharma, or academic medical centers pursuing cell therapy. So we see that is still a significant growth area, you know, despite sort of the biotech capital market.

as far as the capital markets goes. I'd say for immune monitoring, I mean what's pretty exciting in immune monitoring is just in the last 12 months or so we've had two nature medicine papers. In the last period of time we've had two cell papers and a lot of them in JCO et cetera, but a lot of them point to a couple of things. One is in your immune monitoring which is very different than our cell therapy.

You're seeing this in these cell papers and looking at the sort of innate cell compartments, different types of immune cells, in terms of showing early signs of inflammation that sort of lends itself to people that are going into the ICU. So I would say that's a market where the continued publication leadership and major clinical trials are being published with our platform showing differentiation.

health in Q4 especially where you know, biopharma is the biggest purchaser of our immune monitoring systems. We think that's an important and.

resilient market headed into the next few years. Yeah, maybe if I could just sneak one more quick one in. I mean, I think we saw 40,000 system flow cytometry is placed, I think it says in the deck 20,000 system TAM for platforms that could be running CodePlex. I mean, do you see any opportunities to strike a commercial partnership with the flow cytometry companies if you do see the majority of CodePlex?

users sort of using those applications in tandem alongside a flow cytometer.

Yeah, no, I mean, I think it's a very complementary sort of sale. We've had over time co-marketing partnerships with other groups in the cell analysis. It's a very complementary sort of sale. We've had over time co-marketing partnerships with other groups in the cell analysis business, whether it's sort of a...

We've had a couple of co-marketing partnerships with groups that do cell production for cell therapies, where we're the downstream analysis tool for their cell production tools. And so doing partnerships with a flow cytometry cell analysis business is something that's interesting to us from a co-marketing basis at the very least, just given the complementarity of the two solutions and the fact that...

When we launched our technology in May 2018, it was considered pretty novel to look at cells and look at this new dimension of cell proteomic behavior for every single cell. But I think now with all the publications and everything, more and more traditional flow labs are representing our pipeline. And they're saying, well, I can get a deeper dimension of information for every one of my phenotypes that I look at on my flow cytometer. The last thing I'll say is...

we hope to be able to be successful looking at more surface markers per cell on our existing instruments.

And, you know.

We'll come out with more information as we have it, but that becomes really attractive to Flow Labs too because a lot of them are trying to map what we do onto the traditional sort of flow surface marker phenotyping tools and you offer more surface marker phenotypes from let's say immune cells, meaning you get more, you're kind of getting more value for every run. You're getting multiple cell phenotypes per run plus all the additional cell output proteins that we offer. So that's, we've done voice accustomed to that. That's a pretty exciting proposition. So I think.

I think the complementarity versus flow is going to continue and as that market progresses, that's just going to be an attractive market for us.

Great, thanks for taking all my questions.

Thank you.

Thank you. And our next question coming from Lana Puneet Sota with SBB Liran. Kealan is open. Yeah, hi, Sean. So first one is, I mean, really is around, you know, the overall guide. I mean, you have lowered your revenue estimates earlier in the year. And then you had, you know, obviously reduced your workforce by 20%, which you announced earlier. This is a 35% reduction.

next year. So with all that, when we look at Isolite and Isospark very much in the early stages in the market, it appears that you need more marketing awareness of these products to drive them into the lab. So I'm just trying to understand why is 20% growth number for 2022 the right number given some of the challenges that you're seeing in the market? And what does this mean for 2023 growth?

Maybe just talk to us about that and then I'm wondering if you can provide install expectations for this year as well. Let's just put that in place for our next question.

So I think there's a few things, right? Because just when you think about the opportunities we have, what I'll do is I'll talk a little bit about sort of who we are as a company. John I think will talk a little bit about sort of some of the basis for 2022, 2023 as well. The reasoning is just voice a customer, right? When it comes to Duomix versus CodePlex. The Duomix opportunity.

a few things, right? Because, you know, just when you think about the opportunities we have, what I'll do is I'll talk a little bit about sort of who we are as a company. John , I think, will talk a little bit about sort of some of the basis for 2022-2023 as well. The reasoning is just voice a customer, right, when it comes to Duomix versus CodePlex. The Duomix opportunity for multi-omics

is simply put, right, entering a timing in the market where yes, there was some exciting data, but if you went to LGBT, there were so many multi-omic and spatial multi-omic solutions that I think when we talk to customers, you know, what we were hearing is yes, I'm going to demo x many number of systems next year that are all kind of coming out concurrently. It's a little bit difficult to understand the features, benefits, and all the differences and there, you know, multiple companies are coming out with multiple multi-omic and spatial products.

I'd say the focus on CodePlex is just...

We did a lot of voice a customer and people are really excited about you know Labor-constrained market where pharma and biotech are still very labor-constrained You know, we're we're offering effortless automation for multiplex proteomics Differentiated I think that's exciting the customers and so like we're we're excited about that opportunity You know, we're always Cognizant that you know, I think like you said in this stage of the company's lifecycle. We have to choose our

We have to choose our battles widely and so focus and simplification is really important to us. So that's essentially why CodePlex represents such an exciting opportunity. I think for 2022 and the cell analysis business, I think we sort of explained what's changed. And I think it was probably difficult for a number of companies in our space to sort of predict the China lockdowns and the sort of European slowness. And I suspect that...

You know, we'll be in a position at some point in those 2 markets to continue what we had as growth. We had really exciting pipeline in China. It's just tough to actualize. Things like people that put a budget for our system and tenders and stuff like that when people can't actually sort of see each other. Um, you know, and I think I think the cell analysis opportunity is only increasing. We see the same thing. I mean, we. That's that's part of why we see the.

The 20% growth still based on our isocode business is being. Sort of realistic, despite the headwinds that we've experienced so far. John , do you want to talk a little bit about, you know, Q4 of this year as well as. 2023 next year yeah, I think asked about the placement. So with with this morning's red guy, we, we are, we do anticipate 110. Total placements for the year, so it was 25 in the 1st quarter 20 this, this 2nd quarter.

So, $110 for the year and we do see Q3, Q4 breaking down and it's on the place since about 40%, 60%. And as Sean described, we feel good about with things in China progressing as well as just our own internal execution. We feel better about continuing the ramp into 2023. Sean talked about the CodePlex launch.

