Q3 2025 OmniAb Inc Earnings and Business Update Call
Speaker #3: Good afternoon and welcome to OmniAb, Inc. third quarter 2025 financial results and business update . Conference call . At this time , all participants are in a listen only mode .
Speaker #3: A question and answer session will follow the formal presentation . As a reminder , this conference is being recorded and I would now like to turn the call over to Kurt Gustafson OmniAb, Inc. , Chief Financial Officer .
Speaker #3: You may begin .
Speaker #4: Thank you . Operator and good afternoon , everyone . This is Kurt Gustafson . OmniAb, Inc. , chief Financial Officer And thank you all for joining our third quarter 2020 financial results conference call .
Speaker #4: There are slides to accompany today's prepared remarks , and they're available in the investor section of our website at OmniAb, Inc. . Before we begin , I'd like to remind listeners that comments made during this call by OmniAb, Inc. management will include forward looking statements within the meaning of the federal securities laws .
Speaker #4: These forward looking statements involve risks and uncertainties that could cause actual results to be materially different from any anticipated results . These forward looking statements are qualified by the cautionary statements contained in today's press release , our SEC filings .
Speaker #4: Importantly , this conference call contains time sensitive information that is accurate only as of the date of the live broadcast today , November 4th , 2025 , except as required by law .
Speaker #4: Omniab undertakes no obligation to revise or update any forward looking statements to reflect events or circumstances after the date of this call . Joining me this afternoon is Matt for OmniAb, Inc. president and CEO .
Speaker #4: During today's call , we will provide highlights on the company's business and operations partner and technology updates , as well as our recent financial results and outlook .
Speaker #4: At the conclusion of the prepared remarks, we'll open the call to questions. And with that, let me turn the call over to Matt.
Speaker #5: Thanks , Curt . Good afternoon , everyone , and thanks for joining our Q3 call . Starting now with slide number four . We continued to have nice deal flow throughout the third quarter .
Speaker #5: And the number of new program additions this year is far outpacing last year . Our program adds as of the end of Q3 , already equaled the program adds we had in 2020 .
Speaker #5: For we've also grown and diversified our base of active partners , reaching a record high level now exceeding 100 . We all of see this as further validation of our differentiated proprietary technology platforms and their proven value to enable the discovery of next generation therapeutics for our partners .
Speaker #5: We're building the foundational momentum for our recently launched exploration partner , Access program , which is designed to put our high throughput , single B cell screening platform in the hands of our partners .
Speaker #5: The exploration sales funnel continues to grow , generating strong interest and new opportunities for us . And as the latest example of our commitment to pioneering innovations in sector leadership , in December , we'll be launching a brand new technology to add to our stack .
Speaker #5: We're excited to share a little preview today of Omni Ultra , which is the first transgenic chicken that produces cow like antibodies with ultra long cdr-h3 .
Speaker #5: Omni ultra has the potential to open new markets and new business opportunities for us and to expand our reach into enabling the discovery of novel peptide therapeutics .
Speaker #5: I'll provide more on this technology in a moment . While we continued to grow , the number of partners and programs , we also realigned staffing levels in Q3 and further reduced operating expenses to drive efficiencies in our lean .
Speaker #5: Yet scalable operating model . In addition , we enhanced our financial flexibility and strengthened our balance sheet with the closing of a $30 million private placement in late August .
Speaker #5: I want to welcome our new shareholders and thank the existing shareholders who participated in the transaction for their support . Moving to a review of our key business metrics now , starting with slide number five , we ended Q3 with 104 active partners .
Speaker #5: During the third quarter . We've highlighted that we completed new license agreements with Astar and the University of Leeds . The distribution of our active partners by type , including discovery Commercial and academic , continues to hold steady .
Speaker #5: And the same holds true for our distribution of partners on a geographic basis . With just over half of our partners based here in the US .
Speaker #5: And I note that our international reach has continued to grow as we make a concerted effort to expand and diversify our partnership base with regard to new partnerships .
Speaker #5: Increasingly , we also think there are innovative ways in which we can create value in a variety of time horizons , leveraging our technologies or assets that come out of our novel technology development and validation work .
Speaker #5: On slide six , the number of active programs leveraging our technologies increased to 399 . As of the end of Q3 . This includes net addition of 36 programs year to date , of which 18 were added during the third quarter .
