Q4 2025 Harvard Bioscience Inc Earnings Call

March 12, 2026

Speaker #2: Good day, and welcome to the fourth quarter and full year 2025 Harvard Bioscience Earnings Conference Call. All participants will be in a listen-only mode.

Speaker #2: After today's presentation, there'll be a question and answer session. Instructions will be given at that time. Please note this event is being recorded. I would like to turn the conference over to Taylor Krafchik, Senior Vice President at Ellipsis TA.

Speaker #2: Please go ahead.

Speaker #3: Thank you, Operator, and good morning, everyone. Thank you for joining the Harvard Bioscience Fourth Quarter and Full Year 2025 Earnings Conference Call. Leading the call today will be John Duke, President and Chief Executive Officer, and Mark Frost, Chief Financial Officer.

Taylor Krafchik: Thank you, operator, and good morning, everyone. Thank you for joining the Harvard Bioscience Q4 and Full Year 2025 Earnings Conference Call. Leading the call today will be John Duke, President and Chief Executive Officer, and Mark Frost, Chief Financial Officer. In conjunction with today's call, we have provided a presentation that will be referenced during our remarks that is posted to the investor relations section of our website at investor.harvardbioscience.com. Please note that statements made in today's discussion that are not historical facts, including statements on management expectations, or future events, or future financial performance, are forward-looking statements and are made pursuant to Safe Harbor provisions of the Private Securities Litigation Reform Act of 1995. These forward-looking statements reflect the current views of Harvard Bioscience management, and Harvard Bioscience assumes no obligation to update or revise any forward-looking statements.

Speaker #3: In conjunction with today's call, we have provided a presentation that will be referenced during our remarks that is posted to the Investor Relations section of our website at investor.harvardbioscience.com.

Speaker #3: Please note that statements made in today's discussion that are not historical facts, including statements on management expectations or future events or future financial performance, are forward-looking statements and are made pursuant to Safe Harbor provisions of the Private Securities Litigation Reform Act of 1995.

Speaker #3: These forward-looking statements reflect the current views of Harvard Bioscience management, and Harvard Bioscience assumes no obligation to update or revise any forward-looking statements. Actual results may differ materially from those expressed or implied.

Taylor Krafchik: Actual results may differ materially from those expressed or implied. Please refer to today's press release, the Harvard Bioscience Form 10-K, which we expect will be filed within 24 hours of this call, and other filings with the Securities and Exchange Commission for additional disclosures on forward-looking statements and the risks, uncertainties, and contingencies associated therewith. During the call, management will also reference certain non-GAAP financial measures which can be useful in evaluating the company's operations related to our financial condition and results. These non-GAAP measures are intended to supplement GAAP financial information and should not be considered a substitute. Reconciliations of GAAP to non-GAAP measures are provided in today's earnings press release. I will now turn the call over to John. John, please go ahead.

Speaker #3: Please refer to today's press release, the Harvard Bioscience Form 10-K—which we expect will be filed within 24 hours of this call—and other filings with the Securities and Exchange Commission for additional disclosures on forward-looking statements and the risks, uncertainties, and contingencies associated therewith.

Speaker #3: During the call, management will also reference certain non-GAAP financial measures, which can be useful in evaluating the company's operations related to our financial condition and results.

Speaker #3: These non-GAAP measures are intended to supplement GAAP financial information and should not be considered a substitute. Reconciliations of GAAP to non-GAAP measures are provided in today's earnings press release.

Speaker #3: I will now turn the call over to John. John, please go ahead.

Speaker #4: Thanks, Taylor. And good morning, everyone. Thank you for joining us for our fourth quarter and full year 2025 earnings call. On today's call, I'll review our recent actions, provide a brief overview of our fourth quarter financial results, and then discuss our priorities and outlook for 2026.

John Duke: Thanks, Taylor, and good morning, everyone. Thank you for joining us for our Q4 and full year 2025 earnings call. On today's call, I'll review our recent actions, provide a brief overview of our Q4 financial results, and then discuss our priorities and outlook for 2026. 2025 was a pivotal year of foundation building. Over the past 8 months, we improved our financial flexibility, took action to reorganize operations, and clarified our long-term strategic direction. To recap, we took several key actions to improve the health of the business. In December, we completed our comprehensive refinancing. This transaction extended our debt maturity to 2029, reduced annual debt service to $5 million, generating $3 million in annual cash savings and strengthened liquidity and financial flexibility.

