Half Year 2026 AstraZeneca PLC Earnings Call

Speaker #1: Good morning to those joining from the UK and the US. Good afternoon to those in Central Europe, and good evening to those listening in Asia.

Operator: Good morning to those joining from the UK and the US. Good afternoon to those in Central Europe, and good evening to those listening in Asia. Welcome to AstraZeneca's H1 and Q2 2026 webinar for investors and analysts. Before I hand over to AstraZeneca, I'd like to read the Safe Harbor Statement. The company intends to utilize the Safe Harbor provisions of the United States Private Securities Litigation Reform Act of 1995. Participants on this call may make forward-looking statements with respect to the operations and financial performance of AstraZeneca. Although we believe our expectations are based on reasonable assumptions, by their very nature, forward-looking statements involve risks and uncertainties and may be influenced by factors that could cause actual results to differ materially from those expressed or implied by these forward-looking statements.

Speaker #1: Welcome to AstraZeneca’s Half Year and Q2 2026 webinar for investors and analysts. Before I hand over to AstraZeneca, I’d like to read the Safe Harbor statement.

Speaker #1: The company intends to utilize the Safe Harbor provisions of the United States Private Securities Litigation Reform Act of 1995. Participants on this call may make forward-looking statements with respect to the operations and financial performance of AstraZeneca.

Speaker #1: Although we believe our expectations are based on reasonable assumptions, by their very nature, forward-looking statements involve risks and uncertainties, and may be influenced by factors that could cause actual results to differ materially from those expressed or implied by these forward-looking statements.

Speaker #1: Any forward-looking statements made on this call reflect the knowledge and information available at the time of this call. The company undertakes no obligation to update forward-looking statements.

Operator: Any forward-looking statements made on this call reflect the knowledge and information available at the time of this call. The company undertakes no obligation to update forward-looking statements. Please also carefully review the forward-looking statements disclaimer in the slide deck that accompanies this presentation and webinar. There will be an opportunity to ask questions after today's presentation. Please use the raise a hand feature to indicate you wish to ask a question at any time during the call. With that, I'd now like to hand the conference over to the company.

Speaker #1: Please also carefully review the forward-looking statements disclaimer in the slide deck that accompanies this presentation and webinar. There will be an opportunity to ask questions after today's presentation; please use the raise-a-hand feature to indicate you wish to ask a question at any time during the call.

Speaker #1: And with that, I’d now like to hand the conference over to the company.

Speaker #2: A warm welcome to AstraZeneca's Half Year and Second Quarter 2026 presentation conference call and webcast for investors and analysts. I'm Joris Sillon, Head of Investor Relations, and before I hand over to Pascal and members of our executive team, I would like to cover some housekeeping items.

Joris Silon: A warm welcome to AstraZeneca's H1 and Q2 2026 Presentation Conference Call and Webcast for investors and analysts. I'm Joris Silon, Head of Investor Relations. Before I hand over to Pascal and members of our executive team, I would like to cover some housekeeping items. Firstly, all of the materials presented today are available on our AstraZeneca Investor Relations website. Please advance slide. This slide contains our forward-looking statements, including the Safe Harbor provisions, which I would encourage you to take the time to read. We will be making comments on our performance using constant exchange rates, or CER, core financial numbers, and other non-GAAP measures. A non-GAAP to GAAP reconciliation is contained within the results announcement. All numbers quoted are in millions of US dollars, unless stated otherwise. Please advance slide. This slide shows our agenda for today's call.

Speaker #2: Firstly, all of the materials presented today are available on our AstraZeneca Investor Relations website. Please advance the slide. This slide contains our forward-looking statements, including the Safe Harbor provisions, which I would encourage you to take the time to read.

Speaker #2: We will be making comments on our performance using constant exchange rates (CER), core financial numbers, and other non-GAAP measures. A non-GAAP to GAAP reconciliation is contained within the results announcement.

Speaker #2: All numbers quoted are in millions of US dollars, unless stated otherwise. Please advance the slide. This slide shows our agenda for today's call. Following our prepared remarks, we will open the line for questions.

Joris Silon: Following our prepared remarks, we will open the line for questions. As usual, we will try to address as many questions as we can during the allocated time, although please limit the number of questions you ask to allow others a fair chance to participate in the Q&A. With that, please advance to the next slide, Pascal, I will hand over to you.

Speaker #2: As usual, we will try to address as many questions as we can during the allocated time. However, please limit the number of questions you ask to allow others a fair chance to participate in the Q&A.

Speaker #2: And with that, please advance to the next slide. Pascal, I will hand over to you.

Speaker #3: Thank you, Joris, and welcome everyone. I'm really pleased to report that in the first half of 2026, we saw strong growth momentum and continued pipeline delivery.

Pascal Soriot: Thank you, Joris. Welcome everyone. I'm really pleased to report that in H1 2026, we saw strong growth momentum and continued pipeline delivery. Total revenue grew 6%, driven by strong demand for our innovative medicines, excluding the impact of Farxiga and BRILINTA, which are affected by generics, as you know. Total revenue grew 11%. That is a clear demonstration of the underlying strength of our portfolio and our broad geographical footprint. We also saw strong growth in core EPS, increasing 11%. In H1, we announced positive results from six key phase III programs, including three new molecular entities. We secured 30 major market approvals across our diverse portfolio, including the first approvals for two NMEs, ENHERTU in breast cancer, and Baxfendy in hypertension, and increasing our number of approved NMEs to 11 since we outlined our target to achieve 20 by 2030.

Speaker #3: Total revenue grew 6%, driven by strong demand for our innovative medicines, excluding the impact of Farxiga and Brilinta, which are affected by generics, as you know.

Speaker #3: Total revenue grew 11%. That is a clear demonstration of the underlying strengths of our portfolio and our broad geographical footprint. We also saw strong growth in core EPS, increasing 11%.

Speaker #3: In the first half, we announced positive results from six key phase three programs, including three new molecular entities. We secured 30 major market approvals across our diverse portfolio, including the first approvals for two NMEs: ADCAMA in breast cancer and backfending in hypertension.

Speaker #3: An increase in our number of approved NMEs to 11, since we outlined our target to achieve 20 by 2030. Our confidence in reaching our 2030 target is underpinned by the exceptional quality and momentum of our pipeline, together with our proven track record of successful execution and launches.

Pascal Soriot: Our confidence in reaching our 2030 target is underpinned by the exceptional quality and momentum of our pipeline, together with our proven track record of successful execution and launches. We continue to invest in our pipeline and commercial capabilities to bring innovative medicines to patients around the globe, and to support growth through 2030 and beyond. Please move to the next slide. There you can see the breadth of our company remains a key competitive strength. Oncology and rare disease delivered strong double-digit growth in H1. While within BioPharmaceuticals, we see continued momentum in respiratory and immunology that helped mitigate the expected impact of loss of exclusivity in CVRM, in particular, Farxiga and BRILINTA. We delivered strong growth in the US, in Europe, and in the emerging markets outside of China.

Speaker #3: We continue to invest in our pipeline and commercial capabilities to bring innovative medicines to patients around the globe and to support growth through 2030 and beyond.

Speaker #3: So, please move to the next slide. There, you can see the breadth of our company remains a key competitive strength. Oncology and rare disease delivered strong double-digit growth in the first half.

Speaker #3: While within Biopharmaceuticals, we see continued momentum in Respiratory and Immunology that help mitigate the expected impact of loss of exclusivity in CVRM, in particular Farxiga and Brilinta.

Speaker #3: We delivered strong growth in the US, in Europe, and in the emerging markets outside of China. Growth in China was impacted by continued effects from volume-based procurement, and we expect the recent NRDL additions and new regulatory approvals in 2026 to fuel future growth.

Pascal Soriot: Growth in China was impacted by continued effects from volume-based procurement, and we expect the recent NRDL additions and new regulatory approval in 2026 to fuel future growth. Move to the next slide, please. An important message for today is that when we set our $80 billion revenue ambition for 2030, we did so based on the strength of a broad and diversified portfolio, not on a single program. As you know very well, the $80 billion is a risk-adjusted forecast. If everything worked, we would be above the $80 billion. We have, of course, expected setbacks to happen. Unfortunately, the results of the CARDIO-TTRansform trial were not what we hoped, and they were disappointing for our team and most importantly, for the patients we sought to help. This serves as a reminder that transformative science carries an inherent risk and that not every program will succeed.

Speaker #3: Move to the next slide, please. An important message for today is that when we set our $80 billion revenue ambition for 2030, we did so based on the strengths of a broad and diversified portfolio, not on a single program.

Speaker #3: As you know very well, the $80 billion is a risk-adjusted forecast. If everything worked, we would be above the $80 billion. So we have, of course, expected setbacks to happen.

Speaker #3: Unfortunately, the results of the Cardio CTR Transform trial were not what we hoped, and they were disappointing for our team and, most importantly, for the patients we sought to help.

Speaker #3: This serves as a reminder that transformative science carries inherent risk and that not every program will succeed. Our pipeline, however, continued to deliver during the first half.

Pascal Soriot: Our pipeline, however, continued to deliver during H1, with positive results from six high-value phase III programs, including the first pivotal data for three new molecular entities, tozorakimab in COPD, which we look forward to presenting at the ERS, asfotase alfa in HPP, and as announced today, our first wholly-owned ADC, Sone-Ve, including CLDN18.2 positive gastric cancer. We also received eight major market approvals across important indications, including two additional NMEs. We're very happy to see first approvals for ENHERTU in first-line hormone receptor-positive breast cancer with emergent ESR1 mutations in Europe and Japan, and a few other countries. This approval demonstrate the value of this innovative treatment approach, and we continue to have constructive discussions with the FDA.

Speaker #3: With positive results from six high-value Phase III programs, including the first pivotal data for three new molecular entities—Tozorakimab in COPD, which we look forward to presenting at ERS; Epsimphotase Alpha in HPP; and, as announced today, our first wholly owned ADC, SoniV—including 18.2 positive gastric cancer.

Speaker #3: We also received eight major market approvals across important indications, including two additional NMEs. We're very happy to see, first, approvals for ADCAMa in first-line hormone receptor-positive breast cancer with emergent ESR1 mutations, in Europe and Japan.

Speaker #3: And a few other countries. These approvals demonstrate the value of this innovative treatment approach, and we continue to have constructive discussions with the US FDA.

Speaker #3: We also saw US FDA approval for baxdendin, which has the potential to transform outcomes for patients with uncontrolled or resistant hypertension, and we continue our launch activities at pace.

Pascal Soriot: We also saw US FDA approval for Baxfendy, which has the potential to transform outcomes for patients with uncontrolled or resistant hypertension, and we continue our launch activities at pace. This, together with the more than 20 approvals we have achieved in the H1 of this year, support our continued growth trajectory and strengthen our confidence in delivering the 2030 ambition. As you will hear today, we are also working very hard and making great progress on our post-2030 growth. With that, I will hand over to Aradhana to take you through our financials. Please advance to the next slide.

Speaker #3: This, together with the more than 20 approvals we've achieved in the first half of this year, supports our continued growth trajectory and strengthens our confidence in delivering the 2030 ambition.

Speaker #3: And as you will hear today, we're also working very hard on making great progress on our post-2030 growth. And with that, I will hand over to Aradna to take you through our financials.

Speaker #3: Please advance to the next slide.

Speaker #4: Thank you, Pascal, and good morning and good afternoon, everyone. As usual, I will start with our reported P&L. Next slide, please. As Pascal has highlighted, we delivered continued top-line momentum in the first half of the year.

Joris Silon: Thank you, Pascal, and good morning and good afternoon, everyone. As usual, I will start with our reported P&L. Next slide, please. As Pascal has highlighted, we delivered continued top-line momentum in the H1 of the year. Total revenue increased by 6%, with product revenue also growing by 6%.

Speaker #4: Total revenue increased by 6%, with product revenue also growing by 6%. Alliance revenue increased by 29%, reflecting higher profit shares from our partnered medicines and HER2 DataWay and Aspire in markets where our partners record product sales.

Aradhana Sarin: Alliance revenue increased by 29%, reflecting higher profit shares from our partnered medicines in ENHERTU, DARZALEX, and Tezspire in markets where our partners record product sales. Next slide, please. Turning to our core P&L, core growth margin was 83% in the H1. While the margin improved in the Q2 compared to the Q1, we expect lower growth margin in the H2, consistent with prior years, reflecting seasonal demand patterns for lower-margin medicines such as FluMist and Beyfortus. For the full year, we continue to expect a stable to slightly higher core growth margin versus 2025. Core R&D expense increased by 6% in the H1, reflecting continued investment in our pipeline. Following the positive phase IIb results for oral GLP-1 molecule, elecoglipron, we have now initiated comprehensive phase III program in both obesity and type 2 diabetes, with first patients dosed earlier this month.

Speaker #4: Next slide, please. Turning to our core P&L, core gross margin was 83% in the first half. While the margin improved in the second quarter compared to the first quarter, we expect a lower gross margin in the second half, consistent with prior years, reflecting seasonal demand patterns for lower margin medicines such as FluMist and Beyfortus.

Speaker #4: For the full year, we continue to expect a stable to slightly higher core growth margin versus 2025. Core R&D expense increased by 6% in the first half, reflecting continued investment in our pipeline.

Speaker #4: Following the positive Phase 2b results for our oral GLP-1 molecule, elecoglipron, we have now initiated a comprehensive Phase 3 program in both obesity and type 2 diabetes, with the first patients dosed earlier this month.

Speaker #4: Core R&D represented 23% of total revenue in the first half, and we continue to expect R&D expenses to be at the upper end of the low-20s percentage range for the full year, as we continue to build our pipeline for long-term growth opportunities, including bispecifics, cell therapies, and T-cell engagers, in addition to our CVRM portfolio.

Aradhana Sarin: Core R&D represented 23% of total revenue in the H1, and we continue to expect R&D expenses to be at the upper end of the low 20s percentage range for the full year as we continue to build our pipeline for long-term growth opportunities, including bispecifics, cell therapies, T-cell engagers, in addition to our CVRM portfolio. Core SG&A expense also increased by 6% in the H1. During this period, we launched Baxfendy in the US following FDA approval in May, and we continue to make pre-launch investments ahead of anticipated launch of tozorakimab following positive phase III data. Both medicines are expected to be important growth drivers, supporting growth to 2030 and beyond, and we are investing accordingly to maximize their potential.

Speaker #4: Core SG&A expense also increased by 6% in the first half. During this period, we launched Beyfortus in the US, following FDA approval in May, and we continue to make pre-launch investments ahead of the anticipated launch of Tozorakimab, following positive Phase 3 data.

Speaker #4: Both medicines are expected to be important growth drivers, supporting growth to 2030 and beyond, and we are investing accordingly to maximize their potential. Other operating income was $341 million in the first six months, consisting of royalties and small regional divestitures, and we anticipate a broadly similar level in the second half.

Aradhana Sarin: Other operating income was $341 million in H1, consisting of royalties and small regional divestitures, and we anticipate a broadly similar level in H2. Our tax rate in Q2 benefited from a one-time adjustment to deferred tax assets following certain internal legal entity changes. Overall, core EPS grew by 11% in H1, in line with our guidance for the full year. $2.2 billion in H1, a decline versus comparator period. This primarily reflects the LYNPARZA milestone received in Q1 2025, skewing comparisons as well as working capital impact associated with US loss of exclusivity for FARXIGA. We expect these working capital effects to persist through the remainder of the year before normalizing.

Speaker #4: Our tax rate in the second quarter benefited from a one-time adjustment to deferred tax assets following certain internal legal entity changes. Overall, core EPS grew by 11% in the first half, in line with our guidance for the full year.

Speaker #4: $2.2 billion in the first half, a decline versus the comparator period. This primarily reflects the Lymparta milestone receipt in the first quarter of 2025, skewing comparisons, as well as the working capital impact associated with US loss of exclusivity for Farxiga.

Speaker #4: We expect these working capital effects to persist through the remainder of the year before normalizing. Capital expenditure was $1.5 billion in the first half.

Aradhana Sarin: Capital expenditure was $1.5 billion in H1, underscoring our commitment to investing behind our long-term growth ambitions, and as previously communicated, we anticipate CapEx to increase by around a third in 2026. Key investments include our new ADC manufacturing facility in Singapore, along with several other strategic multi-year projects that will enhance our manufacturing network and support sustainable growth well into the next decade. Deal-related payments totaled $3.3 billion and included both milestone payments and the $1.2 billion upfront payment for CSPC collaboration, which closed during Q2. For the full year, we continue to expect milestone payments of approximately $2.5 billion relating to prior business development transactions. We have announced new BD transactions totaling just over $2 billion in upfront payments year to date, including the most recently announced Dizal transaction.

Speaker #4: Underscoring our commitment to investing behind our long-term growth ambitions, and as previously communicated, we anticipate capex to increase by around a third in 2026.

Speaker #4: Key investments include our new ADC manufacturing facility in Singapore, along with several other strategic, multi-year projects that will enhance our manufacturing network and support sustainable growth well into the next decade.

Speaker #4: Deal-related payments total $3.3 billion and are included in both milestone payments and the $1.2 billion upfront payment for the CSPC collaboration that closed during the second quarter.

Speaker #4: For the full year, we continue to expect milestone payments of approximately $2.5 billion relating to prior business development transactions. We have announced new BD transactions totaling just over $2 billion in upfront payments year to date, including the most recently announced DIESEL transaction.

Speaker #4: Our lead liabilities also increased, as we opened our new Kendall Square R&D Center in Cambridge. Our capital allocation priorities remain unchanged. Net debt increased by around $3.5 billion in the first half, primarily reflecting the payment of the second FY2025 interim dividend in March, and the deal payments I just mentioned.

Aradhana Sarin: Our lease liabilities also increased as we opened our new Kendall Square R&D center in Cambridge. Our capital allocation priorities remain unchanged. Net debt increased by around $3.5 billion in H1, primarily reflecting the payment of the second FY 2025 interim dividend in March and the deal payments I just mentioned. We remain comfortable with our level of gross debt. As previously communicated, following refinancing activities earlier in the year, resulting in higher than historic interest rates and lower interest income, we anticipate core finance costs to be higher in H2 compared to H1. Turning to guidance, we are reiterating our outlook for the full year. We expect total revenue to increase by a mid to high single-digit percentage, and core EPS to increase by low double-digit percentage at constant exchange rates.