Speaker #5: As we've continued to see strong program addition momentum during the third quarter, there were six programs that were terminated. And as I've said before and I say often, program attrition is a normal part of our business and will continue to be due to shifts in partner priorities, as well as budgetary and technical factors that affect our partners.
Speaker #5: The graphics on slide number seven highlight the growth of our post-discovery stage programs that are in our portfolio, as well as the advancement of these programs into and through clinical development.
Speaker #5: The number of programs in the Post-discovery stage increased to 50 , increased by 15% year over year . A number of new programs progressed to the preclinical stage of development , and in Q3 , one program moved to the registration phase .
Speaker #5: These 61 post-discovery stage programs have contracted remaining potential milestones to omniab of approximately $1.3 billion , including $700 million from small molecule ion channel programs .
Speaker #5: Slide eight shows the number of active clinical programs and approved products , which totaled 32 at the end of Q3 . As of September 30th , two new partner programs had entered the clinic in the year , and two came out .
Speaker #5: We are proud to report that subsequent to quarter end , the first Omniab derived program entered into human clinical trials as we launched the Omniab single domain discovery platform .
Speaker #5: Less than two years ago, this is a significant milestone for a new technology, especially within such a short period of time.
Speaker #5: We also received confirmation that another bispecific antibody derived from our rodent platforms entered human clinical trials just last week . We'll talk more about both of those new clinical programs after our partners have disclosed more details publicly .
Speaker #5: Overall , given our latest discussions with our partners and our line of sight into their work , we see the potential for a total of five new entries into clinical development for novel Omniab derived programs .
Speaker #5: This year . This is at the lower end of our previous range of projected clinical starts , primarily resulting from select partners simply shifting timing of clinical program initiations into early 2026 .
Speaker #5: Also , in regard to clinical programs , I note that we have multiple partners who will be presenting data at the Ash annual meeting in early December .
Speaker #5: So we're looking forward to that . As well . Turning now to slide nine here . We've highlighted select recent updates for partner programs that are leveraging our technologies at the annual meeting of the American Thyroid Association , Immunovant presented six month durability data from its graves .
Speaker #5: Graves Disease study showing sustained remissions with Mab . Their next generation candidate , Imvt 1402 , is advancing in two potentially registrational phase three trials in grave's disease , with top line results expected in 2027 .
Speaker #5: Moving to the right on this slide , it is more Arcus Biosciences reported median overall survival of 26.7 months from its phase two edge gastric trial .
Speaker #5: The study combines domvanalimab with Omniab derived zimberelimab and chemotherapy in advanced gastric cancer . Clearly reinforcing the potential for this treatment approach . Salubrious Bio announced that China's Nmpa accepted its NDA for Sal oh three , which is a recombinant fully human PK anti-pcsk9 antibody for dyslipidemia .
Speaker #5: So this program moved from our phase three bucket to the registration stage in Q3 . And lastly , Rondo Therapeutics . Abstract . On its first in class CD and Nectin four bispecific antibody was accepted for presentation at the society for Immunotherapy of Cancer meeting , which is taking place this week .
Speaker #5: Turning now to slide ten. Here we highlight our clinical and commercial stage partner pipeline for active programs that carry downstream economics to OmniAb. Placement in this graphic is based on a program's most advanced status in any geography or indication.
Speaker #5: Our partners continue to advance Omniab derived antibodies into and through the clinic , and this latest update shows Salubris Bio's Sal zero three moving to the registration phase .
Speaker #5: As I just mentioned, on slide number 11, I'd like to take just a quick moment to highlight progress with our exploration partner.
Speaker #5: Access program . The early feedback we're getting from partners using the instrument is that exploration is performing extremely well . And that it's driving efficiencies in discovery workflows .
Speaker #5: We're really pleased with the response so far . As exploration continues to gain traction . Since its launch in Q2 with a strong demand for lab demos from partners throughout Q3 , the efficiency and ease of use of exploration are significant differentiators .
Speaker #5: This platform complements our core technology licensing business, as we expect exploration to be accretive to earnings and cash flow in both the short and the long term.
Speaker #5: As we grow our installed base of instruments , we expect to broaden our revenue channels with recurring single use consumable sales , annual subscription services for software and maintenance contracts .
Speaker #5: Ultimately , we're clearly seeing that exploration deepens engagement with partners has the potential to drive new program growth and showcases OmniAb, Inc. innovation in integrating automation , AI powered methods , and discovery .