Slated early 2023, so that helps, we think not only drive instrument sales, but also drives our consumable pull through. So that's an important part of our model also helps drive the gross margin expansion. 1 other thing I think worth noting it's a smaller line item in our revenue mix at the moment, but 1 we're working hard on to increase and that's the service side of the business. And so that's 2 pieces. That's both. Service contracts, you know, on the instruments as they come off warranty.

So we've got an increasing installed base to sell those contracts and we see that growing as a highly profitable, you know, more annuity like revenue stream for us as well as more customers, you know, running samples on our instruments as a service. So, so we see that growing and at this moment, I'm going to fall a little short of just giving, you know, sort of guidance for, for, you know, for next year. But, you know, we, we see.

Europe probably as well. So just wanted to clarify, I mean, where do you stand on that number? That number was 50 customer facing individuals as of the Q1. Can you just elaborate where you stand there? And I appreciate the focus on gross margin and service, but those are some of the things that Lifesight as Stools companies are talking about more once they have driven significant install base into the market, the awareness of the product is high.

So I appreciate you trying to do this right now, but I'm just also just trying to understand, the marketing, sales and marketing efforts that you have ongoing, should we expect those to moderate, I mean, given the OPEX guide that you're providing, should we expect those to sort of moderate? I'm just trying to understand, obviously given the stage of the product, you have to drive the adoption of this product before.

you can start to see leverage from volume and competition among suppliers and whatnot to deliver on that gross margin. Thank you.

Yeah, so we see path to profitability just, you know, we obviously converse with investors all the time. We see path to profitability is very important. Like, let me just say that. I think we see gross margin is very important, right? And gross margin improvement, we're really focused on it. We have 120 member commercial team, right? So if you think about fit for purpose, we talk a lot about fit for purpose. And that's, I think our team is fit for purpose. We have right now we have.

Of those 120 folks, we have 50 customer-facing sales and FAS team members. So that combines basically like the way we position it and the way we think about, again, being productive with sort of sales and FASs and frankly in some degrees creating... – –

when they go out and they own their regions creating somewhat of a profit center.

You know we we look at that split as being important for us to be able to one communicate awareness and to You know to to drive that that revenue I think like when you think about companies that aren't trajectory There's a lot of high-impact publications coming out from our products all the time And I think that that's I think that's an important thing and it's tough to deny when you see that data or a key figure out there

I think the other thing is we've never lacked, like if you look at things like, perhaps they're arbitrary but LinkedIn followers, we tend to have a lot of people following what we do so broad line awareness at the top level of our unique new dimension to sell behavior. I think a lot of it comes down to what the focus of the business has to be and I think frankly just the focus of the business has to be profit and productive behavior from our commercial team as the...

the broader awareness for our technology continues and then simply blocking and tackling. A lot of it what it comes down to is day by day stage gated management of the funnel and sort of...

making ourselves successful by executing and then delivering both the instrument and the consumable usage that we're looking for and that our products are frankly capable of with the customers that we have.

Okay, thank you.

Okay, thank you. Thank you.

Thank you. Now last question coming from the line up. They just have one for Morgan Stanley . The line is open.

Hey guys, good morning and thanks for the time here. Sean, maybe to kick things off, I don't want to slog that horse here and it's come up multiple times in the call, but just given the visibility issues here and the succession of guidance cuts, what really kind of gives you the confidence that this is the bottom and things are going to get sort of incrementally better from this point on? And sort of related to that, why not consider giving just a next quarter guide at least for the time being until...

The world is sort of in a different place than it was. So given that, the best thing we can do and the best thing that we have ahead of us is sort of what we can see in our pipeline and how we can execute according to our pipeline. So I think the second thing is when we look at our pipeline and we look at what's available with the cell analysis business, with full cognizance of what you just said, we can see

What we see is an opportunity to sort of continue along the lines of what John Straley alluded to as far as advancing the installed base and sort of leveraging who we have, the repeat purchasers that we do, and continuing. And finally, I realize you're speaking sort of primarily to the top line, but I'll say when you talk to a lot of investors in the market, they're actually focused on OPEX, right? Okay, and they're focused on know-how because that's pretty much what we see in the fore<|oc|>

Are we going to put our business in a good position to actually be profitable? And I think that that's a really important thing, right? And I think gross margins are really important. And so I'd say, look, we, as John talked about.

We reduced sort of the operating expenditures, excluding the restructuring charges by about 26%. Want to have to continue doing that and that's that's going to put ourselves in a position to sort of. Be a healthy business as as we sort of exit times that are. From for some degrees, macro economic uncertainties and give us the chance to have a differentiated. Sort of personalized lab approach with the.

with our bench top systems. Got it. On Europe , how much was FX playing into customers' delayed purchasing decisions? Is there anything you can really do in the near term to help address some of those issues?

We didn't see the FX issue as really slowing. It's a smaller part of the overall revenue to begin with. We just saw it, I'm sure it's part of it. I'm confident Tejas, but not as a direct sort of obstacle. And so I think what are we doing about it? Sort of the same types of things that we're doing in America and in APAC and that's daily management.

funnel management, advancing opportunities, and addressing the various sales obstacles as they're presented.

Got it. Okay. And so, is there a catch-up dynamic to be thinking about here in the back half of the year, particularly for these delayed purchases or just too early to really tell?

Yeah, I mean, I would just call it there's.

There's a little bit of a procurement dynamic where procurement is going slower, but that can...and so we experienced those in Q3 where procurement was slower, but that dynamic could persist, right? So, you know, meaning it could persist in the next quarter. So I'd say probably too early to tell as far as catch-up dynamic. We're not necessarily factoring that into John's guide.

