Q1 2026 Ligand Pharmaceuticals Inc Earnings Call

May 7, 2026

Operator 3: Hello, everyone. Thank you for joining us, and welcome to Ligand Q1 2026 earnings call. After today's prepared remarks, we will host a question and answer session. If you would like to ask a question, please press star one to raise your hand. To withdraw your question, press star one again. I will now hand the conference over to Melanie Herman. Please go ahead.

Operator: Hello, everyone. Thank you for joining us, and welcome to Ligand Q1 2026 Earnings call. After today's prepared remarks, we will host a question and answer session. If you would like to ask a question, please press star one to raise your hand. To withdraw your question, press star one again. I will now hand the conference over to Melanie Herman. Please go ahead.

Speaker #1: If you would like to ask a question, please press star one to raise your hand. To withdraw your question, press star one again. I will now hand the conference over to Melanie Herman, head please go ahead.

Speaker #2: Good morning, everyone, and welcome to LIGAND's first quarter 2026 earnings call. With me on the call today are CEO Todd Davis, Chief Financial Officer Tavo Espinoza, Vice President of Portfolio Strategy and Investments Lauren Hay, and Vice President of Investments and Business Development Michael Vigilante.

Melanie Herman: Good morning, everyone, and welcome to Ligand's Q1 2026 Earnings Call. With me on the call today are CEO, Todd Davis, Chief Financial Officer, Tavo Espinoza, Vice President of Portfolio Strategy and Investments, Lauren Hay, and Vice President of Investments and Business Development, Michael Vigilante. During the call today, we will review the financial results released earlier today and provide commentary on our partner portfolio and business development activities, followed by a question and answer session. Before we get started, I would like to point out that we will be discussing non-GAAP results, which exclude certain items such as stock-based compensation, amortization of intangible assets, amortization or impairment of financial assets, and gains or losses from derivative assets, amongst others.

Speaker #2: During the call today, we will review the financial results released earlier today and provide commentary on our partner portfolio and business development activities, followed by a question and answer session.

Speaker #2: Before we get started, I would like to point out that we will be discussing non-GAAP results, which exclude certain items, such as stock-based compensation, amortization of intangible assets, amortization or impairment of financial assets, and gains or losses from derivative assets, amongst others.

Speaker #2: I encourage you to review the reconciliation of these non-GAAP measures to their most directly comparable GAAP measures, which can be found in today's release available on our website.

Melanie Herman: I encourage you to review the reconciliation of these non-GAAP measures to their most directly comparable GAAP measures, which can be found in today's release available on our website. We believe these adjusted measures provide valuable insight into our core operating performance, both historically and moving forward. Our earnings release and a link to today's webcast can be found in the investor relations section of our website at ligand.com. This call is being recorded and the audio portion will be archived in the investor section of our website. On today's call, we will make forward-looking statements regarding our financial results and other matters related to the company's business.

Speaker #2: We believe these adjusted measures provide valuable insight into our core operating performance, both historically and moving forward. Our earnings release and a link to today's webcast can be found in the investor relations section of our website, at ligand.com.

Speaker #2: This call is being recorded, and the audio portion will be archived in the investor section of our website. On today's call, we will make forward-looking statements regarding our financial results and other matters related to the company's business.

Speaker #2: Please refer to this safe harbor statement related to these forward-looking statements, which are subject to risks and uncertainties. We remind you that actual events or results may differ materially from those projected or discussed, and that all forward-looking statements are based upon current available information.

Melanie Herman: Please refer to the Safe Harbor statement related to these forward-looking statements, which are subject to risks and uncertainties. We remind you that actual events or results may differ materially from those projected or discussed, and that all forward-looking statements are based upon current available information. Ligand assumes no obligation to update these statements. To better understand the risks and uncertainties that could cause actual results to differ, we refer you to the documents that Ligand filed with the Securities and Exchange Commission, or SEC, that can be found on Ligand's website at ligand.com or on the SEC's website at sec.gov. With that, I will now turn the call over to Todd.

Speaker #2: LIGAND assumes no obligation to update these statements. To better understand the risks and uncertainties that could cause actual results to differ, we refer you to the documents that LIGAND files with the Securities and Exchange Commission, or SEC, that can be found on LIGAND's website, at ligand.com, or on the SEC's website, at sec.gov.

Speaker #2: With that, I will now turn the call over to Todd.

Speaker #3: Thank you, Melanie, and good morning, everyone. We appreciate you joining us today. 2026 is off to an exciting start for LIGAND, with transformative milestones within our existing portfolio, and through the anticipated acquisition of Zoma Royalty Corporation that we announced last week.

Todd Davis: Thank you, Melanie, and good morning, everyone. We appreciate you joining us today. 2026 is off to an exciting start for Ligand with transformative milestones within our existing portfolio and through the anticipated acquisition of XOMA Royalty Corporation that we announced last week. Though it is still early in 2026, we are showing significant financial performance already with 56% royalty revenue growth over the first quarter of 2025 and 23% EPS growth over the same period in 2025. This is in the context of a broad portfolio, so it is not just serendipity or the result of a single fortunate product approval. This is the result of an intentional strategy change that we executed on in 2022. At that point, we shifted into a pure royalty aggregation model and away from the development of infrastructure-heavy technology platforms.

Speaker #3: Though it is still early in 2026, we are showing significant financial performance already, with 56% royalty revenue growth over the first quarter of 2025.

Speaker #3: And 23% EPS growth over the same period in 2025. This is in the context of a broad portfolio, so it is not just serendipity or the result of a single fortunate product approval.

Speaker #3: This is the result of an intentional strategy change that we executed on in 2022. At that point, we shifted into a pure royalty aggregation model and away from the development of infrastructure-heavy technology platforms.

Speaker #3: In 2022 to 2023, we divested two platform businesses, and went from almost 200 employees down to approximately 40. This took operating expenses from the $90 million range down to about the $40 million range.

Todd Davis: In 2022 to 2023, we divested two platform businesses and went from almost 200 employees down to approximately 40. This took operating expenses from the $90 million range down to about the $40 million range. The profitability of the company and the operating leverage of our model improved dramatically. We subsequently added a very experienced investment deal team and began executing on royalty aggregation through three main deal approaches. Royalty monetizations of existing licenses, project finance, and special situations where we engage operationally and rescue good assets trapped in challenging situations. Since then, we have a deal organization of 18 people executing on these various tactics as we pursue assets that address serious unmet needs for patients.

Speaker #3: The profitability of the company and the operating leverage of our model improved dramatically. We subsequently added a very experienced investment deal team and began executing on royalty aggregation through three main deal approaches.

Speaker #3: Royalty monetizations of existing licenses, project finance, and special situations where we engage operationally and rescue good assets, trapped in challenging situations. Since then, we have a deal organization of 18 people executing on these various tactics as we pursue assets that address serious unmet needs for patients.

Speaker #3: We have gone from seven commercial assets to 15 commercial assets and have closed on 18 deals in the last three years, adding high-potential assets into our late-stage clinical pipeline as well.

Todd Davis: We have gone from 7 commercial assets to 15 commercial assets and have closed on 18 deals in the last 3 years, adding high-potential assets into our late-stage clinical pipeline as well. This bodes well for our future growth and for the development of high-value medicines for patients. Pursuing medicines that are impactful for patients is also good for business. Our EPS in that timeframe has gone from $2.44 a share in 2022 to our guidance for 2026 of $8.50 to $9.50 per share. For Q1 of the year, Tavo and Lauren will show significant value opportunity in our commercial portfolio, including growth drivers such as FILSPARI, Ohtuvayre, and Qarziba.

Speaker #3: This bodes well for our future growth and for the development of high-value medicines for patients. Pursuing medicines that are impactful for patients is also good for business.

Speaker #3: Our EPS and net timeframe has gone from $2.44 a share in 2022 to our guidance for 2026 of $850 to $950 per share. For the first quarter of the year, Tavo and Lauren will show significant value opportunity in our commercial portfolio, including growth drivers such as Philspari, O2 There, and Carzeba.

Speaker #3: We also saw exciting progress in Pavella's Qtorin rapamycin for MLMs, which achieved positive top-line phase two results and has the potential to become the first FDA-approved therapy and first-line standard of care treatment for an estimate of more than 30,000 diagnosed patients.

Todd Davis: We also saw exciting progress in Palvella's QTORIN rapamycin for MLMs, which achieved positive top-line phase II results and has the potential to become the first FDA-approved therapy and first-line standard of care treatment for an estimate of more than 30,000 diagnosed patients. In April, we announced our largest deal to date, the acquisition of XOMA Royalty, which will add more than 120 commercial, clinical, and preclinical stage assets into our royalty portfolio. Upon closing, XOMA is expected to be immediately accretive and further accelerate our long-term growth and earnings potential, as reflected in our updated financial guidance. XOMA will add seven marketed products and nearly double our portfolio of phase II and phase III assets, which we believe will create significant value for our stockholders, all through a single transaction.

