Q4 2024 Biogen Inc Earnings Call
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Jennifer: Good morning, my name is Jennifer and I will be your conference operator today. At this time, I'd like to welcome everyone to the Biogen fourth quarter and full year 2024 earnings call and business update.
Jennifer: All lines have been placed on mute to prevent any background noise. After the speaker's remarks, there will be a question and answer session. If you'd like to ask a question during this time, simply press star 1 on your telephone keypad. Please limit yourself to one question to allow other participants time for questions.
Jennifer: If you require any further follow-up, you may press star 1 again to rejoin the queue.
Today's conference is being recorded.
Speaker Change: Thank you. I would now like to turn the conference over to Mr. Tim Power, Head of Investor Relations. Mr. Power, you may begin your conference.
Tim Power: Thanks Jennifer and good morning and welcome to BiGen's fourth quarter and full year 2024 earnings call.
Tim Power: During this call, we make forward-looking statements, which involves risks and uncertainties that may cause actual results to differ materially from our forward-looking statements. We provide a comprehensive list of risk factors in our SEC filings, which I encourage you to review.
Tim Power: Our earnings release and other documents related to our results, as well as reconciliations between GAAP and non-GAAP results discussed on this call, can be found in the investors section of Biogen.com.
Tim Power: We've also posted slides to our website that we'll be using during the call.
Tim Power: On today's call, I'm joined by our President and Chief Executive Officer, Chris Viehbacher, Dr. Priya Singhal, Head of Development, and Mike McDonnell, Chief Financial Officer.
Speaker Change: We'll make some opening comments and then move to Q&A and to allow us to get through as many questions as possible We'll kindly ask that you limit yourself to just one question and with that I'll hand over to Chris
Chris Viehbacher: Thank you, Tim. Good morning, everybody. Perhaps before we get started, I'd just like to note that this is Mike McDonald's last quarterly presentation as CFO of Biogen. Mike, I believe this is your 97th quarter as a publicly quoted CFO, so congratulations on that amazing career, and I'll just take the opportunity to thank you. You've been a terrific partner and team member, and it's been great working with you, and we will miss you. And we, of course, are joined here.
Chris Viehbacher: are also by Robin Kramer. I'm also proud to say that we've been able to promote from within, and it's a great source of pride that we have that level of talent within the organization.
So, let's turn to Q4.
Chris Viehbacher: As you all know, we have been faced with increased competition for our multiple sclerosis franchise.
Chris Viehbacher: And really all of our priorities are thinking about how do we now build a new biogen? How do we build a new phase of growth? And we are focused really around three core priorities.
Chris Viehbacher: The first are clearly the four products that we launched last year in Alzheimer's, Friedrichs ataxia, depression, and ALS.
Chris Viehbacher: You know, each of those products is not only a first-in-class, but first disease-modifying agent in each of these diseases.
Chris Viehbacher: Now that's a source of pride in the level of innovation that Biogen is capable of, but equally from a commercial point of view, this is a significant challenge since the level of education when you're a pioneer in an area is so much greater, and we'll come back and talk a little bit more about that.
Chris Viehbacher: The next is we have really reprioritized the pipeline. It's certainly been my experience over the years that focusing on a number of key projects is core to business success.
Speaker Change: And I'm particularly grateful to both Priya Singhal and Jane Grogan, because they have both really...
Speaker Change: I think cleaned out the pipeline for development, in Priya's case, in research, in Jane's case.
Speaker Change: And we're actually excited now by the products that are in there. We've got a number of key developments that we'll start reading out in 2026.
Speaker Change: We think this is a multi-billion dollar portfolio and we're probably one of the few companies that can look at a pipeline that could be more than our current biopharmaceutical business when it gets to peak sales, if it all obviously comes to market.
Speaker Change: So, if we could go to the, oh, and the third point, of course, is...
Speaker Change: You know, we have redesigned the company with a reduction of operating expenses.
Not just saving costs for the sake of cost.
Speaker Change: but the ability to release resources for investing in growth. And that's what we're continuing to do. We're excited about our pipeline, but we've also freed up an awful lot of cash flow, as you'll see later. And that cash flow we're investing for more substrate in growth. So, yes, now, Dan, please, next slide.
Speaker Change: So, you know, the race really that we are faced with is seeing the erosion of our multiple sclerosis product revenue. But I'm particularly happy to see in 2024 that the revenue from our launch products
Speaker Change: really offset, more than offset the decline in our multiple sclerosis product revenue. And indeed, when you actually look, that total revenue declined by $160 million.
And you note that contract manufacturing declined by $247 million.
Speaker Change: It meant that really our core pharma business actually grew, and that's for the first time in four years.
Speaker Change: And that's really what we're all about in the near term, is trying to make sure that the revenue can exceed the multiple sclerosis product decline. Multiple sclerosis product decline is obviously driven by a number of factors.
Speaker Change: going forward and including the timing of a Tysabri biosimilar in the U.S. and and timing of Tecfidera generics in Europe. Go to the next slide please Dan.
Speaker Change: So as I said, you know, we've got actually four very innovative pioneering products. Lakembi will come on to talk about in some detail. Skyclaris and Friedrichs ataxia, again, very first treatment for Friedrichs ataxia. We have been able to determine from
Speaker Change: from basically medical claims data that there are approximately 4,800 patients in the U.S. That's about what we thought.
One of the complexities is that
It's harder to find these patients because
Speaker Change: You could have a primary care physician in a rural setting that has one single patient and you have to go find them. And we're talking to primary care physicians, talking to cardiologists, talking to pediatricians. So it's quite a large prescriber base for a very narrow patient population.
Speaker Change: But that, of course, is the core of what Rare Diseases does. I remember years ago when we acquired Genzyme when I was at Santa Fe, and the marketing folks were saying, our marketing strategy is looking for needles in haystacks.
Speaker Change: And that is exactly what rare disease is all about, and it's what Biogen is also very good at.
Speaker Change: And, of course, today we've got a lot more technology. We can use tools such as AI and genetic testing to help find those patients.
Speaker Change: But by its very nature, it is unfortunately not going to be the nice smooth progression
Speaker Change: That said, we're particularly proud to say that we have been able to double the number of patients on treatment in the past year.
Not all of those are yet being reimbursed.
Speaker Change: We are able to get a lot of patients on drug and then negotiate with governments, particularly in Europe, to get the reimbursement.
free goods patients to actually revenue-generating treatments.
Speaker Change: There's always a bit of a, in each country, a number of patients who are diagnosed, who have been waiting for treatment, and you can get those quite easily.
Speaker Change: There are a number of older patients who actually have lived with this disease for 30, 40 years, and they're the ones we actually have to go hunt for.