Got it. Okay. And then, Sean, how are you thinking about sort of Salesforce productivity here? You've done the risk, but you called out about 120 people in the commercial team. Obviously, the placement run rate needs to improve here. But how are you sort of like, what are the metrics, I guess, that you're putting in place? Or talk to us about some of the incentive structures that perhaps have evolved over the last few months here to make sure that those products...

daily towards those goals. And so while we're not going to call out exactly what the pipeline looks like, that's at the very least what gives us the understanding that they're passing through what we call our stage gated, we have five stages. We have enough in stage four of the process, meaning it goes stage one, stage two, stage three is when we have our chart of questions that allow us to know that it's likely to move forward to purchase. We have enough in stage four and we have enough sort of early stage opportunity creation.

to position us for Q4, that that's basically what gives us or makes us feel good about the numbers that John put forward. So a lot of the metrics come down to just simple activity-based metrics, whether it's like you know.

lead conversion or its meetings per week and then it's baseline metrics on are we filling the top of the funnel and progressing enough through to stage 4, stage 5 so that we can actually you know, meet and beat these instrument numbers that John's putting out. on a consumable basis, a lot of it comes down to just

Our ability to engage with customers nationally and internationally on a regular basis. So it's about our funnel in that respect is Number of experiments planned right so it comes down It's pretty pretty simple the more number of experiments planned you have at the top of the funnel The more you can convert to consumable sales people use it you sort of refresh that as people get great data You know publish present to their bosses, etc, etc. It creates a virtuous circle in some respects

Got it. And then final one for me on CodeClex, so helpful color there. So thank you for that on the 20,000 lab opportunity and potentially 100 million in sales or TAM, I guess, associated with it. Help us sort of translate that into what it could mean for blended pull-through, Sean. I mean, I think you mentioned sort of low 30s embedded in the guide this year. We probably have that somewhere in the 50s zip code for next year. And CodeClex will be incremental to that.

But how are you thinking about that ramp over the next couple of years as that offering matures?

We do think of it as incremental in some respects. Like if you go to.

Some of our like when we talk to some of our pharma's that use our systems and then purchase You know five six seven systems in the last couple years And we did the voice of customer what we do know is you know

People love things that eliminate the labor constraint or labor technician training that's going on with the high turnover. You know, biotech, bio pharma market right now, just given the. It's not a beta, right? The, the, let's call it the, the importance of the cell therapy, immunotherapy market and the importance of hiring people from those companies. And they're, they're jumping around to sort of take advantage of these opportunities. So I, I, we, what we look at is.

CodePlex will play an important incremental role. We're not going to call it exactly how much on top of, let's say, the current year isopode guide is, but it will play an important incremental role on a per-instrument basis into the end of next year.

Got it. Helpful. Thanks guys. Appreciate the time.

Expected.

Thank you and I'm showing off for showing off for the questions at this time. Thank you for your participation. You may now disconnect. Good day.

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you

We.

Good morning, ladies and gentlemen. Thank you for standing by and welcome to ISOPLIX's second quarter 2022 earnings conference call.

At this time, all participants are on a listen-only mode. After the speaker's presentation, there will be a question and answer session. To ask a question during this session, you will need to press the star 1-1.

Please be advised that today's conference may be recorded.

I would now like to turn the conference over to your speaker host, Carrie Mandeville. Please go ahead.

Thank you.

Earlier today, Isoplexis released financial results for the quarter and did June 30, 2022.

If you have not received this news release or if you'd like to be added to the company's distribution list, please send an email to investors at isoplexist.com. Joining me today from Isoplexist is Sean McKay, Chief Executive Officer, and John Straley, Financial Officer.

Before we begin, I'd like to remind you that management will make statements during this call that are forward-looking statements within the meaning of federal security laws. These statements involve material risks and uncertainties that could cause actual results or events to materially differ from those anticipated. Additional information regarding these risks and uncertainties appears in this section entitled Forward-Looking Statements and the Press Release Isoplex issue today.

For a more complete list and description, please see the Risk Factors section on the company's Annual Report on Form 10-K filed on March 30, 2022, and its other filings with Securities and Exchange Commission.

Except as required by law, isoflexis disclaims any intention or obligation to update or revise any financial projections or forward-looking statements, whether because of new information, future events, or otherwise.

This conference call contains time-sensitive information and is accurate only as of the live broadcast, August 10, 2022.

With that, I'd like to turn the call over to Sean. Thanks, Kerry. Good morning and thank you everyone for joining us for our second quarter 2022 earnings call.

On today's call, I will provide an update on some of the operational and commercial progress we've made to lay the foundation as a leader in the proteomics market with a profitable, sustainable growth business.

Then I will turn the call over to John for a closer look at our financial results and revised outlook for 2022.

We have now reduced our workforce by approximately 35% since the end of Q1 and ended the second quarter with an $18.5 million Opex run rate. Revenue in the second quarter decreased 7% year over year to $4 million with a 52% gross margin. Our trailing 12 months revenue was $18.7 million with a 51% gross margin. The revenue impact in Q2 was driven by a combination of international macroeconomic realities.

and the previously announced isoplexis reduction in force, i.e. the RIF.

driven by our shift to more profitable operations around the whole organization. In particular, we were affected by 1. the China lockdown, 2. overall economic slowness and inflationary challenges in Europe , and 3. our own reorganization and RIF, executed in Q2. To be clear, with the RIF, we retained the core innovation and growth assets embedded in the exoplexing culture, but in this Ali, it wasQL 1.1. Similarly in Q2, weaborized the architecture,

which I'll speak about with our lab-empowering CodePlex solution. We see these macro-oriented realities persisting in 2022.

Across many pipeline indicators, we also believe the market-driven depth is temporal and not reflective of the high need that we need.

As we cross the threshold to our 254th unit with our highly affordable personalized lab system in the benchtop 18 inch footprint isospark

We are also crossing the threshold to a more mainstream land and expand usage across organizations.

Our lab tools empower labs with effortless automation via our easy to use hardware and software to the cells and proteome that drive the biologic and immune-based therapeutics that are changing biotech, pharma, medical centers, and overall human health.

Our risk did provide a temporary disruption to the company. Has involved people navigating new positions with around 35% less staff. Details of which John will speak to later.

This caused slowness for the first month and a half in the quarter.

Yet our new operating structure is now better equipped to drive healthy, more profitable growth into the future, on top of conserving cash at this critical time in the capital markets.

We are focused on 3 core initiatives as we streamline our organizational structure. And we are flexible enough at this stage of the company's life cycle. To make a rapid impact in these areas.