Speaker #3: In April, we announced our largest deal to date, the acquisition of Zoma Royalty, which will add more than $120 commercial, clinical, and preclinical stage assets into our royalty portfolio.

Speaker #3: Upon closing, Zoma is expected to be immediately accretive and further accelerate our long-term growth and earnings potential as reflected in our updated financial guidance.

Speaker #3: Zoma will add seven marketed products and nearly double our portfolio of phase two and phase three assets, which we believe will create significant value for our stockholders, all through a single transaction.

Speaker #3: Also in April, we were pleased to see Traverse announcement of the full FDA approval of Philspari and FSGS, making it the first and only approved medicine for FSGS and marketing its expansion beyond IgA nephropathy into a second rare kidney disease.

Todd Davis: Also in April, we were pleased to see Travere's announcement of the full FDA approval of FILSPARI in FSGS, making it the first and only approved medicine for FSGS and marking its expansion beyond IgA nephropathy into a second rare kidney disease. This is an important milestone for people living with FSGS, who for the first time have an FDA-approved medicine for this rare and devastating condition. FILSPARI is an important program for Ligand and recently became our largest commercial royalty asset. We expect the expansion into FSGS will continue to drive significant growth for Ligand in the coming years. We continue to execute on the strategy that we set place in 2022 and have a strong belief in this business model. The acquisition of XOMA Royalty is expected to add $0.50 a share of adjusted EPS in 2026 and $1.50 in 2027.

Speaker #3: This is an important milestone for people living with FSGS, who for the first time have an FDA-approved medicine for this rare and devastating condition.

Speaker #3: Philspari is an important program for LIGAND and recently became our largest commercial royalty asset. We expect the expansion into FSGS will continue to drive significant growth for LIGAND in the coming years.

Speaker #3: We continue to execute on the strategy that we set place in 2022 and have a strong belief in this business model. The acquisition of Zoma Royalty is expected to add $0.50 a share of adjusted EPS in 2026 and $1.50 in 2027.

Speaker #3: These financial results are validating evidence of this compounding strategy and our acquisition of Zoma Royalty further accelerates our ramping growth. Zoma's significant upside potential also draws from its earlier stage opportunities and longer dated IP and royalty rights, some of which extend past 2040.

Todd Davis: These financial results are validating evidence of this compounding strategy, and our acquisition of XOMA Royalty further accelerates our ramping growth. XOMA's significant upside potential also draws from its earlier-stage opportunities and longer-dated IP and royalty rights, some of which extend past 2040. Over the last couple of years, Ligand has scaled the business and our portfolio management system in anticipation of absorbing new assets into our portfolio. As a result, we anticipate very significant operational and financial synergies as we integrate the XOMA portfolio. We believe this approach will continue to deliver compounding profitable growth for our shareholders. With long-dated royalty cash flow, proprietary financing capabilities, and increased financial strength through this acquisition strengthens our position as a biopharma royalty aggregator. Since we put out our last five-year outlook for royalty receipts in December 2025, we've had several positive catalysts.

Speaker #3: Over the last couple of years, LIGAND has scaled the business and our portfolio management system in anticipation of absorbing new assets into our portfolio.

Speaker #3: As a result, we anticipate very significant operational and financial synergies as we integrate the Zoma portfolio. We believe this approach will continue to deliver compounding, profitable growth for our shareholders, with long-dated royalty cash flow, proprietary financing capabilities, and increased financial strength through this acquisition. This strengthens our position as a biopharma royalty aggregator.

Speaker #3: Since we put out our last five-year outlook for royalty receipts in December of 2025, we've had several positive catalysts, in addition to announcing our acquisition of Zoma Royalty, we expect the FDA's approval of Philspari and FSGS and Pavella's most recently announced positive phase three data in MLM for its Qtorin rapamycin will continue to add significant growth and value accretion over time.

Todd Davis: In addition to announcing our acquisition of XOMA Royalty, we expect the FDA's approval of FILSPARI in FSGS and Pelthos' most recently announced positive phase III data in MLM for its QTORIN rapamycin will continue to add significant growth and value accretion over time. Importantly, we continue to have significant balance sheet strength and cash flows, allowing us to opportunistically execute on additional value-creating partnerships as we have historically done. The pipeline is robust, we will be disciplined, but we are excited about the continued growth and value creation that we can deliver. We will share more about the longer-term view and update our 5-year plan at the Investor Day that we expect to hold in December of this year. With that, I would like to turn it over to Tavo for the financial update.

Speaker #3: Importantly, we continue to have significant balance sheet strength and cash flows, allowing us to opportunistically execute on additional value, creating partnerships as we have historically done.

Speaker #3: The pipeline is robust, and we will be disciplined, but we are excited about the continued growth and value creation that we can deliver. We will share more about the longer-term view and update our five-year plan at the investor day that we expect to hold in December of this year, and with that, I would like to turn it over to Tavo for the financial update.

Speaker #4: Thank you, Todd, and good morning, everyone. We're in a very strong position as a business, with multiple drivers contributing to both near-term performance and long-term growth.

Tavo Espinoza: Thank you, Todd, and good morning, everyone. We are in a very strong position as a business, with multiple drivers contributing to both near-term performance and long-term growth. Importantly, while FILSPARI has become a major growth driver for Ligand, it is only one component of a much broader growth story. The continued launch trajectory in IgAN and the expected expansion into FSGS represent an important inflection point for our royalty portfolio and long-term cash flow profile. At the same time, we're seeing encouraging early progress from ZELSUVMI following the Pelthos spin-out, where we earn a 13% royalty. We're also benefiting from continued contributions across Merck's portfolio, including Vaxnubance, CAPVAXIVE, and Ohtuvayre, which continues to gain traction following its launch. We also continue to benefit from Qarziba, a royalty asset we acquired through our acquisition of Apeiron in 2024.

Speaker #4: Importantly, wealth Philspari has become a major growth driver for LIGAND and is only one component of a much broader growth story. The continued launch trajectory in IGAND and the expected expansion into FSGS represent an important inflection point for our royalty portfolio and long-term cash flow profile.

Speaker #4: At the same time, we're seeing encouraging early progress from Selzubmi following the Pelto spin-out, where we own a 13% royalty. We're also benefiting from continued contributions across Merck's portfolio, including VAX Nubance, CapVaxiv, and O2 There, which continues to gain traction following its launch.

Speaker #4: We also continue to benefit from Carzeba, a royalty asset we acquired through our acquisition of Apiron in 2024. Overlaying all of this is the announced acquisition of Zoma Royalty, which we expect to further diversify and scale the portfolio and serve as a meaningful long-term growth accelerator.

Tavo Espinoza: Overlaying all of this is the announced acquisition of XOMA Royalty, which we expect to further diversify and scale the portfolio and serve as a meaningful long-term growth accelerator. Turning to our Q1 results, total revenue was $52 million, up 14% year-over-year. Royalty revenue was $43 million, increasing 56%, and adjusted EPS was $1.63, up 23%. These results reflect strong underlying momentum in the business, driven primarily by continued growth from FILSPARI, Ohtuvayre, and Qarziba. We ended the quarter with approximately $780 million in cash and investments, along with $200 million of undrawn capacity under our revolving credit facility, giving us nearly $1 billion of available capital as we move toward closing the XOMA transaction.

Speaker #4: Turning to our first-quarter results, total revenue was $52 million, up 14% year over year, royalty revenue was $43 million, increasing 56%, and adjusted EPS was $1.63, up 23%.

Speaker #4: These results reflect strong underlying momentum in the business, driven primarily by continued growth from Philspari, O2 There, and Carzeba. We ended the quarter with approximately $780 million in cash and investments, along with $200 million of undrawn capacity under our revolving credit facility.

Speaker #4: Giving us nearly $1 billion of available capital as we move toward closing the Zoma transaction. Looking more closely at royalties, Philspari continues to perform very well, with strong demand trends and growing position adoption.

Tavo Espinoza: Looking more closely at royalties, FILSPARI continues to perform very well, with strong demand trends and growing physician adoption. Travere has built a field force of over 100 professionals with meaningful overlap between IgAN and FSGS prescribers, which we believe will support a faster launch trajectory in FSGS. Ohtuvayre also delivered strong year-over-year growth. While sales were modestly impacted sequentially by seasonal dynamics and reimbursement timing, trends improved as the quarter progressed. Merck continues to invest in expanding awareness and adoption. On the expense side, R&D expense was $2.1 million in the quarter compared to $50.1 million in the prior year period. As a reminder, last year's results included a one-time $44 million accounting charge related to Castle Creek's funding of the phase III-B.5 study.

