2 Soaring Cathie Wood Stocks to Buy and Hold

Cathie Wood's Ark Invest portfolio highlights CRISPR Therapeutics (CRSP) and Spotify Technologies (SPOT) as strong performers with significant future potential. CRISPR Therapeutics, a gene-editing biotech, is up 85% this year, driven by a promising pipeline including CTX310 for cardiovascular conditions and CTX112 for blood cancers, complementing its approved Casgevy medicine. Spotify, the leading music streaming platform, has seen a 50% gain in 2025, underpinned by its dominant market share, recent profitability improvements, strategic podcasting expansion, and AI initiatives aimed at reaching 1 billion monthly active users by 2030.

Analysis

CRISPR Therapeutics (CRSP) has experienced an 85% year-to-date stock increase, driven by significant progress in its gene-editing pipeline. Its lead candidate, CTX310, targeting LDL cholesterol and triglycerides, shows promising early clinical trial results for a condition affecting 40 million Americans.

The company's broader pipeline includes CTX112 for blood cancers and CTX320 for lipoprotein(a), alongside its approved Casgevy medicine developed with Vertex Pharmaceuticals. Despite inherent clinical setback risks, CRSP's robust pipeline and prior market success suggest considerable future upside potential.

Spotify Technologies (SPOT) shares have risen 50% in 2025, solidifying its position as the leading global music streaming platform. This market dominance is sustained by a strong network effect and strategic expansion into podcasting, despite intense competition from major tech firms.

Spotify has demonstrated significant bottom-line improvements recently, reporting 696 million Q2 MAUs, an 11% year-over-year increase. With a target of 1 billion MAUs by 2030 and engagement-boosting AI initiatives like Spotify DJ, the company's outlook for revenue growth from premium conversions and ad sales appears bright.

Key Decisions for Investors

• Monitor CRISPR Therapeutics' ongoing clinical trial results for CTX310 and other pipeline candidates, as these will be critical determinants of future valuation and potential market entry.
• Evaluate Spotify's continued progress in converting free users to premium subscribers and the impact of AI initiatives on user engagement and advertising revenue growth.
• Consider the long-term competitive landscape for both gene-editing and music streaming, assessing how innovation and market share dynamics could influence sustained growth.