One, process optimization in the commercial arena, driving commercial sales productivity towards more profitable activities that are suited to selling higher volumes of accessible price point, small footprint, proteomic instruments built for any mainstream lab with a commercial group fit for purpose size-wise and according to skill set.

Two, process optimization in the operational arena.

Driving to a higher consumable gross margin in the 70% plus range in the near term, which we are implementing now, we will begin to see progress towards in Q1 2023.

Three, simplification and optimization in development.

We've simplified our broader portfolio to focus on a product we believe deeply in, CodePlex, a high margin, high need economic cell with a clear differentiation in both proteomics.

It's made for this moment in time, and we'll also release this in Q1 2023.

Keep in mind this CodePlex product also runs off our existing instrument with the ISO Spark, providing easy, small footprint access to any lab.

To focus and simplify, we will also de-emphasize Duomic in the beginning of 2023, despite fantastic data, until we establish our both proteomic foothold in the market.

CodePlex has a clear need in a large end market today via voice of customer interviews where Duomix and the wider multi-omic, multi-omic spatial market complexity and volume of new instruments on that market make the immediate timeframe for Duomix less attractive.

In actualizing these three core initiatives, we achieve financial flexibility as our top line becomes higher margin based, our OPEX structure makes profit centers out of our three core business areas, instruments, consumables, and services, and we come out with a suite of products that truly act as critical lab infrastructure at a moment in time that requires a shift to more effortless proteomic data.

Focusing on the commercial aspect of our organizational change.

With the right behaviors on instrument sales, we see proteomics end markets as strong with expansion in blue chip biotech pharma driven customer base in Q2.

We sold 20 instruments in Q2, bringing our total instruments to 254.

We are making progress with the BioPharma end market with several repeat purchases from these customers in the second quarter as well. 35% of the units sold in Q2 were to existing customers.

and more than a fourth of total instrument purchases to date are from customers who have bought multiple instruments. We also now have instruments placed in more than 75% of US comprehensive cancer centers.

To drive profitable instrument sales behavior, we have mapped the value stream to our customers and begun to eliminate unneeded and costly activities to drive efficiencies.

Process improvements include stage-gated sales monitoring and strengthening of our early-stage pipeline through daily management of clarified funnel-based metrics.

Finally, a leaner field service team will drive greater usage of service contracts to build important longer term annuity and recurring revenue base off of our installed instruments.

Moving on to manufacturing operations, we're in the midst of a process to have a leaner, more integrated organization to increase operational productivity and importantly, realize gains in consumable gross margin to drive us to the mid at 70% range in the near term and later to the 80 plus percentile range. The main focus to accomplish this is by optimization taking the better part of a year, namely reagent conservation.

Secondly, we're maturing our consumable supply chain by expanding our number of reagent partners across the board, resulting in a more competitive lower cost structure.

Moving on to development, we simplified our focus from several initiatives to one suite of high value products for early 2023 launch.

We are very focused on becoming critical lab infrastructure with high unmet need for effortlessly automated bulk benchtop proteomics with our novel CodePlex product suite.

We believe this to be a blockbuster product for the both proteomics and market with near-term mass market potential. The product has significant sales potential because of one, effortless automation, onboarding users quickly and maximizing high value lab resources, saving significant labor costs.

in a labor-constrained immune therapy market. Two, excellent intra-appe consistency. Confidence to move quickly to the next step with each sample in low CV triplicate at a higher throughput.

In three, improved lab economics. Ability to run triplicate assays and high throughput at a fraction of status quo cost.

With our cellular analysis products, i.e. single cell proteomics, we're focused on continuing the march as a new behavioral dimension to each cell type analyzed on the 40,000 slow cytometers in existence today.

The unique cell functional behavioral dimension that we add to the cell types or phenotypes captured on flow cytometry continue to prove high utility in the labs and predictive response relative to flow cytometry.

We're focused on multiple metrics to expand our use cases that include publications, panels, phenotypes,

All on the affordable isospark system. We've had a slew of publications in cancer immunology and cell therapy.

across cell types within our cell libraries with multiple major medicine and cell papers back to back, the utility of our cell behavior definitions of a wide array of immune cells is becoming clear.

We've expanded the functional phenotypes within our cell library, and with that, we've also expanded more panels to run those cell types. Secondly, as our isospark continues to proliferate at a faster rate than our isolite, it is clear to us that the low price point of the system relative to flow cytometers is going to be critical to penetrating the broader flow market and driving further consumable utilization.

The software also does not require technicians, which is a large benefit as we start approaching more mass-market cell analysis customers.

Last, we are evaluating early data on our system, which expands surface markers per cell, making a product more attractive within the traditional flow market.

We'll have more to discuss on this part of the pipeline in the future.

Our pipeline bulk proteomics products as a point of focus for Q1 2023 release become an important part of isoplex's future as critical lab infrastructure.

For targeted bulk proteomics, we are excited about our new CodePlex product.

which we are now planning to launch in early 2023.

As we work to simplify our business and concentrate on the most relevant solutions sought after today, CodePlex is important because we see this product as critical lab infrastructure around the entire proteomics universe. We estimate there are roughly 20,000 labs doing some degree of multiplex proteomic work that would be accelerated with our effortlessly automated solution. CodePlex empowers labs who need access to the proteome, yet have difficulty with the workflow and economics of the systems today.

For the first time, highly multiplexed data will come to market with effortless automation, eliminating a tremendous amount of labor costs for biopharma and biotech and eventually medical tense.

We believe CodePlex will form the backbone of many labs' daily proteomic work and the foundation for our products in the coming years.

We've moved single cell multi-elnix as behind codeplexing priority based on the market opportunity.

We're confident that Duomik will bring significant value to the market and our team worked hard in integrating various Omik technologies to make this system work. However, as we discussed, the complexity facing customers in the coming months will be able to hire those who have have the best capabilities to be each other, have the assets and other diverse

for multi-omic and spatial multi-omic offerings make this market less near-term attractive for our company. We believe this incredible new biology is better slated to come out after CodePlex, likely later in 2023 as a service. Isoplexis is on a path to empower a wide range of mainstream labs to leverage the cells and proteome they need to change the course of human health.