Speaker #4: 2025 was a pivotal year of foundation building. Over the past eight months, we improved our financial flexibility, took action to reorganize operations, and clarified our long-term strategic direction.

Speaker #4: To recap, we took several key actions to improve the health of the business. In December, we completed our comprehensive refinancing. This transaction extended our debt maturity to 2029.

Speaker #4: Reduced annual debt service to $5 million, generating $3 million in annual cash savings and strengthening liquidity and financial flexibility. Shortly thereafter, we announced a strategic consolidation of our manufacturing footprint with the phased closure of the Holliston facility and consolidation in the Minneapolis and European centers of excellence.

John Duke: Shortly thereafter, we announced a strategic consolidation of our manufacturing footprint with the phased closure of the Holliston facility and consolidation into Minneapolis and European centers of excellence. This is expected to generate $3 million in savings in 2027 and $4 million of savings thereafter. Since June, we have strengthened our governance by appointing four new board members, and we are in the process of establishing a product and scientific advisory board of experienced industry leaders. We also further solidified our executive leadership as we officially named Mark Frost as Chief Financial Officer. As many of you know, Mark is an experienced CFO and has held that role with several public companies. While we have more work to do, these actions are structural improvements that simplify our operating model and provide the foundation required to scale our business.

Speaker #4: This is expected to generate $3 million in savings in 2027 and $4 million of savings thereafter. Since June, we have strengthened our governance by appointing four new board members, and we are in the process of establishing a product and scientific advisory board of experienced industry leaders.

Speaker #4: We also further solidified our executive leadership as we officially named Mark Frost as Chief Financial Officer. As many of you know, Mark is an experienced CFO and has held that role with several public companies.

Speaker #4: While we have more work to do, these actions are structural improvements that simplify our operating model and provide the foundation required to scale our business.

Speaker #4: All of these actions were driven to take to drive improved financial results, which is what we saw in the fourth quarter. Revenue of $23.7 million was above the midpoint of our guidance range.

John Duke: All of these actions were driven to drive improved financial results, which is what we saw in Q4. Revenue of $23.7 million was above the midpoint of our guidance range. Gross margin of 60% at the high end of guidance and adjusted EBITDA of $3.8 million, reflecting 27% year-over-year growth. The drivers of this performance were favorable mix shift toward higher margin product lines, benefits from cost reductions, disciplined expense management, and sharpened operational execution. We exited the year a leaner and more focused organization with a fortified balance sheet and a clear path to drive sustainable growth. Since I joined as CEO, I've spent considerable time engaging with customers, partners, and employees. What became clear is the life science industry is undergoing a fundamental shift. Drug development remains inefficient.

Speaker #4: Gross margin of 60% at the high end of guidance, and adjusted EBITDA of $3.8 million, reflecting 27% year-over-year growth. The drivers of this performance were a favorable mix shift toward higher-margin product lines, benefits from cost reductions, disciplined expense management, and sharpened operational execution.

Speaker #4: We exited the year a leaner and more focused organization, with a fortified balance sheet and a clear path to drive sustainable growth. Since I joined as CEO, I've spent considerable time engaging with customers, partners, and employees.

Speaker #4: What became clear is the life science industry is undergoing a fundamental shift. Drug development remains inefficient; nearly 90% of candidates that succeed in animal models ultimately fail in human trials.

John Duke: Nearly 90% of candidates that succeed in animal models ultimately fail in human trials. Researchers, regulators, and biopharma customer companies are increasingly embracing new approach methodologies, or NAMs, to improve translational relevance. Harvard Bioscience is uniquely positioned to bridge this gap. We're evolving from a traditional life science tools provider into a leading enabler of translational science, connecting in vivo and in vitro research and helping customers generate more predictive human relevant data earlier in the development cycle. This represents an evolution for a company's products into the $10 billion translational science market. To capitalize on this opportunity, we are focused on executing against our four priorities. First, leading the translational science bridge. We are strengthening our position at the intersection of preclinical and organoid-based research. Our gold standard telemetry capabilities provide a natural extension into organoids and 3D biology platforms. Second, accelerating high margin innovation.

Speaker #4: Researchers, regulators, and biopharma customers and companies are increasingly embracing new approach methodologies, or NAMs, to improve translational relevance. Harvard Bioscience is uniquely positioned to bridge this gap.

