Q1 2026 Ionis Pharmaceuticals Inc Earnings Call

April 29, 2026

Operator: Reminder, this call is being recorded. At this time, I would like to turn over to Wade Walke, Senior Vice President, Investor Relations, to lead off the call. Please begin.

Speaker #1: Finder this call is being recorded. At this time, I would like to turn the call over to Wade Walk, Senior Vice President of Investor Relations, to lead off the call.

Speaker #1: Please begin.

Speaker #2: Thank you, Sabrina. Before we begin, I encourage everyone to go to the Investors section of the IONIS website to view the press release and related financial tables we will be discussing today.

Wade Walke: Thank you, Sabrina. Before we begin, I encourage everyone to go to the investor section of the Ionis website to view the press release and related financial tables we will be discussing today, including a reconciliation of GAAP to non-GAAP financials. We believe non-GAAP financial results better represent the economics of our business and how we manage our business. We have also posted slides on our website that accompany today's call. With me this morning are Brett Monia, Chief Executive Officer, Kyle Jenne, Chief Global Product Strategy Officer, and Elizabeth Hougen, Chief Financial Officer. Onaiza Cadoret-Manier, Chief Development Officer, Eugene Schneider, Chief Clinical Development Officer, and Eric E. Swayze, Executive Vice President of Research, will also join us for the Q&A portion of the call. I'd like to draw your attention to slide three, which contains our forward-looking language statement.

Speaker #2: Including a reconciliation of gap to non-gap financials. We believe non-gap financial results better represent the economics of our business and how we manage our business.

Speaker #2: We have also posted slides on our website that accompany today's call. With me this morning are Brett Monia, Chief Executive Officer; Kyle Jenne, Chief Global Product Strategy Officer; and Beth Hougen, Chief Financial Officer.

Speaker #2: Holly Kordasevich, Chief Development Officer; Eugene Schneider, Chief Clinical Development Officer; and Eric Swayze, Executive Vice President of Research, will also join us for the Q&A portion of the call.

Speaker #2: I'd like to draw your attention to slide three, which contains our forward-looking language statement. During this call, we will be making forward-looking statements that are based on our current expectations and beliefs.

Wade Walke: During this call, we will be making forward-looking statements that are based on our current expectations and beliefs. These statements are subject to certain risks and uncertainties, and our actual results may differ materially. I encourage you to consult the risk factors contained in our SEC filings for additional detail. With that, I'll turn the call over to Brett.

Speaker #2: These statements are subject to certain risks and uncertainties and are actual results may differ materially. I encourage you to consult the risk factors contained in our SEC filings for additional detail.

Speaker #2: And with that, I'll turn the call over to Brett.

Speaker #3: Thanks, Wade. Good morning, everyone, and thank you for joining us today. IONIS entered 2026 with significant momentum, which continued to accelerate through the first quarter of this year.

Brett Monia: Thanks, Wade. Good morning, everyone, and thank you for joining us today. Ionis entered 2026 with significant momentum, which continued to accelerate through the first quarter of this year. Our performance to date highlights our strong execution across the business, which positions us to fuel substantial growth for years to come. We are very pleased with the continued success of TRYNGOLZA. Demand continues to grow, reflecting both a compelling clinical profile and strong launch execution by our team. The launch of TRYNGOLZA is now also underway in Europe through our partner Sobi, expanding access to this transformational therapy for people with FCS. We also continue to advance our launch of Donzera. We're very encouraged by the strong early trajectory and the breadth of prescribers across patient segments. Outside the US, Donzera received European approval earlier this year, and our partner, Otsuka, has now initiated launch activities across the region.

Speaker #3: Our performance to date highlights our strong execution across the business, which positions us to fuel substantial growth for years to come. We are very pleased with the continued success of Trengoza.

Speaker #3: Demand continues to grow, reflecting both the compelling clinical profile and strong launch execution by our team. The launch of Trengoza is now also underway in Europe, through our partner Sobi, expanding access to this transformational therapy for people with FCS.

Speaker #3: We also continue to advance our launch of Donzera. We're very encouraged by the strong early trajectory and the breadth of prescribers across patient segments.

Speaker #3: Outside the US, Donzera received a European approval earlier this year and our partner Atsuka has now initiated launch activities across the region. Together, Trengoza and Donzera give us a strong foundation of successful commercial execution as we look ahead to two additional independent launches this year, with more to come.

Brett Monia: Together, TRYNGOLZA and zilganersen give us a strong foundation of successful commercial execution as we look ahead to 2 additional independent launches this year with more to come. We are on track for the launch of olezarsen in severe hypertriglyceridemia, which represents our first independent launch in a broad patient population. We are pleased to have received Priority Review by the FDA with a PDUFA date of 30 June, reflecting the significant unmet need in SHTG and the groundbreaking results from our landmark CORE and CORE2 studies. In these studies, we demonstrated profound and highly statistically significant reductions in triglycerides and acute pancreatitis events, along with favorable safety and tolerability.

Speaker #3: We are on track for the launch of Olisarsen in severe hypertriglyceridemia, which represents our first independent launch in a broad patient population. We are pleased to have received priority review by the FDA with a PDUFA date of June 30, reflecting the significant unmet needs in SHTG and the groundbreaking results from our landmark core and core two studies.

Speaker #3: In these studies, we demonstrated profound and highly statistically significant reductions in triglycerides and acute pancreatitis events, along with favorable safety and tolerability. Today, based on HCP demand and payer research, we are increasing our annual peak sales estimate for Olisarsen from greater than $2 billion to now greater than $3 billion.

Brett Monia: Today, based on HCP demand and payer research, we are increasing our annual peak sales estimate for olezarsen from greater than $2 billion to now greater than $3 billion, positioning olezarsen to become Ionis' first wholly owned multi-billion dollar medicine as the new standard of care for treating patients with severe hypertriglyceridemia. Zilganersen for Alexander disease is our second planned independent launch this year and the first from our industry-leading neurology pipeline. Zilganersen is the first and only medicine to demonstrate clinically meaningful and disease-modifying benefit in Alexander disease, a devastating and often fatal leukodystrophy with no approved treatments to date. We submitted our NDA in January. Based on the results of our pivotal study, the FDA accepted our NDA with Priority Review and a PDUFA date of 22 September.

Speaker #3: Positioning Olisarsen to become IONIS' first wholly owned multi-billion dollar medicine as the new standard of care for treating patients with severe hypertriglyceridemia. Zilgenersen for Alexander disease is our second planned independent launch this year and the first from our industry-leading neurology pipeline.

Speaker #3: Zilgenersen is the first and only medicine to demonstrate clinically meaningful and disease-modifying benefit in Alexander disease. A devastating and often fatal leukodystrophy with no approved treatments today.

Speaker #3: We submitted our NDA in January and based on the results of our pivotal study, the FDA accepted our NDA with priority review and a PDUFA date of September 22.

Speaker #3: Overall, we are on track to have three independent medicines for four indications on the market in 2026. Trengoza for FCS and SHTG, Donzera for HAE and Zilgenersen for Alexander disease.

Brett Monia: Overall, we are on track to have three independent medicines for four indications on the market in 2026. TRYNGOLZA for FCS and SHTG, Donzera for HAE, and zilganersen for Alexander disease. This marks a major step in Ionis' evolution as a fully integrated commercial biotech company. Complementing our wholly owned portfolio is our partner pipeline, a rich pipeline that continues to advance toward multiple value-driving events this year. Bepirovirsen, our potential first-in-class medicine for chronic hepatitis B, is on track to launch in the US and Japan this year by our partner GSK. Just this week, Bepirovirsen was granted Breakthrough Therapy designation and accepted for Priority Review by FDA with a PDUFA date of 26 October.

Speaker #3: This marks a major step in IONIS' evolution as a fully integrated commercial biotech company. Complementing our wholly owned portfolio is our partner pipeline. A rich pipeline that continues to advance toward multiple value-driving events this year.

Speaker #3: Epirversion, our potential first in-class medicine for chronic hepatitis B, is on track to launch in the US and Japan this year by our partner GSK.

Speaker #3: And just this week, Epirversion was granted breakthrough therapy designation and accepted for priority review by FDA with a PDUFA date of October 26. Next month, at ESIL, GSK will present the unprecedented results of the phase three program in which Epirversion achieved statistically significant and clinically meaningful functional cure rates in patients with chronic hepatitis B.

Brett Monia: Next month at EASL, GSK will present the unprecedented results of the Phase 3 program in which Bepirovirsen achieved statistically significant and clinically meaningful functional cure rates in patients with chronic hepatitis B. We also remain on track for data from two major cardiovascular outcome trials from our partner pipeline this year. The Pelacarsen Lp HORIZON trial in patients with elevated Lp(a) and cardiovascular disease, and the eplontersen CARDIO-TTRansform trial in transthyretin-mediated cardiomyopathy. Including these programs, along with Bepirovirsen, we expect five partner-led launches by the end of next year, creating a diversified stream of royalties and milestones for Ionis with multi-billion dollar potential well into the next decade. In addition to our commercial and pipeline achievements, we also delivered strong financial results in Q1.

Speaker #3: We also remain on track for data from two major cardiovascular outcome trials from our partner pipeline this year. The Pella Carson Lp(a) Horizon trial in patients with elevated Lp(a) in cardiovascular disease and the Epilon Turson Cardiotransform trial in transthyretin-mediated cardiomyopathy.

Speaker #3: Including these programs, along with Epirversion, we expect five partner-led launches by the end of next year. Creating a diversified stream of royalties and milestones for IONIS with multi-billion dollar potential well into the next decade.

Speaker #3: In addition to our commercial and pipeline achievements, we also delivered strong financial results in the first quarter. As a result of this strong Q1 performance and outlook for the balance of the year, today we are announcing a significant improvement to our financial guidance, which Beth will cover in detail in a few moments.

Brett Monia: As a result of this strong Q1 performance and outlook for the balance of the year, today we are announcing a significant improvement to our financial guidance, which Beth will cover in detail in a few moments. Ionis has achieved a great deal of late. Our pipeline and our launches are delivering tremendous value, and we continue to strengthen our financial position. Even more importantly, we are well-positioned and committed to build on this success to drive far greater value for patients and our shareholders. With that, I'll turn the call over to Kyle.

Speaker #3: IONIS has achieved a great deal of late. Our pipeline and our launches are delivering tremendous value, and we continue to strengthen our financial position.

Speaker #3: But even more importantly, we are well positioned and committed to build on the success to drive far greater value for patients and our shareholders.