Speaker Change: We will see another growth driver this year in that we expect to get approval for Skyclaris in Latin America. I was in Brazil last year and
Speaker Change: There are quite a number of patients in Latin America. So, you know, as we started with the US, we moved to Europe and then we're moving to South America.
Speaker Change: and in the areas of the Middle East, you know, we expect to see continued steady growth out of SkyClaris, but again, I can appreciate that it's going to be hard for some of you to model on a quarterly basis.
Speaker Change: ZooZooVate was a very nice launch last year and certainly exceeded our expectations. One of the things that was different from our expectations was that the
Speaker Change: The main prescribers are actually OBGYN and OBGYN. We had actually been targeting originally high prescribing psychiatrists. We still see some of those, but as you can see, 80% of the prescriptions are driven by OBGYNs.
Speaker Change: This is also an area where you could have potentially more people who have ever prescribed for PPD than you actually have patients. And again,
Speaker Change: Targeting and thinking about multi-channel marketing commercial approaches are extremely important.
Speaker Change: We have filed in Europe and would hope to see an approval sometime later this year. CALSADI is not necessarily a big revenue generator, but this is really a breakthrough treatment in ALS. This is the first time we've been able to demonstrate that.
Speaker Change: Neurofilament can really help predict drugs early in development as to whether or not they are likely to work or not, and that allows just the whole research and development in ALS to be accelerated. So we're particularly proud of that. The impact on patients is absolutely extraordinary, and so while we may not be making a big impact on revenue, we're certainly making a big impact on patients' lives.
Go to the next slide, please, Dan.
Speaker Change: Now, I showed this slide in J.P. Morgan, and there were several investors who looked at that chart and said, this is not the chart of a small product. And, you know, we've all been in this business and looked at a lot of launch curves, and we all know that we like to see an acceleration in the curve.
Speaker Change: But, you know, any curve that goes from bottom left to upper right isn't, in my books, good, unless we're talking about operating expenses. And this is good, steady, quarter-on-quarter progress.
Speaker Change: We have seen some questions on the Ex-U.S. launch. Clearly the Ex-U.S. launch is contributing more than we have seen in prior launches in other areas.
Speaker Change: I think part of that is, first, I think ASEI is extremely strong in Asia, and they are leading that launch there. But second, I think the single-payer system removes a lot of the obstacles that we're dealing with in the U.S.
Speaker Change: When you have a single payer, you're not having to negotiate quite so much in terms of PET scans and MRIs.
fusion beds.
and that has facilitated the progress and it's
Speaker Change: It's as strong in China as it is in Japan, not necessarily in patient numbers, but we're seeing very strong growth in China and that is a...
Speaker Change: that is a cash pay market and goes to really a demonstration of how people value the importance of of Lakembi. So we'll go to the next chart please.
Speaker Change: Now, I talked about some of those obstacles, and we certainly see that making this easier for both patients and physicians is going to accelerate the launch, and we have a number of these catalysts.
Speaker Change: The first one has already been achieved, so we have Lakembi IV maintenance that's now FDA approved.
Speaker Change: You know, we now have the first patients who are hitting that 18-month mark. They've cleared their plaque.
Speaker Change: But as the data have demonstrated, you've got to stay on treatment, otherwise some forms of the plaque actually come back. And we have demonstrated three-year data to show that actually staying on treatment, patients do better than those who stop treatment.
and that that's an important message because
Speaker Change: Our competition is actually not able to say that, and so this is also important for the education of the disease. It's not just about plot clearance, it's about maintaining that clearance.
Speaker Change: The second is really the introduction of blood-based diagnostics. Certainly, LabCorp and Quest continue to see rising sales of these diagnostics.
Speaker Change: What I think will really make a difference is getting FDA approval for some of these diagnostics.
Speaker Change: with an evidence base that will give physicians the confidence to be able to confirm diagnosis without the need for a PET scan or a lumbar puncture. And so again, this is something that could not only facilitate the work of the neurologist
Speaker Change: But we might also be able to see this being used increasingly to triage patients.
Speaker Change: something like 50% of patients who actually manage to get into a neurologist are actually not eligible for treatment because they're too far advanced in their disease.
Speaker Change: So if we could actually triage some of these patients, particularly at the primary care level, then we can actually get a higher quotient of patients who visit a neurologist actually being eligible for treatment.
Speaker Change: For maintenance we would expect now on we have a PDUFA date on August 31st.
That, again, will really facilitate.
Speaker Change: The journey both for the patient as well as for the physician, no longer needing the infusion beds, and patients can actually take the drug from the comfort of their own home.
Speaker Change: A major game changer we see as the subcutaneous for initiation, which we expect to have in the first half of next year.
Speaker Change: And that obviously would also facilitate that for the same reasons of not having to deal with infusion beds and patients can have that in the comfort of their own home.
Speaker Change: The AHEAD 345 study is fully recruited. We expect a readout in 2028. This is a landmark study because this is where we could see the promise of potentially
Speaker Change: prevention of Alzheimer's. We know that before patients actually exhibit symptoms they've been accumulating plaques in their brains for many many years and unfortunately a lot of damage is done already by the time patients actually exhibit symptoms.
Speaker Change: So if we can get patients earlier, we think that we can actually have even better efficacy. And in fact, Priya is going to show shortly, again, the low tau patients, which is a marker for earlier stage patients.
Speaker Change: And there we see dramatically improved efficacy versus just the 27% on the CDR sum of boxes that was demonstrated in the clarity study. Next slide, please.
Speaker Change: You know, I think there are three key areas in this to look at. The first is continued investment and commitment to Alzheimer's.
Speaker Change: We gather some of the top leading experts in Alzheimer's from around the world.
They're the ones who are telling us, one, that...
Speaker Change: Nobody is really doing so much research in a broad area of modalities as Biogen.
Speaker Change: But the other is they are extremely excited about the opportunity to reduce tau and the impact that that could have on Alzheimer's.
Speaker Change: So, Alzheimer's is going to be a core franchise for Biogen for decades to come.
Speaker Change: You know, we had very positive data on dipyrilizumab back in September, and we've already initiated the second phase three.
Speaker Change: But we also have Lidofilamab in both CLE and SLE, so we got a nice lupus portfolio of assets coming along.
Speaker Change: I'd remind everybody, yes, people are looking at a lot of potential competitors in phase one, phase two. But out of the dozens and dozens and dozens of molecules that entered the clinic, only three molecules have ever demonstrated.
Speaker Change: A positive phase three result, two are already on the market and Dapiro Luzumab is the third.