Speaker #4: Traverse has built a field force of over 100 professionals, with meaningful overlap between IGAND and FSGS prescribers, which we believe will support a faster launch trajectory in FSGS.

Speaker #4: O2 There also delivered strong year-over-year growth, while sales were modestly impacted sequentially by seasonal dynamics and reimbursement timing, trends improved as the quarter progressed, and Merck continues to invest in expanding awareness and adoption.

Speaker #4: On the expense side, R&D expense was $2.1 million in the quarter, compared to $50.1 million in the prior year period. As a reminder, last year's results included a one-time $44 million accounting charge related to Castle Creek's funding of the phase three DeFi study.

Speaker #4: GNA expense was $21 million, compared with $19 million in the prior year, reflecting higher employee-related costs as we continue to scale our business development function.

Tavo Espinoza: G&A expense was $21 million, compared with $19 million in the prior year, reflecting higher employee-related costs as we continue to scale our business development function. Importantly, we continue to operate with a highly efficient cost structure. As the business scales, we expect to see continued operating leverage. Non-operating expense was $41.6 million compared to $14 million in the prior year period, primarily driven by changes in the fair value of our investment in Pelthos and other equity holdings. These items are excluded from adjusted net income and do not impact the underlying performance of the business. From an earnings perspective, GAAP diluted earnings per share was a loss of $0.67 in Q1 compared to a loss of $2.21 in the prior year period.

Speaker #4: Importantly, we continue to operate with a highly efficient cost structure, and as the business scales, we expect to see continued operating leverage. Non-operating expense was $41.6 million, compared to $14 million in the prior year period.

Speaker #4: Primarily driven by changes in the fair value of our investment in Peltos and other equity holdings. These items are excluded from adjusted net income and do not impact the underlying performance of the business.

Speaker #4: From an earnings perspective, GAAP diluted earnings per share was a loss of 67 cents, in the first quarter, compared to a loss of $2.21 in the prior year period.

Speaker #4: The 2026 loss was primarily driven by fair value adjustments on our equity holdings, while the prior year loss largely reflects a one-time $44 million accounting charge related to our investment in Castle Creek.

Tavo Espinoza: The 2026 loss was primarily driven by fair value adjustments on our equity holdings, while the prior year loss largely reflects a one-time $44 million accounting charge related to our investment in Castle Creek. On an adjusted basis, diluted EPS increased to $1.63, up 23% year-over-year, reflecting strong operating leverage and higher royalty contributions. Turning now to guidance, consistent with the revised guidance we provided in connection with the Zoma announcement and assuming the acquisition closes in Q3, our 2026 total revenue outlook is $270 million to $310 million. Our royalty revenue outlook is $225 million to $250 million, and our adjusted EPS outlook is $8.50 to $9.50.

Speaker #4: On an adjusted basis, diluted earnings per share increased to $1.63, up 23% year over year, reflecting strong operating leverage and higher royalty contributions. Turning now to guidance, consistent with the revised guidance we provided in connection with the Zoma announcement, and assuming the acquisition closes in the third quarter, our 2026 total revenue outlook is $270 million, to $310 million.

Speaker #4: Our royalty revenue outlook is $225 million to $250 million, and our adjusted EPS outlook is $8.50 to $9.50. Looking ahead to 2027, we expect approximately $1.50 per share of incremental adjusted EPS from a full-year contribution of the Zoma portfolio.

Tavo Espinoza: Looking ahead to 2027, we expect approximately $1.50 per share of incremental adjusted EPS from a full-year contribution of the Zoma portfolio. We also expect combined operating cash flow of approximately $300 million, which reflects the benefit of the tax attributes acquired in the Zoma transaction, including Net Operating Losses and Section 174 R&D tax credits. Supports our capital deployment strategy of investing $150 million to $250 million annually in new royalty opportunities. We believe this creates a highly attractive model, one where strong tax-efficient cash generation funds continued portfolio expansion, driving further growth over time. Finally, I'd like to touch on the CVR associated with the Zoma acquisition. The CVR relates to potential proceeds from Zoma's litigation with Janssen.

Speaker #4: We also expect combined operating cash flow of approximately $300 million, which reflects the benefit of the tax attributes acquired in the Zoma transaction, including net operating losses and Section 174 R&D tax credits, and supports our capital deployment strategy of investing $150 annually, in new royalty opportunities.

Speaker #4: We believe this creates a highly attractive model when we're strong tax-efficient cash generation funds continued portfolio expansion driving further growth over time. Finally, I'd like to touch on the CBR associated with the Zoma acquisition.

Speaker #4: The CBR relates to potential proceeds from Zoma's litigation with Janssen, the litigation assets will remain in a post-reorganization Zoma LLC, which will distribute 75% of any net proceeds to former Zoma shareholders through the CBR.

Tavo Espinoza: The litigation assets will remain in a post-reorganization, Zoma LLC, which will distribute 75% of any net proceeds to former Zoma shareholders through the CVR, while Ligand will retain rights to the remaining 25%. Importantly, Ligand has no obligation to fund the litigation. As a result, there is no P&L impact associated with the case, only potential upside. With that, I'll turn it over to Lauren for a portfolio update.

Speaker #4: While LIGAND will retain rights to the remaining 25%. Importantly, LIGAND has no obligation to fund the litigation. As a result, there is no P&L impact associated with the case, only potential upside.

Speaker #4: With that, I'll turn it over to Lauren for a portfolio update.

Speaker #1: Thank you, Thiavo, and good morning, everyone. I'd like to focus today on two very important recent positive events in our portfolio. The first is the announcement of extremely successful phase three Salva trial results for Palvella's Qtorin rapamycin in microcystic lymphatic malformations.

Lauren Hay: Thank you, Tavo, and good morning, everyone. I'd like to focus today on two very important recent positive events in our portfolio. The first is the announcement of extremely successful phase III SELVA trial results for Palvella's QTORIN rapamycin in microcystic lymphatic malformations. QTORIN rapamycin demonstrated a highly statistically significant outcome on the primary endpoint and all secondary endpoints. On the primary endpoint, QTORIN rapamycin demonstrated a +2.13-point improvement on the MLM Investigator Global Assessment. This is clinically transformative for patients and even more compelling considering that there are no FDA-approved treatments for this serious, rare dermatological condition. For context, Palvella had guided to a change on the MLM IGA of +1 as being a decisive win with an upside case of +1.5 points.

Speaker #1: Qtorin rapamycin demonstrated a highly statistically significant outcome on the primary endpoint and all secondary endpoints. On the primary endpoint, Qtorin rapamycin demonstrated a positive 2.13-point improvement on the MLM investigator global assessment scale.

Speaker #1: This is clinically transformative for patients, and even more compelling considering that there are no FDA-approved treatments for this serious rare dermatological condition. For context, Palvella had guided to a change on the MLM IGA of positive one as being a decisive win with an upside case of positive 1.5 points.

Speaker #1: Palvella plans to submit an NDA in the second half of this year and is accelerating US launch readiness efforts. As a reminder, Qtorin rapamycin has been granted breakthrough therapy orphan drug and fast-track designations from the FDA for the treatment of MLM.

Lauren Hay: Palvella plans to submit an NDA in H2 of this year and is accelerating US launch readiness efforts. As a reminder, QTORIN rapamycin has been granted breakthrough therapy, orphan drug, and Fast Track designations from the FDA for the treatment of MLM. Palvella is also developing QTORIN rapamycin for the treatment of cutaneous venous malformations. In December, Palvella announced positive top-line results from its phase II TOIVA study. Palvella recently completed a very successful CVM breakthrough therapy designation meeting with the FDA and plans to submit a breakthrough application shortly. Across the two lead indications, there are estimated to be more than 100,000 patients diagnosed with either MLM or CVM. Based on payer research and orphan analog launches, Palvella projects an annual per-patient price of between $100,000 and $200,000.

Speaker #1: Palvella is also developing Qtorin rapamycin for the treatment of cutaneous venous malformations. In December, Palvella announced positive top-line results from its phase two Toiva study.

Speaker #1: Palvella recently completed a very successful CVM breakthrough therapy designation meeting with the FDA and plans to submit a breakthrough application shortly. Across the two lead indications, there are estimated to be more than 100,000 patients diagnosed with either MLM or CVM.

Speaker #1: Based on payer research and orphan analog launches, Palvella projects an annual per-patient price of between $100 and $200,000. At peak, this positions the US commercial opportunity for Qtorin rapamycin to reach an estimated $1 to $3 billion in US annual sales across the initial two indications.