Speaker #3: And with that, I'll turn the call over to Kyle.

Speaker #4: Thank you, Brett. As we enter 2026, IONIS' capitalizing on the exceptional launch momentum we generated in 2025 to drive even greater impact. We are set up for continued success with our independent launches.

Kyle Jenne: Thank you, Brett. As we enter 2026, Ionis is capitalizing on the exceptional launch momentum we generated in 2025 to drive even greater impact. We are set up for continued success with our independent launches. TRYNGOLZA demand is accelerating. Donzera early launch metrics are tracking extremely well, and enthusiasm continues to build for our upcoming olezarsen launch in SHTG and zilganersen launch in Alexander disease. TRYNGOLZA continues to build on the strong performance from last year. Q1 was our strongest quarter in terms of demand, with patient starts increasing significantly versus prior quarters, and patients on treatment are doing extremely well. Our patient-finding initiatives continue to identify appropriate FCS patients, and we are successfully converting prescriptions to patients on treatment. We are seeing ongoing expansion in both breadth and depth of prescribing, with more clinicians initiating TRYNGOLZA and existing prescribers writing additional scripts.

Speaker #4: Trengoza, demand is accelerating. Donzera, early launch metrics are tracking extremely well. And enthusiasm continues to build for our upcoming Olisarsen launch and SHTG and Zilgenersen launch in Alexander disease.

Speaker #4: Trengoza continues to build on the strong performance from last year. Q1 was our strongest quarter in terms of demand, with patient starts increasing significantly versus prior quarters and patients on treatment are doing extremely well.

Speaker #4: Our patient finding initiatives continue to identify appropriate FCS patients, and we are successfully converting prescriptions to patients on treatment. We are seeing ongoing expansion in both breadth and depth of prescribing, with more clinicians initiating Trengoza and existing prescribers writing additional scripts.

Speaker #4: Prescribers span a broad mix of specialties, including cardiology, endocrinology, and lipidology, which is exactly the prescriber base we want as we prepare for the broader SHTG population.

Kyle Jenne: Prescribers span a broad mix of specialties, including cardiology, endocrinology, and lipidology, which is exactly the prescriber base we want as we prepare for the broader SHTG population. Physicians remain highly satisfied with TRYNGOLZA's overall profile, efficacy, safety, tolerability, and the patient experience, and that is translating into an accelerating rate for new patient starts. Additionally, we are highly encouraged by the updated ACC and AHA clinical practice guidelines, which singles out olezarsen as the recommended treatment to lower triglycerides and reduce pancreatitis risk in patients with FCS. Outside the US, our partner, Sobi, is now in the early stages of launching TRYNGOLZA for FCS in Europe. This is expanding access for FCS patients and will bring in additional revenue over time. Following the groundbreaking CORE and CORE2 data in SHTG, we conducted extensive market research with high volume lipid specialists, cardiologists, and endocrinologists.

Speaker #4: Physicians remain highly satisfied with Trengoza's overall profile. Efficacy, safety, tolerability, and the patient experience—and that is translating into an accelerating rate for new patient starts.

Speaker #4: Additionally, we are highly encouraged by the updated ACC and AHA clinical practice guidelines which singles out Olisarsen as the recommended treatment to lower triglycerides and reduce pancreatitis risk in patients with FCS.

Speaker #4: Outside the US, our partner SOBI is now in the early stages of launching Trengoza for FCS in Europe. This is expanding access for FCS patients and will bring in additional revenue over time.

Speaker #4: Following the groundbreaking core and core two data and SHTG, we conducted extensive market research with high volume lipid specialists, cardiologists, and endocrinologists. That work consistently showed a clear understanding that preventing pancreatitis is the key treatment goal in SHTG and that current options fall short.

Kyle Jenne: That work consistently showed a clear understanding that preventing pancreatitis is the key treatment goal in SHTG and that current options fall short. Strong recognition of olezarsen's differentiated clinical profile, especially the acute pancreatitis data and the very low number needed to treat. HCPs have stated a high intent to prescribe across a range of patient types with initial use expected for individuals with triglyceride levels above 880 milligrams per deciliter or above 500 milligrams per deciliter with a history of acute pancreatitis or other high-risk comorbidities, including progressive cardiovascular disease and type 2 diabetes. In line with our commitment to patient access and to a successful transition into the broader SHTG market, we recently announced an important pricing decision for TRYNGOLZA.

Speaker #4: Strong recognition of Olisarsen's differentiated clinical profile—especially the acute pancreatitis data and the very low number needed to treat—and HCPs have stated a high intent to prescribe across a range of patient types with initial use expected for individuals with triglyceride levels above 880 milligrams per deciliter or above 500 milligrams per deciliter with a history of acute pancreatitis or other high-risk comorbidities—including progressive cardiovascular disease, and type 2 diabetes.

Speaker #4: In line with our commitment to patient access and to a successful transition into the broader SHTG market, we recently announced an important pricing decision for Trengoza.

Speaker #4: Effective April 1st, we set the new annual wholesale acquisition cost to $40,000. Which applies to the current FCS indication and will be maintained for the anticipated SHTG indication across both doses.

Kyle Jenne: Effective 1 April, we set the new annual wholesale acquisition cost to $40,000, which applies to the current FCS indication and will be maintained for the anticipated SHTG indication across both doses. Importantly, by establishing the new price ahead of the 30 June PDUFA date, we are integrating olezarsen into 2027 payer contracting cycles, positioning us for accelerating access following approval. From a go-to-market standpoint, our full US field organization is now in place, trained, and deployed. Today, that team is focused on supporting TRYNGOLZA for FCS and deepening our relationships with the key specialists who also treat SHTG. With this expanded footprint, we are positioned to engage approximately 20,000 high-volume SHTG prescribers across the country. The WAINUA launch is gaining significant momentum in what is largely a switch market in the US.

Speaker #4: Importantly, by establishing the new price ahead of the June 30th PDUFA date, we are integrating Olisarsen into 2027 payer contracting cycles, positioning us for accelerating access following approval.

Speaker #4: From a go-to-market standpoint, our full US field organization is now in place trained and deployed. Today, that team is focused on supporting Trengoza for FCS and deepening our relationships with the key specialists who also treat SHTG.

Speaker #4: With this expanded footprint, we are positioned to engage approximately 20,000 high-volume SHTG prescribers across the country. The Donzera launch is gaining significant momentum in what is largely a switch market in the US.

Speaker #4: We are seeing increasing adoption across all patient segments. Patients switching from existing prophylactic therapies, patients who were previously using on-demand treatment, and treatment-naive patients.

Kyle Jenne: We are seeing increasing adoption across all patient segments, patients switching from existing prophylactic therapies, patients who were previously using on-demand treatment, and treatment-naive patients. Our free trial program has been very effective, with high conversion to paid therapy rate to date. Just as importantly, feedback from both physicians and patients has been consistently positive, highlighting zilganersen's strong efficacy, its differentiated RNA-targeted mechanism, the positive switch data, which HCPs describe as, quote, differentiating and motivating, end quote, and zilganersen's patient-friendly profile that includes a self-administered auto-injector that can be stored at room temperature for up to 6 weeks. We are also seeing a growing base of repeat prescribers, which is a key indicator that zilganersen is providing a substantial benefit for patients.

Speaker #4: Our free trial program has been very effective with high conversion to paid therapy rate to date. Just as importantly, feedback from both physicians and patients has been consistently positive, highlighting Donzera's strong efficacy, its differentiated RNA-targeted mechanism, the positive switch data which HCPs describe as "differentiating and motivating" and Donzera's patient-friendly profile that includes a self-administered autoinjector that can be stored at room temperature for up to six weeks.

Speaker #4: We are also seeing a growing base of repeat prescribers, which is a key indicator that Donzera is providing a substantial benefit for patients. While it will take time to fully transition appropriate patients off legacy therapies, especially in a well-established market like HAE, the launch fundamentals give us confidence that Donzera will contribute significantly to the increase in our commercial revenue in 2026 and beyond.

Kyle Jenne: While it will take time to fully transition appropriate patients off legacy therapies, especially in a well-established market like HAE, the launch fundamentals give us confidence that Donzera will contribute significantly to the increase in our commercial revenue in 2026 and beyond. Outside the US, Donzera is now approved in the EU, and our partner, Otsuka, has initiated launch activities. Over time, we expect ex-US markets to become an important contributor to the global Donzera franchise. We are preparing for our first independent launch from our neurology portfolio with zilganersen for Alexander disease.

Speaker #4: Outside the US, Donzera is now approved in the EU, and our partner, Otsuka, has initiated launch activities. Over time, we expect ex-US markets to become an important contributor to the global Donzera franchise.

Speaker #4: Finally, we are preparing for our first independent launch from our neurology portfolio with Zilgenersen for Alexander disease. On the back of the positive phase three results, we now have FDA priority review with the PDUFA date set of September 22nd and our expanded access program is underway.

Kyle Jenne: On the back of the positive Phase 3 results, we now have FDA Priority Review with the PDUFA date set of 22 September, and our expanded access program is underway. On the commercial side, our focus has been on continuing to strengthen current relationships and build new relationships with the highly specialized community of leukodystrophy and rare neurology HCPs, further advancing partnerships with patient advocacy groups, and ensuring the right support infrastructure is in place for diagnosis, treatment, and ongoing care. Our medical affairs team has been engaging with top leukodystrophy centers, sharing data, and helping to build awareness of Alexander disease. Our marketing and access teams are finalizing the launch strategy. We will hire the customer-facing team closer to approval.

Speaker #4: On the commercial side, our focus has been on continuing to strengthen current relationships and build new relationships with the highly specialized community of leukodystrophy and rare neurology HCPs.

Speaker #4: Further advancing partnerships with patient advocacy groups, and ensuring the right support infrastructure is in place for diagnosis, treatment, and ongoing care. Our medical affairs team has been engaging with top leukodystrophy centers sharing data and helping to build awareness of Alexander disease.

Speaker #4: Our marketing and access teams are finalizing the launch strategy, and we will hire the customer-facing team closer to approval. Zilgenersen is not only an important medicine for people living with Alexander disease, but it's also a template for how we will commercialize future rare first-in-class neurology therapies emerging from our pipeline.

Kyle Jenne: Zilganersen is not only an important medicine for people living with Alexander disease, but it's also a template for how we will commercialize future rare first-in-class neurology therapies emerging from our pipeline. With two independent launches building momentum, two additional launches anticipated this year, and a strong pipeline behind them, we believe Ionis is well-positioned to change the lives of patients around the world. With that, I'll turn the call over to Beth.