Speaker Change: So, you know, we know that you can get excited about a lot of things, but it's not until you actually see phase three results that you can really have conviction.
Speaker Change: but that's a potentially significant market and fits nicely with Biogen because we can take a lot of the learnings from MS and apply that to lupus. And of course the third area
Speaker Change: are really these autoantibodies. We have our anti-CD38. We expect to enter into three phase three trials and three separate indications.
Speaker Change: more data and and people can gain increasing confidence and excitement share our excitement in in our pipeline and so with that I think I'm going to let's continue the story on R&D Priya and I'll turn it over to you. Thank you Chris
Priya Singhal: Biogen's development organization had another very productive quarter. We achieved several important milestones across key strategic areas for the company.
Priya Singhal: I would like to begin with immunology where in collaboration with UCB, as Chris mentioned, we initiated the second phase pre-study for DAPI-PIGOLE in SLE.
Priya Singhal: This follows the positive readout of the first phase 3 study and sharing of detailed study results as a late breaker at the ACR annual meeting last year.
Priya Singhal: Dappy Pagol, as Chris mentioned, is only the third agent with a positive global phase 3 study in SLE.
Priya Singhal: Additionally, Felzartumab was granted orphan drug designation in the EU for both solid organ transplantation and IgA nephropathy.
Priya Singhal: We believe this designation, which is intended to support development of treatments with significant unmet medical need.
Priya Singhal: underscores the potential for Felzartumab to become a meaningful new therapy for serious immune-mediated diseases like AMR, IgAN, and PMN globally.
Priya Singhal: In rare disease, we continued unlocking new geographies for Skyclarus in Friedrichsitaxia and Qolsodi in SARD1 ALS.
Priya Singhal: Leveraging the results of the SkyClaris Positive MOXIE trial, we obtained approval in Chile and currently have 13 additional regulatory filings under review.
Priya Singhal: This includes additional filings in Latin America, where we expect regulatory decisions this year in countries such as Brazil and Argentina as we continue our global rollout.
Priya Singhal: Importantly, we also took significant steps towards expanding the value of key portfolio products for patients.
Priya Singhal: In SMA, regulatory filings for high-dose nusinersen have now been accepted in the U.S. and EU, and we expect an FDA decision in September of this year.
Priya Singhal: And in Alzheimer's disease, we recently received FDA approval for Lekembe, less frequent IV maintenance dosing.
Priya Singhal: I would like to briefly review why there is an urgency to treat now and why maintenance is important based on Lekembi data that we have obtained to date.
Priya Singhal: First, the CLARITY-AD study is unique in that it did not exclude patients based upon tau brain pathology.
Priya Singhal: Therefore, we have placebo-controlled clinical trial data across the full early Alzheimer's disease population, including individuals with no and low Tau, which represent the earliest stages of AD.
Priya Singhal: In this population, 76% of patients showed no decline and 60% showed clinical improvement at 18 months as assessed by CDR sum of boxes.
Priya Singhal: What this means is that in over three-fourths of early A.D. patients,
Priya Singhal: Their disease was stabilized and more than half the patients showed improved symptoms when treated with Lekembe.
Priya Singhal: The reason why this is important is that this data suggests that patients treated early in their disease can see a profound benefit which underscores the importance of initiating treatment early.
Priya Singhal: Furthermore, this data also supports the potential of our ongoing pre-symptomatic AHEAD-345 trial.
Priya Singhal: And now that I've shown you why early treatment initiation is important, let me remind you why the new maintenance IV approval is also very critical.
Priya Singhal: And that is because data shows that Alzheimer's does not stop after plaque removal.
Priya Singhal: Importantly, prior data from the Lekembi Phase 2 study and its open label extension
Priya Singhal: show that discontinuation of treatment is associated with re-accumulation of Alzheimer's biomarkers, including amyloid plaques, and importantly, a reversion back to the placebo rate of clinical decline.
Priya Singhal: With its differentiated mechanism of action, we believe Lekembe is uniquely positioned as it is the only disease-modifying therapy in Alzheimer's today to show additional benefit with continued treatment after plaque reduction.
Priya Singhal: As you can see from this slide, the three-year data from the CLARITY-AD study
Priya Singhal: and its Open Label Extension support the potential for long-term benefit to patients.
Priya Singhal: by showing that continued Lekem V treatment resulted in a doubling of the clinical benefit observed at 18 months as compared to a matched natural history cohort.
Priya Singhal: With these findings in mind, we are working with ASCI to deliver additional options for patients with the aim of maximizing both the convenience and the clinical benefit of Lekembi.
Priya Singhal: This includes a subcutaneous formulation with the potential for at-home administration to further add to patient optionality and convenience.
Priya Singhal: For subcutaneous maintenance dosing, we now have a PDUFA date of August 2025. Next year, in 2026, we aim to introduce subcutaneous dosing for treatment initiation, which we believe will allow even more patients to get started on therapy.
Priya Singhal: And building upon the encouraging results we obtained in the no or low tau population in Clarity AD, we continue to advance evaluating the AHEAD 345, evaluating Lekembe in individuals who have amyloid plaque pathology in the brain, but before the onset of symptoms.
Priya Singhal: which has the potential to further expand the use of the ChemBee.
Priya Singhal: Turning now to the pipeline, we have previously discussed our efforts to augment our pipeline with the objective of rebalancing the risk profile and investing to win in key areas of expected future growth.
Priya Singhal: As a result, we have focused our development efforts on a smaller set of clinical stage programs that we believe are high conviction and well positioned to deliver a regular cadence of pivotal readouts and potential launches.
Priya Singhal: This includes key late-stage programs that have the potential, as you see on the slide, to deliver innovation to benefit patients across Alzheimer's and immunology.
Priya Singhal: We will continue to remain disciplined in our approach as we continue to assess inflection points for our internal development pipeline, but also as we evaluate potential external innovation opportunities that we believe can help support Biogen's goal of sustainable growth.
Mike: With that, I would now like to hand the call over to Mike for a financial update.
Mike: Thank you, Priya. Good morning to everyone. I'd like to begin by providing some highlights from the reported results. Total revenue for the quarter was $2.5 billion, which represents 3% growth from the fourth quarter of 2023.
Mike: Fourth quarter non-GAAP diluted EPS was $3.44, and that's 17% higher than the fourth quarter of 2023.
Mike: For the full year of 2024, total revenue of $9.7 billion represents a decline of 2% from 2023, consistent with our most recent guidance of a low single-digit decline.
Mike: And full year 2024 non-GAAP diluted EPS was $16.47, and that's 12% higher than the full year 2023.