The advantages our ISO code offers, i.e. a new dimension of cell behavior for every phenotype defined by flow cytometry, provides us a meaningful entry point to 40,000 labs.

And the advantages of CodePlex's effortless automation offers to roughly 20,000 both proteomic labs creates an additional large opportunity next year. We have put ourselves on the path with differentiated technology advantages in two large markets to have a strong growth lab tools business with a high margin profile in the foreseeable future. Our team continues to make significant progress as we simplify our business to create a more profitable growth profile.

in single cell and bulk proteomics in the coming years. I will now turn the call over to John for more detail on our financials. Thanks Sean. Total revenue for the second quarter of 2022 was 4 million, down 7% from 4.3 million in the prior year period. As Sean mentioned, our revenue in the quarter was impacted by a few external and internal factors. First, with China, continued lockdown and shutdowns were in effect for nearly 80% of the quarter.

Continued restrictions will likely have an impact on lab usage and instrument purchasing in broader APAC through the end of 2022. Additionally, the impact of lingering supply chain headwinds affecting customers, inflationary pressures, and economic slowness in Europe and elsewhere impacted our ability to effectively sell our instruments in the region.

These elements are manifested in longer purchasing cycles in Europe .

Second, while it's proven to be effective, our Q1 reorganization and efforts to drive operational efficiencies have taken time to execute and process.

Service revenue for the second quarter was 682,000 compared to 200,000 for the prior year quarter, driven primarily by an increase in collaboration business this quarter.

Gross profit for the second quarter of 2022 was 2.1 million dollars. Compared to 2.3Million dollars in the same period of 2021 gross margin was 52% in the second quarter compared to 53% in the second quarter of 2021.

Gross margin expansion is one of the key elements of our long-term growth plan and provides financial flexibility by increasing gross profit dollars realized on recurring sales.

Sean mentioned in his comments, a lot of work has already been accomplished to reduce production costs and diversify the supplier base of our consumable business.

Excluding 3.7 million of restructuring charges taken in April . Operating expenses for the 2nd quarter of 2022 were 22.8M compared to 20.6M in the 2nd quarter of 2021. And importantly represents a significant decrease from the 30.7M last quarter.

R&D expense was $7.1 million, an increase of $1.6 million over the prior year, and SG&A expense was $15.7 million, an increase of $0.6 million over the prior year period.

We are on track to meet our end-of-year OPEX goals. Our efforts to date have focused on four major themes that have contributed to the significant OPEX reduction we have achieved. First, a focus on projects that will generate the most financial benefits of the company over the next couple of years, which led to the April reduction in workforce. Second, a continuous process to reduce the need for third-party professional services. The investments we've made to hire and train our core teams over the last couple of years.

in areas such as software licenses and other expenses indirectly related to organizational headcount.

As Sean described, we are focused on a continuous process to assess business activities and reduce costs and inefficiencies across the organization. Following our reorganization in April , we are continuing to identify efficiencies to further reduce operating expense and leverage our existing infrastructure.

These actions will ensure we maintain a cash runway into mid 2024 and improve our financial profile on a path to profitability quarter after quarter. This includes our modified top line guidance we reported this morning. We continue to expect our operating expenses to be around 17M dollars per quarter by year end. Bringing our full 2022 operating expense, excluding restructuring charges to be in the 90M dollar range. And which includes approximately 9M dollars of non cash expense.

for depreciation and amortization and stock-based compensation. Our net loss was $25.6 million for the second quarter of 2022 compared to $20.6 million in the second quarter of 2021.

We ended the quarter with $71.6 million in cash on the balance sheet. In June , we pulled the remaining $7.5 million available to us in our existing credit agreement. We believe that the cash we have on hand now, coupled with our continuing strategic initiatives, extends our cash runway into mid-2024.

Turning to our revenue outlook for the full year 2022, we now expect revenue for the year to grow by at least 20% over 2021, which is $20.7 million. We remain confident and excited about our future and outlook. Nothing has changed with our end markets and our fundamentals remain strong. Our organization has made us a leaner, more efficient company, which will allow us to continue to deliver high impact products and services, driving top line growth and managing expenses to provide a more clear path to profitability.

At this point, I would like to turn the call back to Shawn for closing comments. Thanks, John . This quarter, we have been focused on our three main initiatives I spoke of earlier. Our mission to empower labs with our cellular and proteomic solutions requires us to continue to execute these initiatives as we evolve the culture of innovation at Isoplexis. We have strong conviction in our prospects in the coming years and are seeing their uniquely accessible products at the time we're in.

Labs need easier access and lower economic costs to accelerate powerful medicines, and we are confident that our team and product suite will create a great deal of value for our customers, stakeholders, and the broader life sciences field. With that, we will now open it up to questions.

Thank you ladies and gentlemen, as a reminder to ask a question, you will need to press star 1 1 please stand by. We'll be compiled in a roster.

Now, first question coming from the line of Vijay Kumar from Avicor. Your line is open. One more time.

Hey guys, thanks for taking my question. Sean, maybe just on the queue itself, so revenues were down year on year. You did cite China macro challenges. What was the China lockdown impact? What percentage of your revenues are from China? It does feel like ex-China, perhaps growth slowed down. So maybe just break out China versus non-China and what's happening in the US and Europe , or activity.

That sounds good, Vijay. So a couple of things. What I'm gonna do is I'm gonna break down where the revenue sort of deceleration came from. I'll also talk about, like I'll start with just generalized, you spoke of the growth and where is the growth. I think you have to take a step back a little bit and think about the lab opportunity ahead, both with this sort of ISO code and CodePlex product suite.

You know, from from our perspective, or our vantage point, we see the ISO code is offering this.

to have what we see as a hundred million dollar business opportunity with a high margin profile that John will speak to in the foreseeable future. And our management team really has strong conviction in our ability to capitalize on that market. Now speaking specifically to Q2 on revenue, it really was a

China and Europe were due to the macroeconomic realities and the US was actually more due to the macroeconomic realities and the US was actually more due to the macroeconomic

the reduction in force that we had for about 35 percent, reducing in force about 35 percent of the organization. So within the China lockdown, it was just difficult to get the customers, right? Our team was actually, you know, in their apartments unable to get to customers. The usage based on our having our Shanghai headquarters out there, the usage was just very low. And so that was impacted. I think our European challenge was

roughly similar to some other growth players in the space, just based on what we see as economic slowness.