Speaker #4: With two independent launches building momentum, two additional launches anticipated this year, and a strong pipeline behind them, we believe IONIS is well positioned to change the lives of patients around the world.

Speaker #4: With that, I'll turn the call over to Beth.

Speaker #3: Thank you, Kyle. The strong operational execution you've heard about this morning translated into very strong first-quarter financial results. We delivered year-over-year revenue growth and maintained disciplined expense management while continuing to invest in our current and upcoming independent launches.

Elizabeth Hougen: Thank you, Kyle. The strong operational execution you've heard about this morning translated into very strong Q1 financial results. We delivered year-over-year revenue growth and maintained disciplined expense management while continuing to invest in our current and upcoming independent launches. Q1 total revenues were $246 million, an increase of 87% compared to Q1 2025. This increase was driven by year-over-year commercial revenue growth from TRYNGOLZA and donzepil and substantial R&D revenue, including approximately $95 million of milestone payments from multiple partnerships. Commercial revenue increased over 42% year-over-year in Q1, driven in large part from TRYNGOLZA and donzepil growth. TRYNGOLZA delivered over $27 million in product sales, reflecting continued strong demand that was offset by an anticipated decline in net price.

Speaker #3: First quarter total revenues were $246 million, an increase of 87% compared to the first quarter of 2025. This increase was driven by year-over-year commercial revenue growth from Trengoza and Donzera and substantial R&D revenue, including approximately $95 million of milestone payments from multiple partnerships.

Speaker #3: Commercial revenue increased over 42% year-over-year in the first quarter, driven in large part from Trengoza and Donzera growth. Trengoza delivered over $27 million in product sales reflecting continued strong demand that was offset by an anticipated decline in net price.

Speaker #3: Donzera contributed meaningfully to commercial revenue, delivering $16 million in the first quarter. An increase of $125% compared to the prior quarter. Collectively, our expanding commercial portfolio positions us for robust revenue growth and is expected to represent an increasing share of total revenue year-over-year.

Elizabeth Hougen: donzepil contributed meaningfully to commercial revenue, delivering $16 million in Q1, an increase of 125% compared to the prior quarter. Collectively, our expanding commercial portfolio positions us for robust revenue growth and is expected to represent an increasing share of total revenue year-over-year. Operating expenses for the quarter were in line with expectations and increased 29% year-over-year, primarily driven by commercial investments supporting TRYNGOLZA and donzepil and launch readiness activities for olezarsen in SHTG and zilganersen in Alexander disease. We ended the quarter with cash of approximately $1.9 billion. The change in cash from year-end 2025 was primarily related to $633 million we used to repay our 0% convertible notes, which were due on 1 April.

Speaker #3: Operating expenses for the quarter were in line with expectations, an increase to $29% year-over-year, primarily driven by commercial investment supporting Trengoza and Donzera and launch readiness activities for Olisarsen and SHTG and Zilgenersen in Alexander disease.

Speaker #3: We ended the quarter with cash of approximately $1.9 billion, the change in cash from year-end 2025 was primarily related to $633 million we used to repay our 0% convertible notes, which were due on April 1st.

Speaker #3: The strength of our balance sheet is the result of our prudent fiscal management, which enables us to make strategic investments as we advance and launch our wholly owned medicines.

Elizabeth Hougen: The strength of our balance sheet is the result of our prudent fiscal management, which enables us to make strategic investments as we advance and launch our wholly owned medicines. Our Q1 performance underscores the value of our diversified revenue model, which combines growing commercial revenue with substantial and recurring R&D revenue from partner programs. Based on our strong year-to-date financial results, accelerating launch momentum, and positive outlook for the rest of the year, we are improving our 2026 financial guidance. We now expect total revenue in the range of $875 to 900 million, an increase of $75 million versus prior guidance, with total revenue weighted slightly more toward commercial revenues. For the first time this year, we are also providing product-level guidance for TRYNGOLZA and donzepil.

Speaker #3: Our Q1 performance underscores the value of our diversified revenue model, which combines growing commercial revenue with substantial and recurring R&D revenue from partner programs.

Speaker #3: Based on our strong year-to-date financial results, accelerating launch momentum and positive outlook for the rest of the year, we are improving our 2026 financial guidance.

Speaker #3: We now expect total revenue in the range of $875 to $900 million. An increase of $75 million versus prior guidance, with total revenue weighted slightly more toward commercial revenues.

Speaker #3: For the first time this year, we are also providing product-level guidance for Trengoza and Donzera. We expect Trengoza product sales to be between $100 and $110 million for the full year, and generally in line with 2025 full-year Trengoza revenue.

Elizabeth Hougen: We expect TRYNGOLZA product sales to be between $100 million and $110 million for the full year and generally in line with 2025 full-year TRYNGOLZA revenue. Our guidance assumes a significant decline in Q2 TRYNGOLZA revenue based on the updated price effective 1 April and a steady return to growth after the 30 June approval for SHTG. We are projecting donzepil product sales to be between $110 million and $120 million for the full year. Our guidance assumes donzepil will continue to be a significant contributor to year-over-year growth in 2026, with revenue steadily increasing as the launch advances. We also anticipate significant R&D revenue from existing collaborations, including potential development and regulatory milestones across our partnered portfolio, demonstrating that R&D revenue is indeed an important financial accelerator.

Speaker #3: Our guidance assumes a significant decline in second-quarter Trengoza revenue based on the updated price effective April 1st and a steady return to growth after the June 30th approval for SHTG.

Speaker #3: We are projecting Donzera product sales to be between $110 and $120 million for the full year. Our guidance assumes Donzera will continue to be a significant contributor to year-over-year growth in 2026, with revenues steadily increasing as the launch advances.

Speaker #3: We also anticipate significant R&D revenue from existing collaborations, including potential development and regulatory milestones across our partnered portfolio demonstrating that R&D revenue is indeed an important financial accelerator.

Speaker #3: In fact, we recently learned that the first patient-initiated treatment in the phase three program for Salinarsen which triggered a $45 million payment we will recognize in the second quarter.

Elizabeth Hougen: In fact, we recently learned that the first patient-initiated treatment in the phase 3 program for zilganersen, which triggered a $45 million payment we will recognize in Q2. Over the balance of the year, we also are eligible to earn additional milestones tied to Sapablursen, Bepirovirsen, pelacarsen, and other partnered programs as they advance. We expect our 2026 operating expenses to increase in the low teen percentage range compared to last year. This modest increase reflects our commitment to financial discipline as we bring multiple medicines directly to patients and advance our pipeline. The key drivers of expense growth will be sales and marketing investments to support TRYNGOLZA and donzepil and to ensure successful launches for olezarsen in SHTG and zilganersen in Alexander disease, assuming approvals. We anticipate our R&D expenses to remain steady this year, similar to last year.

Speaker #3: Over the balance of the year, we also are eligible to earn additional milestones tied to SAPA Blursen that be reversed Pelicarsen and other partnered programs as they advance.

Speaker #3: We expect our 2026 operating expenses to increase in the low teen percentage range compared to last year. This modest increase reflects our commitment to financial discipline as we bring multiple medicines directly to patients and advance our pipeline.

Speaker #3: The key drivers of expense growth will be sales and marketing investments to support Trengoza and Donzera, and to ensure successful launches for Olisarsen and SHTG and Zilgenersen in Alexander disease, assuming approvals.

Speaker #3: We anticipate our R&D expenses to remain steady this year, similar to last year. As late-stage studies reach completion, we are redeploying our resources towards the drugs in our pipeline that we expect to fuel our next phase of growth.

Elizabeth Hougen: As late-stage studies reach completion, we are redeploying our resources towards the drugs in our pipeline that we expect to fuel our next phase of growth. Our focus on improving operating leverage is enabling us to drop the full increase in revenue guidance to the bottom line. As a result, we expect a non-GAAP operating loss between $425 and $475 million, a $75 million improvement over our previous guidance. This is similar to our 2025 operating loss after adjusting for the one-time Sapablursen license fee we earned last year. We are projecting a 2026 year-end cash balance of greater than $1.6 billion. This reflects the repayment of the 0% convertible notes, which were due on 1 April.

Speaker #3: Our focus on improving operating leverage is enabling us to drop the full increase in revenue guidance to the bottom line. As a result, we expect a non-gap operating loss between $425 and $475 million.

Speaker #3: A $75 million improvement over our previous guidance. This is similar to our 2025 operating loss after adjusting for the one-time SAPA Blursen license fee we earned last year.

Speaker #3: We are projecting a 2026 year-end cash balance of greater than $1.6 billion. This reflects the repayment of the 0% convertible notes which were due on April 1st.

Speaker #3: The strength of our balance sheet combined with our diversified revenue streams supports our continued strategic investments in ongoing and planned launches as we advance our wholly owned pipeline.

Elizabeth Hougen: The strength of our balance sheet, combined with our diversified revenue streams, supports our continued strategic investments in ongoing and planned launches as we advance our wholly-owned pipeline. Our financial outlook reflects accelerating commercial launches, a progressing pipeline, and a diversified revenue base, positioning us for continued growth and keeping us on track for cash flow breakeven in 2028. With that, I'll turn the call back over to Ben.

Speaker #3: Our financial outlook reflects accelerating commercial launches, a progressing pipeline, and a diversified revenue base positioning us for continued growth and keeping us on track for cash flow breakeven in 2028.

Speaker #3: And with that, I'll turn the call back over to Beth.

Speaker #1: Thank you, Beth. The first quarter in our outlook for 2026 underscored the strength of IONIS today. With two successful independent launches underway, two more independent launches, anticipated this year, a robust pipeline advancing toward multiple near and mid-term catalysts, and a solid financial position that supports the continued investments we are making to maximize the value of our commercial medicines and pipeline.

Brett Monia: Thank you, Beth. The Q1 and our outlook for 2026 underscore the strength of Ionis today. With two successful independent launches underway, two more independent launches anticipated this year, a robust pipeline advancing toward multiple near and midterm catalysts, and a solid financial position that supports the continued investments we are making to maximize the value of our commercial medicines and pipeline. With all these key elements in place, we're confident in our ability to accelerate revenue growth and deliver increasing value for patients and for all Ionis stakeholders. Now, in closing, I wanna highlight that this week at Ionis, we are holding our annual Why Week. It's a time when our employees come together to hear directly from patients and caregivers about their personal stories and reinforce our purpose, which is bringing better futures to people in need.

Speaker #1: With all these key elements in place, we're confident in our ability to accelerate revenue growth and deliver increasing value for patients, and for all IONIS stakeholders.