Speaker #5: Turning to slide number 12 , our internal innovation engine continues to strengthen our differentiation , especially with our growing suite of genetically engineered chicken based discovery platforms .
Speaker #5: We've had an established history of pioneering the development of advanced discovery technologies that the industry needs. We talk a lot about the advantages that a chicken immunization host presents for novel molecule discovery.
Speaker #5: As about half of all therapeutic targets are more than 90% conserved in mammals . So using a chicken as an immunization host species for discovery can be really important and really valuable in many instances , our Omni chicken technology shown on the lower left of this slide , remains the world's only validated , humanized transgenic chicken for antibody discovery .
Speaker #5: Leveraging the evolutionary distance between birds and mammals , Omni Chicken delivers robust immune responses and generates highly diverse antibody repertoires . This platform has become foundational to many of our partners .
Speaker #5: Discovery pipelines . Building upon this omni incorporated a fixed light chain design enabling seamless combinations of antibodies for bispecific and multispecific applications and omni DAB , our single domain antibody framework extends the utility of chicken derived antibodies into small , stable therapeutic formats and opens up opportunities across a range of modalities .
Speaker #5: Molecules from Omniab are well suited for modular and multi-specific architectures , while maintaining advantages in terms of manufacturability and stability . And as I mentioned , Omniab was launched less than two years ago and it's attracted a lot of new partners and already has generated a program that has entered the clinic .
Speaker #5: And now , as the latest entry in this stack , in December , we're launching our newest transgenic chicken platform , which we are branding as Omni Ultra .
Speaker #5: Moving to slide number 13 , Omni Ultra represents the next evolution of discovery tools , as it's the first and only transgenic chicken producing ultra long cdr-h3 , which is a structural feature of antibodies .
Speaker #5: Typically seen only in cows . Put another way , Omni ultra chickens are engineered to create antibodies with the physical characteristics that are found in cows , but with human features to make them suitable as human therapeutics .
Speaker #5: These ultra long cdr-h3 are designed to enable antibodies to reach unique , deep or recessed binding pockets and previously inaccessible epitopes , potentially unveiling therapeutic opportunities beyond the reach of conventional antibodies or conventional modalities .
Speaker #5: What's especially exciting is the potential ability of these ultra long cdr-h3 to be isolated as novel or autonomous binding fragments , known as pica bodies , which are the smallest known functional antibody fragment .
Speaker #5: Roughly one third the size of an antibody . Pica bodies could open up entirely new therapeutic applications and modalities . Turning now to slide 14 .
Speaker #5: So on the ultra is not only expanding the boundaries of antibody discovery technologies , but also potentially opens up entirely new opportunities for us in peptide based therapeutics , along with its novel architecture , Omni Ultra is engineered for in vivo optimization , allowing for the generation of molecules to essentially be preselected for specificity , affinity , and structural stability .
Speaker #5: This process enhances the discovery of antibodies with unique binding domains, with the potential to target previously inaccessible epitopes. Importantly, as I said on the Ultra, it is also leverageable for peptide therapeutic discovery.
Speaker #5: Now , peptides are obviously a class of molecules that have seen a substantial increase in attention by the industry , in large part as a result of the GLP one drugs that have been so important to patients and to the industry globally .
Speaker #5: That's led to significant growth in investment around peptide therapeutics from a discovery , development and downstream capacity and infrastructure perspective . And that's part of why we think Omni Ultra is really well timed .
Speaker #5: Unlike traditional peptide discovery methods , Omni Ultra uses a transgenic chicken host to biologically produce optimized structured peptides on a validated scaffold . This capability could establish new classes of biologically derived therapeutics with potential applications across modalities on the ultra highlights , our team's innovation , leadership , and extends our platform advantage into new therapeutic spaces .
Speaker #5: Further differentiating our technology , platform and reinforcing our long term growth potential . Slide 15 sets the stage for omni Ultra's formal launch , which is planned to be at the Antibody Engineering and Therapeutics conference down in San Diego next month at ATI , we have two podium presentations and two poster presentations .
Speaker #5: There's a lot more to say about Omni Ultra beyond today's little preview . So while at ATI will be holding an investor webcast related to the Omni Ultra technology , discuss the potential market use and applications and review the potential business impact of this highly innovative and pioneering technology .