It's lower procurement process, et cetera. US, we still experienced, like I think we talked a little bit about a good deal of pharma purchases and repurchases, about 35% of our instruments were purchases from the same customers this quarter. But for about a month and a half, people were getting used to their new roles. And from our perspective, this sort of...

dip in Q2 is a temporal dip in nature. There's going to be some persistence we think international headwinds, which John will speak to and John alluded to in the guide. But we do see our team as gaining footing. We do have 120 people on the commercial team executing. The final thing I'll say is, you know, when you think of the, you know, you really have to look at our respective companies in our space in terms of the business opportunity. you

And the unique business opportunity we have is around a growth company. We revised our guide to 20% growth per year, right? But also it's a lab tools profile that I think is really attractive in that one, we can drive commercial productivity with a small bench top instrument to drive land and expand, which we're already seeing, as I alluded to, again, on a smaller number.

but the 35% sort of repurchase in Q2. I think the consumable gross margin improvements are going to be incredibly important as we sort of...

get some more of that razor blade segment of our revenue. And finally, just, you know, OpEx efficiencies and simplifying the pipeline to CodePlex is also a big part of us sort of achieving that more profitable profile next year. I do want to, on just one, you asked for more details on the revenue. I'll pass it to John just for a little more detailed revenue in OpEx just so you have it.

Yeah, Vijay, just so, you know, given the queue, obviously we took down the guide, which you saw this morning. So just a couple quick things on sort of how we view, you know, the balance of 2022 on the revenue and then and then a couple of comments on the off-acts. So, we did update the revenue this morning, their guide. So we're looking at 20% year over year, at least 20% year over year growth. That'd be 20.7 million. And we get there. We anticipate 110 total instrument sales for 2020.

And 60% in Q4 and just real quickly on the OpEx, you know, we've made a lot of progress to reduce the OpEx in the quarter. And on a non gap basis, our operating expenses net of the restructuring charges. Decline 26% or 7.9Million dollars in the quarter. We're still working diligently on that and we would expect to, you know, tracking our guide, we ended the quarter around an 18.5Million dollar OpEx run rate and we expect to be.

3Q, just talk about the cadence here, 3Q versus Q4 growth. Yeah, nothing different than what Sean described and I think, you know, what we're just being, you know, very cognizant of the persistence of what sort of we saw in the second quarter. You know, I think with every passing day, we're just moving past our risk, you know, from early April and getting better up to speed and improving the cadence overall.

Understood. And then one on gross margins, I think I heard a 70% number. Is that a 70% target for Q1 of 523? Are you referring to consumable gross margins, overall company gross margins? That number was a consumable gross margin number, and what we're saying is, and I think John talked about... we are saying Hospital Dataronic rocking in commercialwomen locations. So, if a YOU timeout is altered to 10-12 0. Kirck Hawaii touls who cannot ph wood and download good bandwidth to interact with present phplayers R A Q Q A

goals to get to 60% margins next year and then you know into the 70% total range. The point of us saying B.J. is 70% is to say that as our business becomes in the majority, the razor blade, via mainly reagent conservation and sort of learning what we actually need from the entire technology stack of the reagents going into our chip. We're actually on the path, we're implementing it now, but you should see those consumable gross margins in the 70s next year. But the total, because still our instrument, we're not going to...

Accelerate from the low 50s up to the 70 mark. The total mix will be in the 60 range next year. Got it, thanks guys.

Thanks, Vijay. Thank you. And our next question coming from the line of Mike Mazzucio from COWAN. Your line is open. engineer on Joe

Hey, thanks for taking the questions, guys. John , just to follow up on the gross margin target, related to that, I think it was near term gross margin target in the mid 60s range. Is that a target that you're looking ahead as you exit 2022 or is that more of a mid 2023 target? Yes, the latter, Max, more of a mid 2023, and I think Sean just was describing really true.

on. So I mean, it sounds like the ramping consumables margins, which I think are sort of marching towards that 70% gross margin level, you know, we'll start moving the needle, you know, starting in the first quarter of next year. It would just be great to hear, you know, how much of you know, the gross margin increases that we do see at the beginning of 2023 are attributable to you know, codeplex.

launch versus volume leverage with ISA code and if there's any meaningful difference in the gross margins for those two products? So what I'll say is when you think about the CodePlex product, it's likely to be a higher margin product. We're not going to see the impact of the mix probably until Q3 or Q4 of next year. The CodePlex product itself is.

If you think about it on a per sample per well basis, it's more like you're doing on an isospark run, you're doing something like 80 wells or 80 samples per run in triplicate. So it's on a price point basis, on a margin basis, yes, it's a slightly higher margin product than isocode. But I just wouldn't expect that to be seen until the mix becomes greater into the...

the codeplex launch cycle. Does that make sense? Yeah, absolutely. And then just one on placements, you know, I saw in the slide deck 165 placements to immune monitoring labs, 89 to cell therapy companies.

or researchers. So I'm just curious, you know, how is the growth in placements to, you know, cell therapy customers compared, you know, to placement growth into immune profiling labs? And then just similarly, if there's been any major difference in the consumable ramp that you've seen for your cell therapy customers versus immune profiling labs, that'd be great.

We're doing a lot, we published a lot more in like TCRT to combine with CAR-T. We published, I believe the first quarter with, or sometime in the last 6 months with some gene edited cell therapy work as well as allogeneic cell therapy work. So, so we're broadening in that area. I think from a pipeline perspective, we see that product analysis, you know, it's continuously really important for a wider and wider array of people, whether they're biotech, biopharma, or academic medical centers pursuing cell therapy. So we see that is still a

significant growth area, despite sort of biotech capital markets, as far as the capital markets goes. I'd say for immune monitoring, what's pretty exciting in immune monitoring is just in the last 12 months or so we've had two nature medicine papers. In the last period of time, we've had two cell papers and a lot of them, you know, have been in the same place for a long time.

in JCO, etc. but a lot of them point to a couple of things. When you're immune monitoring, which is very different than our cell therapy sort of pre-infusion product analysis, when you're immune monitoring patients, which is this, you know, the largest area of sales for flow cytometry, our sort of new dimension of cell behavior, this functionality that you're getting for every cell phenotype, is showing itself to be, you know, predictive relative to flow cytometry. And then...