Speaker #1: Now, in closing, I want to highlight that this week at Ionis, we are holding our annual Y Week. It's a time when our employees come together to hear directly from patients and caregivers about their personal stories and reinforce our purpose, which is bringing better futures to people in need.

Speaker #1: I've never been prouder of the impact we are having on patient lives and clinical medicine. And I'm even more excited about the greater impact we are positioned to make in the near term, and sustainably.

Brett Monia: I've never been prouder of the impact we are having on patient lives and clinical medicine, I'm even more excited about the greater impact we are positioned to make in the near term and sustainably well into the future. With that, we'll now open the call up for questions. Sabrina?

Speaker #1: Well, into the future. And with that, we'll now open the call up for questions. Sabrina.

Speaker #4: Thank you. We will now begin the question and answer session. To ask a question, you may press star than one on your telephone keypad.

Operator: Thank you. We will now begin the question and answer session. The first question comes from Jessica Fye of JP Morgan. Please go ahead.

Speaker #4: If you are using a speakerphone, please pick up your handset before pressing the keys. If at any time your question has been addressed, and you would like to withdraw your question, please press star then two.

Speaker #4: At this time, we will pause momentarily to assemble our roster. The first question comes from Jessica Fee of JP Morgan. Please go ahead.

Speaker #5: Hey, guys. Good morning. Thanks for taking my question. So you once again raised peak expectations for Trengoza. Can you just spend a little time elaborating on what enabled you to increase it from at least $2 billion at J.P. Morgan to now at least $3 billion?

Jessica Fye [Managing Director, Equity Research Analyst: Hey, guys. Good morning. Thanks for taking my question. You once again raised peak expectations for TRYNGOLZA. Can you just spend a little time elaborating on what enabled you to increase it from at least $2 billion at JP Morgan to now at least $3 billion? Can you also talk about your expectation for gross to nets on TRYNGOLZA following this price reset? Thank you.

Jessica Fye: Hey, guys. Good morning. Thanks for taking my question. You once again raised peak expectations for TRYNGOLZA. Can you just spend a little time elaborating on what enabled you to increase it from at least $2 billion at JP Morgan to now at least $3 billion? Can you also talk about your expectation for gross to nets on TRYNGOLZA following this price reset? Thank you.

Speaker #5: And can you also talk about your expectation for growth to nets on Trengoza following this price reset? Thank you.

Brett Monia: Yes, Jess, thank you for the question. Our increase in peak product sales for TRYNGOLZA and SHTG and FCS combined in the US to $3 billion was based on several factors. As you recall, we increased the price, or the peak sales to $2 billion in January, based really solely on the phase 3 data and some preliminary HCP demand research that we had conducted. The demand was very high. Since then, we've completed our HCP demand research, but more importantly, we completed our payer research, which landed on our $40,000 annual WAC price, so price, as well as Priority Review. Those were the biggest drivers of the increase in peak sales that we have put out today.

Speaker #1: Yes. Jess, thank you for the question. So our increase in peak product sales for Trengoza and SHTG NFCS combined in the US, the $3 billion, was based on several factors.

Speaker #1: As you recall, we increased the price or the peak sales to $2 billion in January really solely on the phase three data and the and some preliminary ACP demand research that we had conducted, the demand was very high.

Speaker #1: Since then, we've completed our ACP demand research, but more importantly, we completed our payer research, which landed on our $40,000 annual whack price. So price.

Speaker #1: As well as priority review. Those were the biggest drivers of the increase in peak sales that we have put out today. As far as growth to net, we're not commenting on that at this time.

Brett Monia: As far as gross to net, we're not commenting on that at this time.

Speaker #5: Thank you.

Jessica Fye [Managing Director, Equity Research Analyst: Thank you.

Jessica Fye: Thank you.

Speaker #4: The next question comes from Mike Holtz of Morgan Stanley. Please go ahead.

Operator: The next question comes from Matthew Harrison of Morgan Stanley. Please go ahead.

Matthew Harrison: Good morning. Thanks for taking the question, and congratulations on the progress. Maybe just a question on the TRYNGOLZA trajectory for the year. You mentioned, you know, return to growth in H2, really driven by the SHTG launch. Just curious, in some of your market research, are you picking up on maybe any pent-up demand? You know, could we anticipate a bolus early in the launch here, just given the groundbreaking data? Thanks.

Speaker #6: Good morning. Thanks for taking the question and congratulations on the progress. Maybe just a question on the Trengoza trajectory for the year. You mentioned return to growth in the second half really driven by the SHTG launch.

Mike Ulz: Good morning. Thanks for taking the question, and congratulations on the progress. Maybe just a question on the TRYNGOLZA trajectory for the year. You mentioned, you know, return to growth in H2, really driven by the SHTG launch. Just curious, in some of your market research, are you picking up on maybe any pent-up demand? You know, could we anticipate a bolus early in the launch here, just given the groundbreaking data? Thanks.

Speaker #6: Just curious, in some of your market research, are you picking up on maybe any pent-up demand? Could we anticipate a bolus early in the launch year?

Speaker #6: Just given the groundbreaking data? Thanks.

Speaker #1: Kyle, would you take that, please?

Brett Monia: Kyle, would you take that, please?

Speaker #7: Yeah, Mike, I appreciate that. And I think what's important first is the strong performance that we saw in Q1 in terms of demand. It's the best quarter that we've had in terms of the FCS patient population, the number of scripts that were received, and the number of patients that are starting on therapy.

Kyle Jenne: Matthew Harrison, appreciate that. I think what's important first is the strong performance that we saw in Q1 in terms of demand. It's the best quarter that we've had in terms of the FCS patient population, the number of scripts that were received, and the number of patients that are starting on therapy. That actually lends us a lot of confidence, not only in the FCS space, but also as we get closer to the 30 June PDUFA date in sHTG. I think it's indicating that there is a lot of interest in using olezarsen very broadly in this patient population. In terms of the launch in sHTG, we do know that there are a number of patients that are waiting, right?

Speaker #7: So that actually lends us a lot of confidence, not only in the FCS space, but also as we get closer to the June 30th PDUFA date.

Speaker #7: And SHTG, I think it's indicating that there is a lot of interest in using Olazarsan very broadly in this patient population. In terms of the launch and SHTG, we do know that there are a number of patients that are waiting, right?

Speaker #7: Especially the patients that have a history of acute pancreatitis. Patients that are above 880. And those are really the patients that we're going to focus on out of the gate.

Kyle Jenne: Especially the patients that have a history of acute pancreatitis, patients that are above 880. Those are really the patients that we're gonna focus on out of the gate. The trajectory, I think, is gonna be modest at the beginning here in 2026. I think the revenue guidance that Beth shared, of $100 million to $110 million, is consistent with that expectation, and we'll see it steadily grow over time, with that focus being on the highest risk patient population. Some of the dynamics here, as typically seen, is it takes some time for the HCPs to be educated on the label.

Speaker #7: The trajectory, I think, is going to be modest at the beginning here in 2026. I think the revenue guidance that Beth shared of $100 million to $110 million is consistent with that expectation.

Speaker #7: And we'll see it steadily grow over time, with that focus being on the highest-risk patient population. But some of the dynamics here, as typically seen, is it takes some time for the HCPs to be educated on the label.

Speaker #7: We've got to get those patients into those centers in order to get the prescriptions and then get the execution of the scripts to turn into patients on treatment.

Kyle Jenne: We've got to get those patients into the, into those centers in order to get the prescriptions and then get the execution of the scripts to turn into patients on treatment. It'll be a build over time, and it will, you know, accumulate. We expect a modest and steady growth throughout H2 of this year.

Speaker #7: So it'll be a build over time and it will accumulate. And we expect modest and steady growth throughout the back half of this year.

Speaker #1: Great. Thank you.

Chi Young: Great. Thank you.

Mike Ulz: Great. Thank you.

Speaker #4: The next question comes from Gary Nachman with Canaco Genuity. Please go ahead.

Operator: The next question comes from Gary Nachman, with Canaccord Genuity. Please go ahead.

Speaker #8: Hi, guys. Good morning and congrats on the progress. So again, on SHTG, just talk about how you expect the payer access to ramp up.

Gary Nachman: Hi, guys. Good morning and congrats on the progress. Again, on SHTG, just talk about how you expect the payer access to ramp up, the timing of that, when you think it'll really kick in. You got updated guidelines for FCS. Will you be able to get that for SHTG as well? How long before you think you could expand to a less severe patient population over time? Thanks.

Speaker #8: The timing of that. When you think it'll really kick in. And you got updated guidelines for FCS. Will you be able to get that for SHTG as well?

Speaker #8: And how long before you think you could expand to a less severe patient population over time? Thanks.

Speaker #1: Kyle, you want to take you want to start and I can touch on the guidelines.

Kyle Jenne: Kyle, you wanna take, you know, you wanna start? I can touch on the guidelines. Sure. On the payer access piece, Gary, you know, part of the price change that decision that we made on 1 April to change the WAC price to $40,000 is directly in line with working with those payers, right? It fits into the annual review cycle as they're getting ready for their 2027 decisions to be made. We believe that it will help us get ahead of SHTG a little bit, not only in 2026, but also will help us in anticipation of 2027. That being said, some payers or all payers will actually wait for the final label, right, before they make any payer coverage decisions, because they wanna see what the indication statement is.

Brett Monia: Kyle, you wanna take, you know, you wanna start? I can touch on the guidelines.

Speaker #7: Sure. On the payer access piece, Gary, part of the price change that decision that we made on April 1st to change the whack price to $40,000 is directly in line with working with those payers, right?

Kyle Jenne: Sure. On the payer access piece, Gary, you know, part of the price change that decision that we made on 1 April to change the WAC price to $40,000 is directly in line with working with those payers, right? It fits into the annual review cycle as they're getting ready for their 2027 decisions to be made. We believe that it will help us get ahead of SHTG a little bit, not only in 2026, but also will help us in anticipation of 2027. That being said, some payers or all payers will actually wait for the final label, right, before they make any payer coverage decisions, because they wanna see what the indication statement is.

Speaker #7: It fits into the annual review cycle as they're getting ready for their 2027 decisions to be made. So we believe that it will help us get ahead of SHTG a little bit, not only in 2026, but also will help us in anticipation of 2027.

Speaker #7: That being said, some payers—or all payers—will actually wait for the final label, right, before they make any payer coverage decisions, because they want to see what the indication statement is.

Speaker #7: They want to see what information is in the label including acute pancreatitis. And some of the other clinical study data. That will be included in the label.