Speaker #5: The tech validation work that we completed with Omni Ultra included a broad array of therapeutic targets , and we will touch on that work as well .
Speaker #5: We'll be announcing details of the webcast as we get closer to the event , but for now , please mark your calendars for Monday , December 15th at 5 p.m.
Speaker #5: Eastern Time . Moving now to slide 16 . We're excited about the prospects for Omni Ultra as it's significantly increases our potential universe of partners into the peptide discovery space and also obviously opens up new doors in and opportunities in the antibody discovery space as well as most of those who follow us know our technology license deals generally have several components , including collaboration and service revenue , milestone payments and royalties .
Speaker #5: Upon commercialization of a program , I want to highlight that Omni Ultra builds on our established transgenic chicken capabilities , which require a service contract as our partners cannot perform the discovery service work on their own , and we think the new Omni Ultra platform can drive higher collaboration and service revenue in the near term .
Speaker #5: And with that , let me turn the call over to Kurt for a discussion of our Q3 financials . Kurt .
Speaker #4: Thank you . Matt . So on slide 18 , I'll start with a review of revenue for the third quarter of 2025 . We reported revenue of $2.2 million in .
Speaker #4: This compares with $4.2 million for the same period in 2024 . The decrease was primarily related to a reduction in milestones achieved and lower service revenue .
Speaker #4: Service revenue declined primarily due to the completion of a couple of small molecule ion channel programs earlier this year , and as a small offset to this decrease , the 2025 third quarter included exploration revenue derived from the sale of consumables and a modest increase in royalty revenue .
Speaker #4: On slide 19 , we show our cost and operating expense for the third quarter of 2025 , which decreased to 20.4 million from 23.9 million for the prior year period .
Speaker #4: We saw decreases in both R&D and G&A expenses compared with last year and this quarter also included a non-recurring charge of approximately $800,000 related to a headcount reduction we made earlier in the quarter .
Speaker #4: Turning to slide 20 . I'll focus on a few of the operating expense line items , starting with R&D expense , which decreased to $10.4 million from 13.3 million in the year ago period , primarily related to lower headcount and stock based compensation , as well as a decrease in external expenses due to the completion of certain ion channel programs .
Speaker #4: Earlier this year , G&A expense was $6.8 million for the third quarter of 2025 , compared with 7.1 million for the same period in 2024 .
Speaker #4: With the decrease primarily due to lower legal fees and stock based compensation expense . Net loss for the third quarter of 2025 was 16.5 million , or $0.14 per share , compared to a net loss of 16.4 million , or $0.16 per share , for the same period in 2024 .
Speaker #4: On slide 21 , we have our balance sheet . As of September 30th , 2025 , we ended the quarter with 59.4 or 59.5 million in cash .
Speaker #4: And as Matt mentioned during the quarter , we completed a $30 million private placement of common stock , which netted the company $28 million , I'll conclude with slide 22 with the discussion of our 2025 financial guidance .
Speaker #4: We've recently received information that a few of the milestones that we were expecting in the second half of 2025 will now be pushed to 2026 .
Speaker #4: We also identified further efficiencies in our operating structure , and as a result , we're updating our guidance for this year . We now expect that 2025 revenue will be between 18 and 22 million , and operating expense will be between 82 and $86 million .
Speaker #4: As a reminder , approximately 40% of our operating expense is non-cash , mostly due to stock based compensation and the amortization of intangibles , primarily from a historical company or technology acquisition .
Speaker #4: We continue to expect that our cash use in 2025 will be lower than the cash used in 2024 , excluding financings in both years , and we expect our year end cash balance to be between 52 and $56 million .
Speaker #4: And finally , our guidance on the tax rate remains unchanged at approximately 0% due to a valuation allowance . And with that , I'd like to open up the call for questions .
Speaker #4: Operator .
Speaker #3: Thank you . Ladies and gentlemen , we will now begin the question and answer session . Should you have a question , please press the star , followed by the one on your touchtone phone .
Speaker #3: Should you wish to cancel your request , please press the star , followed by the two . If you are using a speakerphone , please lift the handset before pressing any keys .
Speaker #3: Once again , that is star one . Should you wish to ask a question . Your first question is from Puneet Sudha from Leerink .
Speaker #3: Your line is open .
Speaker #6: Hi guys . You have Micheal Sontag on for Puneet . Congrats on the quarter . I just wanted to start my first question on the private placement .