Speaker #4: We remain comfortable with our level of gross debt, as previously communicated. Following refinancing activities earlier in the year, resulting in higher than historic interest rates and lower interest income, we anticipate core finance costs to be higher in the second half compared to the first half.

Speaker #4: Turning to guidance, we are reiterating our outlook for the full year. We expect total revenue to increase by a mid- to high-single-digit percentage, and core EPS to increase by a low double-digit percentage at constant exchange rates.

Speaker #4: So, to summarize, we delivered another period of strong financial performance while continuing to invest significantly in both our pipeline and our commercial capabilities. We remain on track to deliver on our priorities in the near term and support growth in the long term.

Aradhana Sarin: To summarize, we delivered another period of strong financial performance while continuing to invest significantly in both our pipeline and our commercial capabilities. We remain on track to deliver on our priorities in the near term and support growth in the long term. With that, I will hand over to Dave to take you through the performance of our Oncology business. Next slide, please.

Speaker #4: With that, I'll hand over to Dave to take you through the performance of our oncology business. Next slide, please.

Speaker #1: Thank you, Rodna. Next slide, please. Oncology total revenues grew 15% in the first half to $14.1 billion, underpinned by double-digit growth in all major regions.

David Fredrickson: Thank you, Aradhana. Next slide, please. Oncology total revenues grew 15% in H1 to $14.1 billion, underpinned by double-digit growth in all major regions. Growth in the US and Europe was particularly notable at 18% and 16%, respectively. Focusing in on the quarterly performance of our key medicines. TAGRISSO delivered 6% growth in Q2 to revenues of $1.9 billion, supported by double-digit growth in the US. The share of combination regimens in the first line continues on an upward trajectory in key markets, with FLAURA2 remaining the clear preference. Turning to CALQUENCE, which grew 16% in the quarter, generating more than $1 billion in revenue for the first time in a single quarter. CALQUENCE maintains its position as the leading BTK inhibitor in frontline CLL across major markets, despite intense competition.

Speaker #1: Growth in the US and Europe was particularly notable at 18% and 16%, respectively. Focusing in on the quarterly performance of our key medicines.

Speaker #1: Tagrisso delivered 6% growth in the second quarter, with revenues of $1.9 billion, supported by double-digit growth in the US. The share of combination regimens in the first line continues on an upward trajectory in key markets, with FLAURA2 remaining the clear preference.

Speaker #1: Turning to Calquint, which grew 16% in the quarter, generating more than $1 billion in revenue for the first time in a single quarter. Calquint maintains its position as the leading BTK inhibitor in front-line CLL across major markets, despite intense competition.

Speaker #1: Within the finite duration class, Amplify continues to gain share in reimbursed markets, with encouraging early signs in the US, where it is uniquely positioned as the only BTK inhibitor with both finite and treat-to-progression options.

David Fredrickson: Within the finite duration class, AMPLIFY continues to gain share in reimbursed markets, with encouraging early signs in the US, where it is uniquely positioned as the only BTK inhibitor with both finite and treat to progression options. We continue to see AMPLIFY as a significant growth driver through the remainder of 2026, supported by the clear global trend towards adoption of finite duration treatments. IMFINZI and IMJUDO delivered growth of 25% in aggregate in Q2. IMFINZI growth continues to be driven by a combination of new launches and increasing demand for established indications. Meaningful contributions from MATTERHORN and gastric cancer reflect its rapid establishment as the standard of care in reimbursed markets, and in lung, ADRIATIC continues to be an important additional source of growth.

Speaker #1: We continue to see Amplify as a significant growth driver through the remainder of 2026, supported by the clear global trend towards adoption of finite-duration treatments.

Speaker #1: Infinzi and Imjudo delivered growth of 25% in aggregate in the second quarter. Infinzi's growth continues to be driven by a combination of new launches and increasing demand for established indications.

Speaker #1: Meaningful contributions from Matterhorn and gastric cancer reflect its rapid establishment as the standard of care in reimbursed markets, and in lung, Adriatic continues to be an important additional source of growth.

Speaker #1: We continue to see strong global momentum for Imfinzi in muscle invasive bladder cancer, and while the US market is evolving with competitive entrants, we will continue to expand Imfinzi's reach.

David Fredrickson: We continue to see strong global momentum for IMFINZI in muscle invasive bladder cancer, and while the US market is evolving with competitive entrants, VOLGA will continue to expand IMFINZI's reach. Turning to ENHERTU, we delivered growth of 31% in the quarter and reported revenues of $888 million. Growth continues to be across all regions and reflects sustained market leadership in the HER2 positive and HER2-low breast cancer indications in major markets. This strong position is complemented by increased adoption and additional launches in emerging markets. We are seeing encouraging early signs of adoption and growing awareness in the first-line DESTINY-Breast09 setting in the United States following its approval late last year. Together with the recent simultaneous US approvals of DESTINY-Breast05 and DESTINY-Breast11 in the curative setting, these growth drivers will become increasingly important through the remainder of the year.

Speaker #1: Turning to Inhertio, we delivered growth of 31% in the quarter and reported revenues of $888 million. Growth continues to be across all regions and reflects sustained market leadership in the HER2-positive and HER2-low breast cancer indications in major markets.

Speaker #1: This strong position is complemented by increased adoption and additional launches in emerging markets. We are seeing encouraging early signs of adoption and growing awareness in the first-line DESTINY-Breast09 setting in the United States, following its approval late last year.

Speaker #1: Together with the recent simultaneous US approvals of DESTINY-Breast05 and DESTINY-Breast11 in the curative setting, these growth drivers will become increasingly important through the remainder of the year.

Speaker #1: TrueCap revenues of $233 million in the quarter represent growth of 37% over the prior year. As we've indicated previously, the majority of this growth is from ex-US markets, with the US opportunity at peak in the breast indication.

David Fredrickson: TRUQAP revenues of $233 million in the quarter represent growth of 37% over the prior year. As we've indicated previously, the majority of this growth is from ex-US markets, with the US opportunity at peak in the breast indication. Beyond breast, we are looking forward to bringing TRUQAP to patients with PTEN deficient metastatic hormone sensitive prostate cancer, following the recent approval of CAPItello-281 in the US, and a near-term priority is to establish testing in the setting, which today is not common practice. DATROWAY revenues of $55 million in Q2 demonstrate growing demand in later line EGFR mutated lung cancer, with signs of increasing utilization in the second-line setting in the US. We're excited for the ongoing launch of DATROWAY in patients with triple-negative breast cancer who are not candidates for immunotherapy following the US approval of TROPION-Breast02 earlier in Q2.

Speaker #1: Beyond breast, we are looking forward to bringing TrueCap to patients with PTEN-deficient metastatic hormone-sensitive prostate cancer, following the recent approval of Capitello-281 in the US. In the near term, our priority is to establish testing in common practice.

Speaker #1: Daturay revenues of $55 million in the second quarter demonstrate growing demand in later-line EGFR-mutated lung cancer, with signs of increasing utilization in the second-line setting in the US.

Speaker #1: We're excited for the ongoing launch of Daturay in patients with triple-negative breast cancer who are not candidates for immunotherapy, following the U.S. approval of Tropion Bresto 2 earlier in the quarter.

Speaker #1: Given its differentiated profile, we see this as a significant opportunity and look forward to additional market launches in the second half. With strong momentum demonstrated across our portfolio in the first half, we are well positioned for continued growth through the rest of the year as we deliver innovative oncology medicines to more patients.

David Fredrickson: Given its differentiated profile, we see this as a significant opportunity and look forward to additional market launches in the H2. With strong momentum demonstrated across our portfolio in the H1, we are well-positioned for continued growth through the rest of the year as we deliver innovative oncology medicines to more patients. Please advance to the next slide. Focusing in on EGFR-mutated lung cancer, TAGRISSO is the number one prescribed third-generation EGFR TKI globally, approved across all stages of disease. This leadership position is underpinned by the breadth of our clinical development plan and our differentiated product portfolio. In the first-line combination setting, we have seen significant global market expansion over the past 12 months with FLAURA2, the clear market leader. In the highly competitive US market, FLAURA2 holds around three-quarters of this growing segment.

Speaker #1: Please advance to the next slide. Focusing in on EGFR-mutated lung cancer, Tagrisso is the number one prescribed third-generation EGFR TKI globally, approved across all stages of disease.

Speaker #1: This leadership position is underpinned by the breadth of our clinical development plan and our differentiated product portfolio. In the first-line combination setting, we've seen significant global market expansion over the past 12 months, with FLORA-2 the clear market leader.

Speaker #1: In the highly competitive US market, Flora 2 holds around three-quarters of this growing segment. We were pleased to announce the in-licensing of Zygfrovi, a novel oral eGFR inhibitor, earlier this month.

David Fredrickson: We were pleased to announce the in-licensing of Zegfrovy, a novel oral EGFR inhibitor earlier this month. Zegfrovy is already approved in the US and China for patients whose tumors carry exon 20 insertion mutations following progression on or after platinum-based chemotherapy. Based on the WU-KONG28 data presented at ASCO, filings for the first line have been submitted in China and the US. This deal complements our existing EGFR leadership and allows us to bring a differentiated treatment to patients with limited treatment options globally. Importantly, it is also a clear signal of our intent to remain the definitive leader in this space. I will now hand it over to Susan to discuss some more of the specific near-term pipeline opportunities.

Speaker #1: Zygfrovi is already approved in the US and China for patients whose tumors carry exon 20 insertion mutations, following progression on or after platinum-based chemotherapy.

Speaker #1: Based on the Wukong 28 data presented at ASCO, filings for the first line have been submitted in China and the US. This deal complements our existing EGFR leadership and allows us to bring a differentiated treatment to patients with limited treatment options globally.

Speaker #1: Importantly, it's also a clear signal of our intent to remain the definitive leader in this space. I'll now hand it over to Susan to discuss some more of the specific near-term pipeline opportunities.

Speaker #2: Thank you, Dave. Turning to the right-hand side of this slide, our near-term pipeline readouts provide the opportunity to further strengthen our position in EGFR-mutated lung cancer, with Tagrisso as the backbone TKI.

Susan Galbraith: Thank you, Dave. Turning to the right-hand side of this slide, our near-term pipeline readouts provide the opportunity to further strengthen our position in EGFR-mutated lung cancer with TAGRISSO as the backbone TKI, with two phase III trials due to read out later this year investigating combinations in the sizable post-TKI second-line setting. TROPION-Lung15 evaluates DATROWAY alone and in combination with TAGRISSO, building on the growing position DATROWAY already has in later-line lung cancer based on TROPION-Lung05. SAFFRON then evaluates TAGRISSO combined with ORPATHYS, offering a differentiated combination approach in patients with MET-driven resistance, supported by the encouraging data we have already seen from SAVANNAH and SACHI. Looking further ahead, TROPION-Lung14 then aims to bring the combination of DATROWAY and TAGRISSO into the first line, building directly on the success of FLAURA2.

Speaker #2: With two phase 3 trials due to readout later this year, investigating combinations in the sizable post-TKI second line setting. Tropion Lung 15 evaluates Daturay alone and in combination with Tagrisso, building on the growing position Daturay already has in later line lung cancer, based on Tropion Lung 05.

Speaker #2: Saffron then evaluates Tagrisso combined with Orpathys, offering a differentiated combination approach in patients with MET-driven resistance, supported by the encouraging data we've already seen from SAVANNAH and SACHI.

Speaker #2: Looking further ahead, Tropion-Lung14 then aims to bring the combination of datopotamab deruxtecan and Tagrisso into the first line, building directly on the success of FLAURA2.

Speaker #2: This represents significant long-term opportunity to extend our first-line leadership and improve outcomes with the next-generation combination. Taken together, these opportunities represent a comprehensive strategy to maintain leadership in EGFR-mutated lung cancer for years to come.

Susan Galbraith: This represents significant long-term opportunity to extend our first-line leadership and improve outcomes with a next-generation combination. Taken together, these opportunities represent a comprehensive strategy to maintain leadership in EGFR-mutated lung cancer for years to come. Next slide, please. I am also delighted to share with you today the high-level results from two recent phase III trial readouts. Back in May, we announced positive results from the planned interim analysis of the phase III VOLGA trial for IMFINZI in patients with muscle-invasive bladder cancer who are not candidates for cisplatin. VOLGA builds on our existing presence in this setting, where the NIAGARA regimen has already established IMFINZI as a key treatment option for cisplatin-eligible patients. VOLGA explores whether the combination of enfortumab vedotin and IMFINZI, plus or minus IMJUDO, can improve outcomes for the 50% of patients who are not candidates for cisplatin.

Speaker #2: Next slide, please. I'm also delighted to share with you today the high-level results from two recent Phase 3 trial readouts. Back in May, we announced positive results from the planned interim analysis of the Phase 3 VULCAN trial for Imfinzi in patients with muscle-invasive bladder cancer who are not candidates for cisplatin.

Speaker #2: Vulga builds on our existing presence in this setting, where the NIAGARA regimen has already established Infinzi as a key treatment option for cisplatin-eligible patients.

Speaker #2: Vulga explores whether the combination of Infortimab Vedotin and Infinzi, plus or minus Imdudo, can improve outcomes for the 50% of patients who are not candidates for cisplatin.

Speaker #2: Importantly, in this regimen, Infortimab Vedotin is only given in the neoadjuvant setting, aiming to optimize outcomes whilst balancing the overall benefit-risk profile. Infinzi, in combination with Infortimab Vedotin, demonstrated statistically significant and clinically meaningful improvements in both event-free survival and overall survival, underscoring the potential of this regimen to meaningfully improve outcomes in bladder cancer.

Susan Galbraith: Importantly, in this regimen, enfortumab vedotin is only given in the neoadjuvant setting, aiming to optimize outcomes whilst balancing the overall benefit-risk profile. IMFINZI in combination with enfortumab vedotin demonstrated statistically significant and clinically meaningful improvements in both event-free survival and overall survival, underscoring the potential of this regimen to meaningfully improve outcomes in bladder cancer. The IMJUDO-containing arm also demonstrated a statistically significant improvement in event-free survival, with a favorable trend in overall survival. VOLGA broadens our presence in bladder cancer, enabling more patients to benefit from an IMFINZI-based regimen, complementing NIAGARA in muscle-invasive bladder cancer and the recently US-approved pertemac indication in earlier stage non-muscle invasive disease. We also saw positive NILE results this quarter. Whilst the landscape in the first-line setting has evolved significantly since we started this trial, it further reinforces IMFINZI’s value across the full spectrum of bladder cancer. Turning now to gastric cancer.

Speaker #2: The Imdudo-containing arm also demonstrated a statistically significant improvement in event-free survival, with a favorable trend in overall survival. Vulga broadens our presence in bladder cancer, enabling more patients to benefit from an Infinzi-based regimen—complementing Niagara in muscle-invasive bladder cancer and the recently US-approved Patomac indication in earlier-stage, non-muscle invasive disease.

Speaker #2: We also saw positive NIL results this quarter, and whilst the landscape in the first-line setting has evolved significantly since we started this trial, it further reinforces Infinzi's value across the full spectrum of bladder cancer.

Speaker #2: Turning now to gastric cancer, we announced today positive results from the Phase 3 CLARITY Gastric 01 trial, evaluating Sunicitab Vedotin, or Sunny V, in previously treated patients with advanced gastric cancer expressing Claudin 18.2.

Susan Galbraith: We announced today positive results from the phase III CLARITY-Gastric01 trial evaluating sonesitatug vedotin or SUNIV, in previously treated patients with advanced gastric cancer expressing CLDN18.2. CLARITY-Gastric01 is the first phase III trial to demonstrate an overall survival benefit with a CLDN18.2-targeted antibody-drug conjugate in the second-line plus setting. This is a population with a particularly poor prognosis. Fewer than 20% of patients with advanced gastric cancer survive beyond one year, and at present, there are no targeted options for CLDN18.2 positive, non-HER2 positive tumors in this second-line plus setting. The trial met its overall survival dual primary endpoint, with SUNIV demonstrating a statistically significant and highly clinically meaningful improvement in overall survival versus investigators’ choice of therapy in patients treated with at least two prior therapies. There was also a trend to PFS benefit, which did not meet statistical significance.

Speaker #2: CLARITY Gastric-01 is the first Phase 3 trial to demonstrate an overall survival benefit with a CLDN18.2-targeted antibody-drug conjugate in the second-line plus setting.

Speaker #2: This is a population with a particularly poor prognosis, fewer than 20% of patients with advanced gastric cancer survive beyond one year. And at present, there are no targeted options for chlorine 18.2 positive non-HER2 positive tumors in this second line plus setting.

Speaker #2: The trial met its overall survival dual primary endpoint, with Sunny V demonstrating a statistically significant and highly clinically meaningful improvement in overall survival versus investigator’s choice of therapy in patients treated with at least two prior therapies.

Speaker #2: There was also a trend toward PFS benefit, which did not meet statistical significance. Critically, the trial also met its key secondary endpoint, demonstrating a highly clinically meaningful overall survival benefit in patients treated with at least one prior line, potentially extending the benefit to a broader patient population earlier in their treatment journey.

Susan Galbraith: Critically, the trial also met its key secondary endpoint, demonstrating a highly clinically meaningful overall survival benefit in patients treated with at least one prior line, potentially extending the benefit to a broader patient population earlier in their treatment journey. Importantly, the survival data were demonstrated in patients with CLDN18.2 expression as low as 25% at any staining intensity, a lower threshold than that required by other CLDN18.2-targeted therapies, meaning that SUNIV could potentially benefit around 50% of patients with second-line plus gastric cancer, representing more than 180,000 patients across the US, EU5, China, and Japan. CLARITY-Gastric01 represents a landmark milestone for our oncology portfolio. SUNIV is our second ADC to demonstrate an overall survival benefit in gastric cancer following ENHERTU, and our third positive phase III readout in this tumor type in just two years, following MATTERHORN for IMFINZI and Destiny Gastric 04 for ENHERTU.