Kyle Jenne: They wanna see what information is in the label, you know, including, you know, acute pancreatitis, and some of the other clinical study data that will be included in the label. It'll take a little bit of time. Some payers will say, you know, we're not gonna review anything for 6 to 9 months, for example. That's standard policy with some payers. We hope that we'll be able to get ahead of that with the payers that do review earlier by making that price change and also with our current interactions that we're having leading up to the SHTG approval. We're gonna work quickly, and I think we're in a good spot right now in terms of the way that we're approaching the payers.

Speaker #7: So it'll take a little bit of time. Some payers will say, "We're not going to review anything for six to nine months," for example.

Speaker #7: That's standard policy with some payers. But we hope that we'll be able to get ahead of that with the payers that do review earlier by making that price change and also with our current interactions that we're having leading up to the SHTG approval.

Speaker #7: So we're going to work quickly and I think we're in a good spot right now in terms of the way that we're approaching the payers.

Kyle Jenne: Gary, to your other question, you know, we're very pleased by the fact that the cardiovascular treatment guidelines for FCS has singled out TRYNGOLZA as the treatment of choice for this disease indication. We applaud the aggressiveness that they are taking to update their guidelines for treatments. We believe that SHTG will be part of that in the future, which again, we believe TRYNGOLZA will be a treatment of choice for severe hypertriglyceridemia. They've been very supportive of the new treatments that are coming out, and we think that they will move pretty quickly.

Brett Monia: Gary, to your other question, you know, we're very pleased by the fact that the cardiovascular treatment guidelines for FCS has singled out TRYNGOLZA as the treatment of choice for this disease indication. We applaud the aggressiveness that they are taking to update their guidelines for treatments. We believe that SHTG will be part of that in the future, which again, we believe TRYNGOLZA will be a treatment of choice for severe hypertriglyceridemia. They've been very supportive of the new treatments that are coming out, and we think that they will move pretty quickly.

Speaker #1: And Gary, to your other question, we're very pleased by the fact that the cardiovascular treatment guidelines for FCS has singleed out Trengoza as the treatment of choice for this disease indication.

Speaker #1: And we employed the aggressiveness that they are taking to update their guidelines for treatments, and we believe that SHTG will be part of that in the future.

Speaker #1: Which again, we believe Trengoza will be a treatment if of choice for severe hypertriglyceridemia. They've been very, very supportive of the new treatments that are coming out and we think that they will move pretty quickly.

Kyle Jenne: We're also pleased by the fact that they have increased or updated their guidelines on Lp(a) testing, which bodes well for a potential positive Phase 3 readout for pelacarsen and subsequent launch. It's great news for patients, and it's great news for our pipeline. In terms of the less severe patient population, you know, we'll start with the over 880 and over 500 with history of AP. However, those same physicians that are treating that patient population also have patients that are 500 to 880, for example. The education will be ongoing. We're in the right segment of HCPs in terms of our targets, right? Focused on cardiology, endocrinology, and lipid specialists. They'll see a mix of those patients.

Brett Monia: We're also pleased by the fact that they have increased or updated their guidelines on Lp(a) testing, which bodes well for a potential positive Phase 3 readout for pelacarsen and subsequent launch. It's great news for patients, and it's great news for our pipeline.

Speaker #1: We're also pleased by the fact that they have increased the or updated their guidelines on Lp(a) testing, which bodes well for a potential positive phase 3 readout for Pelicarsan.

Speaker #1: And the subsequent launch. So it's great news for patients and it's great news for our pipeline.

Kyle Jenne: In terms of the less severe patient population, you know, we'll start with the over 880 and over 500 with history of AP. However, those same physicians that are treating that patient population also have patients that are 500 to 880, for example. The education will be ongoing. We're in the right segment of HCPs in terms of our targets, right? Focused on cardiology, endocrinology, and lipid specialists. They'll see a mix of those patients.

Speaker #7: And in terms of the less severe patient population, we'll start with the over 880 and over 500 with history of AP. However, those same physicians that are treating that patient population also have patients that are 500 to 880, for example.

Speaker #7: So the education will be ongoing. We're in the right segment of HCPs in terms of our targets, right? Focused on cardiology, endocrinology, and lipid specialists.

Speaker #7: So they'll see a mix of those patients. So I think some of those patients will already be picked up, especially if they have comorbidities.

Kyle Jenne: I think some of those patients will already be picked up, especially if they have comorbidities, type 2 diabetes and/or ASCVD. You know, the broader population will take a little bit of time just for awareness and for more of the data and information to come out and more experience of using olezarsen in the SHTG population. There's a lot of optimism and a lot of excitement around the category and around the use of a product like this because they've never seen the triglyceride-lowering effects that they're gonna see on top of standard of care, and they've never seen the outcomes in acute pancreatitis like they've seen with the CORE and CORE2 data.

Speaker #7: Type 2 diabetes and/or ASCVD. But the broader population will take a little bit of time just for awareness and for more of the data and information to come out.

Speaker #7: And more experience of using Olazarsan in the SHTG population. So there's a lot of optimism and a lot of excitement around the category and around the use of a product like this because they've never seen the triglyceride-lowering effects that they're going to see on top of standard of care.

Speaker #7: And they've never seen the outcomes in acute pancreatitis like they've seen with the Core and Core 2 data.

Gary Nachman: Great. Thank you very much.

Speaker #1: Great. Thank you very much.

Operator: The next question comes from Jason Gerberry with Bank of America. Please go ahead.

Speaker #4: The next question comes from Jason Garberi with Bank of America. Please go ahead.

Chi Young: Hey, good morning. This is Chi Young for Jason. Thanks for taking our question. On olezarsen SHTG, could you give us an update on the levels of liver fat you observed in the CORE open label extension studies? To what extent those open label extension study data have been incorporated into the NDA as the FDA reviews the totality of the safety data? When would you expect to present the updated OLE data later this year? Thanks so much.

Speaker #9: Hey, good morning. This is Chian for Jason. Thanks for taking our question. On Olazarsan SHTG, could you give us an update on the levels of liver fat you've observed in the Core open label extensions studies?

Speaker #9: To what extent those open label extension study data have been incorporated into the NDA SDFDA reviews the totality of the safety data? And when would you expect to present the updated OLE data later this year?

Speaker #9: Thanks so much.

Brett Monia: Yeah, let me start, Chi. Thank you for the question, and then I'll pass it on to Eugene. Maybe you could comment on where we are in the regulatory process for SHTG briefly. We're very pleased with the ongoing open label extension data that we're continuing to accumulate with respect to MRI as assessment of hepatic fat fraction. As you recall, the increases in hepatic fat that we saw were relatively minor, and there were no clinical sequelae associated with increase in these small increases in triglycerides. We strongly believe this is a non-target effect. It's consistent with other modalities that have taken that silencing approach in lowering APOC3 in this patient population.

Speaker #1: Yeah, let me start, Chi. Thank you for the question and then I'll pass it on to Eugene. Maybe you could comment on where we are in the regulatory process for SHTG briefly.

Speaker #1: But we're very pleased with the ongoing open label extension data that we're continuing to accumulate. With respect to MRI assessment of hepatic fat fraction, as you recall, the increases in hepatic fat that we saw were relatively minor.

Speaker #1: And there were no clinical sequelae associated with increase in these small increases in triglycerides. We strongly believe this is a non-target effect. It's consistent with other modalities that have taken a silencing approach in lowering ApoC3 in this patient population.

Brett Monia: It's completely logical based on the mechanism of inhibition of APOC3, which leads to a rapid and substantial clearance of triglycerides in large part through the liver. We've always felt that the observations in liver fat that we've seen here, again, no clinical sequelae associated, would be transient based on the liver just needing to have a little bit more time to clear out the liver that's being shunted through the liver. That's what we're seeing in the long-term extension data. We're seeing a return to baseline in liver fat. Again, no clinical associate sequelae associated with anything in the long-term extension.

Speaker #1: And it's completely logical based on the mechanism of inhibition of ApoC3, which leads to a rapid and substantial clearance of triglycerides in large part through the liver.

Speaker #1: And we've always felt that the changes in that the observations in liver fat that we've seen here again, no clinical sequelae associated would be transient based on the liver just needing to have a little bit more time to clear out the liver that's being shunted through the liver.

Speaker #1: And that's what we're seeing. In the long-term extension data, we're seeing a return to baseline. In liver fat, again, no clinical sequelae associated with anything in the long-term extension.

Brett Monia: We look forward to presenting the data in H2 of this year at a major medical congress. Stay tuned for that. Eugene, you wanna provide an update on regulatory?

Speaker #1: And we look forward to presenting the data in the second half of this year at a major medical congress. So stay tuned for that.

Speaker #1: Eugene, want to provide an update on regulatory?

Eugene Schneider: Yeah. The application's under review. Everything is going as planned. Of course, the emerging safety data has been provided to the agency as part of routine, day 90 safety updates. That's under review now with no questions asked so far.

Brett Monia: Yeah. The application's under review. Everything is going as planned. Of course, the emerging safety data has been provided to the agency as part of routine, day 90 safety updates. That's under review now with no questions asked so far.

Speaker #7: Yeah, the applications under review, everything is going as planned. Of course, the emerging safety data has been provided to the agency as part of routine day 90 safety updates.

Speaker #7: So that's under review now with no questions asked so far.

Brett Monia: I'll also add that the discontinuations in the long-term extension are extremely low. We're seeing excellent compliance with long-term treatment in the open label extension. Stay tuned. We're very much looking forward to presenting the results.

Kyle Jenne: I'll also add that the discontinuations in the long-term extension are extremely low. We're seeing excellent compliance with long-term treatment in the open label extension. Stay tuned. We're very much looking forward to presenting the results.

Speaker #1: I'll also add that the discontinuations in the long-term extension are extremely low. We're seeing excellent compliance with long-term treatment. In the open label extension.

Speaker #1: So stay tuned. We're very much looking forward to presenting the results.

Kyle Jenne: Great. Thanks.

Chi Young: Great. Thanks.

Speaker #9: Great. Thanks.

Operator: The next question comes from Eliana Merle of Barclays. Please go ahead.

Speaker #4: The next question comes from Elie Merle of Barclays. Please go ahead.

Taj Hasan: Hi, this is Taj Hasan for Ellie. Thanks for taking our question. In SHTG, you have a set of competitor readouts coming up later this year. Curious just how you would frame those data in the context of the space and if any outcomes there would impact your peak sales view in SHTG.

