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Acoramidis Associated with First-Ever Early and Sustained Direct Kidney-Protective Effects in ATTR-CM

Healthcare & BiotechCompany Fundamentals

Post-hoc analyses from the acoramidis initiation show rapid kidney-protective activity, including a reversible hemodynamically mediated eGFR dip and a placebo-corrected 15.5% reduction in UACR by Day 28 (P<0.05). No kidney-related adverse events were observed in these analyses, supporting a cautiously positive efficacy and safety signal.

Analysis

Post-hoc analyses from the acoramidis initiation show rapid kidney-protective activity, including a reversible hemodynamically mediated eGFR dip and a placebo-corrected 15.5% reduction in UACR by Day 28 (P<0.05). No kidney-related adverse events were observed in these analyses, supporting a cautiously positive efficacy and safety signal.

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