Speaker #2: Importantly, the survival data were demonstrated in patients with Claudin 18.2 expression as low as 25% at any staining intensity, a lower threshold than that required by other Claudin 18.2-targeted therapies.

Speaker #2: Meaning that Sunny V could potentially benefit around 50% of patients with second-line plus gastric cancer, representing more than 180,000 patients across the US, EU5, China, and Japan.

Speaker #2: Clarity Gastric 01 represents a landmark milestone for our oncology portfolio. Sunny V is our second ADC to demonstrate an overall survival benefit in gastric cancer following Enhertu, and our third positive Phase 3 readout in this tumor type in just two years, following Matterhorn for Imfinzi and DESTINY-Gastric04 for Enhertu.

Speaker #2: It is also the first Phase 3 data from our wholly owned ADC portfolio, marking an important step as we establish our independent position in this space.

Susan Galbraith: It is also the first phase III data from our wholly owned ADC portfolio, marking an important step as we establish our independent position in this space. We look forward to presenting the data later this year. Together with VOLGA, these data strengthen our conviction in the opportunity to combine IO with ADCs, an approach we believe could be transformative across multiple cancers. Specifically, these two readouts reinforce our confidence in CLARITY-Gastric02, our first-line gastric cancer trial evaluating SUNIV in combination with capecitabine, with or without rilpivirine or nivolumab. With that, please advance to the next slide, and I’ll pass over to Ruud to cover BioPharmaceuticals performance.

Speaker #2: We look forward to presenting the data later this year. Together with Vulga, these data strengthen our conviction in the opportunity to combine IO with ADCs—an approach we believe could be transformative across multiple cancers.

Speaker #2: And specifically, these two readouts reinforce our confidence in CLARITY Gastric 02, our first-line gastric cancer trial, evaluating SUNNAV in combination with capecitabine, with or without vulbegostamig or nivolumab.

Speaker #2: And with that, please advance to the next slide, and I'll pass over to Ruth to cover biopharmaceuticals' performance.

Speaker #1: Thank you so much, Susan. Next slide, please. Our biopharmaceutical business is in a transitional period, and in the first half of 2026, total revenue declined by 5% to $11.2 billion.

Ruud Dobber: Thank you so much, Susan. Next slide, please. Our biopharmaceutical business is in a transitional period. In H1 2026, total revenue declined by 5% to $11.2 billion. This reflected the loss of exclusivity headwinds for Farxiga, BRILINTA, and roxadustat, which were largely offset by the growth of our respiratory portfolio. The strong momentum in respiratory was supported by our established biologics for severe asthma, which generated over $2 billion of in-market sales in H1. Focusing in on the quarter, respiratory and immunology total revenue grew by 11%. Fasenra grew 13% to $570 million, driven by its continued leadership of the IL-5 class. In emerging markets, Fasenra grew 75%, thanks to the ongoing success of its launch in China, where it entered the National Reimbursement Drug List at the start of the year.

Speaker #1: This reflected the loss of exclusivity headwinds for Farxiga, Brilinta, and Roxadustat, which were largely offset by the growth of our respiratory portfolio. The strong momentum in respiratory was supported by our established biologics for severe asthma.

Speaker #1: which generated over $2 billion of in-market sales in the first half. Focusing in on the quarter, respiratory and immunology total revenue grew by 11%.

Speaker #1: Fasendra grew 13% to $570 million, driven by its continued leadership of our five class. In emerging markets, Fasendra grew 75%, thanks to the ongoing success of its launch in China, where it entered the national reimbursement drug list at the start of the year.

Speaker #1: Despite it grew by 45% to $390 million, with strong performances in the United States and Europe, being supplemented by uptake in the emerging markets.

Ruud Dobber: Tezspire grew by 45% to $390 million, with strong performances in the United States and Europe being supplemented by uptake in the emerging markets. In our inhaled portfolio, Breztri continued on its positive trajectory, with 20% growth to $346 million. Breztri received its first approval for asthma this year in the United States, and last week received a positive recommendation for asthma from the CHMP in Europe. We are excited about this important new indication, which will help us bring this therapy to more patients. Symbicort revenues of $671 million were down 8% due to the price pressure in the United States, reflecting a new generic competitor entering the market. Saphnelo revenues increased 24% to $209 million, driven by share gains in the intravenous segment for SLE patients.

Speaker #1: In our in-health portfolio, Dress 3 continued on its positive trajectory, with 20% growth to $346 million. Dress 3 received its first approval for asthma this year in the United States, and last week received a positive recommendation for asthma from the CHMP in Europe.

Speaker #1: We are excited about this important new indication, which will help us bring this therapy to more patients. Symbicort revenues of $671 million were down 8% due to price pressure in the United States, reflecting a new generic competitor entering the market.

Speaker #1: Stavenelo revenues increased 24% to $209 million, driven by share gains in the intravenous segment, where Azalee patients. The new subcutaneous formulation is now available in the US and some European markets, which broadens Stavenelo's reach to patients who favor self-administration.

Ruud Dobber: The new subcutaneous formulation is now available in the US and some European markets, which broadens Saphnelo's reach to patients who favor self-administration. As expected, generic competition for Farxiga entered the US at the start of the quarter. This, along with loss of exclusivity in some other markets and VBP in China, saw Farxiga decline by 90% overall, resulting in $1.8 billion of revenue for the quarter. Navigating these expected life cycle transitions is a natural part of our business, and we remain confident in the long-term strength of our broader portfolio and pipeline. In May, we secured the approval and launch of Baxfendy in the US, and we are now building early market access through affordability programs. We anticipate commercial access for Baxfendy will broaden over the next few quarters in anticipation of Medicare Part D reimbursements from 2028.

Speaker #1: As expected, generic competition for Farxiga entered the US at the start of the quarter, and this, along with loss of exclusivity in some other markets and VBP in China, saw Farxiga decline by 90% overall, resulting in $1.8 billion of revenue for the quarter.

Speaker #1: Navigating these expected life-cycle transitions is a natural part of our business. We remain confident in the long-term strength of our broader portfolio and pipeline.

Speaker #1: In May, we secured the approval and launch of Baxfendi in the US, and we are now building early market access through affordability programs. We anticipate commercial access for Baxfendi will broaden over the next few quarters, in anticipation of Medicare Part D reimbursement from 2028.

Speaker #1: We're also making an early start on our launch preparations for Tozoracemab. We are encouraged by the data, which showed highly clinically meaningful benefits in the OVERALL and TITANIUM trials, representing a broad COPD population, and we are looking forward to bringing this innovation to patients around the world as soon as possible.

Ruud Dobber: We are also making an early start on our launch preparations for tozorakimab. We are encouraged by the data, which showed highly clinical meaningful benefits in the OBERON and TITANIA trials, representing a broad COPD population, and we are looking forward to bringing this innovation to patients around the world as soon as possible. I will now hand over to Sharon to take us through the latest developments in the BioPharmaceuticals R&D pipeline.

Speaker #1: I will now hand over to Sharon to take us through the latest developments in the biopharmaceuticals R&D pipeline.

Speaker #3: Thank you, Ruth. Next slide, please. I'd like to start by acknowledging the Phase 3 CARDIO-TTRANSFORM trial for Wainua in transthyretin-mediated amyloid cardiomyopathy. This trial was conducted in a contemporary ATTR cardiomyopathy patient population, designed to examine the role of Wainua, a gene silencer treatment, on top of today's standard of care, in reducing recurrent cardiovascular events and CV mortality.

Sharon Barr: Thank you, Ruud. Next slide, please. I would like to start by acknowledging the phase III CARDIO-TRANSFORM trial for WAINUA in transthyretin-mediated amyloid cardiomyopathy. This trial was conducted in a contemporary ATTR cardiomyopathy patient population designed to examine the role of WAINUA, a gene silencer treatment, on top of today's standard of care in reducing recurrent cardiovascular events and CV mortality. In this contemporary patient population treated with standard of care, including 57% on a stabilizer, adding WAINUA did not provide a statistically significant benefit on the composite outcome of CV mortality and recurrent CV events. However, in a pre-specified subgroup analysis of patients treated with WAINUA monotherapy as compared to placebo, fewer primary composite events were observed, and this result was nominally significant. In patients who were on stabilizer therapy at baseline, no treatment effect was observed.

Speaker #3: In this contemporary patient population, treated with standard of care, including 57% on a stabilizer, adding Wainua did not provide a statistically significant benefit on the composite outcome of CV mortality and recurrent CV events.

Speaker #3: However, in a prespecified subgroup analysis of patients treated with Wainua monotherapy as compared to placebo, fewer primary composite events were observed, and this result was nominally significant.

Speaker #3: In patients who were on stabilizer therapy at baseline, no treatment effect was observed. Although the trial did not meet its primary endpoint, we believe these results contribute meaningfully to the greater scientific understanding of treatment approaches for the hundreds of thousands of patients worldwide suffering from this progressive and often fatal condition.

Sharon Barr: Although the trial did not meet its primary endpoint, we believe these results contribute meaningfully to the greater scientific understanding of treatment approaches for the hundreds of thousands of patients worldwide suffering from this progressive and often fatal condition. AstraZeneca and Ionis will analyze the full data set to further understand the results, and we look forward to presenting these data at the European Society of Cardiology Congress in August. Turning now to elecoglipron, where we are building strong momentum into phase III. At the American Diabetes Association meeting in June, we presented results from our phase II-B VISTA and SOLSTICE trials, which demonstrated the potential of elecoglipron as a multi-blockbuster asset for AstraZeneca. In VISTA, we observed a clinically meaningful and statistically significant weight loss of up to 11.8% at week 36, importantly, without evidence of a plateau.

Speaker #3: AstraZeneca and Ionis will analyze the full data set to further understand the results, and we look forward to presenting these data at the European Society of Cardiology Congress in August.

Speaker #3: Turning now to Aleco Glipran, where we are building strong momentum into Phase 3. At the American Diabetes Association meeting in June, we presented results from our Phase 2b VISTA and Solstice trials, which demonstrated the potential of Aleco Glipran as a multi-blockbuster asset. We observed a clinically meaningful and statistically significant weight loss of up to 11.8% at week 36.

Speaker #3: Importantly, without evidence of a plateau. In Solstice, there was an up to 1.9% reduction in HbA1c at week 26, with a vast majority of patients with type 2 diabetes reaching their glycemic goals.

Sharon Barr: In SOLSTICE, there was an up to 1.9% reduction in HbA1c at week 26, with the vast majority of patients with type 2 diabetes reaching their glycemic goals. Elecoglipron demonstrated a favorable safety profile with no unexpected safety signals, low discontinuation rates, and tolerability consistent with the GLP-1 receptor agonist class. It is worth emphasizing that elecoglipron is an oral small molecule. This once-daily treatment requires no fasting or fluid restrictions and critically can be combined with other oral small molecules to treat interconnected chronic diseases. Based on the strength of these data, we are advancing an ambitious phase III program. EMBOLD is studying elecoglipron monotherapy in patients with obesity or overweight, with or without type 2 diabetes. The ILLUMINATE program, which includes five phase III trials, evaluates elecoglipron both as monotherapy and in combination with dapagliflozin across broad patient populations with type 2 diabetes.

Speaker #3: Aleco Glipran demonstrated a favorable safety profile, with no unexpected safety signals, low discontinuation rates, and tolerability consistent with the GLP-1 receptor agonist class. It is worth emphasizing that Aleco Glipran is an oral small molecule.

Speaker #3: This once-daily treatment requires no fasting or fluid restrictions and, critically, can be combined with other oral small molecules to treat interconnected chronic diseases. Based on the strength of these data, we are advancing an ambitious Phase 3 program.

Speaker #3: Inbold is studying ALECO-GLIPRAN monotherapy in patients with obesity or overweight, with or without type 2 diabetes. The ILLUMINATE program, which includes five Phase 3 trials, evaluates ALECO-GLIPRAN both as monotherapy and in combination with dapagliflozin across broad patient populations with type 2 diabetes.

Speaker #3: I am pleased to say that we achieved first subject in for both the inBold and Illuminate programs. Beyond these, we also plan to initiate Elevate, an indication-seeking outcomes program designed to demonstrate the value of Aleco Glipran in heart failure with preserved ejection fraction and chronic kidney disease, on the background of dapagliflozin and other standard of care.

Sharon Barr: I am pleased to say that we achieved first subject in for both the EMBOLD and ILLUMINATE programs. Beyond these, we also plan to initiate ELEVATE, an indication-seeking outcomes program designed to demonstrate the value of elecoglipron in heart failure with preserved ejection fraction and chronic kidney disease on the background of dapagliflozin and other standard of care. Finally, I want to highlight a few additional advancements in our BioPharmaceuticals pipeline during Q2. Staying in weight management, the phase II APRICUS trial studying AZD6234, our selective amylin receptor agonist, read out this quarter, and we are now initiating a phase III monotherapy trial. We look forward to sharing the phase II data with the medical community at EASD later this year.

Speaker #3: Finally, I want to highlight a few additional advancements in our biopharmaceuticals pipeline during the second quarter. Staying in weight management, the Phase 2 APRICUS trial studying AZD6234, our selective amylin receptor agonist, read out this quarter.

Speaker #3: And we are now initiating a Phase 3 monotherapy trial. We look forward to sharing the Phase 2 data with the medical community at EASD later this year.

Speaker #3: In dyslipidemia, we look forward to the phase 3 readout of our oral PCSK9, liraprovastat, in the first half of 2027, and we are advancing our first six-dose combination of liraprovastat with rosuvastatin into phase 3.

Sharon Barr: In dyslipidemia, we look forward to the phase III readout of our oral PCSK9, laroprovstat, in H1 2027 and are advancing our first fixed-dose combination of laroprovstat with rosuvastatin into phase III, bringing together the benefits of a statin and a PCSK9 inhibitor in a single tablet. Moving to our respiratory portfolio, we are excited to present the highly clinically meaningful results from the OBERON and TITANIA phase III studies for tozorakimab in COPD at the European Respiratory Society Congress in September, highlighting the compelling profile we have seen for this potential first and best-in-class asset. We have also made exciting progress in other areas of our respiratory portfolio this quarter. Our inhaled TSLP, sunacokimab, which was formerly referred to as AZD8630, read out its phase II study, and we are discussing plans for phase III with our partner, Amgen.

Speaker #3: Bringing together the benefits of a statin and a PCSK9 inhibitor in a single tablet. Moving to our respiratory portfolio, we are excited to present the highly clinically meaningful results from the OBERON and TITANIUM Phase 3 studies for Tozoracamab in COPD at the European Respiratory Society Congress in September.

Speaker #3: Highlighting the compelling profile we have seen for this potential first- and best-in-class asset, we have also made exciting progress in other areas of our respiratory portfolio this quarter.

Speaker #3: Our inhaled TSLP, Sunakimet, which was formerly referred to as AZD8630, read out its Phase 2 study, and we are discussing plans for Phase 3 with our partner, Amgen.

Speaker #3: Additionally, we entered into an exclusive license agreement with CTTQ, a subsidiary of Sino Biopharmaceuticals, for the development, manufacturing, and commercialization of TQC3721, an inhaled small molecule PDE3/4 inhibitor currently in Phase 3 trials in China for COPD.

Sharon Barr: Additionally, we entered into an exclusive license agreement with CTTQ, a subsidiary of Sino Biopharmaceutical, for the development, manufacturing, and commercialization of TQC3721, an inhaled small molecule PDE3/4 inhibitor currently in phase III trials in China for COPD. This licensing agreement strengthens our respiratory portfolio with a novel inhaled option for people living with COPD, a disease with continued patient need, particularly for those who remain symptomatic despite existing treatment options. With that, please proceed to the next slide, and I'll pass over to Marc to cover rare disease.

Speaker #3: This licensing agreement strengthens our respiratory portfolio with a novel inhaled option for people living with COPD, a disease with continued patient need—particularly for those who remain symptomatic despite existing treatment options.

Speaker #3: And with that, please proceed to the next slide, and I'll pass over to Mark to cover Rare Disease.

Speaker #1: Thank you, Sharon. Can I get the next slide, please? Rare disease total revenues grew by 11% in the first half to $4.9 billion, underpinned by double-digit growth across all key medicines.

Marc Dunoyer: Thank you, Sharon. Can I get the next slide, please? Rare disease total revenues grew by 11% in H1 to $4.9 billion, underpinned by double-digit growth across all key medicines. This is driven by increased patient demand and continued global expansion following launches. In Q2, Ultomiris grew 12%, driven by patient demand across indications, including the competitive MG and PNH markets. SOLIRIS revenues continued to decline due to successful conversion to Ultomiris, as well as biosimilar pressure. Strensiq grew 36% year-on-year, reflecting strong patient demand. Strensiq remains one of AstraZeneca's fastest-growing blockbuster medicines, supported by ongoing investment in commercial capabilities, infrastructure, and disease awareness. These investments are driving continued growth today while also laying the foundation for the potential launch of asfotase alfa and future franchise growth.

Speaker #1: This is driven by increased patient demand and continued global expansion following launches. In the second quarter, we ultimately grew 12%, driven by patient demand across indications, including the competitive MG and PNH markets.

Speaker #1: Soliris revenues continue to decline due to successful conversion to Ultomiris, as well as biosimilar pressure. Strensiq grew 36% year on year, reflecting strong patient demand.

Speaker #1: Strensic remains one of AstraZeneca's fastest-growing blockbuster medicines, supported by ongoing investment in commercial capabilities, infrastructure, and disease awareness. These investments are driving continued growth today, while also laying the foundation for the potential launch of a synthetic alpha and future franchise growth.

Speaker #1: Ogelugo continues to deliver strong global momentum, supported by expansion in adult patients with NF1-PN and uptake of the granule formulation in recently launched markets.