Lauren Hay: At peak, this positions the US commercial opportunity for QTORIN rapamycin to reach an estimated $1 to 3 billion in US annual sales across the initial two indications. This could translate into a potential $100 to 300 million peak annual royalty revenue to Ligand if achieved. Moving on to the second major catalyst in our portfolio this year. In April, the FDA granted full approval of FILSPARI for the treatment of FSGS in patients without nephrotic syndrome. In our view, the approval was highly positive, given the broad label encompassing patients with primary, secondary, and genetic FSGS. From a commercial perspective, Travere estimates there are over 30,000 patients in the US with FSGS who are eligible for treatment with FILSPARI. With no approved therapeutic alternatives and serious unmet medical need, we are optimistic about the commercial potential in FSGS.

Speaker #1: This could translate into a potential $100 to $300 million peak annual royalty revenue to LIGAND if achieved. Moving on to the second major catalyst in our portfolio this year, in April, the FDA granted full approval of Sylspari for the treatment of FSGS in patients without nephrotic syndrome.

Speaker #1: In our view, the approval was highly positive, given the broad label encompassing patients with primary, secondary, and genetic FSGS. From a commercial perspective, Travier estimates there are over 30,000 patients in the US with FSGS who are eligible for treatment with Sylspari.

Speaker #1: With no approved therapeutic alternatives and serious unmet medical need, we are optimistic about the commercial potential in FSGS. Travier has an estimated nephrology team of over 100 field professionals with high overlap between IGAND and FSGS, and payer coverage is already established in IGAND, so we expect a rapid and successful launch.

Lauren Hay: Travere has an estimated nephrology team of over 100 field professionals with high overlap between IgAN and FSGS, and payer coverage is already established in IgAN. We expect a rapid and successful launch. Additionally, FILSPARI continues to perform well commercially in IgAN, and FILSPARI now represents the largest royalty in our portfolio. Travere has seen strong sales growth in IgAN, driven by the recent REMS modification, as well as updated KDIGO guidelines, even as new therapies have entered the market. Physician confidence continues to build as real-world experience reinforces the long-term clinical data and its role as a foundational non-immunosuppressive therapy. Across IgAN and FSGS, we believe FILSPARI is well-positioned for meaningful and accelerating revenue growth, and Travere has guided to a $3 billion peak opportunity across both indications, which would translate into a $270 million annual royalty to Ligand if achieved.

Speaker #1: Additionally, Sylspari continues to perform well commercially in IGAND, and Sylspari now represents the largest royalty in our portfolio. Travier has seen strong sales growth in IGAND, driven by the recent REMS modification, as well as updated CADIGO guidelines, even as new therapies have entered the market.

Speaker #1: Physician confidence continues to build as real-world experience reinforces the long-term clinical data and its role as a foundational non-immunosuppressive therapy. Across IGAND and FSGS, we believe Sylspari is well positioned for meaningful and accelerating revenue growth, and Travier has guided to a $3 billion peak opportunity across both indications, which would translate into a $270 million annual royalty to LIGAND if achieved.

Speaker #1: Taking a step back, we have 12 major royalty revenue drivers across our existing portfolio. As you can see by the boxes highlighted in green, five of these 12 products have been approved or acquired since 2022, as we have implemented a strategic focus on generating predictable compounding royalty revenue growth for our shareholders.

Lauren Hay: Taking a step back, we have 12 major royalty revenue drivers across our existing portfolio. As you can see by the boxes highlighted in green, 5 of these 12 products have been approved or acquired since 2022, as we have implemented a strategic focus on generating predictable, compounding royalty revenue growth for our shareholders. Moving to the next slide, we have 8 key pipeline programs we are currently focused on, 6 of which represent new investment activity since 2022. The growth in our commercial and clinical stage portfolio has been strategic, intentional, and methodical, as we are focused on adding high-value assets with the potential to address areas of high unmet medical needs, such as oncology, rare disease, and hypertension. Turning to our recently announced acquisition of XOMA Royalty, which is expected to close in Q3, I'd like to discuss XOMA's royalty portfolio.

Speaker #1: Moving to the next slide, we have eight key pipeline programs we are currently focused on, six of which represent new investment activity since 2022.

Speaker #1: The growth in our commercial and clinical stage portfolio has been strategic, intentional, and methodical, as we are focused on adding high-value assets with the potential to address areas of high unmet medical needs such as oncology, rare disease, and hypertension.

Speaker #1: Turning to our recently announced acquisition of Zoma Royalty, which is expected to close in the third quarter, I'd like to discuss Zoma's royalty portfolio.

Speaker #1: Zoma's assets will enhance LIGAND's portfolio in three distinct stages. First, Zoma's seven commercial programs including three key products, Vabizmo, Ojenda, and Maplifa provide near-term predictable revenue, as well as significant growth potential through geographic and indication expansion.

Lauren Hay: Zoma's assets will enhance Ligand's portfolio in 3 distinct stages. First, Zoma's 7 commercial programs, including 3 key products, Vabysmo, OJEMDA, and Myplxa, provide near-term predictable revenue, as well as significant growth potential through geographic and indication expansion. Zoma's 14 late-stage clinical programs represent the next wave of growth opportunities and are anticipated to further diversify the portfolio. As these programs reach approval and launch, they transition into royalty-generating assets and further expand the predictable compounding revenue base. Beyond that, Zoma has an extremely diverse array of over 100 earlier-stage programs that provide the foundation for long-term royalty portfolio longevity. Not only do these assets have the potential to generate significant long-term royalty revenue, they also have the potential to generate near-term development and regulatory milestone revenue. When we look at the full year, we've already seen several positive events in 2026.

Speaker #1: Zoma's Lefortine late-stage clinical programs represent the next wave of growth opportunities, and are anticipated to further diversify the portfolio. As these programs reach approval and launch, they transition into royalty-generating assets and further expand the predictable compounding revenue base.

Speaker #1: Beyond that, Zoma has an extremely diverse array of over 100 earlier stage programs that provide the foundation for long-term royalty portfolio longevity. Not only do these assets have the potential to generate significant long-term royalty revenue, they also have the potential to generate near-term development and regulatory milestone revenue.

Speaker #1: When we look at the full year, we've already seen several positive events in 2026. In addition to Palvella's positive phase three results in MLM, Palvella also announced the initiation of a phase two trial in clinically significant angiokeratomas.

Lauren Hay: In addition to Palvella's positive phase III results in MLM, Palvella also announced the initiation of a phase II trial in clinically significant angiokeratomas. Turning to FILSPARI, following its FDA approval, the first FSGS patients were treated within just 1 week, which is an encouraging indicator as we monitor the early stages of the launch. Looking ahead to additional potential catalysts expected this year across the Ligand portfolio, we anticipate continued geographic expansion of FILSPARI as Chugai advances towards regulatory submission in IgAN in Japan and Nuance awaits regulatory decisions for Ohtuvayre in China. On the clinical front, Orchestra BioMed and LeonaBio expect to complete enrollment of their pivotal trials this year, both representing important late-stage assets in Ligand's portfolio.

Speaker #1: Turning to Sylspari, following its FDA approval, the first FSGS patients were treated within just one week, which is an encouraging indicator as we monitor the early stages of the launch.

Speaker #1: Looking ahead to additional potential catalysts expected this year across the LIGAND portfolio, we anticipate continued geographic expansion of Sylspari as Chugai advances towards regulatory submission in IGAND in Japan, and Nuance awaits regulatory decisions for Otuvere in China.

Speaker #1: On the clinical front, Orchestra Biomed and Leona Bio expect to complete enrollment of their pivotal trials this year, both representing important late-stage assets in LIGAND's portfolio.

Speaker #1: Turning to the Zoma Royalty portfolio, one of the key pipeline partner programs—Felixavat, in development by Miram Pharmaceuticals for both primary sclerosing cholangitis and primary biliary cholangitis—announced positive phase two B data in patients with PSC earlier this week.

Lauren Hay: Turning to the XOMA Royalty portfolio, one of the key pipeline part-partner programs, volixibat, in development by Mirum Pharmaceuticals for both primary sclerosing cholangitis and primary biliary cholangitis, announced positive phase II-B data in patients with PSC earlier this week. Mirum has a pre-NDA meeting scheduled with the FDA this summer, with a planned NDA submission in H2 of this year. We're excited to see this important milestone for the PSC community, which currently has no approved therapies. Additionally, marketing decisions are expected in Japan for OJEMDA and Europe for Myplxa in H2 of this year, which will be growth drivers for these commercial products. With the vast size of the anticipated combined portfolio, these are just a few of the many important catalysts we expect in the coming months.

Speaker #1: Miram has a pre-NDA meeting scheduled with the FDA this summer, with a planned NDA submission in the second half of this year. We're excited to see this important milestone for the PSC community, which currently has no approved therapies.

Speaker #1: Additionally, marketing decisions are expected in Japan for Ojenda and Europe for Maplifa in the second half of this year, which will be growth drivers for these commercial products.

Speaker #1: With the vast size of the anticipated combined portfolio, these are just a few of the many important catalysts we expect in the coming months.