Mike: Also, consistent with our most recent guidance range of $6.10 to $6.00, $16.10 to $16.60.
Mike: EPS growth and operating income expansion in both the fourth quarter and full year was supported by our Fit for Growth and R&D prioritization initiatives.
Mike: We are pleased that this performance allowed us to generate $722 million of free cash flow in the quarter, which brought us to $2.7 billion for the full year, and that's an improvement of $1.4 billion from $1.3 billion generated in 2023.
Mike: Now I'll turn to a few comments on revenue and commercial dynamics from the fourth quarter.
Mike: Our MS product revenue declined roughly 8% at actual currency and 9% at constant currency as compared to the fourth quarter of 2023, and that was driven primarily by competition in the space, partially offset by some seasonal channel dynamics.
Mike: Interferons continue to be impacted by competition as patients transition to higher efficacy therapies, and Tecfidera continue to be impacted by generic competition globally.
Mike: Ty Sabri has seen some impacts from a biosimilar entrant in Europe, and although a biosimilar has not yet launched in the U.S., we continue to see competition increasing in the high efficacy class.
Mike: Pumerity saw an increase in demand in the quarter and also benefited from some seasonal channel dynamics.
Mike: Next, our rare disease franchise produced revenue of $535 million in the fourth quarter, and that represented growth of 13% at actual currency and 15% at constant currency from the fourth quarter of 2023.
Mike: Global Skyclaris revenue in the fourth quarter was $102 million, an increase of 83% versus the fourth quarter of 2023, with nearly double the number of patients on therapy.
Mike: U.S. Sky Claris revenue in the fourth quarter was $71 million. We continued to add patients in the quarter, but revenue was sequentially impacted by an inventory build in the third quarter that was drawn down in the fourth quarter, as well as some Medicare discount dynamics.
Mike: Global Spinraza revenue of 421 million dollars in the fourth quarter grew two percent year-over-year including growth in the U.S. of six percent year-over-year.
Mike: We are encouraged by the performance here and look forward to a potential future launch of the high-dose option.
Mike: Zerzube delivered approximately $23 million of revenue in the quarter, and that was driven by an increase in demand, partially offset by channel dynamics.
Mike: And we again saw steady sequential growth for Lakembi with fourth quarter global in-market sales booked by ASI of approximately $87 million, and that's up approximately 30% sequentially from the third quarter of 2024.
Mike: Lakembi fourth quarter in-market sales in the U.S. were $50 million and that's up roughly 28% sequentially from the third quarter of 2024.
Thank you.
Speaker Change: I'll now turn to a few comments on dynamics from a few key expense lines.
Speaker Change: Non-GAAP cost of sales as a percentage of revenue improved 300 basis points in the fourth quarter as compared to the fourth quarter of 2023, and that was driven primarily by lower idle capacity charges.
Speaker Change: Fourth Quarter Non-GAAP Core Operating Expense or R&D plus SG&A expense
Speaker Change: increased 4% year-over-year as the benefits from our R&D prioritization and fit-for-growth initiatives allowed us to mostly absorb incremental spend associated with our launches.
Speaker Change: Non-GAAP other expense was 72 million dollars in the quarter and that was driven primarily by net interest expense.
Speaker Change: Non-GAAP diluted EPS was $3.44 in the fourth quarter, representing growth of 17% versus the fourth quarter of 2023.
Speaker Change: Now a brief update on our balance sheet. We generated $2.7 billion of free cash flow in 2024 due to strong operating income.
Speaker Change: Please note that the timing of certain cash tax payments in 2024 also benefited free cash flow.
We ended 2024 with $2.4 billion of cash.
Speaker Change: and roughly 3.9 billion dollars of net debt and continue to believe that our balance sheet remains strong and allows us to continue to invest in both internal and external growth opportunities.
Speaker Change: Turning now to our full year 2025 guidance ranges and assumptions.
Speaker Change: We expect full year 2025 non-GAAP diluted earnings per share of between $15.25.
and $16.25.
Speaker Change: This guidance range, which is based upon FX rates, on February 7th of 2025 includes a 35 cent EPS headwind from foreign exchange when compared to average exchange rates.
in 2024.
Speaker Change: Total revenue for 2025 is expected to decline by a mid-single-digit percentage.
Speaker Change: This is driven primarily by an increased decline in our MS business as compared to 2024.
Speaker Change: The pressure on our MS business is expected to be driven by potential biosimilar entry for Tysabri in the U.S. this year and potential generic entry for TechFedera in certain European markets.
Speaker Change: We expect this decline to be partially offset by continued strong and increasing revenue growth from our new product launches. Please note this revenue range also includes a roughly 1% headwind from foreign exchange.
Speaker Change: In 2025, we expect an impact from Medicare Part D redesign at the total company level to be limited, approximately $50 to $100 million.
Speaker Change: We expect approximately one-third of this impact to be related to SkyClaris, with the remainder coming from MS.
Speaker Change: On operating expenses, we remain on track to deliver the $1 billion of gross and $800 million of net savings from our Fit for Growth initiative by the end of this year.
Speaker Change: With this in mind, we expect full year 2025 combined non-GAAP R&D and SG&A expense to total approximately $3.9 billion.
Speaker Change: And as it will take time for the savings to crystallize, we expect to see higher OPEX in the beginning of the year.
Speaker Change: We expect non-GAAP operating margin percentage to remain relatively flat in 2025 as compared to 2024.
Speaker Change: And on the non-operating side of expenses, I would highlight the components of our non-GAAP other income and expense line. This line includes interest expense on our debt and some other expenses, partially offset by interest income on our cash balances.
Speaker Change: For full year 2025, we expect other income and expense to be a net expense of approximately $180 to $220 million.
Speaker Change: And finally, some additional considerations as you think about your models.
Speaker Change: As has been the case in previous years, we expect the first quarter to be pressured due to seasonality, driven by higher discounts and allowances, as well as channel dynamics in the U.S. And that will mostly impact our MS business.
Speaker Change: I would also note with regard to Phampira that we terminated the license and collaboration agreement effective January 1st of 2025.
Speaker Change: And as I just mentioned, our current year guidance takes account of the stronger dollar today compared with the same time last year. For modeling purposes, each cent change in the Euro versus the U.S. dollar impacts revenue by approximately $15 million.
Speaker Change: I would also refer you to the current slide as well as our press release for other important guidance assumptions.
And in closing, we welcome Robin Kramer as Biogen's CFO.
following my retirement later this quarter.
Speaker Change: This orderly transition plan has been in process for some time now, and I have full confidence that Robin will be a great CFO. I am excited about Biogen's future and will remain a supporter and shareholder of Biogen in the years to come. And with that, we will now open the call up for questions.