Speaker #4: We're evolving from a traditional life science tools provider into a leading enabler of translational science, connecting in vivo and in vitro research and helping customers generate more predictive, human-relevant data earlier in the development cycle.

Speaker #4: This represents an evolution for companies' products into the $10 billion translational science market. To capitalize on this opportunity, we are focused on executing against our four priorities.

Speaker #4: First, leading the translational science bridge. We are strengthening our position at the intersection of preclinical and organoid-based research. Our gold standard telemetry capabilities provide a natural extension into organoids and 3D biology platforms.

Speaker #4: Second, accelerating high-margin innovation. Our new product innovation or NPI pipeline is centered on scalable, differentiated platforms. Such as Soho Telemetry, BTX for bioproduction, MeshMEA, and Incubate.

John Duke: Our new product innovation, or NPI pipeline, is centered on scalable, differentiated platforms such as SoHo Telemetry, BTX for bioproduction, Mesh MEA, and Incubate. These platforms modernize preclinical and translational workflows and reinforce our evolution into a platform-based technology provider. Third, expanding consumables and recurring revenue. Today, approximately 55% of revenue is recurring. We are intentionally prioritizing higher margin consumables, service, and software to improve revenue visibility, increase gross margins, and create a more durable and predictable business model. This mix shift is already contributing to margin expansion, as evidenced by our Q4 performance and our outlook for 2026. Fourth, operational excellence and disciplined growth. Finally, we remain laser-focused on cost discipline and operational efficiency. Manufacturing consolidation and refinancing enable us to improve profitability, fund innovation, and continue deleveraging over time.

Speaker #4: These platforms modernize preclinical and translational workflows and reinforce our evolution into a platform-based technology provider. Third, expanding consumables and recurring revenue. Today, approximately 55% of revenue is recurring.

Speaker #4: We are intentionally prioritizing higher-margin consumables, service, and software to improve revenue visibility, increase gross margins, and create a more durable and predictable business model.

Speaker #4: This mixed shift is already contributing to margin expansion, as evidenced by our Q4 performance and our outlook for 2026. And fourth, operational excellence and disciplined growth.

Speaker #4: Finally, we remain laser-focused on cost discipline and operational efficiency. The manufacturing consolidation and refinancing enable us to improve profitability, fund innovation, and continue deleveraging over time.

Speaker #4: Looking ahead, we're introducing full-year guidance for 2026 that forecasts low single-digit growth in revenue, and high single-digit growth in adjusted EBITDA. Which will be driven by higher margin, NPI growth, as we focus on the translational science market.

John Duke: Looking ahead, we're introducing full year guidance for 2026 that forecasts low single-digit growth in revenue and high single-digit growth in Adjusted EBITDA, which will be driven by higher margin NPI growth as we focus on the translational science market. We continue to monitor NIH funding timing and global macro conditions. We believe our cost structure and diversified geographic footprint put us in a position to manage volatility. 2025 was a strategic reset, and 2026 will be a year of top and bottom line growth. With a technically deep global team, a refreshed board, improved financial flexibility, and a focused translational science strategy, Harvard Bioscience is well-positioned to create long-term shareholder value. I want to thank our employees for their dedication, our customers for their trust, and our shareholders for their continued support.

Speaker #4: We continue to monitor NIH funding timing and global macro conditions. We believe our cost structure and diversified geographic footprint put us in a position to manage volatility.

Speaker #4: 2025 was a strategic reset and 2026 will be a year of top and bottom line growth. With a technically deep global team, a refreshed board, improved financial flexibility, and a focused translational science strategy, Harvard Bioscience is well positioned to create long-term shareholder value.

Speaker #4: I want to thank our employees for their dedication, our customers for their trust, and our shareholders for their continued support. With that, I'll turn the call over to Mark to review the financial results and outlook in more detail.

John Duke: With that, I'll turn the call over to Mark to review the financial results and outlook in more detail.

Speaker #5: Thank you, John. I'll start my comments with our fourth quarter 2025 financial results, the details of which can be found in our Form 10-K, which we expect to be filed within the next 24 hours.