Speaker #1: In closing, with the acquisition of Zoma, we have never felt more confident about the potential of our portfolio both in the short-term and the long-term.

Lauren Hay: In closing, with the acquisition of Zoma, we have never felt more confident about the potential of our portfolio, both in the short term and the long term. With that, I will turn the call back over to Todd for his closing remarks.

Speaker #1: With that, I will turn the call back over to Todd for his closing remarks.

Speaker #2: Thank you, Lauren. We now have a deep and talented team at LIGAND, and we are incredibly proud of our dealmakers for driving our substantial growth.

Todd Davis: Thank you, Lauren. We now have a deep and talented team at Ligand, and we are incredibly proud of our deal makers for driving our substantial growth. The acquisition of XOMA Royalty represents an exciting opportunity to significantly grow our portfolio and accelerate our long-term growth profile with the addition of a highly complementary business. We are pleased with the progress of our incredible partners and late-stage development pipeline, specifically the strong trial results of Palvella's phase III MLM trial and the recent FDA approval of FILSPARI in FSGS. We have strong conviction around these important programs and are encouraged to see both the clinical development progress of QTORIN rapamycin in MLM and the expansion of FILSPARI into a second rare kidney disease.

Speaker #2: The acquisition of Zoma Royalty represents an exciting opportunity to significantly grow our portfolio and accelerate our long-term growth profile with the addition of a highly complementary business.

Speaker #2: Additionally, we are pleased with the progress of our incredible partners and late-stage development pipeline, specifically the strong trial results of Palvella's phase three MLM trial and the recent FDA approval of Sylspari in FSGS.

Speaker #2: We have strong conviction around these important programs and are encouraged to see both the clinical development progress of Q2 and rapamycin in MLM, and the expansion of Sylspari into a second rare kidney disease.

Speaker #2: While we are driving growth for our shareholders, we also do not lose sight of the broader goal of creating greater access to life-saving treatments and improving the lives of patients.

Todd Davis: While we are driving growth for our shareholders, we also do not lose sight of the broader goal of creating greater access to life-saving treatments and improving the lives of patients. We are privileged to be in a business where we can do well by doing good. Thank you, everyone, for joining us for today's earnings call. I will now pass it back to the operator and open it up for questions.

Speaker #2: We are privileged to be in the business where we can do well by doing good. Thank you everyone for joining us for today's earnings call.

Speaker #2: I will now pass it back to the operator and open it up for questions.

Speaker #3: Thank you. We will now begin the question-and-answer session. Please limit yourself to one question and one follow-up. If you would like to ask a question, please press star one to raise your hand.

Operator 3: Thank you. We will now begin the question and answer session. Please limit yourself to one question and one follow-up. If you would like to ask a question, please press star one to raise your hand. To withdraw your question, press star one again. We ask that you pick up your handset when asking a question, and if you are muted locally, please remember to unmute your device. Please stand by while we compile the Q&A roster. Your first question comes from the line of Matthew Hewitt from Craig-Hallum Capital Group. Please go ahead.

Operator: Thank you. We will now begin the question and answer session. Please limit yourself to one question and one follow-up. If you would like to ask a question, please press star one to raise your hand. To withdraw your question, press star one again. We ask that you pick up your handset when asking a question, and if you are muted locally, please remember to unmute your device. Please stand by while we compile the Q&A roster. Your first question comes from the line of Matthew Hewitt from Craig-Hallum Capital Group. Please go ahead.

Speaker #3: To withdraw your question, press star one again. We ask that you pick up your handset when asking a question, and if you are muted locally, please remember to unmute your device.

Speaker #3: Please stand by while we compile the Q&A roster. Your first question comes from the line of Matthew Hewitt from Craig Hallam Capital Group. Please go ahead.

Speaker #4: Good morning and thanks for providing the update and taking the questions. Maybe first up, could you explain how the Zoma deal came to pass and why it makes sense now?

Matthew Hewitt: Good morning, thanks for providing the update and taking the questions. Maybe first up, could you explain how the Zoma deal came to pass and why it makes sense now?

Todd Davis: Sure, Matt. Thanks for the question. For this question, I'll hand it over to Michael Vigilante, who was our deal lead on this. Michael?

Speaker #2: Sure, Matt. Thanks for the question. For this question, I'll hand it over to Michael Bigelante, who is our DEAL lead on this. Michael?

Todd Davis: Sure, Matt. Thanks for the question. For this question, I'll hand it over to Michael Vigilante, who was our deal lead on this. Michael?

Michael Vigilante: Can you hear me?

Speaker #5: Can you hear me?

Michael Vigilante: Can you hear me?

Speaker #2: Yeah. Go ahead.

Todd Davis: Yeah, go ahead.

Speaker #5: All right. Great. Yeah. Good morning, everybody. Yeah. Thanks for the question, Matt. So we've had a longstanding relationship with the Zoma team, a lot of respect for Owen and what they've accomplished.

Michael Vigilante: Hi. Great. Good morning, everybody. Thanks for the question, Matt. You know, Ligand, we've had a longstanding relationship with the Zoma team. A lot of respect for Owen and what they've accomplished. We believe their business has reached an inflection point. The parties engaged fulsomely in December. Ligand spent considerable time diligencing Zoma's portfolio and business at that time. Discussions continued into 2026, where we reached alignment on terms and structure in April. The transaction provides Zoma shareholders with liquidity and tracked returns since their pivot to a royalty aggregator model in 2017. For Ligand, the Zoma deal provides meaningful synergies via broadening our portfolio across commercial, all stages of development, accelerates our growth and has immediate EPS accretion, as well as long-term durable accretion.

Speaker #5: We believe their business has reached an inflection point. The party's engaged fulsomely in December. LIGAND spent considerable time diligencing Zoma's portfolio and business at that time.

Speaker #5: Discussions continued into reached alignment on terms and structure in April. The transaction provides Zoma shareholders with liquidity and attractive returns since their pivot to a royalty aggregator model in 2017.

Speaker #5: For LIGAND, the Zoma deal provides meaningful synergies via broadening our portfolio across commercial, all stages of development, accelerates our growth, and has immediate EPS accretion, as well as long-term durable accretion.

Speaker #4: Got it. Thank you. And then maybe as a follow-up, Todd, I think you noted in your prepared remarks that you've got a robust pipeline of targets.

Matthew Hewitt: Got it. Thank you. Maybe as a follow-up, you know, Todd, I think you noted in your prepared remarks that you've got a robust pipeline of targets. I'm curious, are there others in that pipeline similar to Zoma, meaning, you know, like a portfolio of assets, or do you expect to revert back to more of the individual drug investments? Thank you.

Speaker #4: And I'm curious, are there others in that pipeline similar to Zoma, meaning a portfolio of assets, or do you expect to revert back to more of the individual drug investments?

Speaker #4: Thank you.

Speaker #2: Sure. Good question, Matt. The majority of our pipeline are single or double assets. I think the Zoma portfolio is unique in its breadth. There are not many like this in the market.

Todd Davis: Sure. Good question, Matt. The majority of our pipeline are single or double assets. I think the Zoma portfolio is unique in its breadth. There are not many like this in the market that we know of. It is a fairly unique transaction. There are other special opportunities that would be larger deals that involve multiple assets, but not quite with this level of breadth.

Speaker #2: That we know of. And so it is a fairly unique transaction. There are other special opportunities that would be larger deals that involve multiple assets, but not quite with this level of breadth.

Speaker #4: Got it. Thank you.

Matthew Hewitt: Got it. Thank you.

Operator 3: Your next question comes from the line of Annabel Samimy from Stifel. Please go ahead.

Operator: Your next question comes from the line of Annabel Samimy from Stifel. Please go ahead.

Speaker #3: Your next question comes from the line of Annabelle Samimi from Stifel. Please go ahead.

Speaker #6: Hi. This is Jack Han for Annabelle. Thanks for taking our questions and congrats on the quarter. So to what extent does the earlier stage Zoma portfolio impact your commitment to conducting those four to five deal targets per year?

Jack: Hi, this is Jack on for Annabel Samimy. Thanks for taking our questions, and congrats on the quarter. To what extent does the earlier stage Zoma portfolio impact your commitment to conducting those four to five deal targets per year? It seems like you can do a lot of shopping there already for promising assets. Do you really see yourself needing to go external for additional deals for the remainder of the year?

Jack Padovano: Hi, this is Jack on for Annabel Samimy. Thanks for taking our questions, and congrats on the quarter. To what extent does the earlier stage Zoma portfolio impact your commitment to conducting those four to five deal targets per year? It seems like you can do a lot of shopping there already for promising assets. Do you really see yourself needing to go external for additional deals for the remainder of the year?

Speaker #6: It seems like you can do a lot of shopping there already for promising assets. So do you really see yourself needing to go external for additional deals for the remainder of the year?