Speaker Change: Thanks, Mike. Jennifer, can we go to the first question, please?
Speaker Change: Yes and just as a reminder if you'd like to ask a question please press star 1 on your telephone keypad. As a reminder please limit yourself to one question. If you require any further follow-up you may press star 1 again to rejoin the queue.
Speaker Change: Your first question comes from the line of Salveen Richter with Goldman Sachs.
Salveen Richter: Good morning, thanks for taking my question. What is your latest thinking on the capacity preference and potential timelines for external BD and in terms of your growth outlook just help us understand the balance between the existing pipeline and the assets you could bring in. Thank you.
Speaker Change: Thanks, Salveen. I mean, I think we'll get Mike to give you an update on capacity.
Speaker Change: As I said, we are very excited about the pipeline that we have, but I think one of the things that we'd like to do is continue to reinforce that pipeline.
Speaker Change: Over the years, I've come to the conclusion that you can never have enough pipeline. First element is we've done a major restructuring of research because I think as companies in our industry, it's very expensive to bring in late stage assets.
Speaker Change: And, you know, we would like to have research be our primary source of innovation.
Speaker Change: obviously internally but also externally and and so I think we have completely restructured research to create the the financial capacity as well as well as the talent capacity to do more collaborations and bring assets in particularly pre-GLP talks
Speaker Change: Beyond that, we are looking at virtually every phase, the early phase development. Right now, I would say Priya probably would agree with me that our early stage development pipeline is still relatively thin.
Speaker Change: And, but even if we can find things in, you know, phase three, if it's got a really solid phase two, I'm not big on taking a lot of risk on phase three clinical trials because that gets expensive. And in terms of acquisitions,
You know we have been migrating
in new areas such as immunology and rare diseases.
Speaker Change: And if we can find acquisitions that can bolster our positions in that, we will do so. We don't have a particular size that we're looking for. It could be late-stage development, it could be early-stage commercial.
Speaker Change: The one thing it has to do is make financial sense. I think where we are as a company, we don't need to be taking a huge amount of risk on acquisitions.
Speaker Change: That said, we are always looking. We always have about at least 15 to 20 different projects that we're looking at at any one time. But as you know, you kind of have to look at a hundred things before you find something that is of interest. And Mike, maybe you want to talk about capacity? Yeah, and Salveen, on capacity, you know, the balance sheet remains in excellent shape. As we mentioned in the prepared remarks, we ended the year with...
Mike: $2.4 billion of cash on hand. The EBITDA run rate is north of $3 billion a year, so, you know, with $6.3 billion of gross debt.
Mike: $3.9 billion of net debt, you're, you know, in the zip code of maybe two turns gross and, you know, one, one and a half turns net.
Mike: And we were very pleased with the free cash flow results this year in 2020, or last year I should say, 2024, at $2.7 billion, so that cash balance will continue to grow. So, when you look at the modest amount of leverage, the $2.4 billion of cash on hand and the growing free cash flow,
Mike: The balance sheet is in an excellent position. As Chris said, you know, the plan will be to stay very disciplined and only do things that make good financial sense, but we've got significant capacity to
Mike: Do you know a series of smaller things or perhaps a larger thing if it does make good financial sense?
Thanks Mike. Let's go to the next question please.
We'll take our next question from Michael Yee with Jefferies.
Michael Yee: Thanks. Priya, you mentioned that on the Lakembi slide that one of the important developments is the potential for blood-based diagnostics.
Michael Yee: and my understanding is that that's coming this year. Can you walk through how important that is in terms of any bottlenecks and specifically whether that totally would be able to replace PET or how that actually works since diagnostics are a little bit complicated. Thank you.
Michael Yee: Yes, thanks Mike. So overall I think that you know accurate diagnosis of Alzheimer's disease and confirmation of amyloid remains very important.
Michael Yee: and it is the entry point for the kind of care pathway here so it's important.
Michael Yee: I think with the advent of the anti-amyloid therapies, we've seen amazing momentum there. And as Chris mentioned, you know, we have tests available today that are at triage sort of level.
Speaker Change: The question here is, what is going to be the availability in the near term for an in-vitro diagnostic approved by the FDA that can be used widely and can also be reimbursed and give physicians and neurologists confidence that they can actually trust that outcome and that result versus a pet?
Speaker Change: And we think that this is likely going to happen in the near term. You know, a Fuji Ray bio is already filed. We know there are a couple of others like C2N and Roche that are sort of working on these IBDs or in vitro diagnostics.
Speaker Change: And one was already filed, Puget Bay biofile, last year. We believe that usually the time frame is about six months. I think the next stage will be generating data so that payers and others are confident that it can adequately represent the Medicare population, which tends to be the broader population. So I think concordance is important, as is reimbursement, but we think this is moving really fast and we think we'll see quite a few milestones occur in the near term.
Thanks, Priya. Let's go to the next question, please, Jennifer.
The next question comes from Tim Anderson with Banks America.
Thank you. On your spend, guidance...
You're saying $3.9 billion combined R&D and SG&A.
Speaker Change: which is about 200 million lower than consensus. Revenues are also a little bit lower than consensus so it offsets each other. My question is, how much does the Royalty Pharma deal take out of the R&D line in 2025 specifically? I know it's 250 million in the aggregate that they'll fund.
Speaker Change: What's that? What's that relief to 2025 R&D? And then, on World Pharma, can we expect Biogen to do more of these off-balance sheet types of transactions with pipeline programs over the next one to two years? Thank you.
Speaker Change: So, Tim, Mike speaking on the royalty pharma transaction. Our current expectation is that the
Speaker Change: $200 million that we would receive in 2025 from Royalty Pharma would be accounted for as a reduction to R&D expense. So that would be a dollar-for-dollar reduction that's in the mix of our guidance.
Speaker Change: Well, just in terms of other deals, you know, the remuneration to those providing financing is usually through royalties.
Speaker Change: It's not easy to make work for every product, so I think at the moment we look at this as a one-off transaction, but it is a useful model to take risk off the table and be able to spread the investment across more assets. I mean, it's essentially a way of getting more shots on goal.
Thanks, Chris. Let's go to the next one, please.
We'll go next to Brian Abrahams with RBC Capital Markets.
Hey, good morning. Thanks for taking my question. On SkyClaris,
Speaker Change: Can you elaborate a little bit more on the dynamics you're seeing in the U.S.? Like, are there ways to accelerate patient identification to meaningfully grow revenue there? Should we be expecting this to more be an ex-U.S. international growth product? And how big are the hurdles in terms of reimbursement outside the U.S.? Thanks.