Marc Dunoyer: Koselugo continues to deliver strong global momentum, supported by expansion in adult patients with NF1-PN and uptake of the granule formulation in recently launched markets. Koselugo remained the market leader for pediatric patients with NF1-PN. Overall, we continue to see great momentum across the rare disease portfolio, please advance to the next slide. Turning to our rare disease pipeline, we have continued to build momentum with phase III data presentation across rare disease indications, highlighting the breadth of our portfolio and the strength of our late-stage execution. In IgAN nephropathy, phase III data from the AIKAN trial for Ultomiris showed a 43% reduction in proteinuria, with significant proteinuria reduction seen as early as 10 weeks. Importantly, treatment effects were consistent across patient groups, including those at higher risk of progression and with more inflammatory disease.

Speaker #1: Ocelugo remains the market leader for pediatric patients with NF1-PN. Overall, we continue to see great momentum across the rare disease portfolio. Please advance to the next slide.

Speaker #1: Turning to our rare disease pipeline, we have continued to build momentum with Phase 3 data presentation across rare disease indications, highlighting the breadth of our portfolio and the strength of our late-stage execution.

Speaker #1: In AGN nephropathy, Phase 3 data from the ICANN trial ultimately showed a 43% reduction in proteinuria, with significant proteinuria reduction seen as early as 10 weeks.

Speaker #1: Importantly, treatment effects were consistent across patient groups, including those at higher risk of progression and with more inflammatory disease. While ICAN is becoming an increasingly competitive treatment landscape, the heterogeneity of the disease underscores the importance of multiple treatment approaches, and the data we presented at IRA further support the role of complement in disease pathophysiology.

Marc Dunoyer: While IgAN is becoming an increasingly competitive treatment landscape, the heterogeneity of the disease underscores the importance of multiple treatment approaches. The data we presented at ERA further support the role of complement in disease pathophysiology. The IgAN opportunity represents an important step in the continued expansion and development of our C5 franchise, building on Ultomiris' established leadership across multiple complement-mediated disease. We have now filed in both the US and Japan. For asfotase alfa in hypophosphatasia, data from our phase III pediatric trials, MULBERRY and CHESTNUT, were presented at the International Conference on Children's Bone Health in June. MULBERRY demonstrated clinically meaningful improvement in bone health, function, and quality of life. In our single-arm switch safety study, CHESTNUT showed asfotase alfa was well-tolerated and demonstrated a favorable safety profile in pediatric patients.

Speaker #1: The ICANN opportunity represents an important step in the continued expansion and development of our C5 franchise, building on our established leadership across multiple complement-mediated diseases.

Speaker #1: We have now filed in both the US and Japan. For ensulizumab as ALPha, in April, hypophosphatasia, data from our Phase 3 pediatric trials, Mulberry and Chestnut, were presented at the International Conference on Children's Bone Health in June.

Speaker #1: Mulberry demonstrated clinically meaningful improvement in bone health, function, and quality of life. In our single-arm Swiss safety study, Chestnut showed that synthetic alpha was well tolerated and demonstrated a favorable safety profile in pediatric patients.

Speaker #1: In a pooled analysis of the Phase 3 MULBERRY and ECORI trials, including pediatric, adolescent, and adult patients, treatment with a synthetic alpha resulted in a median of 361 days per year free from injection site reactions.

Marc Dunoyer: In a pooled analysis of the phase III MULBERRY and ECHOE trials, including pediatric, adolescent, and adult patients, treatment with asfotase alfa resulted in a median of 361 days per year free from injection site reactions, and injection site reaction rates were five times lower than with Strensiq. Data from the ECHOE trial will be presented at the American Society for Bone and Mineral Research in October. We are progressing filings across major markets to support a broad HPP patient population. Also, data from the CALYPSO phase III trial was presented in May at ECE. Enibarcestat demonstrated maintenance of serum calcium within the target range, normalization of urinary calcium, and restoration of normal bone turnover in patients with hypoparathyroidism. Anselamimab in kappa light chain amyloidosis patients.

Speaker #1: Injection site reaction rates were five times lower than with Strensic. Data from the ECORI trial will be presented at the American Society for Bone and Mineral Research in October.

Speaker #1: We are progressing filings across major markets to support a broad SPP patient population. Also, data from the Calypso Phase 3 trial were presented in May at ECE; Enablin Paratide demonstrated maintenance of serum calcium within the target range, normalization of urinary calcium, and restoration of normal bone turnover in patients with hypoparathyroidism.

Speaker #1: And on Selamimab in kappa light chain amyloidosis patients, results from the CARES program demonstrated a 62% reduction in all-cause mortality and a 71% reduction in cardiovascular hospitalization, with an overall survival benefit observed even in patients with advanced myostage disease.

Marc Dunoyer: Results from the CARES program demonstrated a 62% reduction in all-cause mortality and a 71% reduction in cardiovascular hospitalization, with an overall survival benefit observed even in patients with advanced Mayo stage disease. Taken together, this program illustrates the strengths of a rare disease pipeline with multiple near and midterm catalysts, with potential approvals and future launches across several high-value rare disease indications. Finally, an update on our Ultomiris phase III trial in adults with thrombotic microangiopathy after ACT. High-level results showed that Ultomiris did not achieve statistical significance for the primary endpoint of event-free survival through 26 weeks compared to placebo in adult and adolescents aged 12 years older with aCT-TMA. Ultomiris showed a trend towards treatment benefit, and discussion with health authorities are ongoing regarding the interpretation of this data, including in the context of real-world evidence.

Speaker #1: Taken together, this program illustrates the strength of our rare disease pipeline, with multiple near- and mid-term catalysts, as well as potential approvals and future launches across several high-value rare disease indications.

Speaker #1: And finally, an update on our Phase 3 trial in adults with thrombotic microangiopathy after ACT. High-level results showed that ultimately did not achieve statistical significance for the primary endpoint of event-free survival through 26 weeks compared to placebo in adults and adolescents age 12 years or older with ACT-TMA.

Speaker #1: Ultimately, it showed a trend towards treatment benefit, and discussions with authorities are ongoing regarding the interpretation of this data, including in the context of real-world evidence.

Speaker #1: In pediatric patients with ACT TMA, we are advancing regulatory filings based on data from the open-label Phase 3 trial we reported in 2025 and data from an external control study.

Marc Dunoyer: In pediatric patients with aCT-TMA, we are advancing regulatory filings based on data from the open label phase III trial we reported in 2025 and data from an external control study. As pioneers in complement biology, we continue to explore and advance treatment approaches in disease where complement is believed to play a central role in disease pathophysiology. With limited treatment option available today, it reflects our ongoing commitment to bringing innovative therapies to patients with severe complement-mediated disease. With that, please advance to the next slide. I will hand back to Pascal.

Speaker #1: As pioneers in complement biology, we continue to explore and advance treatment approaches in diseases where complement is believed to play a central role in pathophysiology.

Speaker #1: With limited treatment options available today, it reflects our ongoing commitment to bringing innovative therapies to patients with severe complement-mediated disease. And with that, please advance to the next slide and I will hand back to Pascal.

Speaker #2: Thank you, Mark. Next slide, please. As the slides show you, we carry strong momentum into the first half—six positive program readouts already delivered and a rich catalyst path ahead.

Pascal Soriot: Thank you, Marc. Next slide, please. As the slide shows you, we carry strong momentum into H1. Six positive program readouts already delivered and a rich catalyst path ahead. Over the next 18 months, we have 25 key phase III trial readouts that are planned, giving us multiple opportunities to add further value and conviction to our trajectory. We expect pivotal data readouts for six new molecular entities in 2027 alone across our portfolio. Some of them are really important, as you can see here, and saruparib is a big one, but there are many other very important readouts over the next 18 months or so. Move to the next slide. Our growth ambition extends well beyond 2030, and we continue to invest behind the transformative technologies that we believe will redefine how many diseases are treated.

Speaker #2: Over the next 18 months, we have 25 key Phase 3 trial readouts that are planned, giving us multiple opportunities to add further value and conviction to our trajectory.

Speaker #2: We expect pivotal data readouts for six new molecular entities in 2027 alone across our portfolio. Some of them are really important, as you can see here, and for instance Saruparib is a big one, but there are many other very important readouts over the next 18 months or so.

Speaker #2: So, let's move to the next slide. Our growth ambition extends well beyond 2030, and we continue to invest behind the transformative technologies that we believe will redefine how many diseases are treated.

Speaker #2: If you remember, back in mid-2024, we identified platforms that we said would drive our growth post-2030—what we called at the time "the day after tomorrow."

Pascal Soriot: If you remember back in mid-2024, we identified platforms that we said would drive our growth past 2030, what we called at the time, the day after tomorrow. I'm pleased to say that we have made very good progress across many of these platforms, as you can see here. The slide highlights the momentum we're building in our next wave of innovation. If we start with weight management and cardio risk factor, as Charles mentioned, we expect the first phase III data for our baxdrostat in H1 2027, and we have now initiated five phase III trials for elecoglipron. You can see here our portfolio is building both scale and optionality and focused on not only weight management, but the risk factors that accompany excess obesity and particular abdominal obesity. In ADC and radio conjugates, we continue to make strong progress.

Speaker #2: And I'm pleased to say that we have made very good progress across many of these platforms, as you can see here. The slide highlights the momentum we're building in our next wave of innovation.

Speaker #2: So, if we start with waste management and cardio risk factor, as Charles mentioned, we expect the first Phase 3 data for Laroprostat in the first half of 2027.

Speaker #2: And we have now initiated five Phase 3 trials for Helicoglipram. So you can see here a portfolio that is building both scale and optionality.

Speaker #2: And focused on not only weight management but the risk factors that accompany excess obesity, and in particular, abdominal obesity. In ADC and radioconjugates, we continue to make strong progress as highlighted today.

Pascal Soriot: As highlighted today, we've just had the first positive phase III readout for Sone-Ve, and we anticipate phase III data for our second wholly owned ADC, puxitatug samrotecan, next year. We also continue to advance our broader program, having dosed patients in our first phase III trials for tovusam and also for zolegolik this quarter. Very good progress across ADCs and radioligands. For our next generation bio-specifics, we now have 16 phase III trials across 8 tumor types, including five in combination with our ADCs. This supports our ambition to replace the current generation of checkpoint inhibitors. Our cell therapy and T-cell engager portfolios are also advancing very rapidly. AZD0120 and surovatamig both have multiple phase III trials underway across hematology, and importantly, both now have extended into autoimmune diseases, underscoring the broader therapeutic potential of these platforms. Very exciting progress across those two products.

Speaker #2: We've just had the first positive Phase 3 readouts for Sunny V, and we anticipate Phase 3 data for our second wholly owned ADC, Puxisan, next year.

Speaker #2: We also continue to advance our broader program, having those patients in our first Phase 3 trials for Torvusam and also for Zadagu this quarter.

Speaker #2: So, very good progress across ADCs and radioligands. For our next-generation biospecific IOs, we now have 16 Phase 3 trials across eight tumor types.

Speaker #2: Including five in combination with our ADCs. This supports our ambition to replace the current generation of checkpoint inhibitors. Our cell therapy, anti-cell engager portfolio is also advancing very rapidly.

Speaker #2: AZD0120 and Sirovatamig both have multiple Phase 3 trials underway across hematology, and importantly, both now have extended into autoimmune diseases. Underscoring the broader therapeutic potential of these platforms, it's very exciting program progress across those two products.

Speaker #2: Beyond these lead programs, we're also investing in off-the-shelf and in vivo cell therapies, which we believe will enable us to reach more patients across more disease areas.

Pascal Soriot: Beyond these lead programs, we're also investing behind off-the-shelf and in vivo cell therapies, which we believe will enable us to reach more patients across more disease areas. These programs continue to advance and are key components of our deep late-stage pipeline of multiple blockbuster opportunities that will underpin our next wave of growth. Move to the next slide. The strength of that opportunity is reflected in this slide. We have three recent launches, WAINUA, Etcamah, Baxfendy, each with peak year revenue potential of more than $5 billion. Beyond these launches, we have a broad portfolio of late-stage assets that are expected to deliver pivotal data before 2030, including multiple programs with multiple blockbuster potential. Together, these assets provide a strong foundation for growth. Into the next decade. It really is important to remember that our $80 billion is risk-adjusted.

Speaker #2: These programs continue to advance and are key components of our deep, late-stage pipeline of multi-blockbuster opportunities that will underpin our next wave of growth.

Speaker #2: So, move to the next slide. The strength of that opportunity is reflected in this slide. We have three recent launches: Dato, Wekama, and Baxfendi, each with peak revenue potential of more than $5 billion.

Speaker #2: Beyond these launches, we have a broad portfolio of late-stage assets that are expected to deliver pivotal data before 2030, including multiple programs with multi-blockbuster potential.

Speaker #2: Together, these assets provide a strong foundation for growth into the next decade. And it really is important to remember that our $80 billion is risk-adjusted.

Speaker #2: If everything worked 100%, we would be well above the $80 billion, of course. But we've also assumed some projects would not work and other projects would work.

Pascal Soriot: If everything worked 100%, we would be much above the $80 billion, of course. We've also assumed some projects would not work and other projects would work. A good example of this is the strong data we obtained for tozorakimab, a product that very few people thought was going to work. We ourselves had a low probability of success for it. We tried because we thought we have a different mechanism of action, and we have a chance, and it actually worked. You will see the data very soon. As a result, we have increased our peak revenue expectation to more than $5 billion. In addition, with a positive readout for Sone-Ve today, we estimate that this ADC could reach peak year revenue between 3 and $5 billion. This is an example of the strengths and the diversification in our pipeline.

Speaker #2: And a good example of this is the strong data we obtained for Tozorakimab, a product that very few people thought was going to work.

Speaker #2: We ourselves had a low probability of success for it. We tried because we thought we had a different mechanism of action and we had a chance.

Speaker #2: And it actually worked. You will see the data very soon. As a result, we have increased our peak revenue expectation to more than $5 billion.

Speaker #2: In addition, with a positive readout for Sunny V today, we estimate that this ADC could reach peak revenue between $3 and $5 billion.

Speaker #2: This is an example of the strengths and the diversification in our pipeline. The likelihood that there will be puts and takes is part of how we plan.

Pascal Soriot: The likelihood that there will be puts and takes is part of how we plan, and we've taken this into account in our growth ambition beyond 2030 as well. We have built what we believe is one of the most exciting pipeline in the industry, one that can now more than offset losses of exclusivity and fuel AstraZeneca growth well into the next decade. In closing, as we move to the next slide, I'd like to say that we delivered strong growth in H1. Again, 11% excluding Farxiga and BRILINTA shows you the strength of the pipeline and the geographical footprint, 6% growth overall. Strong growth in H1. The breadth and depth of our pipeline remain exceptional, and our confidence in reaching $80 billion revenue by 2030 is intact. What excites me most is what comes next.

Speaker #2: We've taken this into account in our growth ambition beyond 2030 as well. We have built what we believe is one of the most exciting pipelines in the industry.

Speaker #2: One that can now more than offset losses of exclusivity and fuel AstraZeneca growth well into the next decade. In closing, as we move to the next slide, I'd like to say that we delivered strong growth in the first half—again, 11%, excluding Farxiga and Brilinta. I showed you the strengths of the pipeline and the geographical footprint.

Speaker #2: Six percent growth overall, and so strong growth in the first half. The breadth and depth of our pipeline remain exceptional, and our confidence in reaching $80 billion in revenue by 2030 is intact.

Speaker #2: But what excites me most is what comes next. With multiple waves of blockbuster assets that are progressing through late-stage development, and transformative technology platforms scaling rapidly, we're building a company that will not just deliver on its 2030 ambition, but continue to grow well into the next decade.

Pascal Soriot: With multiple waves of blockbuster assets that are progressing through each stage of development and transformative technology platforms scaling rapidly, we're building a company that will not just deliver on its 2030 ambition, but continue to grow well into the next decade. We have the science, we have the pipeline, and we have the team to make that happen. With that, please advance to the next slide, and we'll move to the Q&A. As Joris mentioned at the start of the call, please limit the number of questions you ask to allow others a fair chance to participate. Please use the raise hand function on Zoom. Now let's move to the first question, who actually is from Rajan Sharma at Goldman Sachs. Rajan, over to you.

Speaker #2: We have the science, we have the pipeline, and we have the team to make that happen. With that, please advance to the next slide, and we'll move to the Q&A.

Speaker #2: As Joris mentioned at the start of the call, please limit the number of questions you ask to allow others a fair chance to participate.

Speaker #2: Please use the raised hand function on Zoom. Now, let's move to the first question, which is actually from Rajan Sharma at Goldman Sachs.

Speaker #2: Rajan, over to you.

Rajan Sharma: Hi. Thanks for taking my question. Firstly, just on the oral PCSK9, which you highlighted there, could you just outline your expectations ahead of the data next year and how do you expect this to compare relative to Merck's LIPFENDRA? Maybe you could just comment on your expectations for pricing in that market, given we now have a list price for your competitor. Secondly, on Sone-Ve, you're going into 3 to $5 billion in peak sales now. Can you just help us understand how much of that is in the first line versus the data that you've disclosed today? Maybe could you just talk about geographical split of patients and potential revenues? Thank you.

Speaker #3: Hi. Thanks for taking my question. Firstly, just on the oral PCSK9, which you highlighted there—could you outline your expectations ahead of the data next year? And how do you expect this to compare relative to Merck's Lipfendra?

Speaker #3: And maybe you could just comment on your expectations for pricing in that market, given we now have a list price for your competitor. And then, secondly, on Sunny V, you're now going into $3 to $5 billion in peak sales.

Speaker #3: Can you just help us understand how much of that is in the first line versus the data that you've disclosed today? And maybe could you just talk about the geographical split of patients and potential revenues?

Speaker #3: Thank you.

Speaker #2: That's great. Thank you very much. Rajan, maybe Ruth could take the first question and dive into the second one.

Pascal Soriot: That's great. Thank you very much, Rajan. Maybe Ruud could take the first question and Dave, the second one.

Speaker #4: Yes, of course, Pascal. Overall, I think we are excited about our oral PCSK9. We will see the first data reading out in the first half of 2027.