Speaker #6: I was curious if you could offer some color on what motivated the timing of the placement and if you have any thoughts on the cash runway that now gives you .
Speaker #6: If you expect to get you to where your consistently cash flow break even ?
Speaker #4: Yeah , maybe I'll provide some additional or some some thoughts and then maybe Matt can jump in there . You know , these are conversations that we have with our board .
Speaker #4: We took a look at our forecasts and decided it was the right time to sort of bolster the balance sheet. Markets seemed to start becoming a little bit more favorable.
Speaker #4: And so we took that opportunity to to strengthen the balance sheet . You know , we don't provide any sort of long term guidance .
Speaker #4: I kind of gave you the guidance that we have for this year with regards to cash burn and cash balance. But, you know, I think this puts us in a good position.
Speaker #4: I feel like the company is now , you know , well capitalized on . Matt . Anything else to add .
Speaker #5: Yeah . I mean I'll add as well . Again this provides us a level of flexibility for the business and and made sense .
Speaker #5: And as Kurt said , we think the business is is well capitalized as we you know , look out into , the coming years .
Speaker #5: We'll , we'll we'll provide further guidance . But we feel good about where we are .
Speaker #6: Okay , great . And then on exploration , I was wondering if you could provide some I additional color on customer conversations . What kind of customers in your partner base are you seeing some more interest and if you have any thoughts on I guess , bookings or order timelines , any color you can provide , there would be helpful .
Speaker #5: Yeah , yeah . Michael , thanks . Yeah , it's been very busy on the exploration front and interest has been has been very strong .
Speaker #5: I would say , you know , generally now we've got obviously a a partner base or a partner . Universe . Now of 104 partners .
Speaker #5: It is definitely the higher tier of partners . Who are the ones who are the most and likely the ones who will benefit the most from exploration .
Speaker #5: We've been very busy with demos here at our Emeryville site , as well as at some partner sites , as well . So I think that bodes well for how things are lining up .
Speaker #5: Obviously , exploration itself in terms of the instrument purchase is a is a capital expenditure , and we feel like our timing of launch was quite good .
Speaker #5: And being very busy in the demo space in Q3 and into Q4 is very good timing . As as partners develop their budgets for 2026 and their capital spend plans .
Speaker #5: So we feel we feel good about where where we're placed , the feedback has been very positive around the efficiency of the instrument , the ease of use and kind of the broad user base from a lab perspective that exploration can enjoy .
Speaker #5: So we're feeling good about it .
Speaker #6: Great . Thank you very much .
Speaker #4: Thanks , Michael .
Speaker #3: Thank you. Your next question is from Joseph from H.C. Wainwright. Your line is now open.
Speaker #4: Hey , Joe , are you .
Speaker #7: There ?
Speaker #8: Yeah . Hi . Can you hear me ? This is Sarah on for Joe . Sorry if it was muted . Hey .
Speaker #4: Yeah , we can hear you now . Sarah .
Speaker #8: Yeah . Great . Thanks for taking the question . I just had one regarding Omni ultra and just wanted to get a sense of launch readiness .
Speaker #8: And if you're able to at this point , you know elaborate on the readiness of Omni Ultra for launch , has there been any beta or pilot projects completed or any potential partners that you already have lined up to adopt the platform ?
Speaker #8: Once it goes live next month ? Thank you .
Speaker #5: Yeah , yeah . Sarah , we've done a substantial amount of validation work around Omni Oltra with many , many targets that we know are of interest to the industry .
Speaker #5: So that's that's work we've been doing here internally . And part of why we're launching the technology with two podium presentations at at the Att conference .
Speaker #5: So we'll talk in a lot more detail about that specific work at at the scientific conference at the time of launch . So we have a really good sense of the breadth of applicability of this technology .
Speaker #5: And I think are really well positioned for for the launch in December . So hopefully that answers your question .
Speaker #9: I guess what I'm getting at .
Speaker #8: Yeah , it does . Thanks .
Speaker #9: Just starting right . Like how much is necessary to say . That .
Speaker #3: Thank you . Your next question is from Kripa Deverakonda from tryst . Your line is open .
Speaker #4: Hi .
Speaker #10: This is Alex on for Kripa . We also have a question on exploration and it sounds like the conversations have been going really well and do you have any update on the new thinking as to how much revenue can be generated from ?
Speaker #10: Exploration and over what time period ?