We're seeing that in checkpoint inhibitor therapies when you're doing clinical trials. You're seeing this in these cell papers and looking at the sort of innate cell compartments, different types of immune cells. In terms of showing early signs of inflammation that sort of lends itself to people that are going into the ICU. So, I would say that's a market where the continued publication leadership and major clinical trials being published with our platform showing differentiation.

health in Q4 especially where you know, biopharma is the biggest purchaser of our immune monitoring systems. We think that's an important and.

resilient market headed into the next few years. Yeah, maybe if I could just sneak one more quick one in. I mean, I think we saw 40,000 system flow cytometry is placed, I think it says in the deck 20,000 system TAM for platforms that could be running codeplex. I mean, do you see any opportunities to strike up commercial partnership with the flow cytometry companies if you do see the majority of codeplex users sort of using those applications in tandem alongside.

business, whether it's sort of a, you know, we've had a couple of co-marketing partnerships with groups that do cell production, right, for cell therapies where we're the downstream analysis tool for their cell production tools. And so, you know, doing partnerships with a flow cytometry cell analysis business is something that's interesting to us from a co-marketing basis at the very least, just given the complementarity of the two solutions and the fact that…

When we launched our technology in late 2018, it was considered pretty novel to look at cells and look at this new dimension of cell proteomic behavior for every single cell. But I think now with all the publications and everything, more and more traditional flow labs are representing our pipeline. And they're saying, well, I can get a deeper dimension of information for every one of my phenotypes that I look at on my flow cytometer. The last thing I'll say is, we hope to be able to be successful.

looking at more surface markers per cell on our existing instruments. And, you know, we'll come out with more information as we have it, but that becomes really attractive to flow labs too, because a lot of them are trying to map what we do onto the traditional sort of flow surface marker phenotyping tools. And you can offer more surface marker phenotypes from, let's say, immune cells, meaning you get more, you're kind of getting more value for every run. You're getting multiple cell phenotypes per run plus.

all the additional cell output proteins that we offer, we've done voice of customer, that's a pretty exciting proposition. So I think the complementarity versus flow is going to continue as that market progresses, that's just going to be an attractive market for us.

Great. Thanks for taking all my questions. Thank you. And our next question coming from Lana Puneet Sota with SBB Liran. Killen is open. Yeah, hi Sean. So first one is I mean really is around you know the overall guide. I mean you have lowered your revenue estimates earlier in the year. And then you had you know obviously reduced your workforce by 20% which you announced earlier now.

that when we look at Isolite and Isospark very much in the early stages in the market, it appears that you need more marketing awareness of these products to drive them into the lab. So I'm just trying to understand why is 20% growth number for 2022 the right number given some of the challenges that you're seeing in the market and what does this mean for 2023 growth. Maybe just talk to us about that and then I'm wondering if you can provide install expectations for this year as well.

for multi-omics is simply put, right, entering a timing in the market where yes, there was some exciting data, but if you went to LGBT, there were so many multi-omic and spatial multi-omic solutions that I think when we talk to customers, what we were hearing is, yes, I'm going to demo X many number of systems next year that are all kind of coming out concurrently. It's a little bit difficult to understand the features, benefits, and all the differences.

And there are multiple companies are coming out with multiple multi-omic and spatial products together. And I think that's a, for a business where we don't sell to sequencing markets, first of all. And second of all, even companies that do, I think that's a highly complex area right now. We felt far more positively about the business opportunity of selling into people that traditionally do immunology, they care about proteomics, right? And that they basically run cells and proteomics.

cognizant that, you know, I think like you said in this stage of the company's life cycle, we have to choose our battles widely. And so focus and simplification is really important to us. So that's essentially why CodePlex represents such an exciting opportunity. I think for, you know, 2022 and the cell analysis business, I think we sort of explained what's changed, right? And I think, I mean, it was probably difficult for a number of companies in our space to sort of predict the China lockdowns and, you know, the sort of European slowness that I...

I suspect, right, that we'll be in a position at some point in those two markets to continue what we had as growth. We had a really exciting pipeline in China. It's just tough to actualize things like people that put a budget for our system and tenders and stuff like that when people can't actually sort of see each other. I think the cell analysis opportunity is only increasing. We see the same thing. That's part of why we see the...

The 20% growth still based on our ISOCO business as being sort of realistic, despite the headwinds that we've experienced so far. John , do you want to talk a little bit about, you know, Q4 of this year as well as. 2023 next year. Yeah, I think asked about the placement. So with with this morning's red guy, we, we are, we do anticipate 110. Total placements for the year, so it was 25 in the 1st quarter 20 this the 2nd quarter. So 110 for the year and.

We do see Q3, Q4 breaking down and it's on the place since about 40%, 60%. And as Sean described, we feel good about with things in China progressing as well as just our own internal execution. We feel better about continuing the ramp into 2023. Sean talked about the CodePlask launch that's slated early 2023. So that helps, we think, not only drive instrument sales, but also drives our

consumable pull through. So that's an important part of our model also helps drive the gross margin expansion. 1 other thing I think worth noting is it's a smaller line item in our revenue mix at the moment, but 1 we're working hard on to increase. And that's the service side of the business. And so that's 2 pieces. That's both. A service contracts on the instruments as they come off warranty. So we've got an increasing installed base to sell those contracts and we see that growing as a highly profitable.

you know, more annuity-like revenue stream for us, as well as more customers, you know, running samples on our instruments as a service. So we see that growing. And at this moment, Puneet, I'm going to fall a little short of just giving, you know, sort of guidance for next year. But, you know, we see, for all the reasons Sean and I just described here, you know, we're looking at substantially higher growth rates than, you know, this 20...

individuals as of the Q1. Can you just elaborate where you stand there? And you know, I appreciate the focus on gross margin and service, but those are some of the things that you know Lifesight Stools companies are talking about more once they have driven significant install base into the market, the awareness of the product is high. So I appreciate you trying to do this right now, but I'm just also just trying to understand, you know, the marketing, sales and marketing efforts that you have ongoing.