[Analyst] (Barclays): Hi, this is Taj Hasan for Ellie. Thanks for taking our question. In SHTG, you have a set of competitor readouts coming up later this year. Curious just how you would frame those data in the context of the space and if any outcomes there would impact your peak sales view in SHTG.

Speaker #8: Hi, this is Tejasan for Elie. Thanks for taking our question. In SHTG, you have a set of competitor readouts coming up later this year.

Speaker #8: Curious just how you would frame those data in the context of the space. And if any outcomes there would impact your peak sales view in SHTG?

Brett Monia: We'd rather not comment on competitor data that doesn't even exist yet today. I mean, we're looking forward to seeing any additional data that comes out this year, next year, and years to come in SHTG from other programs. All I'll say is that phase three data that we presented at American Heart Association in late-breaking clinical trial section session last year is incredibly compelling. It's a very high bar to me with respect to efficacy, with respect to safety, with respect to tolerability. 85% reduction in acute pancreatitis, which has resonated very well in the HCP community, as Kyle highlighted earlier in his prepared remarks. 72% reduction in triglycerides on top of standard of care.

Speaker #1: We'd rather not comment on competitor data that doesn't even exist yet today. I mean, we're looking forward to seeing any additional data that comes out this year, next year, and years to come.

Speaker #1: In SHTG, from other programs. All I'll say is that the phase 3 data that we presented at American Heart Association in late breaking clinical trial section session last year was incredibly compelling.

Speaker #1: It's going to be it's a very high bar. To me, with respect to efficacy, with respect to safety, with respect to tolerability, 85% reduction in acute pancreatitis.

Speaker #1: Which has resonated very well in the HCP community as Kyle highlighted earlier in his prepared remarks. 72% reduction in triglycerides on top of standard of care.

Brett Monia: We're focused on our program. We're ready to launch in June. I'll just leave it right there. Thank you.

Speaker #1: We're focused on our program. We're ready to launch in June. And we're not and I'll just leave it right there. Thank you.

Kyle Jenne: I'll just add, this is a large market, greater than 3 million patients that are potentially addressable here. We have a lot of confidence in the greater than $3 billion peak that we've put out there. That's really based on the Phase 3 clinical trial outcomes that we have. It's based on our HCP demand research. It's based on the comprehensive, payer research that we've done and also the final pricing decision that we made. You know, we stand behind the increase, and we're excited about launching this program and getting it to as many patients as possible after the 30 June PDUFA date.

Speaker #8: I'll just add, this is a large market. Greater than 3 million patients that are potentially addressable here. We have a lot of confidence in the greater than 3 billion dollar peak that we've put out there.

Speaker #8: That's really based on the phase 3 clinical trial outcomes that we have. It's based on our HCP demand research. It's based on the comprehensive payer research that we've done.

Speaker #8: And also the final pricing decision that we made. So we stand behind the increase in we're excited about launching this program and getting it to as many patients as possible after the June 30th PDUFA date.

Operator: The next question comes from Jay Olson with Oppenheimer. Please go ahead.

Speaker #4: The next question comes from Jay Olson with Oppenheimer. Please go ahead.

Jay Olson: Oh, hey, congrats on the quarter, and thank you for this update. Maybe I'll shift gears to donzepil. Can you talk about how you expect the competitive landscape to evolve in HAE and any feedback that you're getting from patients and physicians on donzepil and any color that you're getting on what % of patients are currently on every 8-week dosing? Thank you.

Speaker #10: Oh, hey, congrats on the quarter and thank you for this update. Maybe I'll shift gears to Donzera. Can you talk about how you expect the competitive landscape to evolve in HAE and any feedback that you're getting from patients and physicians on Donzera and any color that you're getting on what percent of patients are currently on every eight-week dosing?

Speaker #10: Thank you.

Brett Monia: Take that.

Kyle Jenne: Yeah, happy to, Jay. Thanks for the question. The competitive landscape obviously is evolving. I mean, there was some, you know, recent announcement as late as this week related to some of the dynamics in the marketplace. Keep in mind that in the United States, over 75% of the patients are currently on a prophylactic treatment. You know, this is a switch market as we understand the dynamics to be. We're really pleased with the momentum that we're seeing in terms of the interest in using donzepil, which is the first RNA-targeted therapy modality in order to treat these patients.

Speaker #7: Yeah, happy to, Jay. Thanks for the question. The competitive landscape obviously is evolving. I mean, there was some recent announcement as late as this week related to some of the dynamics in the marketplace.

Speaker #7: Keep in mind that in the United States, over 75% of the patients are currently on a prophylactic treatment. This is a switch market as we understand the dynamics to be.

Speaker #7: And we are really pleased with the momentum that we're seeing in terms of the interest in using Donzera, which is the first RNA-targeted therapy modality in order to treat these patients.

Kyle Jenne: The patient and HCP feedback has been extremely positive when they've been able to transition over to donzepil or start donzepil as a naive patient. What led into this, you know, in terms of our market research is consistently being played out in the market. This is about efficacy, it's about tolerability and convenience. All three of those things are stacking up very nicely with the profile of donzepil, and patients are responding very positively to the therapy. The majority of patients start on a 4-week dosing schedule. This is to make sure that they get transitioned over, that they're well-controlled, and then they have the option, per the labeled indication, to move over to every 8 weeks if they choose to do so.

Speaker #7: The patient and HCP feedback has been extremely positive. When they've been able to transition over to Donzera or start Donzera as a naive patient.

Speaker #7: What led into this in terms of our market research is consistently being played out in the market. Really, this is about efficacy; it's about tolerability and convenience.

Speaker #7: And all three of those things are stacking up very nicely with the profile of Donzera in patients who are responding very positively to the therapy.

Speaker #7: Now, the majority of patients start on a four-week dosing schedule. This is to make sure that they get transitioned over, that they're well controlled, and then they have the option per the labeled indication to move over to every eight weeks if they choose to do so.

Kyle Jenne: As early in the launch as we are right now, you would anticipate that the majority of patients would be on a four-week regimen. We will expect over time that they'll be able to progress onto an eight-week schedule as they're doing well on therapy, and we saw that in the clinical trial as well. Patients are doing great. Momentum is very strong, and we're encouraged by what we're seeing in terms of the metrics with the launch at this point.

Speaker #7: So as early in the launch as we are right now, you would anticipate that the majority of patients would be on a four-week regimen.

Speaker #7: And we will expect over time that they'll be able to progress onto an eight-week schedule as they're doing well on therapy. And we saw that in the clinical trial as well.

Speaker #7: So patients are doing great momentum is very strong. And we're encouraged by what we're seeing in terms of the metrics with the launch at this point.

Operator: Great. Thank you. The next question comes from Moritz Reiterer with Guggenheim Securities. Please go ahead.

Jay Olson: Great. Thank you.

Speaker #10: Great. Thank you.

Operator: The next question comes from Moritz Reiterer with Guggenheim Securities. Please go ahead.

Speaker #4: The next question comes from Moritz Reiterer with Guggenheim Securities. Please go ahead.

Moritz Reiterer: Hi, this is Moritz on for David. Thanks for taking our questions. I'll continue on donzepil. Your 2026 guidance for donzepil is essentially above what consensus was going into the quarter. I was just trying to understand a little bit better what data drove this guidance number. Also, if you could comment a little bit more on the current mix between new patient starts versus switches, and how you expect this to evolve through the end of the year. Thank you.

Speaker #11: Hi, this is Moritz. I'm for debit. Thanks for taking our questions. I'll continue on Donzera. Your 2026 guidance for Donzera is potentially above what consensus was going into the quarter.

Speaker #11: So it's just trying to understand a little bit better what data drove this guidance number and also if you could comment a little bit more on the current mix between new patient starts versus switches and how you expect this to evolve through the end of the year.

Speaker #11: Thank you.

Kyle Jenne: Yeah, I'd be happy to touch on that. Thanks for the question. You know, we had a very strong first quarter. $16 million in net product sales. This is a 128% increase over Q4. I just spoke about the momentum that we're seeing in this market and the dynamics and also the receptivity by both HCPs and patients as they get started and gain experience with donzepil. All of those things that I just described are really what is encouraging us, and I think where we feel very confident that $110 to 120 million in sales this year is very achievable.

Speaker #8: Yeah, I'd be happy to touch on that. Thanks for the question. We had a very strong first quarter, 16 million dollars in net product sales.

Speaker #8: This is 128% increase over Q4. And I just spoke about the momentum that we're seeing in this market. And the dynamics and also the receptivity by both HCPs and patients as they get started in gaining experience with Donzera.

Speaker #8: So all of those things that I just described are really what is encouraging us. And I think where we feel very confident that 110 to 120 million dollars in sales this year is very achievable.

Kyle Jenne: In terms of the new patient starts, the majority are switches, right? This is a switch market. Greater than 75% of the patients are on a prophylactic therapy in the United States. It's gonna take time and time to build, you know, the revenues quarter over quarter. That it's happening the way that we expected it based on what we're seeing in the trends with Q4 as well as Q1. In addition to that, we are seeing some patients that haven't been on a prophylactic therapy before start on donzepil. Those patients, in addition to those that are being treated with an acute therapy only today, that are starting on donzepil.

Speaker #8: In terms of the new patient starts, the majority are switches, right? This is a switch market, greater than 75% of the patients are on a prophylactic therapy in the United States.

Speaker #8: So it's going to take time and time to build the revenues quarter over quarter. But it's happening the way that we expected it based on what we're seeing in the trends with Q4 as well as Q1.

Speaker #8: In addition to that, we are seeing some patients that haven't been on a prophylactic therapy before start on Donzera. So those patients, in addition to those that are being treated with a cute te therapy only today, that are starting on Donzera, those three patient segments I think speak to the fact that the profile is very strong and what patients and HCPs are looking for.

Kyle Jenne: You know, those three patient segments, I think, speak to the fact that the profile is very strong in what patients and HCPs are looking for. We have a differentiated mechanism of action, our sales execution and market access teams are doing a great job in terms of supporting these patients to get started and stay on treatment.

Speaker #8: We have a differentiated mechanism of action. And our sales execution and market access teams are doing a great job in terms of supporting these patients to get started and stay on treatment.

Operator: The next question comes from Yaron Werber of TD Cowen. Please go ahead.

Speaker #4: The next question comes from Yaron Werber of TD Cohen. Please go ahead.