Todd Davis: That's a great question. We don't need to do additional deals to sustain, you know, over 20% growth for the next 5 years. We have an immense amount of growth embedded in the current portfolio, but there's so much opportunity in kind of the late stage private to mid-cap project finance arena that we've been scaling the team to execute on that. We expect the addition of new deals and new assets in the portfolio to continue to compound the growth and drive it even higher, which is good for our investors. We will continue to do that.

Speaker #2: That's a great question. We don't need to do additional deals to sustain over 20% growth for the next five years. We have an immense amount of growth embedded in the current portfolio.

Speaker #2: But there is so much opportunity in kind of the late-stage private to mid-cap project finance arena that we've been scaling the team to execute on that.

Speaker #2: And so we expect the addition of new deals and new assets in the portfolio to continue to compound the growth and drive it even higher, which is good for our investors.

Speaker #2: So we will continue to do that.

Speaker #4: Great. Thanks.

Jack: Great. Thanks.

Jack Padovano: Great. Thanks.

Speaker #3: Your next question comes from the line of Igao Notromovich from Citigroup. Please go ahead.

Operator 3: Your next question comes from the line of Yigal Nochomovitz from Citigroup. Please go ahead.

Operator: Your next question comes from the line of Yigal Nochomovitz from Citigroup. Please go ahead.

Speaker #7: Hi. This is Juan Kim on for Igao. Thanks so much for taking our question. Maybe just two quick ones from us. Firstly, we noticed that you had reiterated guidance for the year following Trivia's record high new PSF for Sylspari.

Juan Kim: Hi, this is Juan Kim on for Yigal. Thanks so much for taking our question. Maybe just two quick ones from us. Firstly, we noticed that you had reiterated guidance for the year following Travere's record high new PFS for FILSPARI. Could you elaborate on the key performance indicators or specific achievements you would be looking for that might lead to an upward revision of FILSPARI's projected contribution for the remainder of the year?

Joohwan Kim: Hi, this is Joohwan Kim on for Yigal. Thanks so much for taking our question. Maybe just two quick ones from us. Firstly, we noticed that you had reiterated guidance for the year following Travere's record high new PFS for FILSPARI. Could you elaborate on the key performance indicators or specific achievements you would be looking for that might lead to an upward revision of FILSPARI's projected contribution for the remainder of the year?

Speaker #7: Could you elaborate on the key performance indicators or specific achievements you would be looking for that might lead to an upward revision of Sylspari's projected contribution for the remainder of the year?

Speaker #2: Yeah. Todd, go ahead.

Todd Davis: Yeah. Tavo, go ahead.

Speaker #6: Yeah. We had Sylspari for FSGS on a risk-adjusted basis included. In our model, coming into the year, and we talked about that at investor day.

Tavo Espinoza: Yeah. You know, we had FILSPARI for FSGS on a risk-adjusted basis included in our model coming into the year. We talked about that at Investor Day. Now that obviously it's approved, it's de-risked. It did as you'll recall, it did move over about a quarter. It was originally scheduled for approval in early January. It subsequently got approved in April. You know, that's a quarter of the year that kind of offsets the de-risking. It's incremental at best here in 2026, where we'll see a significantly more impactful impact from FSGS sales as we get out into, you know, 2028 and beyond.

Speaker #6: And so now that obviously it's approved, it's de-risked. But it did, as you'll recall, it did move over about a quarter. It was originally scheduled for approval in early January.

Speaker #6: It subsequently got approved in April. So that's a quarter of the year. That kind of offsets the de-risking. So it's incremental. At best, here in 2026, where we'll see a significantly more impactful impact from FSGS sales is as we get out into 2028 and beyond.

Speaker #6: But no impact on the 50. The 50 cent increase in guidance is purely related to the Zoma acquisition.

Tavo Espinoza: No impact on the 50. The $0.50 increase in guidance is purely related to the Zoma acquisition.

Speaker #4: Got it. Thanks so much. And if I could just throw in a second one here. We noticed the AK filing on in April regarding the tier beta program termination of Viking.

Juan Kim: Got it. Thanks so much. If I could just throw in a second one here. We noticed the 8-K filing in April regarding the tier beta program termination of Viking. Could you help us understand the strategic thinking here, specifically if twenty-eight oh nine and zero two one four assets are reclaimed, would you seek to repartner these out? Just to help frame the potential impact, how are these assets being carried on the books to set off from a royalty contribution standpoint?

Joohwan Kim: Got it. Thanks so much. If I could just throw in a second one here. We noticed the 8-K filing in April regarding the tier beta program termination of Viking. Could you help us understand the strategic thinking here, specifically if twenty-eight oh nine and zero two one four assets are reclaimed, would you seek to repartner these out? Just to help frame the potential impact, how are these assets being carried on the books to set off from a royalty contribution standpoint?

Speaker #4: Could you help us understand the strategic thinking here, specifically if the 2809 and 0214 assets are reclaimed, would you seek to repartner these out and just to help frame the potential impact?

Speaker #4: How are these assets being carried on the books, if at all, from a royalty contribution standpoint?

Speaker #2: Yeah. Thanks for the question. I'll let Todd answer the how it's being carried question. But our objective with 2809 is to move it forward in development so that patients can benefit from it.

Todd Davis: Yeah. Thanks for the question. I'll let Tavo answer the how it's being carried question. You know, our objective with 2809 is to move it forward in development so that patients can benefit from it. We think it's very high potential. We think it's demonstrated by the current MASH product that's in the market. There's strong demand and a need for products like 2809, and that it has very high potential to be a differentiated product in that market, which is quite large. Our objective is to get it moving forward in development, really. That's the reason for that. With regard to the how it's being carried, Tavo?

Speaker #2: We think it's very high potential. We think, as demonstrated by the current MASH product that's in the market, there is strong demand and a need for products like 2809, and that it has very high potential to be a differentiated product in that market, which is quite large.

Speaker #2: So our objective is to move is to get it moving forward in development, really. And that's the reason for that. And with regard to the how it's being carried, Todd?

Speaker #6: Yeah. There's nothing we don't carry anything on the balance sheet that we did have intangible assets on the books. Related to these at some point, those are fully amortized and financial impact as a result of this, maybe just some minor incremental legal expenses that nothing that will impact what we've already guided.

Tavo Espinoza: Yeah. There's nothing. We don't carry anything on the balance sheet that we did have intangible assets on the books related to these. At some point, those are fully amortized. Financial impact as a result of this, maybe just some minor incremental legal expenses, but nothing that will impact what we've already guided.

Speaker #4: Great. Thanks so much. Appreciate the call.

Juan Kim: Great. Thanks so much. Appreciate the color.

Joohwan Kim: Great. Thanks so much. Appreciate the color.

Speaker #3: Your next question comes from the line of Jason Sinanski from Bank of America. Please go ahead.

Operator 3: Your next question comes from the line of Jason Simansky from Bank of America. Please go ahead.

Operator: Your next question comes from the line of Jason Zemansky from Bank of America. Please go ahead.

Speaker #8: Hi. This is Jackie on for Jason. Congrats on the quarter and thanks for taking our question. Appreciating that Seafield is a smaller part of the portfolio, but with the recent label expansion to age one from age eight for the delaying progression to stage three type one diabetes, how does this change your view on the size of the opportunity?

Jackie: Hi, this is Jackie on for Jason. Congrats on the quarter, thanks for taking our question. Appreciating that C-field is a smaller part of the portfolio, with the recent label expansion to H1 from H8 for the delaying progression to stage 3 type 1 diabetes, how does this change your view on the size of the opportunity? Should we expect a meaningful shift in peak sales potential, how might that translate into royalties for Ligand? Thank you.

Jackie Plesset: Hi, this is Jackie on for Jason. Congrats on the quarter, thanks for taking our question. Appreciating that C-field is a smaller part of the portfolio, with the recent label expansion to H1 from H8 for the delaying progression to stage 3 type 1 diabetes, how does this change your view on the size of the opportunity? Should we expect a meaningful shift in peak sales potential, how might that translate into royalties for Ligand? Thank you.

Speaker #8: Should we be expecting meaningful shift in peak sales potential? And how might that translate into royalties for Ligon? Thank you.

Speaker #2: Yeah. Lauren, you want to take that?

Todd Davis: Yeah. Lauren, you want to take that?

Speaker #9: Yeah. Sure. So we were certainly encouraged to see that label expansion I think it's great for patients and their families that are on the younger end of the spectrum in terms of the type one diabetes onset.

Lauren Hay: Yeah, sure. We were certainly encouraged to see that label expansion. I think it's great for patients and their families that are on the younger end of the spectrum in terms of the type 1 diabetes onset. I'd say that it'd probably be an incremental addition to what we're seeing in terms of the KDIGO sales. This is really a market where we're having to identify patients before they become symptomatic, so it's quite a bit of investment that Sanofi is undertaking to go out and screen family members who are newly diagnosed and then find patients who'd be eligible in that kind of stage 2 of the disease.