Should we expect those to moderate, I mean given the OPEX guide that you're providing, should we expect those to sort of moderate, I'm just trying to understand, you know, obviously given the stage of the product, you have to drive the adoption of this product before you can start to see leverage from volume and competition among suppliers and whatnot to deliver on that gross margin. Thank you. Yeah, so we see path to profitability just, you know, we.

and FAS team members. So that combines basically like the way we position it and the way we think about again being productive with sort of sales and FASs and frankly in some degrees creating when they go out and they own their regions creating somewhat of a profit center.

You know we we look at that split as being important for us to be able to one communicate awareness and to You know to to drive that that revenue. I think like when you think about companies in our trajectory There's a lot of high-impact publications coming out from our products all the time And I think that that's I think that's an important thing And it's tough to deny when you see that data or a key figure out there I think the other thing is we've never lacked like if you look at like things like Perhaps they're arbitrary, but LinkedIn followers we we tend to

Because, you know.

Making ourselves successful by executing and then delivering both the instrument and the consumable usage that They were looking for and then our products are, you know, frankly capable of with with the customers that we have. Okay, thank you.

successful by executing and then delivering both the instrument and the consumable usage that we're looking for and that our products are frankly capable of with the customers that we have. Okay, thank you.

Thank you. Now, last question coming from the line up. They just have one for Morgan Stanley . Yolande is open. Hey guys. Good morning and thanks for the time here. Sean, maybe to kick things off, I don't want to flog that horse here and it's come up multiple times on the cloud, but just given the visibility issues here and succession of guidance cuts, what really gives you the confidence that this is the bottom and the things are going to get incrementally better from this point on? Related to that,

Why not consider giving just the next quarter guide at least for the time being until things stabilize versus laying out some of these annual guides or perhaps qualitative commentary on 23 and then having to walk back those expectations given the size of the company, given the tough macro backdrop that you've spoken about here.

Yeah, no, I think there are a lot of tough macro backdrops. I don't think we're unique to that. I think that you understand that. The world is sort of in a different place than it was. So given that, the best thing we can do and the best thing that we have ahead of us is sort of what we can see in our pipeline and how we can execute according to our pipeline. So I think the second thing is when we look at our pipeline and we look at what's available with the cell analysis business.

with full cognizance of what you just said, what we see is an opportunity to sort of continue along the lines of what John Straley alluded to as far as advancing the installed base and sort of leveraging who we have, the repeat purchasers that we do, and continuing. And finally, I realize you're speaking sort of primarily to the top line, but I'll say when you talk to a lot of investors in the market, they're actually focused on OpEx, right? They're actually focused on, are we going to put our business in a good position to actually be...

profitable. And I think that that's a really important thing, right? And I think gross margins are really important. And so I say, look, we as John talked about.

with our bench top systems. Got it. On Europe , how much was FX playing into customers, I guess, delayed purchasing decisions, and is there anything you can really do in the near term to help address some of those issues?

funnel management, advancing opportunities, and addressing the various sales obstacles as they're presented.

Got it. Okay. And so, is there a catch-up dynamic to be thinking about here in the back half of the year, particularly for these delayed purchases, or just too early to really tell? Yeah, I would just call it – there's a little bit of a procurement dynamic where procurement's going slower, definitely.

And so we experienced those in Q3 where procurement was slower, but that dynamic could persist, right? So, you know, meaning it could persist in the next quarter. And so I'd say probably too early to tell as far as catch-up dynamic. We're not necessarily factoring that into John's guide. Got it. Okay. And then, Sean, how are you thinking about sort of Salesforce productivity here, right? You've done the risk, but you called out about 120 people in the commercial team. Obviously, the placement run rate…

and there's basically on a per regional basis a certain number of instrument quotes, a certain number of new instrument opportunities we expect to see.

every week and we manage daily towards those goals. And so while we're not going to call out exactly what the pipeline looks like, that's at the very least what gives us the understanding that they're passing through what we call our stage gated, we have five stages, we have enough in stage four of the process meaning it goes stage one, stage two, stage three is when we have our chart of questions that allow us to know that it's likely to move forward to purchase. We have enough in stage four and we have enough sort of early stage opportunity creation.

to position us for Q4, that's basically what gives us, or makes us feel good about the numbers that John put forward. So a lot of the metrics come down to just simple activity based metrics, whether it's like you know, lead conversion or it's meetings per week, and then it's baseline metrics on are we filling the top of the funnel and progressing enough through to stage 4, stage 5 so that we can actually meet and beat these instrument numbers that John's putting out. So on a consumable basis, a lot of it comes down to just...

Got it. And then final one for me on CodePlex, so helpful color there. So thank you for that on the 20,000 lab opportunity and potentially 100 million in sales or TAM, I guess, associated with it. Help us sort of translate that into what it could mean for blended pull-through, Sean. I think you mentioned sort of low 30s embedded in the guide this year. We probably have that somewhere in the 50s zip code for next year and CodePlex will be incremental to that.

But how are you thinking about that ramp over the next couple of years here as that offering matures? Yeah, we do think of it as incremental in some respects. Like if you go to

Some of our, like, when we talk to some of our farmers that use our systems and then purchase, you know, 5, 6, 7 systems in the last Couple of years, and we did the voice of customer. What we do know is, you know, People love things that eliminate the labor constraint or labor technician training that's going on with like The high turnover biotech, biopharma market right now, just given the It's not abated, right? The, let's call it the importance of the cell therapy, immunotherapy market and the importance of hiring people from those companies.

And they're jumping around to sort of take advantage of these opportunities. So, I, what we look at is code will play an important incremental role. We're not going to call it exactly how much on top of, let's say the current year. I suppose guide is, but it will play an important incremental role on a per instrument basis into the end of next year.

Got it. Helpful. Thanks guys. Appreciate the time.

Thank you and I'm showing off for the questions at this time. Ladies and gentlemen, that's asking our conference for today. Thank you for your participation. You may now disconnect. Good day.

Q2 2022 IsoPlexis Corp Earnings Call

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