[Analyst] (TD Cowen): Hi, this is Steve, in on for Yaron Werber. Thank you very much for the update and congratulations on the progress. On the collaborative revenues for the rest of the year and for maybe 2027, can you talk about what you're projecting? 'Cause those came out a bit higher, I think, than consensus may have. Further on zilganersen, can you talk about how any patients' awareness efforts have found any new updates to the size of the market? You had mentioned before that about 50% of patients have been identified. Any update to the sizing there would be helpful. Thank you very much.

Speaker #11: Hi, this is Steven On for your own thank you very much for the update. And congratulations on the progress. On the collaborative revenues for the rest of the year and for maybe the 2027, can you talk about what your projecting?

Speaker #11: Because those came out a bit higher, I think, than consensus may have. Further, on Zilgenersen, can you talk about how any patients' awareness efforts have found any new updates to the size of the market?

Speaker #11: You had mentioned before that about 50% of patients have been identified. Any update to the sizing there would be helpful. Thank you very much.

Kyle Jenne: If you wanna start and then, Kyle take the second part.

Brett Monia: If you wanna start and then, Kyle take the second part.

Speaker #8: If you want to start and then Kylie take the second part.

Elizabeth Hougen: Sure. On the collaborative revenue for this year, the way to think about it is we've raised our revenue guidance for the total year to $875 million to $900 million. That is slightly weighted towards commercial revenue. You can think about that split being slightly more weighted towards commercial revenue versus R&D revenues. Obviously, we've already realized and recognized $95 million in milestones, plus our ongoing collaborative revenue, which put us, you know, well over $100 million, closer to $130 million, $140 million for the first quarter. We've got a host of other milestones that we could potentially earn over the remainder of this year, plus our ongoing collaborative revenue from WAINUA cost share and amortization.

Speaker #12: Sure. So I'm a collaborative revenue for this year. The way to think about it is we've raised our revenue guidance for the total year to 875 million to 900 million dollars.

Speaker #12: That is slightly weighted towards commercial revenue. So you can think about that split being slightly more weighted towards commercial revenue versus R&D revenues. Obviously, we've already realized and recognized 95 million dollars in milestones plus our ongoing collaborative revenue which put us well over 100 million closer to 130, 140 million dollars for the first quarter.

Speaker #12: We've got a host of other milestones that we could potentially earn over the remainder of this year. Plus our ongoing collaborative revenue from we knew a cost share and amortization.

Elizabeth Hougen: That is, you know, all the items that really give us confidence in the overall collaborative revenue for this year. For 2027, we've got. Think about it this way: There's some very large potential milestones for approvals coming in 2027 with the Phase 3 data that we're expecting to see from Pelacarsen, Tofersen in particular. Those milestones are likely gonna drive collaborative revenue in 2027.

Speaker #12: So that is all the items that really give us confidence in the overall collaborative revenue for this year. And then for '27, we've got think about it this way.

Speaker #12: There's some very large potential milestones for approvals coming in '27 with the phase three data that we're expecting to see from Hella Carson in particular.

Speaker #12: And those milestones are likely going to drive collaborative revenue in '27.

Brett Monia: Yeah.

Brett Monia: Our launch preparations are going really well, right?

Speaker #8: Yeah. And our launch preparations are going really well, right?

Brett Monia: Our launch preparations are going really well, right?

Kyle Jenne: For Zilganersen, I just, you know, just reinforce the excitement that we've got around this program. You know, this is gonna be our first anticipated neurology launch program. To be able to potentially bring this therapy to patients living with Alexander disease, I think is really an exciting opportunity for the community and also exciting for Ionis. In terms of the approach here, we're really gonna be focused on the patients that are currently on the clinical trial and helping get those patients moved over so that they can maintain treatment. The second area that we'll focus on are patients that are going to be enrolled in our expanded access program, which is ongoing and going very well.

Brett Monia: For Zilganersen, I just, you know, just reinforce the excitement that we've got around this program. You know, this is gonna be our first anticipated neurology launch program. To be able to potentially bring this therapy to patients living with Alexander disease, I think is really an exciting opportunity for the community and also exciting for Ionis. In terms of the approach here, we're really gonna be focused on the patients that are currently on the clinical trial and helping get those patients moved over so that they can maintain treatment. The second area that we'll focus on are patients that are going to be enrolled in our expanded access program, which is ongoing and going very well.

Speaker #11: Yeah. For Zilgenersen, I want to just reinforce the excitement that we've got around this program. This is going to be our first anticipated neurology launch program.

Speaker #11: And to be able to potentially bring this therapy to patients living with Alexander disease I think is really an exciting opportunity for the community and also exciting for IONIS.

Speaker #11: In terms of the approach here, we're really going to be focused on the patients that are currently on the clinical trial. And helping get those patients moved over so that they can maintain treatment.

Speaker #11: The second area that we'll focus on is patients who are going to be enrolled in our expanded access program, which is ongoing and going very well.

Kyle Jenne: As you asked, what about the patients that are currently being identified and how do we help get those patients on treatment? We believe that there are approximately 300 or so Alexander disease patients in the United States. About 50% of those have been identified thus far. Some of them are on therapy that I just referenced. We are doing some expanded work through our omni-channel and through our non-personal promotion campaigns to help identify more and more of these patients. What we want to make sure of is that they have the opportunity to experience zilganersen as the patients in the clinical trial did, to potentially have the positive outcomes that were seen in that trial.

Brett Monia: As you asked, what about the patients that are currently being identified and how do we help get those patients on treatment? We believe that there are approximately 300 or so Alexander disease patients in the United States. About 50% of those have been identified thus far. Some of them are on therapy that I just referenced. We are doing some expanded work through our omni-channel and through our non-personal promotion campaigns to help identify more and more of these patients. What we want to make sure of is that they have the opportunity to experience zilganersen as the patients in the clinical trial did, to potentially have the positive outcomes that were seen in that trial.

Speaker #11: And then as you asked, what about the patients that are currently being identified and how do we help get those patients on treatment? We believe that there are approximately 300 or so Alexander disease patients in the United States about 50% of those have been identified thus far.

Speaker #11: Some of them are on therapy that I just referenced. But we are doing some expanded work through our omnichannel and through our non-personal promotion campaigns to help identify more and more of these patients.

Speaker #11: And really, what we want to make sure of is that they have the opportunity to experience Zilgenersen as the patients in the clinical trial did, to potentially have the positive outcomes that we're seeing in that trial.

Kyle Jenne: Patient identification will be a key area of focus, and we're doing that while we're really making sure that we're gonna take care of the patients that are on treatment today and those that are awaiting treatment that have already been identified.

Speaker #11: So patient identification will be a key area of focus. And we're doing that while we're really making sure that we're going to take care of the patients that are on treatment today and those that are awaiting treatment that have already been identified.

Brett Monia: Patient identification will be a key area of focus, and we're doing that while we're really making sure that we're gonna take care of the patients that are on treatment today and those that are awaiting treatment that have already been identified.

Operator: The next question comes from Luca Issi of RBC Capital Markets. Please go ahead.

Speaker #4: The next question comes from Luca Issi of RBC Capital Markets. Please go ahead.

Cassian: Thank you. Thanks so much for taking our questions. This is Cassian for Luca. Good morning, team. Quick question on WAINUA. What happened to WAINUA for the quarter? Drug is actually down 35% versus the Q4. What drove the weakness here? It looks like AstraZeneca is flagging the availability of the drug now as a prefilled syringe to be administered by healthcare provider. Did that have a negative impact on growth to net? Any color there is much appreciated. Thank you so much.

[Analyst] (RBC Capital Markets): Thank you. Thanks so much for taking our questions. This is Cassian for Luca. Good morning, team. Quick question on WAINUA. What happened to WAINUA for the quarter? Drug is actually down 35% versus the Q4. What drove the weakness here? It looks like AstraZeneca is flagging the availability of the drug now as a prefilled syringe to be administered by healthcare provider. Did that have a negative impact on growth to net? Any color there is much appreciated. Thank you so much.

Speaker #12: Thank you. Thanks so much for taking our questions. This is Cassian for Luca. And good morning, team. Quick question now. I knew what happened to I knew for the quarter.

Speaker #12: Drug is actually down 35% versus the fourth quarter. What drove the weakness here? And it looks like AstraZeneca is flagging the availability of the drug now as a prefill syringe to be administered by healthcare provider.

Speaker #12: Did that have a negative impact on growth to net? Any color there is much appreciated. Thank you so much.

Kyle Jenne: Yeah. At Q1, we continued to see very strong demand in terms of patients on therapy as well as new patient starts. Demand is still there. Oftentimes you see some some January, February pressure as it relates to reauthorizations and the timing of those reauthorizations, which drove some of the pressure early in the quarter. We expect to see that pick up in subsequent quarters and in return to revenue growth as we move into Q2 and beyond in the US. You asked about the prefilled syringe. Really, that's been put out there for optionality, right?

Speaker #11: Yeah. So in Q1, we continued to see very strong demand. In terms of patients on therapy as well as new patient starts. So demand is still there.

Speaker #11: Oftentimes you see some January, February pressure as it relates to reauthorizations and the timing of those reauthorizations which drove some of the pressure early in the quarter.

Speaker #11: But we expect to see that pick up in subsequent quarters and in return to revenue growth as we move into Q2 and beyond in the US.

Speaker #11: You asked about the prefilled syringe. Really, that's been put out there for optionality. Right? It's flexibility of dosing and it's to allow HCPs to determine if they want to use the auto injector or if they want to be able to treat these patients in some of the major centers with a prefilled syringe.

Kyle Jenne: It's flexibility of dosing, and it's to allow HCPs to determine if they wanna use the auto-injector or if they wanna be able to treat these patients in some of the major centers with a prefilled syringe. It's really optionality for the program. That is not impacting the gross to net at this point. It's way too early to see any impact of that. You know, I would just keep an eye towards future quarters. Again, this is the hereditary polyneuropathy space. The market is growing rapidly on the cardiomyopathy space and the eye towards CARDIO-TTRansform readout and getting ready for that launch is definitely where the line of sight is.

Speaker #11: So it's really optionality for the program. That is not impacting the gross to net. At this point, it's way too early to see any impact of that.

Speaker #11: And so I would just keep an eye towards future quarters and again, this is the hereditary polyneuropathy space. The market is growing rapidly on the cardiomyopathy space.

Speaker #11: And the eye towards cardio-transform readout and getting ready for that launch is definitely where the line of sight is.

Cassian: All right. Thank you.

[Analyst] (RBC Capital Markets): All right. Thank you.

Speaker #4: Got it. Thank you. The next question is from Yananzu. With Wells Fargo Securities, please go ahead.

Operator: The next question is from Yanan Xu with Wells Fargo Securities. Please go ahead.