Ruud Dobber: Yes, of course, Pascal. Overall, I think we are excited about our oral PCSK9. We will see the first data reading out in H1 2027. I think we will have, hopefully we will have a competitive profile versus the compound of Merck. I think the breadth of our portfolio for cholesterol-lowering medicines is broader than only the oral PCSK9. As Sharon has mentioned, we have started the first combination with rosuvastatin. I think we have a unique opportunity because it's a true oral medicine in order to combine that with other products in our portfolio. Hence, that will increase the level of competitiveness. Regarding the pricing, of course, we have seen the official first list price of our competitor in the United States. It will not change dramatically our own outlook. Of course, I'm not going to disclose our pricing strategy moving forward.

Speaker #4: I think we will have, and hopefully we will have, a competitive profile versus the compound of Merck. But I think the breadth of our portfolio for cholesterol-lowering medicines is broader than only the oral PCSK9.

Speaker #4: As Sharon has mentioned, we have started the first combination with rosuvastatin. I think we have a unique opportunity because it is a true oral medicine.

Speaker #4: In order to combine that with other products in our portfolio, and hence, that will increase the level of competitiveness. Regarding the pricing, of course, we have seen the official first list price of our competitor in the United States.

Speaker #4: It will not change dramatically. Our own outlook, of course—I'm not going to disclose our pricing strategy moving forward. It also depends on what we are going to see in our clinical trials.

Ruud Dobber: It also depends on what we are going to see in our clinical trials. Overall, I think we are well on track in order to develop a very competitive oral PCSK9 moving forward.

Speaker #4: But overall, I think we are well on track to develop a very competitive oral PCSK9 moving forward.

Speaker #2: Thanks for your.

Pascal Soriot: Thanks.

David Fredrickson: Thanks, Ruud. Just picking up on the question about Sone-Ve and CLARITY-Gastric, and after I'm done, turn it over to Susan, who can talk a bit more about the life cycle plan beyond CLARITY-Gastric01. We're very excited about these results and look forward to getting an opportunity to presenting them soon. Specifically, the CLARITY-Gastric01 opportunity has potential to be a blockbuster indication. Some of that will depend, obviously, on indications that we are able to achieve. The dataset looks good. We look forward to sharing it. I think a couple of important points. First, we will pursue discussions across all major markets: US, Europe, China, Japan, and throughout the emerging markets. This dataset, we think, supports those discussions. Secondly, as you saw, overall survival being an absolute gold standard within this setting we think well positions Sone-Ve for uptake upon approval.

Speaker #3: So just picking up on the question about Sunny V and Clarity Gastric, and after I'm done I'll turn it over to Susan, who can talk a bit more about the lifecycle plan beyond CG01.

Speaker #3: But we're very excited about these results and look forward to getting an opportunity to present them soon, specifically the CGO1 opportunity, which has the potential to be a blockbuster indication.

Speaker #3: Now, some of that will depend, obviously, on indications that we are able to achieve, but the data set looks good. We look forward to sharing it.

Speaker #3: I think a couple of important points. First, we will pursue discussions across all major markets: US, Europe, China, and Japan, as well as throughout the emerging markets.

Speaker #3: This data set, we think, supports those discussions. Secondly, as you saw, overall survival, being an absolute gold standard within this setting, we think is well positioned.

Speaker #3: Sunny, V for uptake upon approval. And we expand the definition of CLAUDE 18.2 positivity with the cutoff that we're using in this study. That cutoff is greater than 25%.

David Fredrickson: We expand the definition of CLDN18.2 positivity, with the cutoff that we're using in this study, and that cutoff is greater than 25%, and that represents about half of the patients with gastric GEJ cancer. It's a great opportunity, and one that we're really looking forward to getting an opportunity to launch as quickly as possible. Susan, do you want to talk a little bit about the life cycle plan beyond CLARITY-Gastric01?

Speaker #3: And that represents about half of the patients with gastric GEJ cancer. So it's a great opportunity, and one that we're really looking forward to getting an opportunity to launch as quickly as possible.

Speaker #3: Susan, do you want to talk a little bit about the lifecycle plan beyond CGO1?

Speaker #5: Yes. So obviously, in the first line, there's an opportunity to combine with IO agents, as I've discussed with both Wilbur Gostomek, plus the backbone of Cape Side Spin.

Susan Galbraith: Yes. Obviously, in the first line there's an opportunity to combine with IO agents, as I've discussed with both volrustomig, plus a backbone of capecitabine. The CLARITY-Gastric 02 study has 2 cohorts, one in the PD-L1 greater than 1%, but also has a cohort in the less than 1%, where we're looking at Sone-Ve plus a 5-FU-based regimen versus a standard of care as well. I think that gives us an opportunity to have a broad first-line opportunity to have a IO and ADC combination in the relevant patient population. It is a big segment in gastric cancer. Then again, I think there are opportunities to consider based on the data that we've got with MATTERHORN, whether there's an opportunity to go into the earlier stage setting.

Speaker #5: And the CLARITY Gastric Code 2 study has two cohorts, one in the PD-L1 greater than 1%, but also has a cohort in the less than 1% where we're looking at sunny-V plus 5-FU-based regimen versus a standard of care as well.

Speaker #5: So I think that gives us an opportunity to have a broad first-line opportunity to have an IO and ADC combination in the relevant patient population.

Speaker #5: And it is a big segment in gastric cancer. And then again, I think there are opportunities to consider based on the data that we've got with Matterhorn, whether there's an opportunity to go into the earlier-stage setting.

Speaker #5: Plus, Coordinating Point is not just expressed on gastric cancer, but also on some pancreatic cancers and biliary tract cancers. And we're exploring those in our ongoing Phase 1.

Susan Galbraith: CLDN18.2 is not just expressed on gastric cancer, but also on some pancreatic cancers and biliary tract cancers, and we're exploring those in our ongoing phase I, and we're encouraged by the data that we've seen to date. I think this can be a broad program for Sone-Ve across all of these GI-based cancers.

Speaker #5: And we are encouraged by the data that we've seen to date. So I think this can be a broad program for SUNY-V across all of these GI-based cancers.

Speaker #2: Thank you, Susan, Dave, and Ruth. Maybe one thing I could add to the PCSK9 is that another fixed-dose combo we have developing is together with our Elicoglipron, our Glipron oral.

Pascal Soriot: Thank you, Susan, David, and Ruud. Maybe one thing I could add to the PCSK9 is that another fixed-dose combo we are developing is with, together with our elecoglipron. If you have high elevated cholesterol, typically you also need to lose a bit of weight. This is a good example of how we can differentiate our PCSK9, but also differentiate our elecoglipron by providing convenient formulations to patients who are typically polymedicated in these circumstances. Next question is, I think Richard. Yes, Richard Vosser at JPMorgan. Over to you, Richard.

Speaker #2: Because if you have highly elevated cholesterol, typically you also need to lose a bit of weight. This is a good example of how we can differentiate our PCSK9, but also differentiate our Glipron by providing convenient formulations to patients, who are typically polymedicated in these circumstances.

Speaker #2: So the next question is, I think, Richard. Yes, Richard Vosser at JPM. Over to you, Richard.

Speaker #3: Thanks, Pascal. One question, please. On Camizestrant, just now we've seen the Persevera data in detail at ASCO. I don't think when we last spoke we'd seen it.

Richard Vosser: Thanks, Pascal. One question, please, on camizestrant. Just now we've seen the PERSEVERE data in detail ASCO. I don't think when we last spoke we'd seen it. Could you give us your latest thoughts around how SERENA-4 could differ in terms of patients enrolled and how that impacts your thinking around potential benefit of cami, what it could deliver in the trial? Does the data you've seen change your view of the importance of endocrine sensitivity for generating a benefit, and how endocrine sensitive do you think you have in the trial? Thanks very much.

Speaker #3: Could you give us your latest thoughts on how Serena IV could differ in terms of patients enrolled, and how that impacts your thinking around the potential benefit of Cami and what it could deliver in the trial?

Speaker #3: And does the data you've seen change your view of the importance of endocrine sensitivity for generating a benefit? And how endocrine sensitive do you think you have in the trial?

Speaker #3: Thanks very much.

Speaker #2: Susan?

Pascal Soriot: Susan, do you want to take that?

Speaker #5: Take that. Yeah. Okay, thanks. So, thanks for the question. As you said, the goal for SERENA-4 is to enrich for endocrine sensitivity. Again, as a reminder, we have a larger sample size.

Susan Galbraith: I can take that. Yeah. Okay, thanks. Thanks for the question. As you said, the goal for SERENA-4 is to enrich for endocrine sensitivity. Again, as a reminder, we have a larger sample size, 1,370 patients enrolled compared to PERSEVERE. I think what you've seen with the PERSEVERE data is evidence of activity which varies across the different subgroups there. I can't comment on the exact subgroups today. Obviously, we're anticipating the trial readout in the second half of this year, and obviously we have to wait for that readout to really see. Again, we have striven to enrich for that endocrine sensitive population with the design of those subgroups. Again, I think what we're happy with the SERENA-6 data is the overall tolerability profile that we've seen with camizestrant.

Speaker #5: 1,370 patients enrolled compared to Persevera. And I think what you've seen with the Persevera data is evidence of activity, which varies across the different subgroups there.

Speaker #5: I can't comment on the exact subgroups today. Obviously, we're anticipating the trial readout in the second half of this year, and we have to wait for that readout.

Speaker #5: To really see. But again, we have striven to enrich for that endocrine sensitive population. With the design of those subgroups. And again, I think what we're happy with with the Serena VI data is the overall tolerability profile that we've seen with Camicistrant, low rates of GI side effects that are seen and a very low discontinuation rate with good tolerability overall in that trial.

Susan Galbraith: Low rates of GI side effects that are seen and a very low discontinuation rate with good tolerability overall in that trial. I think we have to wait and see at this point. That's why we run phase III trials, and we're very happy to share the data with you as soon as we have them.

Speaker #5: So I think we have to wait and see at this point. That's why we run Phase 3 trials, and we're very happy to share the data with you as soon as we have them.

Speaker #2: Thanks, Susan. Next question is from Simon Baker at Redburn. Simon, over to you.

Pascal Soriot: Thanks, Susan. Next question is from Simon Baker at Redburn. Simon, over to you.

Speaker #3: Thank you, Pascal. If I may, on some...

Simon Baker: Thank you, Pascal. One, if I may, on sumberzinib. The profile based on the data we've seen so far looks very impressive indeed against the competition, just wanted to get your perspectives on how you see the profile of sumberzinib in that setting. Also, the significance or otherwise of the far loop versus near loop mutation performance. It appears to be particularly differentiated on far loop. Is that a significant factor or is that less important than it perhaps it might seem? Thanks so much.

Speaker #4: Vasertinib? The profile, based on the data we've seen so far, looks very impressive indeed against the competition. But I just wanted to get your perspectives on how you see the profile of vasertinib in that setting.

Speaker #4: And also, the significance or otherwise of the far loop versus near loop mutation performance. It appears to be particularly differentiated on far loop. Is that a significant factor, or is that less important than perhaps it might seem?

Speaker #4: Thanks so much.

Speaker #5: Okay. So, you're talking about Pascal. Do you want me to take this one?

Susan Galbraith: Okay, you're talking about Zegfrovy. Pascal, do you want me to take this one?

Speaker #2: Yes, please. Yes, if you don't mind, please go ahead.

Pascal Soriot: Yes, please. Yes, if you don't mind, please go ahead.

Speaker #5: Okay. So Zegprovi is obviously the asset that we've licensed from DSAL for exon 20 mutations, but it also has activity in a group of mutations that are non-classical as well, which is about a similar size patient population.

Susan Galbraith: Okay. Zegfrovy is obviously the asset that we've licensed from Dizal for exon 20 mutations, but also has activity in a group of mutations that are non-classical as well, which is about a similar size patient population. I think what the profile is that we see overall, first of all, it's potent against the exon 20. It's delivering this high and durable response rate there. And really has differentiated activity in that second-line setting, which has already provided the label that we've got in the US and China. In the first-line setting, the data were presented at ASCO. There was an oral presentation at ASCO, if people want to have a look at that, and that will form the basis of the filing in the first-line setting.

Speaker #5: So, I think what the profile is that we see overall, first of all, it's potent against the exon 20. It's delivering this high and durable response rate there.

Speaker #5: And really, it has differentiated activity in that second-line setting, which has already provided the label that we've got in the US and China.

Speaker #5: In the first-line setting, the data were presented at ASCO. So, there was a normal presentation at ASCO, if people want to have a look at that.

Speaker #5: And that will form the basis of the filing in that first-line setting. So we've looked forward to having discussions with the regulatory authorities, given the high response rate that we've seen and the really good progression-free survival, which was obviously the primary endpoint in that randomized trial.

Susan Galbraith: We look forward to having discussions with the regulatory authorities, given the high response rate that we've seen and the really good progression-free survival, which was obviously the primary endpoint in that randomized trial. Yeah, I think if you look at that compared with the other competitors in this space, it's oral, easy to administer at home. The tolerability profile, I think is competitive with other agents, and the potency is also competitive. Again, we're excited to have this as another agent to build on our legacy in EGFR mutant lung cancer.

Speaker #5: So yeah, I think if you look at that compared with the other competitors in this space, it's oral, easy to administer at home. The tolerability profile, I think, is competitive with other agents, and the potency is also competitive.

Speaker #5: So again, we're excited to have this as another agent to build on our legacy in EGFR mutant lung cancer.

Speaker #2: Thanks, Susan. It may be good to hear also from Dave, telling you about what we're trying to do to solidify the Tagrisso franchise, because we are under, of course, two major competitive threats.

Pascal Soriot: Susan, it may be good to hear also from Dave telling you about what we're trying to do to solidify the TAGRISSO franchise, because we are under, of course, two major competitive threats. One in China, which is the multiplicity of EGFR in the market, and very competitive market. We're doing well, but it's competitive. The second is, of course, the Marqibrosar regimen, which again, we are still doing well. As Dave mentioned before, market share is still very strong for TAGRISSO. Beyond that, we are actually trying to build a variety of ways to differentiate TAGRISSO. Maybe, Dave, if you can give us the whole picture again, that would be useful.

Speaker #2: One in China, which is the multiplicity of EGFR in the market, and a very competitive market. We're doing well, but it's competitive. And the second is, of course, the Mariposa regimen, which again, we are still doing well.

Speaker #2: As Dave mentioned before, market share is still very strong for Tagrisso. But beyond that, we are actually trying to build a variety of ways to differentiate Tagrisso.

Speaker #2: So maybe, Dave, if you can give us the whole picture again, that would be useful.

Speaker #3: That'd be my pleasure. And let me use this as just an opportunity also to comment that the strength of FLORA II is really laying the foundation right now for the expansion of the clinical development plan, to build off of the combination approach to a Tagrisso backbone, in order to improve outcomes in EGFR-mutated lung cancer.

David Fredrickson: It'd be my pleasure. Let me use this as just an opportunity also to comment that the strength of FLAURA2 is really laying the foundation right now for the expansion of the clinical development plan to build off of the combination approach to a TAGRISSO backbone, in order to improve outcomes in EGFR mutated lung cancer. As Susan quite nicely articulates, Zegfrovy adds to the group of patients that we now have an opportunity to be able to engage physicians about and offer a new therapy. I think just very importantly, we're seeing double-digit volume growth, and in fact, double-digit revenue growth in the US in the face of the competition with TAGRISSO right now. What that's allowing us also then to do is get ready for both the DATROWAY and the ORPATHYS combinations, which we're looking forward to.

Speaker #3: And as Susan quite nicely articulates, Zegprovi adds to the group of patients that we now have an opportunity to be able to engage physicians about and offer a new therapy.

Speaker #3: I think, just very, very importantly, we're seeing double-digit volume growth—and, in fact, double-digit revenue growth—in the US, in the face of the competition with Tagrisso right now.

Speaker #3: What that's allowing us also, then, to do is get ready for both the Dato and the Orpathys combinations, which we're looking forward to. I think that with Dato, obviously, we've got TROPION-Lung15 in the later lines and also TROPION-Lung14 in the frontline setting.

David Fredrickson: I think that with DATROWAY, obviously, we've got TROPION-Lung15 in the later lines and also TROPION-Lung14 in the frontline setting. I think relative to what we see with the other Trop2 class players, this is a very differentiated position of having the TAGRISSO combination as a way of bringing this set of therapies into these settings. We've got SAFFRON on the horizon, and that's with the ORPATHYS combination. We are very enthusiastic about TAGRISSO continuing to be an important driver of growth and contributing meaningfully to the 2030 ambition that we've laid out.

Speaker #3: I think, relative to what we see with the other Trope II class players, this is a very differentiated position—having the Tagrisso combination as a way of bringing this set of therapies into these settings.

Speaker #3: We've got Saffron on the horizon, and that's with the Orpathis combination. We are very enthusiastic about Tagrisso continuing to be an important driver of growth and contributing meaningfully to the 2030 ambition that we've laid out.

Speaker #2: Thank you, Dave. This is a very good example of what we’ve told you before—the ability we have to combine products throughout our portfolio.

Pascal Soriot: Thank you, Dave. This is a very good example of what we've told you before. The ability we have to combine products through our portfolio to defend our various franchises and build beyond where we are. With the addition of Zegfrovy, we are also addressing a gap in our coverage of this EGFR market. You can see we are really reducing the space where the competition could actually have an impact over time. The next question will be from Sarita Kapila at Morgan Stanley. Sarita, over to you.

Speaker #2: To defend our various franchises and build beyond where we are. And then we see the addition of Zegprovi. We are also addressing a gap in our coverage of this EGFR market.

Speaker #2: So you can see we are really reducing the space where the competition could actually have an impact over time. So, the next question will be from Sarita Kapila at Morgan Stanley.

Speaker #2: Sarita, over to you.

Speaker #6: Thanks, Pascal, for taking my questions. On Avanza, we notice it has the PFS and OS endpoints in both Trop II-positive and ITT populations.