Mark Frost: Thank you, John. I'll start my comments with our Q4 2025 financial results, the details of which can be found in our Form 10-K, which we will expect to be filed within the next 24 hours, and in the earnings presentation that we posted to our IR site. Starting on slide 4 of the presentation, revenue was $23.7 million, just above the midpoint of our $22.5 to $24.5 million guidance and below the $24.6 million we reported in the Q4 of 2024. The government shutdown of 43 days impacted our ability to overachieve within the quarter. Gross margin of 59.7% was at the high end of our 58% to 60% guidance range and is up 260 basis points from 57.1% in the Q4 of 2024.

Speaker #5: And in the earnings presentation that we posted to our IR site, starting on slide four of the presentation, revenue was $23.7 million, just above the midpoint of our $22.5 to $24.5 million guidance.

Speaker #5: And below the $24.6 million we reported in the fourth quarter of 2024. The government shutdown of 43 days impacted our ability to overachieve within the quarter.

Speaker #5: Gross margin of 59.7% was at the high end of our 58% to 60% guidance range and is up 260 basis points from 57.1% in the fourth quarter of 2024.

Speaker #5: This is the highest gross margin we've recorded over the last seven quarters. We continue to improve our gross margin returns based on cost actions we took at the end of 2024 and in 2025 as well.

Mark Frost: This is the highest gross margin we've recorded over the last seven quarters. We continue to improve our gross margin returns based on cost actions we took at the end of 2024 and in 2025 as well as the increasing benefit we are receiving from higher margin NPI revenue. Operating income of $1.7 million was up from flat last year, and adjusted operating income of $3.3 million was up from $2.5 million last year. The improvement in GAAP and adjusted operating income was primarily from cost reductions in manufacturing and SG&A. Now adjusted EBITDA was up 27% year-over-year to $3.8 million in Q4, driven by cost reductions including decreased costs related to manufacturing and SG&A headcount as well as expense management. Now moving to slide five for full year results.

Speaker #5: As well as the increasing benefit we are receiving from higher margin NPI revenue. Operating income of 1.7 million was up from flat last year and adjusted operating income of 3.3 million was up from 2.5 million last year.

Speaker #5: The improvement in gap and adjusted operating income was primarily from cost reductions in manufacturing and SG&A. Now, adjusted EBITDA was up 27% year over year to $3.8 million in the fourth quarter, driven by cost reductions, including decreased costs related to manufacturing and SG&A headcount, as well as expense management.

Speaker #5: Now, moving to slide five for full-year results. Revenue of 86.6 million was down from 94.1 million primarily from the impact of tariffs and the delayed NIH funding.

Mark Frost: Revenue of $86.6 million was down from $94.1 million, primarily from the impact of tariffs and the delayed NIH funding. Tariff impact started to subside later in the year, while NIH funding delays continued to impact timing of some orders, in particular our preclinical telemetry products. Gross margin of 57.77% was down from 58.2% last year due to lower revenue in 2025, but a larger margin impact was partially offset by our cost actions in manufacturing.

Speaker #5: Tariff impacts started to subside later in the year, while NIH funding delays continued to impact timing of some orders, in particular our preclinical telemetry products.

Speaker #5: Gross margin of 57.7% was down from 58.2% last year due to lower revenue in 2025, but a larger margin impact was partially offset by our cost actions in manufacturing.

Speaker #5: Operating income of negative $48.6 million was down from negative $6.2 million last year, and adjusted operating income of $6.2 million was up from $5.3 million last year.

Mark Frost: Operating income of negative $48.6 million was down from negative $6.2 million last year, and adjusted operating income of $6.2 million was up from $5.3 million last year. The GAAP difference stems from the goodwill impairment we took earlier in the year, and the improvement in adjusted operating income was due to cost reductions, improved expense management, and favorable mix of higher margin products. Now, Adjusted EBITDA increased 12.5% to $8.1 million from $7.2 million in 2024, as mentioned, due to cost reductions, improved expense management, and strong execution throughout the year. Now looking at slide 6, I will outline the revenue results for the quarter and year by product family and region. Overall revenue, revenues in the Q4 were up 15% sequentially and down 3% year-over-year.

Speaker #5: The gap difference stems from the goodwill impairment we took earlier in the year, and the improvement in the adjusted operating income was due to cost reductions, improved expense management, and a favorable mix of higher-margin products.

Speaker #5: Now, adjusted EBITDA increased 12.5% to 8.1 million from 7.2 million in 2024. As mentioned, due to cost reductions, improved expense management, and strong execution throughout the year.

Speaker #5: Now, looking at slide six, I will outline the revenue results for the quarter and year by product family and region. Overall, revenues in the fourth quarter were up 15% sequentially and down 3% year over year.