Yanan Xu: Great. Thanks for taking our questions. Wondering for the FCS, you mentioned a great continued growth in demand. Could you help quantify that a little bit in terms of percent growth, given that, you know, the price change making it difficult for us to appreciate? Can you talk about how to think about SHTG in 2027? What kind of growth could we expect from, you know, the initial launch quarters in 2026? Obviously, you guided for peak revenue at $3 billion. Any sense that how long that might take? Any color would be super helpful. Thank you.

Speaker #13: Great. Thanks for taking our questions. So wondering for the FCS, you mentioned a great continued growth in demand. Could you help quantify that a little bit in terms of percent growth given that the price change making it difficult for us to appreciate?

Speaker #13: And then can you talk about how to think about SHTG in 2027? What kind of growth could we expect from the initial launch quarters in 2026?

Speaker #13: Obviously, you guided for peak revenue 3 billion. Any sense that how long that might take? Any color would be super helpful. Thank you.

Brett Monia: Yeah. Yanan, let me start. Kyle already touched on what expectations are for 2026 launch in SHTG. He could cover that again, but maybe comment on 2027. For FCS, as Kyle mentioned earlier, our Q1 of this year is our strongest quarter to date on patient demand and gaining access to TRYNGOLZA for FCS. That's purely a product of patient finding and the great experiences the HCPs and patients are having with TRYNGOLZA in managing their disease from an efficacy standpoint and from a tolerability standpoint. Demand has never been higher. We're thrilled with what we're seeing, and we think that that's gonna bode quite well for the SHTG launch.

Speaker #8: Yeah. Yeah. And let me start and then I'll and Kyle already touched on what expectations are for 2026 launch and SHTG. You can cover that again.

Speaker #8: But maybe comment on 2027. But for FCS, as Kyle mentioned earlier, our first quarter of this year has our strongest quarter to date. On patient demand and gaining access to trend goals for FCS.

Speaker #8: And that's purely a product of patient finding and the great experiences that HCPs and patients are having, with trend goals in managing their disease from an efficacy standpoint and from a tolerability standpoint.

Speaker #8: So demand has never been higher and we're thrilled with what we're seeing. And we think that that's going to bode quite well. For the SHTG launch.

Brett Monia: On to trajectory.

Speaker #8: Launch trajectory?

Kyle Jenne: I think what's important again is to mention that in 2026, the revenue guidance is $100 to $110 million for olezarsen this year. We expect that to grow steadily over time. As I also described, the focus initially is going to be on the high risk SHTG patient population over 880 or over 500 with history of AP. As we get into 2027, I would expect that more and more patients will start to come on board that are broader than that, type 2 diabetes, ASCVD, et cetera, as I described.

Speaker #11: Yeah. I think what's important again is to mention that in 2026, the revenue guidance is 100 to 110 million for Olazarsan this year. We expect that to grow steadily over time.

Speaker #11: As I also described, the focus initially is going to be on the high-risk SHTG patient population: those over 880, or over 500 with a history of AP.

Speaker #11: And then as we get into 2027, I would expect that more and more patients will start to come on board that are broader than that.

Speaker #11: Type 2 diabetes, ASCVD, etc. As I described. And the launch momentum will build. And so will the patient base as we get these patients on as HCPs get experience in seeing the triglyceride-lowering levels and seeing the reduction in acute pancreatitis that we're demonstrating in core and core 2.

Kyle Jenne: The launch momentum will build and so will the patient base, as we get these patients on, as HCPs get experience in seeing the triglyceride lowering levels and seeing the reduction in acute pancreatitis, that were demonstrated in CORE and CORE2. I think that experience and that evidence ultimately will help us drive the trajectory into next year.

Speaker #11: And I think that experience and that evidence ultimately will help us drive the trajectory into next year.

Yanan Xu: Great. Thanks. Very helpful.

Speaker #13: Great. Thanks. Very helpful.

Operator: The next question comes from Salveen Richter of Goldman Sachs. Please go ahead.

Speaker #4: The next question comes from Salvin Richter of Goldman Sachs. Please go ahead.

[Analyst] (Goldman Sachs): Hi, this is Mark on for Salveen. Thank you guys so much for taking our question. Congrats on the quarter. You kind of touched on the donzepil quarterly dynamics, but we were wondering what are the specific drivers for the quarter over quarter jump, and are there quarterly dynamics we should be aware of for the rest of 2026? How are you thinking of these dynamics going into 2027 and beyond?

Mark Belsey: Hi, this is Mark on for Salveen. Thank you guys so much for taking our question. Congrats on the quarter. You kind of touched on the donzepil quarterly dynamics, but we were wondering what are the specific drivers for the quarter over quarter jump, and are there quarterly dynamics we should be aware of for the rest of 2026? How are you thinking of these dynamics going into 2027 and beyond?

Speaker #14: Hi. This is Mark on for Salvin. Thank you guys so much for taking our question. Congrats on the quarter. You kind of touched on the Donzera quarterly dynamics, but we were wondering what are the specific drivers for the quarter-over-quarter jump?

Speaker #14: And are there quarterly dynamics we should be aware of for the rest of 2026? And how are you thinking of these dynamics going into 2027 and beyond?

Kyle Jenne: Yeah, the real quarter-over-quarter growth is coming from the switch cadence that we are expecting to see, right? This being a switch market. We expect that to continue throughout the course of this year. That's the big driver, right? We know that, you know, that there's a need. We know that the profile of donzepil meets the need of many of those patients, being efficacy, tolerability, and convenience. We've got the data with the switch data to help support how to move those patients over from existing prophylactic treatments over to donzepil.

Speaker #11: Yeah. The real quarter-over-quarter growth is coming from the switch cadence that we are expecting to see. Right? This being a switch market. And we expect that to continue throughout the course of this year.

Speaker #11: But that's the big driver. Right? We know that there's a need. We know that the profile of Donzera meets the need of many of those patients.

Speaker #11: Being efficacy, tolerability, and convenience. And we've got the data with the switch data to help support how to move those patients over from existing prophylactic treatments over to Donzera.

Kyle Jenne: As HCPs are gaining experience, we're seeing more and more HCPs not only prescribe for the first time, but we're also seeing those that have used the treatment before use it again and again. I think that plus payer coverage tells us that we've got an optimistic outlook in terms of what 2026 looks like. I think the $110 million to $120 million, the guidance is in line with that expectation.

Speaker #11: And as HCPs are gaining experience, we're seeing more and more HCPs not only prescribe for the first time, but we're also seeing those that have used the treatment before use it again and again.

Speaker #11: So I think that plus payer coverage tells us that we've got an optimistic outlook in terms of what 2026 looks like and I think the 110 to 120 million dollar guidance is in line with that expectation.

Brett Monia: We have time for 1 more question, please.

Speaker #8: And we have time for one more question, please.

Operator: The last question comes from Myles Minter with William Blair. Please go ahead.

Speaker #4: The last question comes from Miles Minter of With William Blair. Please go ahead.

Myles Minter: Hey, thanks for letting me in and congrats on the quarter. Just on the TTR cardiomyopathy market, you know, Pfizer did settle for a potential generic entry from tafamidis in mid 2031 versus something like, you know, 2035. Does that change the way you or AstraZeneca are thinking about the cardiomyopathy market moving forward, and how much emphasis you're gonna place on that stabilizer background therapy subgroup in CARDIO-TTRansform? Thanks very much.

Speaker #15: Hi. Thanks for letting me sneak in, and congrats on the quarter. Just on the TTR cardiomyopathy market—Pfizer did settle for a potential generic entry for Vyndamax in mid-2031 versus something like in 2035.

Speaker #15: Does that change the way you're AstraZeneca are thinking about the cardiomyopathy moving market moving forward and how much emphasis you're going to place on that stabilizer background therapy subgroup in cardio TTR transform?

Speaker #15: Thanks very much.

Brett Monia: Thank you, Myles. You know, the news that has been emerging this past week or so on genericizing tafamidis versus brand pricing has not come terribly surprising to us. It's consistent with our product sales guidance that we've put out there with AstraZeneca previously. We believe, we remain completely and believe that the silencer class will end up being the mechanism of choice for TTR amyloidosis. We believe that the silencer class will be utilized as first line treatment, as well as in those patients that inevitably progress on stabilizers.

Speaker #8: Thank you, Miles. The news that has been emerging this past week or so on genericizing to faminists versus brand pricing has not come terribly surprising to us.

Speaker #8: It's consistent with our product sales guidance that we've put out there with AstraZeneca previously. We believe we remain completely in belief that the silencer class will end up being the mechanism of choice for TTR amyloidosis.

Speaker #8: We believe that the silencer class will be utilized as first-line treatment as well as in those patients that inevitably progress unstabilizers. And combination usage to your question.

Brett Monia: Combination usage, to your question, will also be utilized, very, very, you know, robustly, especially if there's data supporting that combination usage will add further benefit to these patients that inevitably are progressing on current treatments. Our study is designed to actually generate the data that we believe could be convincing to HCPs who are asking the question whether or not combination of a stabilizer with a silencer will add further benefit to these patients. It's the largest study ever conducted in ATTR cardiomyopathy, and the combination subgroup is quite sizable. We're looking forward to the data in the H2 of this year.

Speaker #8: We'll also be utilized very, very robustly. Especially if there's data supporting that combination usage will add further benefit to these patients that inevitably are progressing on current treatments.

Speaker #8: And our study is designed to actually generate the data that we believe will could be convincing to HCPs who are asking the question whether or not combination of a stabilizer with a silencer will add further benefit to these patients.

Speaker #8: So it's the largest study ever conducted in ATTR cardiomyopathy and the combinations subgroup is quite sizable. So we're looking forward to the data in the second half of this year.

Brett Monia: We're prepared to submit the NDA by the end of this year and to launch next year. Thank you, Myles, for that. Thank you for the question, Myles. Thank you everybody who joined us today and participated on our call. We're looking forward to an outstanding year and sharing our progress along the way. Until then, thank you and have a great day, everybody.

Speaker #8: And we're prepared to submit the NDA by the end of this year and to launch next year. So thank you, Miles, for that question.

Speaker #8: Thank you for the question, Miles. Thank you, everybody. Who joined us today and participated on our call. We're looking forward to an outstanding year.

Speaker #8: And sharing our progress along the way. So until then, thank you and have a great day, everybody.

Operator: Goodbye. The conference has now concluded. Thank you for attending today's presentation. You may now disconnect.

Q1 2026 Ionis Pharmaceuticals Inc Earnings Call

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