Speaker Change: In the U.S. I think there have been already a number of creative approaches.
Speaker Change: You know, one is using AI and looking across social media to be able to identify where patients are.
Speaker Change: You know, as I said before, there's quite a large number of potential prescribers you could go to. The question is, how do you zero that down to a geography and a type of physician that makes the visit?
And so we've, say, we've used the AI.
Whenever you develop a treatment for a disease,
there's a greater interest in diagnosing it.
Speaker Change: And so I think one of the things that we're seeing is a much greater use of genetic testing.
Speaker Change: You know genetic testing does have a cost and and physicians have not always been interested in using it.
Speaker Change: If it wasn't going to lead to a treatment, but now that Skyclaris is there, we are seeing that increased.
Utilization
Now the final thing is using multi- and omni-channel marketing.
Speaker Change: to be able to reach physicians, just to educate them about what is Friedrich's ataxia. There are also multiple ataxias out there. And so that's where the genetic testing can become important. But when you listen to the patient journeys,
Speaker Change: It can take often three, four years before a patient gets a definitive diagnosis. You know, a lot of particularly younger people are just...
Speaker Change: It takes a while because there are a lot of physicians who have never even heard of Frederick's ataxia. So that's where the education is.
Speaker Change: is needed. I would say today with the technology we have, we have a lot of tools that we didn't have even 15 years ago, but it is still finding patient by patient. You know, we look at how many patients we found every week.
Speaker Change: And, you know, then it's, the reimbursement isn't really an issue in the U.S.
Speaker Change: There are hurdles too. This is where Biogen is particularly good. We have a very adept group that can help patients navigate the reimbursement system. In Europe...
Speaker Change: I don't think we're necessarily going to find any issues of reimbursement. It's mostly getting through the whole process, presenting the cost effect of this data. But we are very encouraged by the uptake. Once you have uptake, then...
Speaker Change: That's a good demonstration of the value of the medicine when it comes to discussing things with reimbursing countries. So it'll be progressive. I think there are 10 countries today in Europe which reimburse.
Speaker Change: and every quarter we'll be adding more countries and the same will be true ex-Europe and in Latin America for example.
Can we go to the next question please, Jennifer?
And next to you, Marc Goodman with Lering Partners.
Marc Goodman: Yeah, good morning. Could you give us a little more flavor on what's happening with Spinraza in the U.S. and their U.S., just dynamics and how much inventory is there?
Marc Goodman: It's mattering what's happening with pricing just in a little more color there. Thanks
Mike, take the inventory question. You know, Spinraza,
Marc Goodman: So this is a very competitive market with a very limited number of patients. So you've got a gene therapy, an oral therapy, and an intrathecal therapy, all competing for a relatively small patient number.
Marc Goodman: There are actually quite a number of patients who have not been diagnosed or treated, so we tend to be in younger patients.
Marc Goodman: but there is actually a much larger adult patient population. And getting at those is a lot like the same process that I just described for Friedrich's ataxia. So we are doing that.
Marc Goodman: So, the interesting thing is, how do you compete in a market like that? And, you know, we've all grown up in this business and we say, okay, one pill a day beats two pills a day, a pill beats an injection.
Marc Goodman: The reality is, in a lot of these devastating diseases, it's efficacy that matters. And that's really the story of Spinraza.
The high-dose, I think, will be important because...
Marc Goodman: you can get to the therapeutic levels of drug that you need much faster and in a neurodegenerative disease that that's extremely important. So we we will be able to cut the number of loading doses if you like from four to two and then you go to three injections per year. One of the things that I think will be important is we are developing a device that hopefully will hit the market about I think 2026 Priya the and it's a port that you
Marc Goodman: You can insert under the skin pretty much anywhere on the body, but certainly around the abdomen as an example, and it has tiny catheters that lead to the spinal column.
Marc Goodman: And that means that you can actually just do the injection directly under the skin. That has had huge patient positive response.
Marc Goodman: And that could actually make intrathecal injections a whole lot more patient-friendly, not just in SMA, but pretty much for all of the intrathecal products that we're developing. So, I think that one will also be a game-changer going forward. And Mike, did you want to talk about the inventory dynamics? Yeah, and Marc, nothing to call out on inventory. You know, we did see some lumpiness in Spinraza revenue throughout 2024 due to some...
Mike: shipment timing and so forth outside of the U.S. but the fourth quarter the global 2% growth and that the 6% in the U.S. nothing material to call out in terms of inventory or channel dynamics.
Let's go to the next question, please.
We'll go next to Paul Mattis with Stiefel.
Hey, good morning. Thanks so much for taking my question.
Chris
Speaker Change: If you take a step back now, you've got to be at a point, I would think, with Zerzuefe, SkyClaris, you know, Kanimat to some degree, although maybe the variance of outcomes there is a little bit wider, where at least for the next couple years, you probably have a pretty good window into the range of outcomes.
Speaker Change: So, I guess taking a step back, do you feel like you can get back to sustainable revenue growth based on what you have internally and what you have high visibility into? Or how important, I guess, is getting a big upside win from the pipeline or buying growth externally via BD?
All right. Well, we've got about
Speaker Change: If you add in everything, there's probably about $4.5 billion of revenue in MS left and probably about $3 billion of profit.
Speaker Change: So that's going to be the headwind over the next five to ten years because actually some of these products are actually...
Speaker Change: quite sticky with patients because patients do well on these products and tend to stay on them. So it's a slower decline.
Speaker Change: So that's the problem we're solving for. When you look at it, the number one product that has the most potential to offset is clearly Lekembi.
Speaker Change: And, you know, there I think we are encouraged by the more recent results, and I think we feel pretty confident that these...
Speaker Change: These catalysts could offer the potential to see some acceleration of growth. So, we do believe that, you know, there's a tremendous unmet need in Alzheimer's. People forget that this is a fatal disease. And, you know, when you look at the data that Priya showed,
Speaker Change: I think had extremely productive discussions with our partner ASI on the commercial approach. And, you know, there was an awful lot of effort at the start just to explain care pathways and the side effects and the reimbursement.
Speaker Change: And I think now we can actually focus a lot more on the value proposition and why treating patients.
Speaker Change: I think there's a huge opportunity in expanding the prescriber base. We have focused on a smaller number just because of the effort involved by the neurologist.
Speaker Change: But I think with things like the subcutaneous formulations and the...
Speaker Change: The maintenance, we have an opportunity to go broader. There's about 13,000 physicians who are targets, and we have a small fraction of those today.
We're actually prescribing.
Speaker Change: So there's a lot there and Sky Clarus will continue to grow as we said. Zerzouve is certainly an interesting, I'd call it kind of a two-base hit in baseball terms.