Speaker #9: I'd say that it'd probably be an incremental addition to what we're seeing in terms of the two deal sales. This is really a market where we're having to identify patients before they become symptomatic.

Speaker #9: So it's quite a bit of investment that Sanofi is undertaking to go out and screen family members who are newly diagnosed and then find patients who'd be eligible in that kind of stage two of the disease.

Speaker #9: So, I'd say it'd be incremental. And we're certainly encouraged to see access available for some of the youngest patients who would now be eligible for treatment.

Lauren Hay: I'd say it'd be incremental, and we're certainly encouraged to see access available for some of the youngest patients, who would be now eligible for treatment. Thanks for the question.

Speaker #9: So thanks for the question.

Speaker #8: Great. Thank you.

Jackie: Great. Thank you.

Jackie Plesset: Great. Thank you.

Speaker #3: Your next question comes from the line from Sahil Dingray from RBC. Please go ahead.

Operator 3: Your next question comes from the line from Sahil Dhingra from RBC. Please go ahead.

Operator: Your next question comes from the line from Sahil Dhingra from RBC. Please go ahead.

Speaker #2: Hi. This is Sahil for Daphne. Thank you so much for taking our questions. My first question is on the captace on performance in the quarter, which was down year over year.

Sahil Dhingra: Hi, this is Sahil Dhingra for Daphne. Thank you so much for taking our questions. My first question is on the Captisol performance in the quarter, which was down year over year. How should we think about the pacing of contract revenue for the remainder of the year?

Sahil Dhingra: Hi, this is Sahil for Daphne. Thank you so much for taking our questions. My first question is on the Captisol performance in the quarter, which was down year over year. How should we think about the pacing of contract revenue for the remainder of the year?

Speaker #2: What gives you confidence in achieving the full-year captace on guidance? And also, how should we think about the pacing of contract revenue for the remainder of the year?

Speaker #10: Yeah. Todd, would you want to take the captace all question? And what was the second part? Pacing on deals?

Todd Davis: Yeah, Tavo, you wanna take the Captisol question? Was the second part, pacing on deals?

Tavo Espinoza: Contract revenue.

Speaker #2: Contract revenue.

Speaker #10: Yeah. Go ahead on both of those, Todd.

Todd Davis: Go ahead. I'll both of those, Tavo.

Speaker #2: Yeah.

Tavo Espinoza: Hi, Sahil. Thanks for the question. On the Captisol revenue line, we do have visibility to orders, you know, into early parts, into the early part of 2027. We're, you know, confident we'll be able to meet our guidance range of $35 to 40 million. It tends to be, you know, inconsistent. It's not linear quarter to quarter, largely due to the kind of the nature of the orders, the size of the orders that we get from some of our larger customers. You can expect the amounts to normalize here over the next few quarters. In terms of contract revenue, that's another one that's lumpy.

Speaker #6: Hi, Sahil. Thanks for the question. Yeah. On the captace all revenue line, we do have visibility to orders into early part into the early part of 2027.

Speaker #6: So we're confident we'll be able to meet our guidance range of 35 to 40 million dollars. It tends to be inconsistent. It's not linear.

Speaker #6: Quarter to quarter, largely due to the kind of the nature of the orders, the size of the orders that we get from some of our larger customers.

Speaker #6: But you can expect the amount to normalize here over the next three quarters. And in terms of contract revenue, that's another one that's lumpy.

Tavo Espinoza: It's, you know, the nature of that line that's, you know, obviously dependent on regulatory and commercial milestones reached by our partners. We have over 18 different milestone opportunities. Obviously, not all of those will come in at various sizes. Again, we feel very comfortable that we'll be able to meet our guidance range.

Speaker #6: It's the nature of that line that's obviously dependent on regulatory and commercial milestones reached by our partners. We have over 18 different milestone opportunities.

Speaker #6: Obviously, not all of those will come in at various sizes. But again, we feel very comfortable that we'll be able to meet our guidance range.

Speaker #2: Great. Thanks, Todd. And then my next question is related to the Zoma acquisition. Can you comment on the ease of challenge of integrating Zoma post-closing and how much in synergies are you expecting from that transaction?

Sahil Dhingra: Great. thanks, Tavo. My next question is related to the Zoma acquisition. Can you comment on the ease or challenge of integrating Zoma post-closing, and how much in synergies are you expecting from that transaction? Also, does integrating Zoma impact your deal activity in the near term, either in terms of deal size, capacity, or timelines? Thank you.

Speaker #2: And also, does integrating Zoma impact your deal activity in the near term, either in terms of deal size, capacity, or timelines? Thank you.

Speaker #10: Sure. Yeah. I think on the with regard to synergies on the Zoma, transaction, they're extremely high. Approaching 100%. Now, we are scaling our business, so we probably will pick off some of their team, which is talented.

Todd Davis: Sure. Yeah, I think on the with regard to synergies on the Zoma transaction, they're extremely high, approaching 100%. Now, we are scaling our business, so we probably will pick off some of their team, which is talented, if they're interested, obviously. There's a lease obligation, but the synergy is potentially approaching something, you know, close to 100%. This business is worth quite a bit, quite a bit to us. Plus, the tax benefits are immediately beneficial to us. We've kind of set up the business to absorb these types of partnerships, contractual passive partnerships, which is a very highly leverageable acquisition for us. The operating leverage around this is very beneficial. Could you just repeat, Sahil, the second part of your question?

Speaker #10: If they're interested, obviously. And there's a lease obligation, but the synergy is potentially approaching something close to 100%. So that's this business is worth quite a bit to us.

Speaker #10: Plus, the tax benefits are immediately beneficial to us. So we've kind of set up the business to absorb these types of partnerships, contractual passive partnerships, which is a very highly leverageable acquisition for us.

Speaker #10: So the operating leverage around this is very beneficial. And could you just repeat Sahil the second part of your question?

Speaker #2: Yeah. It was related to the other transactions. So does integrating Zoma impact your deal activity in the near term as it relates to size of a deal or timeline?

Sahil Dhingra: Yeah. It was related to the other transactions. Does integrating Zoma impact your deal activity in the near term as it relates to size of the deal or timelines?

Speaker #10: Yeah. Yeah. So we'll have access to a couple hundred million dollars post-transaction here. Our deal pace has been 150 to 250 million a year.

Todd Davis: Yeah. Yeah. We'll, we'll have access to, you know, a couple hundred million dollars post-transaction here. Our deal pace has been, you know, $150 to 250 million a year. And we're generating now, we're approaching, we're not quite there, but we're approaching, you know, $300 million a year in cash flow generation. We have, at this pace, essentially reached kind of a self-funding status almost. There's no need to do an immediate financing or anything like that. Our balance sheet will be in good shape. I will say that the opportunity in this late-stage private kind of midcap space for project financing and co-development funding and things like that is really very significant for non-dilutive capital.

Speaker #10: So and we're generating now we're approaching. We're not quite there, but we're approaching 300 million dollars a year in cash flow generation. So we have at this pace, essentially reached kind of a self-funding status almost.

Speaker #10: So there's no need to do an immediate financing or anything like that or balance sheet will be in good shape. I will say that the opportunity in this late-stage private's kind of mid-cap space for project financing and co-development funding and things like that is really very significant for non-dilutive capital.

Speaker #10: And so we have continued to scale our team and our execution capabilities. Our accelerating. So our pace could go up a little bit. But again, from a balance sheet and cash generation perspective, we're in a strong position to do that.

Todd Davis: We have continued to scale our team, and our execution capabilities are accelerating. Our pace could go up a little bit. Again, from a balance sheet and cash generation perspective, we're in a strong position to do that.

Speaker #2: Thank you.

Sahil Dhingra: Thank you.

Speaker #3: Your next question comes from the line of Joe Pantogenas from HC Wainwright & Co. Please go ahead.

Operator 3: Your next question comes from the line of Joseph Pantginis from H.C. Wainwright & Co. Please go ahead.

Operator: Your next question comes from the line of Joe Pantginis from H.C. Wainwright & Co. Please go ahead.

Speaker #11: Hey, everybody. Good morning. Thanks for taking the question. So I'm going to go a little bit slightly into the weeds on Zoma, and I'm also curious whether this could apply to your broader portfolio as well at Ligand.

Joseph Pantginis: Hey, everybody. Good morning. Thanks for taking the question. I'm gonna go a little bit slightly into the weeds on Zoma, and I'm also curious whether this could apply to your broader portfolio as well at Ligand. Zoma had acquired a few or multiple companies over the last 18 months or so, with the hope of outlicensing those assets.