Speaker #5: Full-year revenue was down 8% year over year. Geographically, quarter four revenues in the Americas were down 2% year over year, driven by lower farmer sales for preclinical and lower academic sales in CMT.

Mark Frost: Full year revenue was down 8% year-over-year. Geographically, Q4 revenues in the Americas were down 2% year-over-year, driven by lower pharma sales for preclinical and lower academic sales in CMT. Full year revenues in the Americas were down 7% year-over-year, driven primarily by academic sales. In Europe, Q4 revenues were down 12% year-over-year due to lower academic sales. Full year revenues in Europe were down 6% year-over-year due to distribution and academic sales. In China and Asia Pacific, Q4 revenues were up 10% year-over-year, thanks to growth in preclinical distribution. Full year revenues in China and Asia Pacific were down due to lower distribution revenue. Now I'll move to slide seven to discuss further financial metrics.

Speaker #5: Full-year revenues in the Americas were down 7% year over year, driven primarily by academic sales. In Europe, Q4 revenues were down 12% year over year due to lower academic sales. Full-year revenues in Europe were down 6% year over year due to distribution and academic sales.

Speaker #5: And in China and the Asia Pacific, Q4 revenues were up 10% year over year, thanks to growth in preclinical distribution. Full-year revenues in China and Asia Pacific were down due to lower distribution revenue.

Speaker #5: Now, I'll move to slide seven to discuss further financial metrics. GAAP EPS in quarter four was negative $0.06 compared to flat last year, and quarter four adjusted EPS was flat compared to $0.06 last year.

Mark Frost: GAAP EPS in Q4 was negative $0.06 compared to flat last year, and Q4 adjusted EPS was flat compared to $0.06 last year. As I've mentioned in the past, the differences between GAAP EPS and adjusted EPS are typically the impact of stock compensation, amortization, and depreciation. These differences between net loss and adjusted EBIT are highlighted in the reconciliation tables on slide 10 and are all non-cash items. For the full year, GAAP loss per share was $1.28 compared to negative $0.28 in 2024. Adjusted loss per share was negative $0.02 compared to adjusted earnings per share of $0.03 in 2024. The majority of the higher GAAP loss was from the goodwill charge we took in Q1.

Speaker #5: As I've mentioned in the past, the differences between gap EPS and adjusted EPS are typically the impact of stock compensation, amortization, and depreciation. These differences between net loss and adjusted EBITDA are highlighted in the reconciliation tables on slide 10 and are all non-cash items.

Speaker #5: For the full year, GAAP loss per share was $1.28 compared to negative $0.28 in 2024. Adjusted loss per share was negative $0.02 compared to adjusted earnings per share of $0.03 in 2024.

Speaker #5: The majority of the higher GAAP loss was from the goodwill charge we took in the first quarter. Now, cash flow from operations at the end of the year was $6.7 million, up from $1.4 million at the end of 2024.

Mark Frost: Cash flow from operations ended the year at $6.7 million, up from $1.4 million at the end of 2024. The significant improvement in the year is due to disciplined working capital management, improved operating income, and our efforts on payroll tax refunds. Net debt is down $1.8 million from last year to $31.4 million, reflecting payments made on our prior syndicated debt facility as well as additional liquidity we gained as part of the new agreement. Now, as John discussed in Q4, we were pleased to announce the completion of our debt refinancing with a structured deal.

Speaker #5: The significant improvement in the year is due to discipline working capital management, improved operating income, and our efforts on payroll tax refunds. Net debt is down 1.8 million from last year to 31.4 million reflecting payments made on our prior syndicated debt facility as well as additional liquidity we gained as part of the new agreement.

Speaker #5: Now, as John discussed in the fourth quarter, we were pleased to announce the completion of our debt refinancing with a structured deal. The deal completed repayment of our prior credit facility, extended the maturity of our debt, and enhanced our financial flexibility as we worked to position the company for growth, including reducing our debt service in the first two years by $3 million.

Mark Frost: The deal completed repayment of our prior credit facility, extended the maturity of our debt, and enhanced our financial flexibility as we work to position the company for growth, including reducing our debt service in the first two years by $3 million. Full details on the deal can be found in our 17 December press release and accompanying SEC filing. Now another significant accomplishment during 2025 was the successful remediation of material weaknesses and the one significant deficiency. This is another step in building the foundation of a healthier business. I'll now move to slide 9 to discuss our outlook for Q1 and full year 2026. Now first, a few call-outs. We are introducing full year guidance as we are taking a more long-term oriented view of the business and helping us manage our broader expectations as we go through the year.