Speaker #5: Yeah , it's still early days and the exploration launch , obviously , we have said we expect exploration to be accretive to both earnings and cash flow in both the short and the long term .
Speaker #5: That has a lot to do with kind of how the technology has been designed and how we're implementing the launch . There are multiple revenue streams that are associated with exploration .
Speaker #5: Of course , the instrument sale itself , which which will bring revenue . And we have a nice margin on on the instrument .
Speaker #5: And then we also have single use proprietary consumables as well as service contracts and maintenance contracts . So we've not given precise guidance at this point .
Speaker #5: I think as we progress through the launch , as we get additional instruments sold and deployed , we'll have more visibility there . But but we're feeling really good about how it's positioned .
Speaker #10: That makes sense . And a little bit of a follow up . Are there other trade shows that you're also demonstrating the technology and partnerships with , or is it mainly through the the conversations directly with the companies ?
Speaker #5: No , we are also present at at at trade shows where we know our partners will be actually in addition to launching Omni Ultra at Att , for instance , we'll also have a substantial exploration presence there as well .
Speaker #5: And then we have some other other ones lined up as well , where we'll have demo units and be doing either virtual or planning in person demos with partners .
Speaker #10: All right . Thank you very much .
Speaker #3: Thank you . Your next question is from Matt from Craig-hallum . Your line is now open .
Speaker #11: Good afternoon . Thanks for taking the questions . Maybe first up , it sounds like you had and I realize this is just part of the the the business , but you had a couple of customers that pushed out programs until 2026 .
Speaker #11: Milestones that you would anticipated later this year got pushed to 26 . Are you seeing any improvement ? We've heard from several companies this earnings season that between the M&A activity , that's that's been pretty active as well as the funding environment that's been improving for small and mid-size pharma that the R&D budgets are kind of coming back online , that they're they're starting to to spend .
Speaker #11: And I'm just curious if if this is just kind of a one off with a . Couple partners or are you seeing a little bit more of a broad trend that things are getting pushed to 2026 ?
Speaker #5: Yeah . Thanks , Matt . I mean , broadly , and we kind of noted this really starting late in Q4 of last year with strong program additions , momentum .
Speaker #5: Right . We are seeing continued momentum in program additions . That has been sustained through this year , which is very good to see .
Speaker #5: And and I think we're continuing to see momentum there . The , the connection , the or the element of milestones being pushed into 2026 .
Speaker #5: I would in this instance , categorize that as more what I consider standard development stuff . Right ? So it's timing of of clinical batches or , or , you know , processes in clinical startup , things like that .
Speaker #5: In some , in some instances these were programs where partners had communicated to us their plan to start in Q4 and also had had committed that plan publicly .
Speaker #5: But just with kind of development items had drifted into early 2026 . So a variety of factors . But we are seeing standard what you were describing in terms of industry momentum .
Speaker #5: We're seeing that in the form of strong program additions . Interestingly , we're also seeing with some of our academic partners . In increased focus on forming spin out companies around assets and being much more focused on monetization of programs and assets that have come or can come out of our technology .
Speaker #5: So that's kind of another interesting thing . We're starting to see as well . But hopefully that that gives you some color .
Speaker #11: No , that's very helpful . Thank you . And then maybe kind of a similar line here but and I realize it's early .
Speaker #11: It's it's October . But as you're having these conversations with your partners , what are you hearing as far as 26 R&D budgets are concerned ?
Speaker #11: I think there was a lot of
Speaker #11: guess , excitement that 2025 budgets looked pretty good similar to relative to 24 . And I realize there's been some fits and starts during the year , but it does feel like maybe those budgets are going to get spent or conversations kind of indicating that we might see an increase in R&D budgets .
Speaker #11: And I guess tied to that with exploration . Do you anticipate that the feedback that you're getting is that , you know , this is a Q1 purchase decision , or could you still see some of these boxes sold already this year ?
Speaker #11: Thank you .
Speaker #5: Yeah . Thanks , Pat . So probably our one of our best is in the form of program starts . Right . That's really what we see is that when you see a new program start for a novel target .
Speaker #5: Right . A lot of work in terms of novel biology goes on upstream of that by the partner . They've obviously committed a project team and they're starting a program so that , again , we've seen really nice , strong program addition momentum .