Joe Pantginis: Hey, everybody. Good morning. Thanks for taking the question. I'm gonna go a little bit slightly into the weeds on Zoma, and I'm also curious whether this could apply to your broader portfolio as well at Ligand. Zoma had acquired a few or multiple companies over the last 18 months or so, with the hope of outlicensing those assets.

Speaker #11: So Zoma had acquired a few or multiple companies over the last 18 months or so. With the hope of outlicensing those assets, I was curious if you will be taking on that responsibility. And also, is that a potential for Ligand's current assets where, beyond attrition because of, say, negative news, do you have any assets in the future you might want to potentially offload?

Joseph Pantginis: Was curious if you will be taking on that responsibility, and also is that a potential for Ligand's current assets where, you know, beyond attrition because of, say, negative news, you have any assets in the future you might want to potentially offload?

Joe Pantginis: Was curious if you will be taking on that responsibility, and also is that a potential for Ligand's current assets where, you know, beyond attrition because of, say, negative news, you have any assets in the future you might want to potentially offload?

Speaker #10: Yeah. So I think that our we're in the business of identifying really high-value clinical opportunities that either require funding or require partnering. And so that's why we have kind of the three-pronged approach is sometimes it needs additional management or it needs a new home.

Todd Davis: I think that we're in the business of identifying really high-value clinical opportunities that either require funding or require partnering. That's why we have kind of the three-pronged approach, is sometimes it needs additional management or it needs a new home, sometimes it needs capital. We get involved in all of the above. That's why we've kind of scaled our portfolio management capability, because it's not just about doing new deals for us, it's about making sure that we farm the existing portfolio that we own and making it as highly productive as possible. We're constantly prioritizing and reprioritizing our own set of assets.

Speaker #10: Sometimes it needs capital. And we get involved in all of the above. And so that's why we've kind of scaled our portfolio management capability because it's not just about doing new deals for us.

Speaker #10: It's about making sure that we farm the existing portfolio that we own and making it as highly productive as possible. So we're constantly prioritizing and reprioritizing our own set of assets and if they stall out or if they need new partnering, we definitely will be engaged in outlicensing finding new homes, partnering, helping to back potentially those new companies or existing companies that we help finance to move valuable assets forward.

Todd Davis: If they stall out or if they need new partnering, we definitely will be engaged in out-licensing, finding new homes, partnering, helping to back potentially those new companies or existing companies that we help finance to move valuable assets forward. That's really the business that we're in. It's far more than just, you know, acquiring or monetizing passive royalties. We get involved with the portfolio management. Lauren Hay is heading that effort up, who's on the phone, so I'll just ask her to weigh in with any additional comments.

Speaker #10: So that's really the business that we're in. It's far more than just acquiring or monetizing passive royalties. We get involved with the portfolio management.

Speaker #10: And Lauren Hay is heading that effort up, who's on the phone, so I'll just ask her to weigh in with any additional comments.

Speaker #12: Yeah. So thanks for the question, Joe. I think Todd summarized things really well. We have a sizable existing portfolio at Ligand that we're always looking for opportunities to potentially repartner assets.

Lauren Hay: Yeah. Thanks for the question, Joe. I think that Todd summarized things really well. You know, we have a sizable existing portfolio at Ligand that we're always looking for opportunities to potentially repartner assets if the situation presents itself. You know, we did have an example of that late last year with lazofoxifene and getting that over to LeonaBio, which is now Leocor Bio. And we're really encouraged by the progress that that team is making on completing the phase III trial there, where we expected a readout next year. With the expected acquisition of the Zoma portfolio, that'll be certainly, you know, an opportunity for us to look across their existing programs in all stages of development and look for similar opportunities.

Speaker #12: If the situation presents itself, we did have an example of that late last year with Lisa Foxefine and getting that over to Ethereal, which is now Leona Bio.

Speaker #12: And we're really encouraged by the progress that that team is making on completing the phase three trial there. Where we expected a readout next year.

Speaker #12: And so with the expected acquisition of the Zoma portfolio, that'll be certainly an opportunity for us to look across their existing programs in all stages of development and look for similar opportunities.

Speaker #12: So we're well set up to do that and adding some resources to that effort. And we're excited about the opportunities in the short term and long term there.

Lauren Hay: We're well set up to do that and adding some resources to that effort, and we're excited about the opportunities in the short term and long term there. Thanks for the question.

Speaker #12: Thanks for the question.

Speaker #11: Great. Thank you very much.

Joseph Pantginis: Great. Thank you very much.

Joe Pantginis: Great. Thank you very much.

Speaker #3: Your final question comes from the line of John VanderMoosen from Zach. Please go ahead.

Operator 3: Your final question comes from the line of John Vandermosten from Zacks. Please go ahead.

Operator: Your final question comes from the line of John Vandermosten from Zacks. Please go ahead.

Speaker #13: Thank you. I wanted to start out with a question on the milestones. And if you look at Zoma's revenues last year, there was a good chunk from things like that.

John Vandermosten: Thank you. Wanted to start out with a question on the milestones. You know, if you look at Zoma's revenues last year, there was a good chunk from things like that. I'm wondering if you anticipate any milestones from Zoma in H2 of the year, 2026.

Speaker #13: And I'm wondering if you anticipate any milestones from Zoma in the second half of the year, 2026?

Speaker #10: Probably. Go ahead.

Todd Davis: Tavo, go ahead.

Speaker #2: Hey, John. Good morning. Thanks for the question. Yes. Zoma with the Zoma portfolio along with that comes a number of milestones, some of which we do have the opportunity to realize here in the second half of 2026.

Tavo Espinoza: Okay, John. Good morning. Thanks for the question. Yes, Zoma, with the Zoma portfolio, along with that comes a number of milestones, some of which we do have the opportunity to realize here in H2 2026, obviously, assuming the acquisition happens as expected in Q3. Yeah, that's, we do have an opportunity to realize some of those and significantly more as we get into the 2027 and 2028 beyond years.

Speaker #2: Obviously, assuming the acquisition happens as expected in the third quarter. But yeah, that's we do have an opportunity to realize some of those and significantly more as we get into the '27 and '28 beyond years.

John Vandermosten: Okay. Just taking a look at the R&D assets and the NOLs, you did mention that I guess there's some benefit from that expected in 2027. How quickly will you be able to use them, and I guess, what's the amount that you'll be able to use? Are you gonna lose any due to, you know, M&A restrictions or anything like that?

Speaker #13: Okay. And just taking a look at the R&D assets and the NOLs, you did mention that I guess there's some benefit from that expected in 2027.

Speaker #13: How quickly would we be able to use them? And I guess what's the amount that you'd be able to use? Are you going to lose any due to M&A restrictions or anything like that?

Speaker #2: Yeah. No, good question on that one, John. It is significant. We have been disclosed the quantum we're going to let the deal close and make sure we get through our entire financial diligence before we disclose the amount.

Tavo Espinoza: Good question on that one, John. It is significant. We haven't disclosed the quantum. We're gonna let the deal close and make sure we get through our entire financial diligence before we disclose the amount. You can get a sense if you want by looking at their financial statements, their annual report in particular. The NOLs that they've accumulated over time will be limited. However, the Section 174 R&D tax credits will come over 100%, and we will be able to make use of them immediately. It's gonna put us in a very tax-efficient position.

Speaker #2: You can get a sense if you want by looking at their financial statements, their annual report in particular. The NOLs that they've accumulated over time will be limited.

Speaker #2: However, the Section 174 R&D tax credits will come over 100%. And we will be able to make use of them immediately. So it's going to put us in a very tax-efficient position, so.

John Vandermosten: Great. Thanks, Tavo. That's all for me.

Speaker #13: Great. Thanks, Thabo. That's all from me.

Speaker #2: Yeah.

Tavo Espinoza: Yeah.

Speaker #3: At this time. There are no further questions. This concludes today's call. Thank you all for attending. You may now disconnect.

Operator 3: At this time, there are no further questions. This concludes today's call. Thank you all for attending. You may now disconnect.

Operator: At this time, there are no further questions. This concludes today's call. Thank you all for attending. You may now disconnect.

Speaker #10: Thank you.

Todd Davis: Thank you.

Speaker #3: And we're all clear. Thank you, everyone.

Operator 3: We're all clear. Thank you, every.

Operator: We're all clear. Thank you, every one.

Operator 1: This event has now concluded. Thank you for joining Ligand Q1 2026 Earnings Call. The line will disconnect automatically.

Operator: This event has now concluded. Thank you for joining Ligand Q1 2026 Earnings Call. The line will disconnect automatically.

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Q1 2026 Ligand Pharmaceuticals Inc Earnings Call

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Ligand Pharmaceuticals

LGND

Earnings

Q1 2026 Ligand Pharmaceuticals Inc Earnings Call

Thursday, May 7th, 2026 at 12:30 PM

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Ligand Pharmaceuticals

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