Speaker #5: Full details on the deal can be found in our December 17th press release and accompanying SEC filing. Now, another significant accomplishment during 2025 was the successful remediation of material weaknesses in the one significant deficiency.

Speaker #5: This is another step in building the foundation of a healthier business. I'll now move to slide nine to discuss our outlook for the first quarter and full year 2026.

Speaker #5: Now, first, a few callouts. We are introducing full-year guidance as we are taking a more long-term oriented view of the business and helping us manage our broader expectations as we go through the year.

Speaker #5: We are also introducing adjusted EBITDA guidance on both a quarterly and a full-year basis. This is a key metric for us and is one that we believe helps to demonstrate our core operating performance.

Mark Frost: We are also introducing Adjusted EBITDA guidance on both a quarterly and a full-year basis. This is a key metric for us, and is one that we believe helps demonstrate our core operating performance. This metric is also linked to a key covenant in our recently structured debt agreement that we thought would be helpful for investors to have visibility. We were reporting GAAP and adjusted gross margin in 2026 due to the restructuring impact from our manufacturing consolidation. Now lastly, with the expected growth in the business in 2026, we have reinstated bonuses and merit-based compensation for our employees, which was suspended in 2025 due to macro headwind impacts. This reinstatement will have an impact on our year-over-year Adjusted EBITDA comparison, which is already built into our full-year guidance.

Speaker #5: This metric is also linked to a key confidant in our recently structured debt agreement that we thought would be helpful for visitor investors to have visibility.

Speaker #5: We will be reporting GAAP and adjusted gross margin in 2026 due to the restructuring impact from our manufacturing consolidation. Now, lastly, with the expected growth in the business in 2026, we have reinstated bonuses and merit-based compensation for our employees, which was suspended in 2025 due to macro headwind impacts.

Speaker #5: This reinstatement will have an impact on our year-over-year adjusted EBITDA comparison, which has already been built into our full-year guidance. We appreciate our employees and all their hard work as they have supported us through a difficult time for the business.

Mark Frost: We appreciate our employees and all their hard work as they have supported us through a difficult time for the business. With that, let's dive into the outlook. In the first quarter, we expect revenue between $20 and $22 million, adjusted gross margin between 57% and 59%, and adjusted EBITDA between $1 and $2.2 million. I would note that Q1 of last year only saw minimal impact from NIH challenges. For the full year 2026, we expect revenue growth of 2% to 4%, gross margin of 58% to 60%, and adjusted EBITDA growth of 6% to 10%. Additional color is we expect revenue to ramp throughout the year on a year-over-year percentage basis, supported by stronger NPI revenue.

Speaker #5: With that, let's dive into the outlook. In the first quarter, we expect revenue between $20 and $22 million, adjusted gross margin between 57% and 59%, and adjusted EBITDA between $1 and $2.2 million.

Speaker #5: I would note that Q1 of last year only saw minimal impact from NIH challenges. For the full year 2026, we expect revenue growth of 2 to 4 percent, gross margin of 58 to 60 percent, and adjusted EBITDA growth of 6 to 10 percent.

Speaker #5: Additional color is we expect revenue to ramp throughout the year on a year-over-year percentage basis supported by stronger NPI revenue. Now, to sum up the performance, we're pleased with the fourth quarter and believe the improvements we've made to date with our operational efficiency sets us up well for the future.

Mark Frost: Now to sum up the performance, we're pleased with Q4 and believe the improvements we've made to date with our operational efficiency sets us up well for the future. With streamlined costs and a focus on high margin products in an emerging market, we expect to realize increased profitability going forward, and we're proud to have been able to demonstrate a glimpse of that in a year where macro conditions were challenging. Lastly, I'm excited to have been appointed CFO on a permanent basis and look forward to continuing to work with John, the Harvard Bioscience team, our board, and engaging further with our customers and investors. To that point, we will be attending the KeyBanc Healthcare Forum next week, and I look forward to seeing some of you there. I'll now turn the call back to our operator to take questions. Operator?

Speaker #5: With streamlined costs and a focus on high margin products in an emerging market, we expect to realize increased profitability going forward and we're proud to have been able to demonstrate a glimpse of that in the year where macro conditions were challenging.