Speaker #5: This year . And that's been good to see . So I think that's a good indicator . Most of our specific discussions around budget and budget planning more recently have been centered around exploration .
Speaker #5: And that's really just in the capital . Capital realm . And and then downstream exact timing of orders can obviously be dependent on a variety of factors at the partner in terms of what what work they're doing , when and how they're gating out their capital .
Speaker #5: Spend in 2026 . So that's that's kind of what we're seeing . .
Speaker #5: yeah , line is now
Speaker #11: All right . Thank you .
Speaker #3: Thank you for your next question is from Brendan Smith from TD . Karen . Your
Speaker #3: open .
Speaker #6: Great . Thanks guys for taking the .
Speaker #12: Questions . Maybe just a quick one . First on on Omni ultra . Again fully appreciate it early . But can you maybe just help us understand how you all are thinking about the potential economics of some of those partnerships ?
Speaker #12: Maybe just relative to some of the other offerings that you guys have , or ones on the books ? And if you're envisioning maybe there could be different terms based on how they want to use it , whether for antibodies or peptides or what have you .
Speaker #12: And maybe just if you anticipate any of those could potentially replace some of the existing partnerships in any instances . Thanks .
Speaker #5: Yeah . Brendan , I think we Omni Ultra as additive to the business right . Broadly applicable . And opening up new fields for us .
Speaker #5: Obviously , our our stable and large ecosystem of antibody based partners . Now at 104 , many of those have or will have or already have expressed interest in Omni ultra for things like Bispecifics or Car-T therapies .
Speaker #5: We have a number of partners in the radio pharma space , which is also a space that is growing rapidly as well . And I think we'll continue to expand .
Speaker #5: But this really also adds an entirely new set of potential partners who are interested in peptide discovery . For some of our our larger partners .
Speaker #5: They also are working in peptides as well as antibodies . But then there's see a completely new set of of partners who are are more peptide focused .
Speaker #5: And that has really increased over the last couple of years with , you know , the the successes of the GLP one drugs , etc.
Speaker #5: . So there's a there's a lot of investment going on in the peptide space . So we see it really as additive in terms of your question of of agreement structure .
Speaker #5: I think this does open new opportunities for us to drive service revenue in the near term for a variety of reasons . There's also a lot of precedent out there for peptide related discovery deals that follow the frameworks that we've built around upfront payments , service payments , milestones , and royalties .
Speaker #5: But precise terms will obviously be an interplay of of a variety of factors . Associated with with each license .
Speaker #12: Okay . Got it . And then maybe just quickly , if I could , with the follow up just on the partner pipeline , can you just speak a little bit to how you all are thinking about maybe the initial ramp in some of these royalties ?
Speaker #12: Just I know it's kind of a range of different spaces . You know , you all are partnered in between and Pcsk9 . PD one .
Speaker #12: So just kind of wondering where you maybe see the fastest opportunity for some of those royalties to grow versus others that might just take a little bit longer to get up and running .
Speaker #12: Thanks , guys .
Speaker #5: Yeah , yeah . I mean , I'll maybe I'll talk generally about some of the programs and then Kurt can , can maybe talk a little bit about kind of the revenue generally modeling around how milestones and royalties come into play .
Speaker #5: But now obviously we have two , two drugs that are in the in the registration bucket . Both of those currently in , in China , the newest is the Sal W003 , which is the anti Pcsk9 .
Speaker #5: You referred to . So that was news here just from , you know , 4 or 5 weeks back from from Salubris . And they reported they submitted their , their NDA submission .
Speaker #5: It was accepted in China . They mentioned in their , their public disclosures that the NDA aligns with China's accelerated approval framework for high impact biologics .
Speaker #5: So that was generally good to hear . And then they've stated publicly they're positioning for market entry in 2026 . They've also kind of highlighted comparable or superior efficacy to other anti-pcsk9 therapies .
Speaker #5: And one that will be that was developed domestically in China . So we'll we'll continue to to keep an eye on that . That's a drug that came originally out of our partner early partnership with Wuxi for our rodent platforms .
Speaker #5: And it has a 3% global royalty associated with it . So that's that's probably the newer one . And then as you look at the phase three assets and phase two assets , there are a number in there that folks are rightly paying attention to .
Speaker #5: Immunovant doing great work around Imv 1402 and has a couple of expected data events next year that that we're obviously keeping an eye on with Genmab is in phase three trials as well .