Sarita Kapila: Thanks, Pascal, for taking my question. On AVANZAR, we notice it has the PFS and OS endpoints in both Trop2 positive and ITT populations. Could you give us any more color on the testing hierarchy? For example, are you looking at PFS and then OS in Trop2 followed by PFS and OS and ITT? What is the minimum outcome that would be filing enabling? For example, would a PFS win in Trop2 positive patients be sufficient without a clear OS benefit? This is just a quick one, taking a step back, how should we think about DATROWAY profile versus sacituzumab, particularly post the positive OptiTROP-Lung06 data and ahead of the PD-L1 on their dress data, in 2027? Thank you.

Speaker #6: Could you give us any more color on the testing hierarchy? So, for example, are you looking at PFS and then OS in TropII, followed by PFS and OS in ITT?

Speaker #6: And what is the minimum outcome that would be filing-enabling? So, for example, would a PFS win in Trop II-positive patients be sufficient without a clear OS benefit?

Speaker #6: And this is just a quick one. Taking a step back, how should we think about Datuate's profile versus SAT TMT, particularly post the positive Optitrop Lung-06 data?

Speaker #6: And ahead of the PD-L1 bedrest data in 2027. Thank you.

Speaker #2: Thanks, Sarita. Those are good questions. Two good questions for you, Susan.

Pascal Soriot: Thanks, Sarita. They're good questions. Two good questions for you, Susan.

Speaker #5: Okay, thanks. Pascal, thanks for the question. So, as a reminder, what we previously said about Avanza is that we have both the ITT and the biomarker-positive patient populations at the top of the multiple-testing procedure.

Susan Galbraith: Okay. Thanks, Pascal. Thanks for the question. As a reminder, what we previously said about AVANZAR is that we have both the ITT and the biomarker positive patient populations at the top of the multiple testing procedure. It is possible to get a positive study with success in either the ITT or in the biomarker positive group. I hope that answers your first question. Obviously, regulators will be interested in the effect size, the meaningfulness, and the differentiation between those groups in discussions. In terms of differentiation from the competitors, I think we have a best-in-class Trop2-based ADC based on the design, which is based on the stable linker.

Speaker #5: So it is possible to get a positive study with success in either the ITT or in the biomarker-positive group. So I hope that answers your first question.

Speaker #5: Obviously, regulators will be interested in the effect size and the meaningfulness of the differentiation between those groups in discussions. In terms of differentiation from the competitors, I think we have a best-in-class Trop II-based ADC, based on the design, which uses a stable linker.

Speaker #5: And you can see that based on the half-life of the molecule and also the lower rate of bone marrow toxicity, because you see higher rates of bone marrow toxicity with ADCs that have less stable linkers and so more exposure to the free payload.

Susan Galbraith: You can see that based on the half-life of the molecule and also the lower rate of bone marrow toxicity, because you see higher rates of bone marrow toxicity with ADCs that have less stable linkers and so more exposure to the free payload. That, I think, underpins the data that we've seen in the triple-negative breast cancer, where we saw differentiated activity with high response rate, progression-free survival, and leading to overall survival in that first-line triple-negative breast cancer. That underpins our confidence in the design of this ADC. I do think that the data that's been seen from the OptiTROP trials in lung cancer underpin the potential for Trop2-based ADCs in this first-line setting in combination with IO.

Speaker #5: That, I think, underpins the data that we've seen in triple-negative breast cancer, where we saw differentiated activity with higher response rate, progression-free survival, and leading to overall survival in that first-line triple-negative breast cancer.

Speaker #5: So that underpins our confidence in the design of this ADC. I do think that the data that's been seen from the Optitrop trials in lung cancer underpin the potential for Trop II-based ADCs in this first-line setting, in combination with IO.

Speaker #5: But I think, given the design that we have of the molecule and the design that we have of the AVANZA study, with that ability to look in the ITT and the biomarker, we have the ability to be first into first-line and to be best based on those combinations and that differentiation.

Susan Galbraith: I think given the design that we have of the molecule and the design that we have of the AVANZAR study, with that ability to look in the ITT and the biomarker, we have the ability to be first into first-line and to be best based on those combinations and that differentiation. We look forward to seeing the results. Again, I should just caveat, as we do with all of our phase III, whilst we're confident in the hypothesis that we've got, we obviously have to wait for the phase III trials. Nobody is keener than I am to see the data. As soon as we've got it, we'll share it with you.

Speaker #5: So we look forward to seeing the results. And again, I should just caveat, as we do with all of our phase threes: whilst we're confident in the hypothesis that we've got, we obviously have to wait for the phase three trials.

Speaker #5: And nobody is keener than I am to see the data, and as soon as we've got it, we'll share it with you.

Speaker #2: Thank you, Susan. Next question is from Gonzalo Artiash at Danske. Over to you, Gonzalo.

Pascal Soriot: Thank you, Susan. Next question is from Gonzalo Artigas at Danske. Over to you, Gonzalo.

Speaker #4: Hi, and thank you for taking my question. Gonzalo Artiash from Danske Bank. I have one for Sharon and one for Mark. For Sharon, on clear amitug, your TPR depleter, I know the phase 3 study with clear amitug monotherapy keeps moving as planned.

Gonzalo Artigas: Hi, thank you for taking my questions. Gonzalo Artigas from Danske Bank. I have one for Sharon and one for Marc. For Sharon, on eplontersen, your TTR depleter. I know the phase III study with eplontersen monotherapy keeps moving as planned. Could you give us some color on how you are seeing this drug moving forward in case the phase III hits the line? Is it something that you could put out as monotherapy or the ideal case would be to give it in combination with now, for example, AMVUTTRA, given the failed CARDIO-TTRansform study? I'm just trying to figure out what you are thinking on this molecule from today. A second question on Strensiq for Marc. You guys are confident on these $3 to 5 billion peak sales for asfotase alfa based on the results presented so far.

Speaker #4: But could you give us some color on how you are seeing this drug moving forward in case the phase three hits the line? Is it something that you could put out as monotherapy, or is the ideal case to give it in combination with, for example, Ambutra, given the failed CardioTransform study?

Speaker #4: I'm just trying to figure out what you are thinking on this molecule from today. And a second question on Strensic for Mark: You guys are confident on these three to five billion pixels for its synthetic alpha based on the results presented so far.

Speaker #4: But I was wondering if you could give us some color on the dynamics across commercial regions expected between Strensic and synthetic alpha. How should we expect those to play out in the market?

Gonzalo Artigas: I was wondering if you could give us some color on the dynamics across commercial regions expected between Strensiq and asfotase alfa. How should we expect those to play out in the market? Thank you so much.

Speaker #4: Thank you so much.

Speaker #2: Thanks, Gonzalo. It's probably two questions for Mark, actually, because clear amitug is developed by Alexion. Over to you, Mark.

Pascal Soriot: Thanks, Gonzalo. It's probably two questions for Marc, actually, because eplontersen is developed by Alexion. Over to you, Marc.

Speaker #3: Gonzalo, thank you for the two questions. So let me take the first one. So to your question on the add-on design, so clear amitug is the trial we are doing on clear amitug is as an add-on to either stabilizer FMED, so ACORAMIDIS, and silencers.

Marc Dunoyer: Thank you for the two questions. Let me take the first one. To your question on the add-on design. The trial we are doing on eplontersen is as an add-on to either stabilizer, tafamidis or acoramidis, and silencers. The trial is not done as a monotherapy. What is very important to understand is the difference of mechanism, as the class indicates, the eplontersen is a depleter and therefore depletes the amyloid burden in the tissues, the amyloid plaque in the tissues. This has been confirmed during our phase I-B studies over one year for eplontersen. We have also read across from another product, another depleter that we are developing in another disease for the light chain amyloidosis, and the product is called anselamimab.

Speaker #3: So the trial is not done as a monotherapy. What is very important to understand is the difference of mechanism. As the class indicates, the clear amitug is a depleter and therefore depletes the amyloid burden in the tissues, in the amyloid plaque in the tissues.

Speaker #3: This has been confirmed during our phase one B studies over one year for clear amitug. We have also read across from another product that another depleter that we are developing in another disease called the glycine amylodosis and the product is called enzyme amimab.

Speaker #3: We have seen with this product a very clear outcome benefit, both on mortality as well as cardiovascular events, following cardiac remodeling, as well as improvements in many, many cardiac functions.

Marc Dunoyer: We have seen on this product a very clear outcome benefit both on mortality as well as cardiovascular event following cardiac remodeling, as well as improvements of many, many cardiac functions. It's not the same disease exactly, but we have a reasonably good read across of the depleter mechanism in the treatment of amyloidosis. For eplontersen, we are expecting the results in the future, and we look forward to demonstrating again the same benefit or improvement of cardiac remodeling improvement and outcome benefit in both all-cause mortality and cardiovascular hospitalization. We look forward to these results. To the second question on Strensiq. Strensiq today has been on the market since 2015. We do not have a very wide coverage, and I think this is what efzimfotase alfa is going to bring us. It's going to have a much wider coverage in terms of countries.

Speaker #3: So it's not the same disease exactly, but we have a reasonably good read-across of the depleter mechanism in the treatment of amyloidosis. So for clear amitug, we are expecting the results in the future, and we look forward to demonstrating again the same benefit or improvement of cardiac remodeling improvements.

Speaker #3: And outcome benefit in both mortality and cardiovascular hospitalization. And we look forward to these results. To the second question on Strensic: So Strensic today has been on the market since 2015.

Speaker #3: We do not have very wide coverage. And I think this is what a synthetic is going to bring us. It's going to have much wider coverage in terms of countries.

Speaker #3: Possibly we would have a wider label than Strensic, but this remains to be discussed with regulatory authorities. What the big difference between those two products is the greater tolerability of the synthetic, which, I remind you, is administered every two weeks instead of being administered either daily or every other day for Strensic.

Marc Dunoyer: Possibly we would have a wider label than Strensiq, this remains to be discussed with regulatory authorities. What the big difference between those two products is the greater tolerability of efzimfotase alfa, which is, I remind you, administered every 2 weeks instead of administered either daily or every other day for Strensiq. There are big difference for the patient's utilization. In terms of tolerability, just to give you some numbers, patients who are on efzimfotase alfa basically have 5 days of injection site reaction on average in a given year. This is many times lower than what is experienced with Strensiq. We also know that the retention of Strensiq is often impacted by this issue of tolerability.

Speaker #3: So, there are big differences in the patients' utilization. And in terms of tolerability, just to give you some numbers, patients who are on a synthetic alpha basically have five days of injection site reaction on average in a given year.

Speaker #3: And this is many times lower—many times lower—than what is experienced with Strensic. We also know that the retention of Strensic is often impacted by this issue of tolerability.

Speaker #3: So, that's why we remain confident that a synthetic will grow in terms of the number of countries, the breadth of patients, and also in the retention of patients once they are on therapy.

Marc Dunoyer: That's why we remain confident that efzimfotase alfa will grow in terms of number of countries, in the breadth of patients, and also in the retention of patients once they're on therapy.

Speaker #2: Thank you, Mark. And maybe going back to clear amitug, Gonzalo, you see from Mark's response that clear amitug can be used as a monotherapy, but it can also be used on top of Vitrucian, and it can be used on top of stabilizers.

Pascal Soriot: Thank you, Marc. Maybe going back to eplontersen, Gonzalo, you see from Marc's response that eplontersen can be used as monotherapy, it can be used on top of Stabilizers. We'll have to show that it adds something, that's potentially a broad use for this agent. Next question is Sachin Jain at Bank of America.

Speaker #2: Of course, we'll have to show that it adds something, but that's potentially a broad use for this agent. Next question is Sachijen at Bank of America.

Speaker #5: Hi there. Thanks for my questions. One financial and one pipe. So financial, can you talk about balancing the investment in pipe and launches that are at the top two versus delivering margin expansion?

Sachin Jain: Hi there. Thanks. My question is one financial and one pipe. Financial, can you talk about balancing the investment in pipe and launches that Aradhana talked to versus delivering margin expansion? As we think about H2 2026 and 2027 cost growth

Speaker #5: So, as we think about second half '26 and '27 cost growth, is the 1H and DHNA cost growth of 6% a good proxy? Or should we think about acceleration into the second half of this year and into next year?

Sachin Jain: Is the H1 R&D SG&A cost versus 6% a good proxy, or should we think about acceleration into H2 of this year and into next year? Quick hits on one oncomab, one biopharma and 2027 pipe. CAMBRIA-1, the switch study due next year. Perhaps, Susan, you could just talk to how you think about the probability of success in that study relative to 3 and 4, and where it sits on the endocrine sensitivity continuum. One for Ruud. Farxiga lifecycle management. Just a simple question. You've got substantial peak sales of almost $10 billion across the various fixed-dose combos. Consensus basically has nothing. Where do you think our consensus is missing on these assets? Thank you.

Speaker #5: And then quick hits on Oncom, One Biopharma, and 27PIPE. So, Cambria one, the SWITCH study due next year—perhaps, Susan, you could just talk to how you think about the probability of success in that study.

Speaker #5: Relative to three and four, and where it sits on the endocrine sensitivity continuum. And then one for Rued Farasiga, lifecycle management—just a simple question.

Speaker #5: You've got substantial peak sales of almost $10 billion across the various fixed-dose combos. Consensus basically has nothing. Where do you think consensus is missing on these assets?

Speaker #5: Thank you.

Speaker #2: Oh, it's great. Sachin, thank you. You are very ambitious with many questions, but we like ambition. So maybe I could now cover the first one.

Pascal Soriot: That's great. Sachin, thank you. You are very ambitious with many questions, but we like ambition. Maybe Ana could cover the first one, then Susan, and then Ruud. Is that okay, Ana, will you start?

Speaker #2: Then Susan, and then Rude. Is that okay? Now, would you start?

Speaker #6: Great. Thank you, Sachin. So for 2026, we've given, obviously, our revenue and EPS, and we give, I think, enough detail on other line items, as you've seen—whether it's on R&D or some of the other moving parts on gross margin and other income.

Aradhana Sarin: Great. Thank you, Sachin. For 2026, we've given, obviously, our revenue and EPS, and we give, I think, enough detail on other line items as you've seen, whether it's on R&D or some of the other moving parts on gross margin and other income, et cetera. I think for 2027, we will obviously give guidance for 2027 at the beginning of 2027. We will start our annual budgeting process later this year. We start that in a few months. As you know, there's a lot more readouts still to come and investments still to make, whether it's on tozo or we'll see how some of the other events read out. All of that is going to be part of our planning, and we base our guidance for 2027 or any year, we base our guidance on our budget and on our planning process.

Speaker #6: Et cetera. So, I think for 2027, we will obviously give guidance for 2027 at the beginning of 2027. We will start our sort of annual budgeting process later this year.

Speaker #6: So we start that in a few months. And as you know, there's a lot more readout still to come, and investment still to make, whether it's on Tozo or we'll see how some of the other events read out.

Speaker #6: So all of that is going to be part of our planning. And we base our guidance for 2027, or any year, on our budget and on our planning process.

Speaker #6: So, we'll give more detail on that when we do that early next year. Susan?

Aradhana Sarin: We'll give more view on that when we do that early next year.

Pascal Soriot: Susan?

Speaker #4: Okay, thank you. So, thanks for the question about Cambria One. Just as a reminder, Cambria One is an extended adjuvant trial in patients with intermediate- to high-risk hormone receptor-positive and HER2-negative breast cancer.

Susan Galbraith: Okay. Thank you. Thanks for the question about CAMBRIA-1. Just as a reminder, CAMBRIA-1 is an extended adjuvant trial in patients with intermediate to high risk hormone receptor-positive and HER2-negative breast cancer. It's already been well established that extension of duration of endocrine therapy in this adjuvant setting improves outcomes. By taking patients who've completed 2 to 5 years of adjuvant endocrine therapy with or without a CDK4/6 inhibitor, which is this switch design, and randomizing them to continuation of AI or tamoxifen or to camizestrant, we're actually taking what is an endocrine-sensitive patient population. The patients that have got higher risk factors will likely have progressed through that initial period of adjuvant treatment. By focusing on the intermediate or high risk, we're taking out those patients with low-risk disease who are likely already cured with current standard of care.

Speaker #4: So, it's already been well established that extension of the duration of endocrine therapy in this adjuvant setting improves outcomes. By taking patients who've completed two to five years of adjuvant endocrine therapy, with or without a CDK4/6 inhibitor—which is this switch design—and randomizing them to continuation of AI or tamoxifen, or to camizestrant, we're actually taking what is an endocrine-sensitive patient population.

Speaker #4: The patients that have got higher-risk risk factors will likely have progressed through that initial period of adjuvant treatment. And by focusing on the intermediate or high risk, we're taking out those patients with low-risk disease who are likely already cured with current standard of care.

Speaker #4: So, I think it does select for an endocrine-sensitive patient population, in a setting where endocrine intensification has already been proven with other trials.

Susan Galbraith: I think it does select for an endocrine-sensitive patient population in a setting where endocrine intensification has already been proven with other trials. I think from that perspective, and given the profile that we've seen with camizestrant to the tolerability and efficacy within the SERENA-6 study, I think it has a good probability of success together with the data that we've seen from a competitor in the adjuvant setting.

Speaker #4: So, I think from that perspective, and given the profile that we've seen with camizestrant, the tolerability and efficacy within the SERENA-6 study, I think it has a good probability of success, together with the data that we've seen from a competitor in the adjuvant setting.

Speaker #1: Okay, thanks, Susan. So let me quickly address the question from Sachin regarding the combinations. We currently have three combinations in development. All those combinations are addressing patient populations where there's a high risk and where there is almost no current treatment.

Ruud Dobber: Okay. Thanks, Susan. Let me quickly address the question of Sachin regarding the combinations. We have currently three combinations in development. All those combinations are addressing patient populations where there's a high risk and where there's almost no current treatment. If I take Zebo/Dapa as one example, it's in phase III. It has recruited very fast, clearly showing the high medical needs in proteinuric CKD. Those patients are very ill, their kidney function is declining, and we know the beneficial effects of dapagliflozin, and on top of that, we hope to see a beneficial effect of an endothelin receptor antagonist. The other one is Delzy/Dapa in heart failure patients with a low eGFR, where mortality is very high, normally twice as you see normally in a heart failure patient. There's no data available. Again, it's a highly risky patient population.