Speaker #5: Lastly, I'm excited to have been appointed CFO on a permanent basis and look forward to continuing to work with John, the Harvard Bioscience team, our Board, and engaging further with our customers and investors.

Speaker #5: To that point, we will be attending the KeyBank Healthcare Forum next week, and I look forward to seeing some of you there. I'll now turn the call back to our operator to take questions.

Speaker #5: Operator? Thank you. To ask a question, please press *11. If your question has an answer and you'd like to remove yourself from the queue, please press *11 again.

Operator: Thank you. To ask a question, please press star one one. If your question has been answered and you'd like to remove yourself from the queue, please press star one one again. Our first question comes from Paul Knight with KeyBanc Capital Markets. Your line is open.

Speaker #5: Our first question comes from Paul Knight with KeyBanc Capital Markets. Your line is open.

Speaker #6: Hi, yeah. Thanks for the question. Regarding the NIH, that was finally approved February 3rd or so. How quickly do you think that approval turns into a better academic environment for you?

Paul Knight: Hi, yeah, thanks for the question. Regarding the NIH, you know, that was finally approved 3 February or so. How quickly do you think that approval turns into a better academic environment for you?

Speaker #2: Yeah, Paul, thanks for the question. As you could imagine, I would love for it to turn into a better academic environment in one day.

John Duke: Yeah, Paul, thanks for the question. As you could imagine, it would love for it to turn into a better academic environment in one day. We have, as you know, about 20 salespeople in North America who call on, you know, biopharma as well as academic customers. From what we have heard, there was a lot of grant submissions which were waiting to be approved, and we expect to start to see, you know, a positive impact both towards the end of Q1 as well as going into Q2.

Speaker #2: As you know, we have about 20 salespeople in North America who call on biopharma as well as academic customers. From what we have heard, there were a lot of grant submissions that were waiting to be approved, and we expect to start seeing a positive impact both towards the end of Q1 as well as going into Q2.

Speaker #6: In NIH's water, about 40% of the company now?

Paul Knight: NIH is what? About 40 percent of the company now?

Speaker #2: No, I'll clarify. It is about NIH revenue; it is about 20% of our US revenue, Paul. And one point—I'll just build on John's point—is we are a build-to-order business.

Mark Frost: No, I'll clarify. It is about NIH revenue is about 20% of our US revenue, Paul. One point I'll just build on John's point is we are a build-to-order business, so we're starting to see improvement in orders. In order to get the revenue, it actually needs to come in the first half of a quarter. Most of the benefit we'll start seeing probably in Q2 from the NIH release.

Speaker #2: So we're starting to see improvement in orders, but in order to get the revenue, it actually needs to come in in the first half of a quarter.

Speaker #2: So most of the benefit will start being seen probably in the second quarter from the NIH release.

Speaker #6: Yeah, okay. And then I know BTX and MeshMEA are some of your key products. Could you talk about your growth there and specifically what's your expected growth for these focused businesses in 2026?

Paul Knight: I know BTX and Mesh MEA are some of your key products. Could you talk about your growth in there and, you know, specifically, what's your expected growth for these focus businesses in 2026?

Speaker #2: Yes, so you are correct. They are a key part of our NPI, and we expect both of them to grow in double digits this year.

John Duke: Yes. You are correct. They are a key part of our NPI, and we expect both of them to grow in double digits this year.

Speaker #6: Okay. And then that schedule, is there a quarterly pay down year targeting or what do you want to do?

Paul Knight: Okay. That schedule, you know, is there a quarterly pay down you're targeting or what do you wanna do?

Speaker #2: A quarterly pay down. Could you clarify, Paul?

John Duke: A quarterly pay down? Could you reclarify, Paul?

Speaker #6: Pay down your debt this year, or are you just kind of—yeah.

Paul Knight: Pay down your debt this year or are you just kinda?

Mark Frost: Oh.

Paul Knight: Yeah.

Speaker #2: Yeah, no, the structure of the deck was structured in a couple of ways. One, to allow us flexibility that there's no amortization in the first two years of the deal.

Mark Frost: Yeah, no. The structure of the debt was structured in a couple ways. One, to allow us flexibility that there's no amortization in the first two years of the deal. We also, Paul, have the ability to convert Term Loan A to an ABL, which will give us likely a lower interest rate and more flexibility. The Term Loan C is structured that potentially could be converted to equity, which would reduce, you know, which would deleverage us in the future.