Speaker #5: That's another one that that folks are paying attention to . And then now we're starting to see growing attention around Teva's 53 408 , which is an IL 15 for celiac .
Speaker #5: And and they're also pursuing some other indications . They've been really moving that quite aggressively . And highlighting the program . So we're cheering that on as well .
Speaker #5: But maybe you want to talk through the .
Speaker #4: Yeah , I mean I think in terms of , you know , how we think about the royalty ramp , we typically take a look at what , you know , analysts consensus are for these drugs .
Speaker #4: So both occasions and the 1402 compound I mean Genmab has been out there said that they expect to launch in 2028 . When I take a look at analyst estimates , that's sort of what they're projecting as well .
Speaker #4: And there's a ramp associated with that . Similar with similar timing for 1402 . So we take a look at those . Analysts expectations in terms of how we how we model the royalties that we might ultimately get .
Speaker #4: And , you know , they're pretty nice ramps . And people have pretty nice forecasts associated with both of those compounds . They're they're expected to be very large drugs .
Speaker #12: Got it. Makes sense. Thanks, Chris.
Speaker #4: Thanks , Brendan .
Speaker #3: Thank you . Your next question is from Steven Wyllie from Stiefel . Your line is now open .
Speaker #13: Hey . Good afternoon . This is Josh on for Steve . Thanks for taking our question . I just had a quick question on on the ultra and how it differs from Omniture .
Speaker #13: I think I remember Domnitor platform sounded very similar with this generation of these ultra long CDR or Cdr3 . Could you maybe just provide some color on how these platforms actually differ ?
Speaker #5: Yeah , yeah yeah , great . Great question . Josh , and I'll try not to get too geeky and technical . Omniture actually leverages cows , right ?
Speaker #5: So these are sequences that are derived out of cows and also we've developed some downstream workflows and other things that , that drive value in Omniture .
Speaker #5: And we actually have a number of active omniture programs , some of which are now at the preclinical stage approaching approaching IND Omni Ultra leverages a chicken host to get that advantage of the evolutionary distance .
Speaker #5: Right . So you're you're able to leverage that distance of chickens from mammals to elicit a stronger immune reaction . And we've also engineered in some other other features that have increased kind of the broad applicability of of omni Ultra into a variety of spaces , including opening up opportunities in the peptide space .
Speaker #5: So that the core the difference is , is the host . But there are obviously a number of other kind of finer technical details that that broaden the applicability of Omni Ultra .
Speaker #13: Okay , great . Thank you . And then just another question on the exploration revenues . Is there any color you could maybe offer as to the breakdown between , you know , maybe the consumables versus the software versus the hardware ?
Speaker #13: And do you think do you anticipate maybe in the future , providing any kind of metrics around the breakdown of sales related to exploration platform ?
Speaker #4: Yeah . No , it's a it's a good question . I think there's there's not really a breakdown that we'll have for you this quarter .
Speaker #4: You know , it wasn't a huge amount of revenue . It was , I guess I would say it was mostly related to consumables .
Speaker #4: You know , I think it's still early days with the exploration launch . As we get more into it , I think we'll probably be able to provide some a little bit more color on sort of what the average consumable usage is per instrument and , you know , put put out some other metrics like that .
Speaker #4: But at this point , it's still pretty early . So , you know , stay stay tuned for that . As as we see the launch continue and progress , hopefully we'll be able to provide that type of color .
Speaker #13: Great . Thanks for taking our question .
Speaker #4: Yeah . No thank you .
Speaker #3: Thank you . There are no further questions at this time . I will now hand the call back over to Matt for for the closing remarks .
Speaker #5: Great . Thank you . Operator , I'd like to thank everyone for joining us today . On today's call . And for your questions .
Speaker #5: And engagement . We look forward to discussing our fourth quarter financial results early next year . In the meantime , we'll be participating in a number of investor conferences later this month , including Truist Biopharma Symposium .
Speaker #5: This week in New York , Healthcare Conference . That is next week , and the Jefferies Global Health Conference in London . So as I mentioned , on December 15th , we'll also have a we'll be formally launching Omni Ultra , and we'll have an investor webcast that day as well .
Speaker #5: And we look forward to providing additional details on that webcast next month. So, thanks again, and have a great afternoon.
Speaker #3: Thank you , ladies and gentlemen , the conference has now ended . Thank you all for joining . You may also connect your lines .