Speaker Change: in in the US. Europe will probably be a more limited set of markets that will actually be able to reimburse this product. I think we've got a lot that we can be doing. I think
Speaker Change: You know, I think the real growth story is when you start to see the pipeline coming through because
Speaker Change: You know, as the MS portfolio declines and the new products become a bigger part of the equation, then suddenly you add a pipeline product on top of that. And, you know, the nice thing about Biogen is that a billion dollars really moves the needle. So we don't need a lot here to really have a meaningful impact on our growth.
Speaker Change: And so I think it's a combination of all of the above, Paul. We will see an increasing percentage of our business coming from these new products, and the pipeline can only augment that.
Thanks Chris, let's go to the next question please.
We'll go next to Umer Raffat with Evercore.
Umer Raffat: Hi guys, thanks for taking my question and I want to say thank you to Mike for all your help over time and welcome to Tim.
Speaker Change: I have two questions today, if I may. First, maybe for Priya. Priya, in a scenario where Lilly hits trailblazer Alzheimer's 3 in preclinical on the progression endpoint,
Speaker Change: How does that factor into your thinking around how you could accelerate timelines?
Speaker Change: for AHEAD 345 and also your comfort with the endpoint being used there.
Umer Raffat: And secondly, Chris, maybe a big picture question, it seems like where the valuation stands today around $20 billion in market cap relative to the amount paid for RIATA as well as the amount of balance sheet available for
An additional deal coming up.
I guess...
Umer Raffat: So the market is almost reflecting somewhat of a view that the M&A choices in the last couple of years may not have been what the market was expecting or perhaps the expectations were higher. I guess how do you think about all of that and what learnings are you taking from that into additional capital deployment because it will be a very significant move if there were to be a $10 billion deal again.
I can get started. Thanks, Umer.
Umer Raffat: So, I think overall, you know, we remain excited as I shared in my prepared remarks about the potential for a Head 345.
Umer Raffat: Just a reminder is that we completed enrollment last year. It's a four-year therapy, and so we expect, and ESA has recently actually reiterated the outcome expected in 2028.
Umer Raffat: Now that said, we always retain and we always continue to evaluate optionality for earlier readouts and earlier cuts, and we continue to engage with regulators like the FDA very closely on this, and all of that is progressing well. Now the most, so that's kind of the acceleration piece.
Umer Raffat: I think the important piece here is the way we've designed the trial.
Umer Raffat: It is quite specific for amyloid load, and as you know, it's two sister trials, one with a lower amyloid load, that's a HED-3, and then 4-5, which is a higher amyloid load.
Umer Raffat: Now, in the AHEAD-3, we have a biomarker outcome, which is amyloid clearance, essentially. But in the 4-5, where patients have a higher load of amyloid, we are looking at a very important
Umer Raffat: Endpoint, that's called the PAC-5, which is the Preclinical Alzheimer's Cognition Composite.
Umer Raffat: This comprises elements of memory, you know, the intelligence test, MMSE, and other components, and it is supposed to be quite sensitive and specific for preclinical AD.
Umer Raffat: Trailblazer 3 has different outcomes like CDR global score and is also doing a time-to-event.
Umer Raffat: So I think we'll wait to see more on how that unfolds, but I think we feel very confident about the design of this trial and what it can actually tell us about preventing or slowing down onset of Alzheimer's disease.
Over to you, Chris.
Chris Viehbacher: Yeah, I mean, Umer, look, there's a human factor here, right? One of the things I have seen over the years is that
Chris Viehbacher: inversely proportional to your level of confidence in what you've already got in your pipeline. So if you don't think you have a lot in your pipeline, you're more likely to be interested in spending more externally.
Thank you. Bye.
Chris Viehbacher: And whether that's logical or not, it is tended to be where you are. And I have to say...
Chris Viehbacher: Coming into Biogen, you know, we tended to go after the hardest problems to solve, where we didn't understand the underlying disease biology, where we didn't really have Phase II data that could really predict
Chris Viehbacher: where we were in phase three. And at that point, you sort of say, well, if you don't know what you've got, you're more interested in looking at things.
Speaker Change: I would say where we are now, two years down the road, is I think, you know, Priya with her steely eye has really taken a lot of the
the stuff out of our pipeline that
Speaker Change: either was never going to make it to market, or if it did make it to market, was never going to have much impact. And what we do have, and we've got more data now,
Speaker Change: gives us a whole lot more confidence. I mean, when you've got a dipyrrolizumab now with a phase 3, I mean, lidofilumab has advanced.
Speaker Change: The high bio acquisition we see as pretty transformative for our pipeline because that is exactly what we would like to see more of, is data in phase 2 that really gives you a sense of some level of conviction into phase 3, recognizing that
Speaker Change: There are never any guarantees in R&D. So I think where we are is...
Speaker Change: We could continue to do more of the high biotype transactions. We actually like the RIATA transaction, you know, maybe the street had a different view, but I don't think the street really...
Speaker Change: completely understands how how some of these rare diseases really work. For us, over time, we believe that Skyclaris is going to be a significant product. I think it is already a significant product.
Speaker Change: If we found another RIATA where we, you know, you've got a product that is about to be launched on the market and you could buy it for a price that generates a return for our shareholders, then we would do it. But I think part of the problem is...
I don't think the...
Speaker Change: The people who are selling companies have quite integrated a lot of the pressures that are on this industry.
Speaker Change: You know, the IRA is a de facto reduction in patent life for our industry, and there's a lot of pricing pressure from around the world. So, the total commercial return for any one molecule today is not what it was even five years ago.
Speaker Change: and and yet I don't see really any shift in the in the premiums being paid or the price being paid and and there's always an asymmetry between the the products that you know and the products that you're going to buy and and so you know I think right now we say we will look if we could find another Riata we would probably do it
Speaker Change: We don't particularly want to do one deal that takes all of our cash flow because I think there is an interest in building the pipeline with multiple assets.
Speaker Change: If we could do more high bios, that's probably a nice sweet spot for us.
Speaker Change: You know we've kind of concluded that actually we can probably manage quite nicely until the the pipeline matures even even further. So we don't feel any particular pressure to do things.
Speaker Change: But I do think it's the job of every leadership person in this business to constantly look outside if we can find other sources of innovation.
Speaker Change: They'll say, I'm actually feeling very good about where Biogen is. You know, our share price may or may not reflect it, but I'm certainly not alone in this interest in thinking that the share price doesn't reflect where we are, and I think that's
Speaker Change: It's a function of a lot of the uncertainty around our industry, but we are just keeping our heads down and executing on our launches and making sure these products get to market.