Speaker #2: We also, Paul, have the ability to convert Term Loan A to an ABL, which will likely give us a lower interest rate and more flexibility.

Speaker #2: And then the term loan C is structured that potentially could be converted to equity which would reduce which would de-leverage us in the future.

Speaker #6: Okay. Thank you.

Paul Knight: Okay. Thank you.

Speaker #5: Thank you. Our next question comes from Bruce Jackson with StoneX. Your line is open.

Operator: Thank you. Our next question comes from Bruce Jackson with StoneX. Your line is open.

Speaker #7: Hi, good morning. Thanks for taking my questions. We got a nice pop in the Asia-Pac revenue this quarter. I was wondering if—and we've had some issues in the past with Asia-Pac.

Bruce Jackson: Hi. Good morning. Thanks for taking my questions. We got a nice pop in the Asia Pacific revenue this quarter. I was wondering if and we've had some issues in the past with Asia Pacific. Is this the sign of a turnaround? Can you tell us a little bit about what your expectations are for 2026?

Speaker #7: Is this the sign of a turnaround? Can you tell us a little bit about what your expectations are for 2026?

Speaker #2: Yeah. It's a good question, Bruce. You're well aware last year when the tariffs hit, the China business ground to a halt. And we started to definitely see improvement.

Mark Frost: Yeah. It's a good question, Bruce. You're well aware, last year when the tariffs hit, the China business ground to a halt. We started to definitely see improvement, and those orders came in and were filled in the Q4. We had a fair amount of catch up, not fully. Our expectation is we will get back to a normal cadence, in Asia, notwithstanding obviously if there's further news on the tariff front, that changes that situation, Bruce.

Speaker #2: And those orders came in and were filled in in the fourth quarter. So we had a fair amount of catch-up—not fully—so our expectation is we will get back to a normal cadence in Asia.

Speaker #2: Notwithstanding, obviously, if there's further news on the tariff front that changes that situation, Bruce.

Bruce Jackson: Okay. Got it. Last quarter, you spoke about a backlog. Have you seen any changes in that during Q4?

Speaker #7: Okay, got it. And then last quarter, you spoke about a backlog. Have you seen any changes in that during the fourth quarter?

Speaker #2: Yeah, we actually ended up the year, Bruce, with the highest backlog we've had in over two years. And we've continued to maintain that. So, yeah, we're pretty positive about where we are on our backlog.

Mark Frost: Yeah. We actually ended up the year, Bruce, with the highest backlog we've had in over two years, and we've continued to maintain that. Yeah, we're pretty positive of where we are on our backlog.

Speaker #7: Okay, and then last question around the pharmaceutical biotech CRO side of the business: how would you characterize that business? We've been hearing that, for example, some of the large-cap pharma companies are kind of back to normal, while some of the smaller biotech-type companies are not, due to the uncertainty around pharmaceutical reimbursement.

Bruce Jackson: Okay. Last question over on the pharmaceutical biotech CRO side of the business. How would you characterize that business? We've been hearing that, for example, some of the large cap pharma companies are kind of back to normal, while some of the smaller biotech type companies are not due to the uncertainty around the pharmaceutical reimbursement. Where are you seeing the demand right now for your products on the pharmaceutical drug development side of the business?

Speaker #7: Where are you seeing the demand right now for your products on the pharmaceutical drug development side of the business?

Speaker #2: So Bruce, yeah, thanks for asking that. Year to date, we are seeing that portion of the market, the pharma and biotech, that business is up.

John Duke: Bruce, yeah, thanks for asking that. You know, year to date, we are seeing that portion of the market, the pharma and biotech, that business is up, and we expect that to continue, which, you know, clearly factored into our guidance for the year.

Speaker #2: And we expect that to continue. Which clearly factored into our guidance for the year.

Speaker #7: Okay, great. That's it for me. Thank you.

Bruce Jackson: Okay, great. That's it for me. Thank you.

Operator: Thank you. I'm showing no further questions. This does conclude the question and answer session, and you may now disconnect. Everyone, have a great day.

Speaker #5: Thank you. I'm showing no further questions. Does that conclude the question and answer session? And you may now disconnect. Everyone, have a great day.

Q4 2025 Harvard Bioscience Inc Earnings Call

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