Speaker #1: So if I take Zebodapa as one example, it's in Phase III. It has recruited very fast, clearly showing the medical need in proteinuric CKD.

Speaker #1: Those patients are very ill. The kidney function is declining. And we know the beneficial effects of dapagliflozin, and on top of that, we hope to see a beneficial effect of an endothelin receptor antagonist.

Speaker #1: The other one is Belcidapa in heart failure patients with a low eGFR, where mortality is very high—normally twice what you see in a typical heart failure patient.

Speaker #1: And there's no data available. So again, it's a highly, highly risky patient population. The estimates of the epi data have shown that more than 12 million patients in the top eight markets are eligible for a treatment like this.

Ruud Dobber: The estimates of the epi data has shown that more than 12 million patients in the top eight markets are eligible for a treatment like this. It clearly shows the potential if the study is reading out. Both of those fix-dose combinations, we are expecting to see data in H1 2027. Last but not least, baxdrostat and the combination with dapagliflozin. That is in a high-risk population in chronic kidney disease and hypertension. We know that hypertension is a very important risk factor for the development of chronic kidney disease, and we hope to see a slow down of the progression of kidney disease. Again, a high-risk patient, and I think not everyone is, let's say, addressing and seeing the potential of those new combinations. Those are really new molecular entities if they are successful.

Speaker #1: So it clearly shows the potential if the study is reading out. Both of those fixed-dose combinations—we're expecting to see data in the first half of 2027.

Speaker #1: And then, last but not least, Bexastat and the combination with dapagliflozin. Also, that is in a high-risk population with chronic kidney disease and hypertension.

Speaker #1: We know that hypertension is a very important risk factor for the development of chronic kidney disease, and we hope to see a slowdown of the progression of kidney disease.

Speaker #1: So again, a high-risk patient. And I think not everyone is, let's say, addressing and seeing the potential of those new combinations. Those are really new molecular entities, if they are successful.

Speaker #1: So I think, building on the massive experience we are having with dapagliflozin—60 million patients are currently treated with dapagliflozin—I think it's the backbone of heart failure and chronic kidney disease patients.

Ruud Dobber: I think building on the massive experience we are having with dapagliflozin, 60 million patients are currently treated with dapagliflozin. I think it's the backbone of heart failure and chronic kidney disease patients, and adding those new mechanisms hopefully will lead to a much more beneficial effect, both from a mortality perspective, but also from a kidney disease progression perspective.

Speaker #1: And adding those new mechanisms, hopefully, will lead to a much more beneficial effect both from a mortality perspective, but also from a kidney disease progression perspective.

Speaker #2: Thank you. Sorry, I had not realized we had many more questions in the line. So if we can stick to one question per person, it would be great.

Pascal Soriot: Sure. I had not realized we had many more questions in the line, if we can stick to one question per person, it would be great. Graham Parry at Citi. Over to you, Graham. Graham, are you on mute maybe?

Speaker #2: Graham Parry at Citi Overture. Graham? Graham, are you on mute maybe?

Speaker #5: Yeah, thanks for taking the question. So I had one on efusivitase alfa. So, you said you're filing for a broad label. Can you confirm that does include adults?

Graham Parry: Yeah. Thanks for taking the question. I had one on efzimfotase alfa. You said you're filing for a broad label. Can you confirm that does include adults? Was that based on any discussion with regulators to date, the acceptability of the HICKORY trial, and the trend benefit in the pediatric-onset adult population? Does the $3 to 5 billion sales outlook include the adult population, or is that just in pediatrics? Thank you.

Speaker #5: And was that based on any discussion with regulators to date as to the acceptability of the Hickory trial and the trend benefit in the pediatric and adult population?

Speaker #5: And does the three to five billion cells outlook include the adult population, or is that just in pediatrics? Thank you.

Speaker #2: Mark.

Pascal Soriot: Marc?

Marc Dunoyer: Thank you very much for the question. The broad population, the filings will be above 2 years of age for a broad population, as I said in my prepared remarks. This has been done in discussion with regulatory authorities. Obviously, they will need to look at the detail of the studies that we have completed and submitted. To your second question on the adult population, the adult population is segmented into 2 parts, adult with pediatric onset, which is in several countries already obtained with Strensiq, and adult with adult onset, where Strensiq is not approved today. Your second question on the $3 to 5 billion, even if we get less than the totality of the label that we have filed for, we expect to be within the range of $3 to 5 billion.

Speaker #1: Yeah, thank you very much for the question. So the broad population—so the filings will be above two years of age for a broad population.

Speaker #1: As I said in my prepared remarks, this has been with regulatory authorities. But obviously, they will need to look at the detail of the three studies.

Speaker #1: But we have completed and submitted. To your second question—so, the adult population is segmented into two parts: adults with pediatric onset, which is in several countries already obtained.

Speaker #1: With transient, an adult with adult-onset, where transient is not approved today. Your second question on the $3 to $5 billion: even if we get less than the totality of the label that we have filed for, we expect to be within the range of $3 to $5 billion.

Speaker #2: Thank you, Mark. Next is James Gordon from Barclays. James, maybe unmute, please.

Pascal Soriot: Thank you, Marc. Next is James Gordon, Barclays. James? You may be on mute, James.

Speaker #5: Can you hear me?

James Gordon: Can you hear me?

Speaker #2: Yep.

Pascal Soriot: Yep.

Speaker #5: Great, thanks for taking the question. Pascal called out Saruparib, so the selective PARP in prostate cancer, where we're getting data next year. I think this has been described as a $5 billion-plus product.

James Gordon: Great. Thanks for taking the question. Pascal called out saruparib, the selective PARP in prostate cancer where we're getting data next year, and this has been described as a $5 billion-plus product. There was some excitement about the asset a few years ago, it wasn't partnered with Merck, and maybe there was a thinking that Lynparza is a pretty high bar to beat. How big could it be if it works next year? Is the $5 billion, a lot of that is de-risked by the data next year, or does that need a lot of other trials to work? How excited are you about that readout? If I could just squeeze in a quick clarification. Other operating income or OOI.

Speaker #5: There was some excitement about the asset a few years ago, but then it wasn't partnered with Merck. And maybe there's a thinking that Lynparza is a pretty high bar to beat.

Speaker #5: So, how big could it be if it works next year? Is the $5 billion a lot of that's de-risked by the data next year?

Speaker #5: Or does that need a lot of other trials to work? And how excited are you about that readout? And then, if I could just squeeze in a quick clarification.

Speaker #5: So, other operating income, or OOI—so, the updated 2026 guidance implies higher OOI and higher OPEX. And then you’re reiterating the guide because you’re reinvesting the higher OOI.

James Gordon: The updated 2026 guidance implies higher OOI and higher OpEx, then you're reiterating the guide because you're reinvesting the higher OOI. How much of this year's OOI is ongoing versus one-off? Is that going to create a headwind next year when you don't have the OOI, or is most of this year's going to repeat again next year from an ongoing source?

Speaker #5: But how much of this year's OOI is ongoing versus one-off? So, is that going to create a headwind next year when you don't have the OOI?

Speaker #5: Or is most of this year's going to repeat again next year? It's from an ongoing source.

Speaker #2: Thank you, James. Suzanne, do you want to cover the SO Unpaired question? I mentioned it, James, just as an example. There are many projects in our pipeline that nobody talks about. We seem to be facing almost an obsessive focus on two readouts that are important, of course.

Pascal Soriot: Thank you, James. Susan, do you want to cover the saruparib question? I mentioned it, James, just as an example of many projects in our pipeline that nobody talks about. We seem to be facing almost an obsession for Crucem to readouts that are important, of course. I don't want to underestimate them. I just wanted to highlight the fact that we have many more projects, and what we showed you today are only the most important ones, and saruparib is certainly one of the most important ones as well. Susan, over to you.

Speaker #2: I don't want to underestimate them, but I just wanted to highlight the fact that we have many, many more projects, and what we showed you today are only the most important ones.

Speaker #2: And Saruparib is certainly one of the most important ones as well. Suzanne, over to you.

Speaker #4: Thank you. So, as you'll have seen from the clinical trials appendix, there's a significant effort that we've got with saruparib in prostate cancer. One of the key trials is the EVA-PAR Prostate 01, which is in metastatic hormone-sensitive prostate cancer, including both the HRR-mutant and non-HRR-mutant cohorts.

Susan Galbraith: Thank you. As you'd have seen from the clinical trials appendix, there's a significant effort that we've got with saruparib in prostate cancer. One of the key trials is the IVAPAR prostate 01, which is in metastatic hormone-sensitive prostate cancer, including both the HRM and non-HRM cohorts. We already have seen from the PROPEL study in a later line that we do have activity for PARP inhibition in combination with androgen receptor inhibitors. What we've done is taken the learnings from the PROPEL study and moved this into an earlier line setting and powered a study for both our HRM and non-HRM. Of course, having seen the data for the talazoparib and elacridar datasets coming out, I think there's significant opportunity in this setting to improve the tolerability profile, increase the potency of inhibition on PARP, and see benefits in both those subgroups.

Speaker #4: So we have already seen from the PROPEL study, in a later line, that we do have activity for PARP inhibition in combination with androgen receptor inhibitors.

Speaker #4: And what we've done is taken the learnings from the PROPEL study and moved this into an earlier line setting, and powered the study for both that HR-OM and non-HR-OM.

Speaker #4: And of course, having seen the data from the Talisoprib and Zolismide datasets coming out, I think there's significant opportunity in this setting to improve the tolerability profile, increase the potency of inhibition on PARP, and see benefits in both those subgroups.

Speaker #4: You will recall that we did see a positive effect on PFS in the non-HRM in the PROPEL data set. But there was a lot of discussion at the time of the ODAC.

Susan Galbraith: You will recall that we did see a positive effect on PFS in the non-HRM in the PROPEL dataset. There was a lot of discussion at the time of the ODAC. We've addressed those concerns with the design of this study, and I think that's a significant opportunity. It's also backed up by other studies in other segments in prostate cancer and also in the IVAPAR breast opportunity as well. When you look at the totality of the saruparib opportunity, it is significant and definitely in the $5 billion range, and we're excited to see these data read out.

Speaker #4: We've addressed those concerns with the design of this study, and I think that's a significant opportunity. But it's also backed up by other studies in other segments in prostate cancer and also in the EVAPAR breast opportunity as well.

Speaker #4: So when you look at the totality of the Saruprib opportunity, it is significant. I'm definitely in the $5 billion range, and we're excited to see these data read out.

Speaker #2: Thank you, Suzanne.

Pascal Soriot: Thank you, Suzanne.

Speaker #3: And just to address.

Pascal Soriot: Just to address-

Pascal Soriot: Let's park this one and revisit it at the end, we give everybody a chance to ask one question, we may have a chance to cover it as part of another financial question. The next is Christopher at SEB. Christopher, go ahead.

Speaker #2: Let's park this one and revisit it at the end, so we give everybody a chance to ask one question. We may have a chance to cover it as part of another financial question.

Speaker #2: And next is Christopher Ruder at SEB. Christopher, go ahead.

Speaker #6: Hi, thank you very much for taking my question. I guess this one would be for Beck Fendi, noting that you have the primary aldosteronism trial reading out next year.

[Analyst] (SEB): Hi. Thank you very much for taking my question. I guess this one would be on Baxfendy, noting that you have the primary aldosteronism trial reading out next year now. Today, screening for aldosteronism is not really du jour or active, what are you doing to try to ensure as rapid a rollout, that that would not be a break on your launch? Thank you.

Speaker #6: Now, so today, screening for aldosteronism is not really du jour or active. So, what are you doing to try to ensure as rapid a rollout so that this would not be a brake on your launch?

Speaker #6: Thank you.

Speaker #2: Sean, do you want to cover this?

Pascal Soriot: Sharon, do you want to cover this?

Speaker #7: All right. So first, I'll say thank you for noticing the potential for Baxter-Stat in primary aldosteronism. This is a really important and unmet medical need.

Sharon Barr: All right. First, I'll say thank you for noticing the potential for baxdrostat in primary aldosteronism. This is a really important and unmet medical need. It's really a group of disorders in which aldosterone production is unusually high for sodium status, and it is relatively autonomous of the normal regulators. This is a major unmet medical need and a key driver of cardiovascular damage, and is the leading cause of secondary hypertension. We think it could affect as many as 5% to 10% of all hypertensives and up to 20% of resistant hypertension. You're right, relatively few of those patients today are being screened because there hasn't been a therapy to give them.

Speaker #7: It's really a group of disorders in which aldosterone production is unusually high for sodium status, and it is relatively autonomous of the normal regulators.

Speaker #7: So, this is a major unmet medical need and a key driver of cardiovascular damage. It is the leading cause of secondary hypertension. We think it could affect as many as 5 to 10 percent of all hypertensives, and up to 20 percent of resistant hypertension.

Speaker #7: And you're right. Relatively few of those patients today are being screened because there hasn't been a therapy to give them. Now, we have the first approved aldosterone synthase inhibitor with an excellent treatment profile, or target product profile.

Sharon Barr: Now we have the first approved aldosterone synthase inhibitor with an excellent treatment profile or target product profile, and we think that this is going to be pivotal in helping to drive uptake now that there is a recognized therapy that addresses aldosteronism. We're running that study. As we have disclosed, it has accrued very rapidly, so we're accelerating that timeline for primary aldosteronism and excited to see the interest around Baxfendy as a leading molecule. Increasing uptake will, I think, follow through naturally from what we hope will be a positive data set. The rapid recruitment that we're seeing for our studies really speaks to the major unmet medical need and the general enthusiasm of the clinical community for this mechanism.

Speaker #7: And we think that this is going to be pivotal in helping to drive uptake now that there is a recognized therapy that addresses aldosteronism.

Speaker #7: So we're running that study and, as we have disclosed, it has accrued very rapidly. So we're accelerating that timeline for primary aldosteronism.

Speaker #7: I'm excited to see the interest around Bax Fendi as a leading molecule. So, increasing uptake will, I think, follow through naturally from what we hope will be a positive data set.

Speaker #7: And the rapid recruitment that we're seeing for our studies really speaks to the major unmet medical need and the general enthusiasm of the clinical community for this mechanism.

Speaker #2: Thank you, Sean. Peter Verdoult at BNP.

Pascal Soriot: Thank you, Sharon. Peter Verdult at BNP.

Speaker #5: Thanks, Peter. I'll add BNP. Two quick ones—Pascal, one for Ruud on IL-33 and the $5 billion target for TOSO. Are you anticipating any competition here?

Peter Verdult: It's Peter Verdult at BNP. Two quick ones, Pascal. One for Ruud on IL-33 and the $5 billion target for Tozo. Are you anticipating any competition here? The reason for the question is we're hearing Sanofi and their partner, Regeneron, might not undertake the third phase III study for itepekimab that will be required for approval in light of your data and probably the fact you now enjoy a three-year head start. First quick question on Tozo, and then secondly, the obligatory sort of MFN pricing question. When you think about Cammy approved in Europe, hopefully will get approved in the US, how have your thoughts on pricing strategy evolved if we compare it to historical precedents like Calquence and Tagrisso? Thank you.

Speaker #5: And the reason for the question is we're hearing Sanofi and their partner Regeneron might not undertake the third Phase 3 study, but it's beco-mab that will be required for approval in light of your data, and probably the fact you now enjoy a three-year head start.

Speaker #5: So, first, a quick question on TOSO. And then, secondly, the obligatory sort of MFN pricing question. When you think about CAMI approved in Europe, hopefully we'll get approved in the US.

Speaker #5: How have your thoughts on pricing strategy evolved compared to historical precedents like CalQuint and Tagrisso? Thank you.

Speaker #2: Thanks. So, Rud, do you want to cover the IL-33 COPD question? I will return to the MFN pricing at the end.

Pascal Soriot: Thanks. Ruud, do you want to cover the IL-33 COPD question, and we'll return to the MFN pricing at the end?

Speaker #5: Yeah, for sure. Now, I think, Peter, it's a fair question, but it's so difficult for me to answer this one because I simply don't know what Roche or Sanofi are planning to do.

Ruud Dobber: Yeah, for sure. No, I think, Peter, it's a fair question, but it's so difficult for me to answer this one because I simply don't know what Roche or Sanofi are planning to do. What I can tell you is that the data set, hopefully you will see at the ERS, is very convincing, and we get many questions about why do we think that our IL-33 was successful in those two pivotal trials. We truly believe that the mechanism of action is very specific to our anti-IL-33. It's inhibiting the anti-inflammatory pathway, but equally the mucus pathway, and I think that combination makes this a quite unique molecule. Let's see how the competition is going to react to the data, but of course, we keep a close eye on it.

Speaker #5: What I can tell you is that the data set, hopefully you will see at the ERS, is very convincing. And we get many questions about why we think that our IL-33 was successful in those two pivotal trials.

Speaker #5: And we truly believe that the mechanism of action is very specific to our anti-IL-33. It's inhibiting the anti-inflammatory pathway, but equally, the mucus pathway.

Speaker #5: And I think that combination makes this a quite unique molecule. So let's see how the competition is going to react to the data. But of course, we keep a close eye on it.

Speaker #2: Thank you. What's Steve Scarlat's comment?

Pascal Soriot: Thank you, Ruud. Steve Scala, Cowen.

Speaker #6: Thank you very much. Pascal, you have been bullish on China for years, although headwinds were clear in the quarter. All things considered, are you as confident as you have been in the past?

Steve Scala: Thank you very much. Pascal, you have been bullish on China for years, although headwinds were clear in the quarter. All things considered, are you as confident as you have been in the past? How threatening are the local companies on the global stage? Just a very brief question, should we view it as possible that SERENA-4 and AVANZAR are presented at ESMO? Thank you.

Speaker #6: And how threatening are the local companies on the global stage? And just a very brief question: Should we view it as possible that SERENA-IV and AVANZAR are presented at ESMO?

Speaker #6: Thank you.

Speaker #2: Thank you, Steve. I'll cover the first question, and we'll return to the S4 question at the end. China is still very bullish, for reasons that have evolved, I must say.