Speaker Change: and finding if there are shareholder value enhancing transactions that can be done at pretty much any stage of the value chain. Let's go to the next one please Jennifer.
We'll go next to Chris Schott with J.P. Morgan.
Chris Schott: Great, thanks so much for the question. Just wanted to come back to the OPEX space. I know the company's wrapping up its Fit for Growth program, and there's some moving pieces here with the Royalty Pharma deal, but as we think about the P&L going forward, is this kind of $3.9 billion or so OPEX space a good rough number to think about for Biogen going forward, or is there any other color about how to think about margin progression as we think about the next few years? Thank you.
our revenue expectations and
Chris Schott: I think that, you know, as we head, as we exit.
Chris Schott: 2025 and go into future years. Obviously, if we have launches to support and other things, we'll need to invest in those appropriately, but I think the way that you described it is correct and that the program will be completed at the end of this year and the $3.9 billion base rate is a good number to use as your baseline model.
Chris Schott: And clearly business development every time you do a deal you bring in potentially new R&D expense but I think what you've seen us do is
prioritize. We've actually...
Chris Schott: stopped a number of internal programs, which actually creates the financial capacity to bring other assets in, you know.
Chris Schott: One of the biggest problems of business development typically has been is that the R&D budget is full.
Chris Schott: And there isn't any room to bring in new things. Well, we are actually making some of those difficult choices. And the same is true on research. We have dramatically reduced our research.
budget, but the idea was not necessarily to just...
Chris Schott: The idea was that we wanted a different mix in there, and by prioritizing, we can actually do business development without having to increase our overall expenditure, at least that's what we've been able to do so far.
Chris Schott: I know we're running short on time. Maybe get to squeeze one or two last ones in. Let's go to the next one.
We'll go next to Evan Seigerman with BMO Capital Markets.
Evan Seigerman: Hi guys, thank you so much for taking my question. Mike, congrats on your retirement. You will be missed. Robin, I'm really looking forward to working with you. And Tim, congrats on your first Biden earnings call. I got that all in.
Speaker Change: I want to touch very briefly on the use of GLP-1s in Alzheimer's disease.
Speaker Change: Nova Nordis has talked a lot about the EVOKE trial, high risk, high reward. What happens if that hits and this could evolve the standard of care for the kind of prevention of Alzheimer's disease? Priya, maybe we'll love your thoughts there. Thank you.
Priya Singhal: Yes, thank you, Evan. You know, it's a very interesting hypothesis and it's supported by some preclinical data as well as meta-analyses that was looking at all-cause dementia and then some subsets which also had Alzheimer's disease.
And really the scientific hypothesis behind it is thinking through...
about how glucose metabolism or regulation of that.
Priya Singhal: can impact neuroinflammation, vascular health, all of that and contribute to kind of more brain health situation.
Priya Singhal: And I think that that is a, it's, it's worthy of exploring. I mean, I think we need to remember that some randomized controlled trials have failed in the space.
Priya Singhal: you know, Takeda with pioglitazone, and then actually Novo with liraglutide. Small trials, 72 subjects, the LADD trial, you know, they didn't meet their primary endpoints. That said, I think we look forward to seeing the outcomes.
Priya Singhal: What I think is really important to continue to remember is that when you're tackling something like Alzheimer's disease, you need to tackle the central pathology.
Priya Singhal: We also know that the central pathology is not an overnight buildup, but builds up over years.
Priya Singhal: So for that reason, we continue to believe that an anti-amyloid agent like Lekembe that really addresses plaque, but continues to address
Priya Singhal: Soluble toxic species after plaque clearance will have an important role to play. So I think we're looking forward to the results of Evoque and Evoque Plus just like, you know, everybody. But I think we continue to believe that this is going to be, Lakembi is going to play and continue to play an important role.
Let's go to our last one, please.
Our last question comes from Phil Nadeau.
T.D. Cowan
Thank you. Thank you. Thank you.
Speaker Change: Good morning. Thanks for fitting us in. Let me add our congratulations to Mike, Robin, and Tim on their transitions. Just to drill down on McKimbey's short-term trajectory a little bit more closely, in Q4, revenue was up 30%, but the revenue recognized was only up $1 million. Can you talk about the dynamics?
Speaker Change: Behind that, were there one-time issues or is there an increase in spend that we should project into 2025? And looking at 2025 trends, growth in 2024 was largely driven, not entirely driven, but largely driven by Ex-U.S.
Speaker Change: Is that replicable in 2025 or are the low-hanging fruit of those markets already picked? Thanks.
Well, I think Lekembi in the U.S. was, was...
Speaker Change: was certainly up 200% Q4 on on Q1. And so we are seeing significant growth in the US. Yes, the ex US has certainly been been strong as well. But I think it's both. So, you know, I think, I think for 2025
Speaker Change: You know, in the absence of anything else, we see pretty much continuing trends, would be our best guess at this.
There may be some acceleration with the IV maintenance.
Speaker Change: But, you know, we're not going to get the subcutaneous for maintenance until really in the last part of the year. The blood-based diagnostics could play a role, but, you know, we all know that it takes a while to get diagnostics to be actually accepted and reimbursed.
Speaker Change: So I think we're going to just see good, steady progress quarter on quarter. You know, there hasn't been that much impact yet on the Nanomab. That could have a role at some point, but I think they're dealing with the same issues that we are. I think the big thing is really to, as I say, to expand the prescriber base.
I think really focus on the benefit of treatment.
Speaker Change: and roll out these new formulations. So I think it's going to be continued progress. We obviously continue to believe that Alzheimer's
Speaker Change: can be a significant market and that's why we're investing not only in Tau but in other modalities. The unmet need is incredible, 500,000 new patients every year. It's one of the leading causes of death.
Speaker Change: certainly amongst over 65 year olds but it's even a top 10 cause of death just in the general population. So not to mention the the devastation that this causes to families. So the the unmet need is huge. It is clear that in the short term
Speaker Change: We have a lot of capacity constraints, but I think we've made a lot of progress in relieving some of those. And so I think now, with these new formulations, such as SubQ, and with the blood-based diagnosis, we have an opportunity to accelerate our growth.
I would say over the next two to three years.
Speaker Change: And Phil, on the numbers, just to reiterate something we said in the prepared remarks, the Lakembi fourth quarter in-market revenue was $87 million globally. That's up about 30% sequentially from the third quarter of 2024 in the U.S. It was of the $87 million, $50 million in the U.S., and that's up about 28% sequentially.
Speaker Change: Thanks Mike and thanks everybody for your time today. The IR team is available if you've got questions later today. Thank you