Pascal Soriot: Thank you, Steve. I'll cover the first question, and we'll return to the S4 question at the end. China, still very bullish for reasons that have evolved, I must say. I mean, the potential in China is still large. On top of it, the innovation potential is also enormous, as you've seen from the various deals we've made, but also other companies have made. Today, Chinese companies are innovating at great speed, and they tend to partner with global companies like ours to globalize the development and the commercialization. It's reasonable to expect that over time they will expand globally. Expanding globally is not that simple, right? I mean, because their profitability in China is not that high. Prices are low.

Speaker #2: I mean, the potential in China is still large. But on top of it, the innovation potential is also enormous, as you've seen from the various deals we've made, but also other companies have made.

Speaker #2: And today, Chinese companies are innovating at great speed, and they tend to partner with global companies like ours to globalize the development and the commercialization.

Speaker #2: But it's reasonable to expect that, over time, they will expand globally. Expanding globally is not that simple, right? I mean, because their profitability in China is not that high.

Speaker #2: Prices are low. So if you don't have a very strong domestic business from a profit viewpoint, it's not that simple to globalize. But you have to assume they will at some point.

Pascal Soriot: If you don't have a very strong domestic business from a profit viewpoint, it's not that simple to globalize, but you have to assume they will at some point. What we're doing is collaborating, but we're also competing. You saw the competition in the TAGRISSO market is very intense and in the ADC market, very intense, too. We learn to compete with them, and Sony will take those learnings globally when they become global companies, if they do. We're also learning from them in terms of how they develop products and how fast they operate. We've made some changes in the way we operate. For instance, Sone-Ve, that read out that we announced this morning is a good example of the role our Chinese team has played in the speedy development of this product.

Speaker #2: So what we're doing is collaborating, but we're also competing. You saw the competition in the Tagrisso market is very intense, and in the ADC market, very intense too.

Speaker #2: So we learn to compete with them, and suddenly, we'll take those learnings globally when they become global companies, if they do. We are also learning from them in terms of how they develop products and how fast they operate.

Speaker #2: And we've made some changes in the way we operate. For instance, the Sony V that we announced this morning is a good example of the role our Chinese team has played in the speedy development of this product.

Speaker #2: So, I think being present in China—very present and strong—enables us to collaborate with companies, learn from them, and learn to compete as well.

Pascal Soriot: I think being present in China, very present and strong, enables us to collaborate with companies, learn from them, and learn to compete as well. The next one is Corinne White at UBS.

Speaker #2: So, the next one is Colin White at UBS.

Speaker #6: Hey, Colin White. Yeah, sure. Thanks for taking my questions. I had a quick question on the C5 franchise. I was wondering if it's impacted by longer-acting C5 inhibitors like Regeneron's or Simdiziran.

Corinne White: Thanks for taking my questions. I had a quick question on the C5 franchise. I was wondering if you could talk about how much you expect it might be impacted by longer-acting C5 inhibitors like Regeneron's cemdisiran. Just quickly, if you could comment on Beyfortus arbitration in the US, the timelines, possible outcomes of that would be helpful. Thank you.

Speaker #6: And then, just quickly, if you could comment on the status of sabatolimab in the US, the timelines, and possible outcomes of that, that would be helpful.

Speaker #6: Thank you.

Speaker #2: Thank you, Mark. Do you want to cover the C5 question? We'll cover Before too a little later.

Pascal Soriot: Thank you. Marc, do you want to cover the C5 question? We will cover Beyfortus a little later.

Speaker #4: So, obviously, there have been a number of competitors against the C5 franchise. We continue to grow. But, obviously, novel mechanisms or similar products from the C5 complement biology will also compete with us.

Marc Dunoyer: Obviously there have been a number of competitors against the C5 franchise. We continue to grow, but obviously, other mechanism or similar products from the C5 complement biology also will compete with us. What we have been doing with Ultomiris since the acquisition of Alexion, was also to explore and pioneer in new indications, and we are going to continue doing that. I mentioned today, IgAN, we saw the results in HSCT-TMA. We have other trials such as the delayed graft function. We will be developing several other areas in the renal rare disease, but also with other nodes of the complement biology to propose answers to diseases that have no response today. We are continuing to compete in the C5, but also outside of the C5 from within the complement biology.

Speaker #4: What we have been doing with Ultramere is, since the acquisition of Alexio, also to explore and pioneer new indications, and we are going to continue doing that.

Speaker #4: I mentioned today IgAN. We saw the results in HTPMA. We have other trials, such as delayed graft function, and then we will be developing several other areas in the renal rare disease, but also with other nodules or nodes of the complement biology, to propose answers to diseases that have no response today.

Speaker #4: So, we are continuing to compete in the C5, but also outside of C5 from within the complement biology.

Speaker #2: Thank you, Mark. And as you can see, I mean, long-acting could have a place, of course, but you have to develop every single one of those indications.

Pascal Soriot: Thank you, Marc. As you can see, long-acting could have a place, of course, but you have to develop every single one of those indications. It takes time and it takes money. Next question is Michael Leuchten at Jefferies.

Speaker #2: So, it takes time and it takes money. Next question is from Michael Luchten at Jefferies.

Speaker #5: Hey, Pascal. Maybe

Michael Leuchten: Hey, Pascal. Maybe if I could just go back to Ratna on the other operating income question. We have that covered. How much of that is sustainable going forward? How much does the higher run rate cause a higher base that makes 2027 a little bit more challenging? Thank you.

Speaker #6: If I could just go back to Ratna on the other operating income question so we have that covered. How much of that is sustainable going forward?

Speaker #6: How much does the higher run rate cause a higher base that makes '27 a little bit more challenging? Thank you.

Speaker #2: That's great. Ratna, you got your question.

Pascal Soriot: That's great. Ratna, you got your question.

Speaker #3: So again, we don't provide the split of other income, but there is a portion of that, obviously, that is relating to royalties and some milestones that we get. And then there's a portion for this year that also relates to, like I said, smaller regional divestitures.

Aradhana Sarin: Again, we don't provide the split of other income, but there is a portion of that, obviously, that is relating to royalties and some milestones that we get. Then there's a portion from this year that also relates to, like I said, smaller regional divestitures we've done. Again, as we clean up the portfolio, again, all of these are small legacy products that we continue to sell and monetize those. There is a portion of that that is consistent and will likely continue into 2027.

Speaker #3: We have done it again, as we clean up the portfolio. Again, all of these are small legacy products that we continue to sell and monetize.

Speaker #3: But there is a portion of that which is consistent and will likely continue into 2027.

Speaker #2: Thank you, Ratna. So if we return to the—sorry, no, there’s a question from Seamus, Guggenheim. Seamus, go ahead.

Pascal Soriot: Thank you, Ratna. Sorry, there's a question from Seamus Fernandez. Seamus, go ahead.

Speaker #7: This is Zach Dunham for Seamus Fernandes. Thank you for the question. I just want to touch on BD. More specifically, is the current Phase 3 pipeline sufficient to deliver a stable profile during the main patent expiration period in 2032 plus?

Zach Dunn: This is Zach Dunn on for Seamus Fernandez. Thank you for the question. I just want to touch on BD. More specifically, is the current phase III pipeline sufficient to deliver a stable profile during the main patent expiration period in 2032 plus? It seems to us that the current pressure on the multiple has much less to do with 2030 and much more to do with 2032 and beyond, and that larger BD may be necessary to drive growth in that timeframe. Thank you.

Speaker #7: It seems to us that the current pressure on the multiple has much less to do with 2030, and much more to do with 2032 and beyond.

Speaker #7: And that larger BD may be necessary to drive growth in that timeframe. Thank you.

Speaker #2: Thanks so much. Well, I think on this one, I can be very clear. The answer is no, we don't need more BD to deliver.

Pascal Soriot: Thanks, Seamus. Well, I think on this one I can be very clear. The answer is no, we don't need more BD to deliver. of course, to deliver this growth post-2030. again, it assumes that the aggregate probability of success across our pipeline of new products will be at least as we plan it. again, there's no one or two projects, it's the aggregate view of the pipeline. then if you look at that, the average probability of success across phase III for the industry is 60% and 65%. I think Aradhana mentioned it earlier. The aggregate probability of success that we use across our pipeline, and we looked at it again recently, it's around 60%. we are more or less planning as if we were going to develop the industry average, in fact, a little bit lower. we have consistently developed higher.

Speaker #2: But of course, to deliver this growth post-2030. But again, it assumes that the aggregate probability of success across our pipeline of new products will be at least as we plan it.

Speaker #2: Because, again, there's not just one or two projects—it's the aggregate view of the pipeline. And if you look at that, the average probability of success across Phase 3 for the industry is 60 to 65 percent.

Speaker #2: I think Ratna mentioned it earlier. The probability, the aggregate probability of success that we use across our pipeline—and we looked at it again recently—is around 60%.

Speaker #2: So, we are more or less planning as if we were going to develop at the industry average—in fact, a little bit lower. But we have consistently developed higher.

Speaker #2: Ratna mentioned 75 percent-plus has been our record. So, if we deliver what we have in our plan as a probability of success or more, then we actually don't need more BD.

Pascal Soriot: Aradhana mentioned 75% plus has been our record. if we deliver what we have in our plan as a probability of success, or more, then actually we don't need more BD. The reason we need more BD is really to continue planning long-term and continuously strengthen our franchises. The most recent one we just talked about is how do we strengthen the TAGRISSO franchise. net-net is no, we don't need new BD to achieve this goal. I don't know where this idea comes from, probably from people who haven't analyzed the pipeline in detail, I have to say. Luisa Hector, do you want to go ahead?

Speaker #2: So, the reason we need more BD is really to continue planning long term and continuously strengthen our franchises. The most recent one we just talked about is, how do we strengthen the—sorry—the Tagrisso franchise?

Speaker #2: So net-net is no, we don't need new BD to achieve this goal. I don't know where this idea comes from—probably from people who haven't analyzed the pipeline in detail.

Speaker #2: I have to say, Luisa, Berenberg, do you want to go ahead?

Speaker #8: Thank you very much, Pascal. So, at the start of the year, you highlighted over $10 billion in combined and risk-adjusted peak sales from the 2026 readouts.

Luisa Hector: Thank you very much, Pascal. at the start of the year, you highlighted over GBP 10 billion combined and risk-adjusted peak sales from the 2026 readouts. today we see a couple of increases with tozorakimab and then sonesitatug vedotin. also hearing consistent messages from Susan on SERENA-4 and Evanzel, kind of balanced and consistent. does that guidance still stand or have there been some risk adjustment changes maybe that were negative to the cohort? Thank you.

Speaker #8: And today we see a couple of increases in Tozzo, and then Sonny, and also hearing consistent messages from Susan on Serena 4 and Avanza—our kind of balance and consistent.

Speaker #8: So does that guidance still stand, or have there been some risk adjustment changes, maybe, that were negative for the cohort? Thank you.

Speaker #2: No, when you're talking about the 2030 targets, right?

Pascal Soriot: No. You're talking about the 2030 targets, right?

Speaker #8: No, the $10 billion peak sales potential from the readouts this year—2026—was a slide you had at the full-year 2025 results. Yes.

Luisa Hector: No, the $10 billion peak sales potential from the readouts this year, 2026. With the slide you had at the full year-

Pascal Soriot: Oh, okay.

Luisa Hector: 2025 results. Yeah.

Speaker #2: Ratna, do you want to cover this one?

Pascal Soriot: Aradhana, do you want to cover this one?

Aradhana Sarin: Sorry. The $10 billion was the peak year estimate with the risk unwind. What that means is, as risk unwinds for the 2026 cohort, we would say $10 billion. Some of them have unwound in a positive manner, like Tezspire. Some of them have unwound in not so positive manner, like WAINUA. I think, again, all of those being probability adjusted, I still think we'll unwind close to $10 billion. That $10 billion is not a 2030 number, that's a peak year sales number. The peak for some of these products may hit beyond 2030.

Speaker #3: Sorry. So the $10 billion was the peak year estimate with the risk unwind. So what that means is, as risk unwinds for the 2026 cohort, we would still say $10 billion.

Speaker #3: Now, some of them have unwound in a positive manner, like Tozzo. Some of them have unwound in not so positive a manner, like Venua.

Speaker #3: But I think, again, all of those being probability-adjusted, I still think we'll unwind close to $10 billion. Now, that $10 billion is not a 2020–2030 number.

Speaker #3: That's a peak year sales number, and the peak for some of these products may hit beyond 2030.

Speaker #2: Maybe the one thing I would add to this is that our probability of success, in our risk-adjusted overall forecast, the probability of success we gave to Tozzo was on the low side.

Pascal Soriot: Maybe the one thing I would add to this is that our probability of success in our risk-adjusted overall forecast, the probability of success we gave to Tezspire was on the low side, and I'm sure you would agree with that. Nobody thought it was going to work. We thought it had a good chance, but we still gave it a low PTS. We had a higher, a sort of a good PTS for WAINUA, more industry standard because we had good reasons to believe, based on what the entire cardiology community was saying, a good reason it was going to work. The end result is we've unlocked Tezspire, the uplift in sales is much higher than the down-lift in sales from WAINUA, if you consider the low PTS we had for Tezspire. That's one. Two is the profitability of Tezspire is higher.

Speaker #2: And I'm sure you would agree with that. Nobody thought it was going to work. We thought it had a good chance, but we still gave it a low, higher sort of a good PTS for Venua, more industry.

Speaker #2: Standard, because we had good reasons to believe—based on what the entire cardiology community was saying—good reason it was going to work. So the end result is we've unlocked Tozzo, and so the uplift in sales is much higher than the downlift in sales from Venua.

Speaker #2: If you consider the low PTS we had for Tozzo, that's one. And two is the profitability of Tozzo is higher—we own this product 100 percent.

Pascal Soriot: We own this product 100%, whereas with WAINUA, we were going to share it with our partners at Ionis. Clearly we gained more with Tezspire than we lost with WAINUA. That was the last question. We'll take the questions we left sideways. Maybe Dave, you could cover both the MFN impact on the pricing of cammy and also the question about S4 and will it be at ESMO?

Speaker #2: Whereas with Venua, we were going to share it with our partners at Ionis. So, clearly, we gained more with Tozzo than we lost with Venua.

Speaker #2: I think maybe we'll take that as the last question. So we'll take the questions we left sideways, and maybe, Dave, you could cover both the MFN impact on the pricing of Kami and also the question about S4.

Speaker #2: Will it be at S4?

Speaker #4: Thanks, Pascal. Well, on the second question, we will present it when we have our high-level results at whatever congress we can make it to.

David Fredrickson: Thanks, Pascal. Well, on the second question, we will present it when we have our high-level results at whatever congress we can make it to. We're not going to be able to comment any more specifically than that, in terms of where we'll see the presentation of that. On MFN, we don't give brand-specific pricing commentary on MFN and don't plan to. That said, our pricing approach across all of launches now has really evolved in response to MFN. With the US now referencing a basket of countries and setting its price, we are seeing productive engagement with payers in the wealthy nations within that context.

Speaker #4: So we're not going to be able to comment any more specifically than that in terms of where we'll see the presentation of that. On MFN, we don't give brand-specific pricing commentary on MFN and don't plan to.

Speaker #4: That said, our pricing approach across all of our launches now has really evolved in response to MFN. And with the US now referencing a basket of countries and setting its price, we are seeing productive engagement with payers and the wealthy nations within that context, with it—Kama specifically.

David Fredrickson: With it, camizestrant specifically, we're still early in the commercial life cycle in the markets where we have approvals, but the early negotiations are reflecting this new reality, that funding for innovation needs to rise in line with a country's GDP per capita. We do anticipate that these will be discussions that are going to take more time than perhaps sometimes in the past. We do think that so far, the objective that was set by the US for prices in wealthy nations to come up and US prices to come down a bit, we think is the direction of travel.

Speaker #4: We're still early in the commercial life cycle in the markets where we have approvals, but the early negotiations are reflecting this new reality: that funding for innovation needs to rise in line with a country's GDP per capita.

Speaker #4: We do anticipate that these will be discussions that are going to take more time than perhaps sometimes in the past. But we do think that, so far, the objective that was set by the US—for prices in wealthy nations to come up and US prices to come down a bit—we think is the direction of travel.

Speaker #2: And as far as S4—Serena 4?

Pascal Soriot: S4 at ESMO? Saranafour.

Speaker #4: Yes, I commented on that at the beginning and said we will share, when we have the data, what the timing of the Congress will be.

David Fredrickson: Yeah, I commented on that at the beginning and said we will share when we have data, what the timing of the congress will be.

Speaker #2: Okay, thanks. And the last question is maybe for Ruth, about Beyfortus.

Pascal Soriot: Okay, thanks. The last question is maybe for Ruud, about Beyfortus.

Speaker #5: Pascal, there's not much I can comment on for this one. As we mentioned in our legal disclosures, we have started an arbitration process regarding Befortus.

Ruud Dobber: Pascal, there's not so much I can comment on this one. As we mentioned in our legal disclosures, we started an arbitration process regarding Beyfortus in the United States. As we normally do, we are not commenting on either an arbitration or legal procedure.

Speaker #5: In the United States, and as we normally do, we are not commenting on either an arbitration or a legal procedure.

Speaker #2: Thank you, Ruth. So we'll close the Q&A here. Thank you so much for all your great questions and being close listeners. Thank you for joining us, for your interest in our company, and also let me restate that we are firmly on track for our 2030 goal, and also on track with our post-2030 growth ambition.

Pascal Soriot: Thank you, Ruud. We'll close the Q&A here. Thank you so much for all your great question, in closing, I want to thank you for joining us, for your interest in our company. Also restate that we are firmly on track for our 2030 goal, but also on track with our post-2030 growth ambition. Again, we don't need additional BD. Doesn't mean we will not do additional BD, but we don't need additional BD if we continue delivering as we expect to across the pipeline. Again, thank you, and have a good day.

Speaker #2: And again, we don't need additional bidding. It doesn't mean we will not do additional bidding, but we don't need additional bidding if we continue delivering as we expect to across the pipeline.